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Journal Articles

Genetic Knockin Approaches to Reconstructing DLBCL-Subtypes from Human Germinal Center B-Cells

Dhruv Khanduja, Mark E Robinson, David Fonseca Arce, Lars Klemm, Etienne Leveille, Shalin Kothari, Rebecca Caeser, Daniel James Hodson, Markus Müschen

Blood (2023) 142 (Supplement 1): 1627.

https://doi.org/10.1182/blood-2023-190634

Published: 2023

Journal Articles

Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies

Franz Ketzer, Lars Klemm, Mark E Robinson, Christian Loucks, David Fonseca Arce, Kadriye Nehir Cosgun, Shalin Kothari, Markus Müschen

Blood (2023) 142 (Supplement 1): 1396.

https://doi.org/10.1182/blood-2023-189221

Published: 2023

Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Blood (2022) 140 (Supplement 1): 1698–1699.

https://doi.org/10.1182/blood-2022-170324

Published: 2022

Journal Articles

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

Kohei Kume, Zhengshan Chen, Lai N. Chan, Mark E. Robinson, Etienne Leveille, Jaewoong Lee, Kadriye Nehir Cosgun, David Fonseca Arce, Dhruv Khanduja, Lars Klemm, Markus Müschen

Blood (2022) 140 (Supplement 1): 5900–5901.

https://doi.org/10.1182/blood-2022-170396

Published: 2022

Journal Articles

CD25 As Feedback Regulator of Oncogenic TCR Signaling in T-Cell Lymphoma

Ruifeng Sun, Jaewoong Lee, Tim Wartewig, Mark E. Robinson, Alberto Bigogno, David Fonseca Arce, Abu-Sayeef Mirza, Andrew Takeda, Lars Klemm, Vivasvan Vykunta, Brian Shy, Alexander Marson, Markus Müschen

Blood (2022) 140 (Supplement 1): 5975–5976.

https://doi.org/10.1182/blood-2022-170076

Published: 2022

Journal Articles

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

Blood (2020) 136 (2): 210–223.

https://doi.org/10.1182/blood.2019001417

Published: 2020

Includes: Supplemental data

Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Blood (2019) 134 (Supplement_1): 393.

https://doi.org/10.1182/blood-2019-131270

Published: 2019

Journal Articles

Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL

Gang Xiao, PhD, Kohei Kume, PhD, Huimin Geng, PhD, Than Than Han, MS, Lars Klemm, MS, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 3785.

https://doi.org/10.1182/blood-2019-128719

Published: 2019

Journal Articles

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Xi Qin, Rui Su, PhD, Lu Yang, PhD, Anthony K. N. Chan, PhD, Xiaolan Deng, Ying Qing, Lars Klemm, MS, Markus Müschen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD

Blood (2019) 134 (Supplement_1): 1465.

https://doi.org/10.1182/blood-2019-129849

Published: 2019

Journal Articles

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Kadriye Nehir Nehir Cosgun, PhD, Anna Hecht, MD, Xin Yang, MD, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Lars Klemm, Msc, Chao Hong, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Hans Clevers, MD PhD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 3989.

https://doi.org/10.1182/blood.V130.Suppl_1.3989.3989

Published: 2017

Journal Articles

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

Zhengshan Chen, MD PhD, Huimin Geng, PhD, Lars Klemm, BSc, MSc, Lai N Chan, PhD, Brass Daniel, PhD, Warren S. Alexander, PhD, Cheryl L. Willman, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4069.

https://doi.org/10.1182/blood.V128.22.4069.4069

Published: 2016

Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4088.

https://doi.org/10.1182/blood.V128.22.4088.4088

Published: 2016

Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD

Blood (2016) 128 (22): 2738.

https://doi.org/10.1182/blood.V128.22.2738.2738

Published: 2016

Journal Articles

IFITM3 (CD225) Links the B Cell Antigen CD19 to PI3K-AKT Signaling in Human ALL Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Eugene PARK, PhD, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Muschen, MD PhD

