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Journal Articles

C1-INH and atiii inhibit vaso-occlusion and vascular inflammation in sickle cell disease mice

John Belcher, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Conglin Ruan, Larisa Belyanskaya, Sigurd Knaub, Olaf Walter, Gregory Vercellotti

Blood (2025) 146 (Supplement 1): 835.

https://doi.org/10.1182/blood-2025-835

Published: 2025

Journal Articles

Prothrombin complex concentrate in managing direct oral anticoagulant (DOAC)-associated bleeding and real-world use in vitamin k antagonist (VKA)-associated bleeding: The ongoing lex-210 and lex-212 studies

Ravindra Sarode, Stephan Maack, Cristina Solomon, Sigurd Knaub, Dmitrii Matveev, Doris Hinterberger, Pierantonio Russo, Sam Schulman

Blood (2025) 146 (Supplement 1): 4868.

https://doi.org/10.1182/blood-2025-4868

Published: 2025

Journal Articles

Fibrinogen concentrate versus cryoprecipitate for bleeding in cardiac surgery patients stratified by surgery risk in the phase 3 fibres Study

Jeannie Callum, Keyvan Karkouti, Cristina Solomon, Sylvia Werner, Sigurd Knaub

Blood (2025) 146 (Supplement 1): 4860.

https://doi.org/10.1182/blood-2025-4860

Published: 2025

Journal Articles

Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Cardiac Surgery Patients: Protocol Update for an Ongoing Phase 3, Double-Blind, Placebo-Controlled, Multicenter Study

Jerrold H Levy, Catrin Argyle, Cristina Solomon, Sigurd Knaub

Blood (2024) 144 (Supplement 1): 4026.1.

https://doi.org/10.1182/blood-2024-205111

Published: 2024

Journal Articles

Updated Protocol for the Phase 3, Randomized, Double-Blinded Lex-210 Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Factor Xa Inhibitor Therapy

Ravindra Sarode, Stephan Maack, Cristina Solomon, Sigurd Knaub, Gita Pezeshki, Sam Schulman

Blood (2023) 142 (Supplement 1): 1256.

https://doi.org/10.1182/blood-2023-188990

Published: 2023

Journal Articles

Randomized, Active-Control Phase 3 Study of Four-Factor Prothrombin Complex Concentrate Versus Frozen Plasma in Bleeding Adult Cardiac Surgery Patients

Keyvan Karkouti, Jeannie Callum, Kenichi Tanaka, Deep Grewal, Cristina Solomon, Sigurd Knaub, Sylvia Werner, Jerrold H Levy

Blood (2023) 142 (Supplement 1): 5515.

https://doi.org/10.1182/blood-2023-186539

Published: 2023

Journal Articles

Nuwiq Dosing and Outcomes in the Management of Women/Girls with Haemophilia a Needing FVIII Treatment for Surgery - an International, Open-Label, Non-Controlled Study (NuDIMENSION)

Johannes Oldenburg, Natascha Marquardt, Martina Jansen, Sigurd Knaub

Blood (2022) 140 (Supplement 1): 11323–11324.

https://doi.org/10.1182/blood-2022-156405

Published: 2022

Journal Articles

The Nupower Study: Nuwiq for Perioperative Management of Patients with Haemophilia a on Emicizumab Regular Prophylaxis

Sylvia Werner, Sigurd Knaub

Blood (2022) 140 (Supplement 1): 5625–5626.

https://doi.org/10.1182/blood-2022-156401

Published: 2022

Journal Articles

Efficacy and Safety of Prophylaxis with a Plasma-Derived Von Willebrand Factor/ Factor VIII Concentrate in Previously Treated Patients with Von Willebrand Disease

Robert F. Sidonio, Jr., Ana Boban, Leonid Dubey, Adlette Inati, Csongor Kiss, Toshko Lissitchkov, Dzmitry Novik, Elina Peteva, Ali T. Taher, Margarita Arkadevna Timofeeva, Kateryna V. Vilchevska, Vladimir Vdovin, Sylvia Werner, Sigurd Knaub, Claudia Khayat

Blood (2022) 140 (Supplement 1): 8438–8439.

https://doi.org/10.1182/blood-2022-162358

Published: 2022

Journal Articles

Atenativ, a Plasma-Derived Antithrombin Concentrate, Used in Patients with Congenital Antithrombin Deficiency Undergoing Surgery or Parturition: Study Description (NCT04918173)

Craig M. Kessler, Claudio Sandoval, Martina Jansen, Cristina Solomon, Sigurd Knaub, Michael D Tarantino

Blood (2022) 140 (Supplement 1): 8548–8549.

https://doi.org/10.1182/blood-2022-166246

Published: 2022

Journal Articles

A Phase 3, Randomized, Double-Blinded Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Direct Oral Anticoagulant Therapy with Factor Xa Inhibitor: The Lex-210 Study

Ravi Sarode, Stephan Maack, Cristina Solomon, Sigurd Knaub, Sam Schulman

Blood (2021) 138 (Supplement 1): 3235.

https://doi.org/10.1182/blood-2021-152697

Published: 2021

Journal Articles

Prospective, Phase III Study of the Efficacy, Safety, and Pharmacokinetics of a Human Antithrombin III Concentrate in Congenital Antithrombin Deficiency during Surgery or Childbirth

Bruce A. Schwartz, Cristina Solomon, Sigurd Knaub, Craig M. Kessler

Blood (2021) 138 (Supplement 1): 3238.

https://doi.org/10.1182/blood-2021-152594

Published: 2021

Journal Articles

Safety and Efficacy of Fibrinogen Concentrate in Congenital Fibrinogen Deficiency: A Post-Marketing Observational Study

Bruce A. Schwartz, PhD, Flora Peyvandi, MD PhD, Cristina Solomon, Sigurd Knaub, Balazs Toth

Blood (2019) 134 (Supplement_1): 4971.

https://doi.org/10.1182/blood-2019-129891

Published: 2019

Journal Articles

Efficacy and Pharmacokinetics of a New Fibrinogen Concentrate in Treating Acute Bleeding in Adolescent Patients with Congenital Fibrinogen Deficiency

Flora Peyvandi, MD PhD, Bruce A. Schwartz, Sigurd Knaub

Blood (2018) 132 (Supplement 1): 2501.

https://doi.org/10.1182/blood-2018-99-116572

Published: 2018

Journal Articles

Fibrinogen Concentrate Vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study

Ashok Roy, Nigel Sargant, Savita Rangarajan, Sue Alves, John Bell, Sophia Stanford, Cristina Solomon, Irina Kruzhkova, Sigurd Knaub, Faheez Mohamed

Blood (2018) 132 (Supplement 1): 2549.

https://doi.org/10.1182/blood-2018-99-118145

Published: 2018

Journal Articles

Efficacy and Safety of Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and for Surgical Prophylaxis in Subjects with Congenital Fibrinogen Deficiency — a Phase 3 Study

Flora Peyvandi, MD PhD, Bruce A. Schwartz, Sigurd Knaub

Blood (2018) 132 (Supplement 1): 2502.

https://doi.org/10.1182/blood-2018-99-116440

Published: 2018

Journal Articles

Final Results from a Non-Interventional Safety and Efficacy Study of a VWF/FVIII Concentrate (wilate ® ) in Patients with Von Willebrand Disease

Hassan M. Yaish, MD, