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Journal Articles

Overcoming Multidrug Resistance in B Cell Malignancies By Antagonism of Stromal Mediated TGF-β Signalling

Eugene Park, PhD, Jingyu Chen, PhD, Andrew Moore, PhD, Michael Leitges, Seth E. Frietze, PhD, Ingo Ringshausen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-141952
Published: 2020
Journal Articles

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

Eun Ji Gang, Hye Na Kim, Yao-Te Hsieh, Yongsheng Ruan, Heather A. Ogana, Solomon Lee, Jennifer Pham, Huimin Geng, Eugene Park, Lars Klemm, Cheryl L. Willman, William L. Carroll, Steven D. Mittelman, Etan Orgel, Matthew J. Oberley, Chintan Parekh, Hisham Abdel-Azim, Deepa Bhojwani, Alan S. Wayne, Adèle De Arcangelis, Elisabeth Georges-Labouesse, Elizabeth Wayner, Halvard Bonig, Aspram Minasyan, Johanna ten Hoeve, Thomas G. Graeber, Markus Müschen, Nora Heisterkamp, Yong-Mi Kim
Journal: Blood
Blood (2020) 136 (2): 210–223.
https://doi.org/10.1182/blood.2019001417
Published: 2020
Includes: Supplemental data
Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2738.
https://doi.org/10.1182/blood.V128.22.2738.2738
Published: 2016
Journal Articles

Prevalence of Anti-Human Factor VIII Binding IgG Antibodies in Sickle Cell Disease Patients before and after Hematopoietic Stem Cell Transplantation

Jay N Lozier, MD PhD, Eugene Park, BS, Chutima Kumkhaek, PhD, Mary E Link, BSN, Wynona Coles, MPH, Tiffani Taylor, PA, John F. Tisdale, MD, Matthew Hsieh, MD
Journal: Blood
Blood (2016) 128 (22): 3842.
https://doi.org/10.1182/blood.V128.22.3842.3842
Published: 2016
Journal Articles

Combined Targeting of JAK2 with a Type II JAK2 Inhibitor and mTOR with a TOR Kinase Inhibitor Constitutes Synthetic Activity in JAK2-Driven Ph-like Acute Lymphoblastic Leukemia

Ce Shi, PhD, Lina Han, PhD, Qi Zhang, Kathryn G. Roberts, Eugene Park, Yoko Tabe, MD PhD, Rodrigo Omar Jacamo, PhD, Hong Mu, MD PhD, Shuo-Chieh Wu, Jin Zhou, Helen Ma, Zhihong Zeng, MD, Nitin Jain, MD, Elias J Jabbour, MD, Markus Muschen, MDPhD, Sarah K Tasian, MD, Charles G. Mullighan, MBBS, MSc, MD, David M. Weinstock, David Fruman, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2529.
https://doi.org/10.1182/blood.V126.23.2529.2529
Published: 2015
Journal Articles

CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia

Jae-Woong Lee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Eugene PARK, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1434.
https://doi.org/10.1182/blood.V126.23.1434.1434
Published: 2015
Journal Articles

IFITM3 (CD225) Links the B Cell Antigen CD19 to PI3K-AKT Signaling in Human ALL Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Eugene PARK, PhD, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1325.
https://doi.org/10.1182/blood.V126.23.1325.1325
Published: 2015
Journal Articles

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

Courtney L. Jones, Christy M. Gearheart, Susan Fosmire, Cristina Delgado-Martin, Nikki A. Evensen, Karen Bride, Angela J. Waanders, Faye Pais, Jinhua Wang, Teena Bhatla, Danielle S. Bitterman, Simone R. de Rijk, Wallace Bourgeois, Smita Dandekar, Eugene Park, Tamara M. Burleson, Pillai Pallavi Madhusoodhan, David T. Teachey, Elizabeth A. Raetz, Michelle L. Hermiston, Markus Müschen, Mignon L. Loh, Stephen P. Hunger, Jinghui Zhang, Michael J. Garabedian, Christopher C. Porter, William L. Carroll
Journal: Blood
Blood (2015) 126 (19): 2202–2212.
https://doi.org/10.1182/blood-2015-04-639138
Published: 2015
Includes: Supplemental data
Journal Articles

FOXM1 Mediates Drug-Resistance and Represents a Therapeutic Target in Pre-B Acute Lymphoblastic Leukemia

Maike Buchner, PhD, Eugene Park, Lars Klemm, Huimin Geng, PhD, Dragana Kopanja, Pradip Raychaudhuri, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 790.
https://doi.org/10.1182/blood.V124.21.790.790
Published: 2014
Journal Articles

Mechanisms of Clonal Evolution of Pre-Leukemic Clones in Childhood Pre-B Acute Lymphoblastic Leukemia

Srividya Swaminathan, PhD, Lars Klemm, Eugene Park, Anthony M Ford, PhD, Soo-mi Kweon, PhD, Daniel Trageser, Brian Hasselfeld, Nadine Henke, Huimin Geng, PhD, Klaus Schwarz, MD, Rafael Casellas, David G. Schatz, PhD, Michael R Lieber, MD PhD, Elli Papaemmanuil, PhD, Mel Greaves, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 861.
https://doi.org/10.1182/blood.V124.21.861.861
Published: 2014
Journal Articles

IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Jae-Woong Lee, PhD, Zhengshan Chen, MD PhD, Behzad Kharabi Masouleh, MD, Christian Hurtz, PhD, Eugene Park, Gang Xiao, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 788.
https://doi.org/10.1182/blood.V124.21.788.788
Published: 2014
Journal Articles

The Linker Protein GAS7 Negatively Regulates Pre-B Cell Differentiation and Amplifies Proliferation and Survival Signals in Acute Lymphoblastic Leukemia

Jae-Woong Lee, PhD, Maike Buchner, PhD, Huimin Geng, PhD, Srividya Swaminathan, PhD, Eugene Park, Angela Park, Sue Lin-Chao, Chi Wai So, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3777.
https://doi.org/10.1182/blood.V124.21.3777.3777
Published: 2014
Journal Articles

BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1 -Driven Leukemia

Eugene Park, Srividya Swaminathan, PhD, Mohammed Firas Sadiyah, PhD, Kazuhiko Igarashi, PhD, Ari Melnick, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 513.
https://doi.org/10.1182/blood.V124.21.513.513
Published: 2014
Journal Articles

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Eugene Park, Angela Park, Lars Klemm, Charles Bailey, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 1070.
https://doi.org/10.1182/blood.V124.21.1070.1070
Published: 2014
Journal Articles

Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199

Marina Konopleva, MD, PhD, Juliana M Benito, PhD, Karine G. Harutyunyan, PhD, Isabel Marzo, LaKiesha Debose, Oscar Gonzalo, Ping Zhou, Rodrigo Jacamo, PhD, Eugene Park, Markus Muschen, MD, PhD, James C. Mulloy, PhD, Linda J Bendall, BSc, PhD, Patrick A Zweidler-McKay, MD, PhD, Kevin R. Coombes, PhD, Yihua Qiu, MD, Nianxiang Zhang, PhD, Joel Leverson, PhD, Deborah A. Thomas, MD, Susan O'Brien, MD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3919.
https://doi.org/10.1182/blood.V122.21.3919.3919
Published: 2013
Journal Articles

Ifitm3 (CD225) Mediates CD19-Dependent Survival and Proliferation During Normal B Cell Development and In Ph + ALL

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD, PhD, Eugene Park, Lars Klemm, Charles C Bailey, Markus Muschen, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2505.
https://doi.org/10.1182/blood.V122.21.2505.2505
Published: 2013
Journal Articles

Gas7 Induces The Proliferation Of Ph + ALL Cells and Prevents The Differentiation Of Early B Cell Progenitors Into CD25 high Small Pre-B Cells

Jaewoong Lee, PhD, Maike Buchner, PhD, Huimin Geng, PhD, Srividya Swaminathan, PhD, Eugene Park, Lars Klemm, Sue Lin-Chao, Chi Wai So, Markus Muschen, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2506.
https://doi.org/10.1182/blood.V122.21.2506.2506
Published: 2013
Journal Articles

Identification Of FOXM1 As Therapeutic Target In BCR-ABL1 Positive Acute Lymphoblastic Leukemia

Maike Buchner, PhD, Eugene Park, Lars Klemm, MSc, Huimin Geng, PhD, Dragana Kopanja, Pradip Raychaudhuri, PhD, Markus Muschen, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1250.
https://doi.org/10.1182/blood.V122.21.1250.1250
Published: 2013
Journal Articles

BCL-2-Selective BH3 Mimetic ABT-199 Is a Potent Agent For Acute Myeloid Leukemia

Rongqing Pan, MS, LaKeisha Debose, MS, Juliana M Benito, PhD, Leonard S Golfman, PhD, Patrick A Zweidler-McKay, MD, PhD, Lina Han, PhD, Karine G. Harutyunyan, PhD, Hong Mu, MD, PhD, Vivian R Ruvolo, MA, Eugene Park, Markus Muschen, MD, PhD, Joel Leverson, PhD, Gautam Borthakur, MD, Hagop M Kantarjian, MD, Peter P. Ruvolo, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1456.
https://doi.org/10.1182/blood.V122.21.1456.1456
Published: 2013
Journal Articles

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

Brief Report
Yao-Te Hsieh, Eun Ji Gang, Huimin Geng, Eugene Park, Sandra Huantes, Doreen Chudziak, Katrin Dauber, Paul Schaefer, Carlton Scharman, Hiroyuki Shimada, Seyedmehdi Shojaee, Lars Klemm, Reshmi Parameswaran, Mignon Loh, Eun-Suk Kang, Hong Hoe Koo, Wolf-Karsten Hofmann, Jacob Andrade, Gay M. Crooks, Cheryl L. Willman, Markus Müschen, Thalia Papayannopoulou, Nora Heisterkamp, Halvard Bönig, Yong-Mi Kim
Journal: Blood
Blood (2013) 121 (10): 1814–1818.
https://doi.org/10.1182/blood-2012-01-406272
Published: 2013
Includes: Supplemental data