Blood (2015) 126 (23): 1325.

https://doi.org/10.1182/blood.V126.23.1325.1325

Published: 2015

Journal Articles

Exposure to Inflammatory Immune Responses As Driver of Clonal Evolution in Childhood Acute Lymphoblastic Leukemia

Lars Klemm, BSc, MSc, Srividya Swaminathan, DPhil, Elli Papaemmanuil, PhD, Anthony M Ford, Mel Greaves, Rafael Casellas, David Schatz, Michael R. Lieber, MDPhD, Markus Muschen, MD PhD

Blood (2015) 126 (23): 166.

https://doi.org/10.1182/blood.V126.23.166.166

Published: 2015

Journal Articles

FOXM1 Mediates Drug-Resistance and Represents a Therapeutic Target in Pre-B Acute Lymphoblastic Leukemia

Maike Buchner, PhD, Eugene Park, Lars Klemm, Huimin Geng, PhD, Dragana Kopanja, Pradip Raychaudhuri, PhD, Markus Muschen, MDPhD

Blood (2014) 124 (21): 790.

https://doi.org/10.1182/blood.V124.21.790.790

Published: 2014

Journal Articles

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Zhengshan Chen, MD PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jae-Woong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, OC, PhD DSc, FRSC, FRS, Markus Muschen, MDPhD

Blood (2014) 124 (21): 792.

https://doi.org/10.1182/blood.V124.21.792.792

Published: 2014

Journal Articles

Mechanisms of Clonal Evolution of Pre-Leukemic Clones in Childhood Pre-B Acute Lymphoblastic Leukemia

Srividya Swaminathan, PhD, Lars Klemm, Eugene Park, Anthony M Ford, PhD, Soo-mi Kweon, PhD, Daniel Trageser, Brian Hasselfeld, Nadine Henke, Huimin Geng, PhD, Klaus Schwarz, MD, Rafael Casellas, David G. Schatz, PhD, Michael R Lieber, MD PhD, Elli Papaemmanuil, PhD, Mel Greaves, PhD, Markus Muschen, MD PhD

Blood (2014) 124 (21): 861.

https://doi.org/10.1182/blood.V124.21.861.861

Published: 2014

Journal Articles

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Eugene Park, Angela Park, Lars Klemm, Charles Bailey, Markus Muschen, MDPhD

Blood (2014) 124 (21): 1070.

https://doi.org/10.1182/blood.V124.21.1070.1070

Published: 2014

Journal Articles

Ifitm3 (CD225) Mediates CD19-Dependent Survival and Proliferation During Normal B Cell Development and In Ph + ALL

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD, PhD, Eugene Park, Lars Klemm, Charles C Bailey, Markus Muschen, MD, PhD

Blood (2013) 122 (21): 2505.

https://doi.org/10.1182/blood.V122.21.2505.2505

Published: 2013

NARROW

Genetic Knockin Approaches to Reconstructing DLBCL-Subtypes from Human Germinal Center B-Cells

Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

CD25 As Feedback Regulator of Oncogenic TCR Signaling in T-Cell Lymphoma

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

IFITM3 (CD225) Links the B Cell Antigen CD19 to PI3K-AKT Signaling in Human ALL Cells

Exposure to Inflammatory Immune Responses As Driver of Clonal Evolution in Childhood Acute Lymphoblastic Leukemia

FOXM1 Mediates Drug-Resistance and Represents a Therapeutic Target in Pre-B Acute Lymphoblastic Leukemia

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Mechanisms of Clonal Evolution of Pre-Leukemic Clones in Childhood Pre-B Acute Lymphoblastic Leukemia

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Ifitm3 (CD225) Mediates CD19-Dependent Survival and Proliferation During Normal B Cell Development and In Ph + ALL

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American Society of Hematology

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ASH Publications

American Society of Hematology

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