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Journal Articles

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Kohei Kume, Zhengshan Chen, Mark E Robinson, Lai N Chan, Etienne Leveille, Kadriye Nehir Cosgun, Zhangliang Cheng, David Fonseca Arce, Dhruv Khanduja, Thomas Graeber, Markus Müschen

Blood (2023) 142 (Supplement 1): 2977.

https://doi.org/10.1182/blood-2023-191006

Published: 2023

Journal Articles

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

Kohei Kume, Zhengshan Chen, Lai N. Chan, Mark E. Robinson, Etienne Leveille, Jaewoong Lee, Kadriye Nehir Cosgun, David Fonseca Arce, Dhruv Khanduja, Lars Klemm, Markus Müschen

Blood (2022) 140 (Supplement 1): 5900–5901.

https://doi.org/10.1182/blood-2022-170396

Published: 2022

Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Blood (2022) 140 (Supplement 1): 1698–1699.

https://doi.org/10.1182/blood-2022-170324

Published: 2022

Journal Articles

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Teresa Sadras, PhD, Mickaël Martin, MD PhD, Lauren Kim-Sing, Jevon Cutler, PhD, Gal Lenz, PhD, Anne Marie Knapp, Dana Ghergus, MD PhD, Fabien Delmotte, Cédric Schleiss, Anne-Sophie Korganow, MD PhD, Pauline Soulas-Sprauel, PharmD, PhD, Zhengshan Chen, MD PhD, Akhilesh Pandey, MD PhD, David M. Weinstock, MD, Hassan Jumaa, PhD, Eric Meffre, PhD, Thierry Martin, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 295.

https://doi.org/10.1182/blood-2019-128999

Published: 2019

Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Blood (2019) 134 (Supplement_1): 393.

https://doi.org/10.1182/blood-2019-131270

Published: 2019

Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 2782.

https://doi.org/10.1182/blood-2019-127615

Published: 2019

Journal Articles

Autoimmunity Checkpoints As Therapeutic Targets in B-Cell Malignancies

Zhengshan Chen, MDPhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 1587.

https://doi.org/10.1182/blood-2018-99-113674

Published: 2018

Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Blood (2018) 132 (Supplement 1): 776.

https://doi.org/10.1182/blood-2018-99-117553

Published: 2018

Journal Articles

Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies

Teresa Sadras, PhD, Jevon Cutler, Julia Aguade-Gorgorio, PhD, Zhengshan Chen, MD PhD, Kadriye Nehir Cosgun, PhD, Akhilesh Pandey, MD PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 3922.

https://doi.org/10.1182/blood-2018-99-116954

Published: 2018

Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 568.

https://doi.org/10.1182/blood-2018-99-115536

Published: 2018

Journal Articles

IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation

Jae-Woong Lee, PhD, Huimin Geng, PhD, Derek S Dinson, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Zhengshan Chen, MDPhD, Michael Farzan, MDPhD, Jae U Jung, PhD, Arun P Wiita, MDPhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 552.

https://doi.org/10.1182/blood-2018-99-117472

Published: 2018

Journal Articles

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Kadriye Nehir Cosgun, PhD, B Hilda Ye, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 1336.

https://doi.org/10.1182/blood-2018-99-115514

Published: 2018

Journal Articles

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 3834.

https://doi.org/10.1182/blood.V130.Suppl_1.3834.3834

Published: 2017

Journal Articles

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Kadriye Nehir Nehir Cosgun, PhD, Anna Hecht, MD, Xin Yang, MD, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Lars Klemm, Msc, Chao Hong, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Hans Clevers, MD PhD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 3989.

https://doi.org/10.1182/blood.V130.Suppl_1.3989.3989

Published: 2017

Journal Articles

Autoimmunity Checkpoints As Therapeutic Targets in B- and T-Cell Malignancies

Zhengshan Chen, MDPhD, Anna Hecht, MD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 718.

https://doi.org/10.1182/blood.V130.Suppl_1.718.718

Published: 2017

Journal Articles

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Zhengshan Chen, MDPhD, Lai N Chan, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Cheryl L. Willman, MD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 1440.

https://doi.org/10.1182/blood.V130.Suppl_1.1440.1440

Published: 2017

Journal Articles

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

Zhengshan Chen, MD PhD, Huimin Geng, PhD, Lars Klemm, BSc, MSc, Lai N Chan, PhD, Brass Daniel, PhD, Warren S. Alexander, PhD, Cheryl L. Willman, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4069.

https://doi.org/10.1182/blood.V128.22.4069.4069

Published: 2016

Journal Articles

Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia

Lai N Chan, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Gang Xiao, PhD, Zhengshan Chen, MD PhD, Thomas Ernst, MD, Andreas Hochhaus, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 2771.

https://doi.org/10.1182/blood.V128.22.2771.2771

Published: 2016

Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD

Blood (2016) 128 (22): 2738.

https://doi.org/10.1182/blood.V128.22.2738.2738

Published: 2016

Journal Articles

PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia

Gang Xiao, PhD, Zhengshan Chen, MD PhD, Brass Daniel, PhD, Lai N Chan, PhD, Huimin Geng, PhD, Xiaoyan Jiang, MD PhD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 1056.

https://doi.org/10.1182/blood.V128.22.1056.1056

Published: 2016

NARROW

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Autoimmunity Checkpoints As Therapeutic Targets in B-Cell Malignancies

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Autoimmunity Checkpoints As Therapeutic Targets in B- and T-Cell Malignancies

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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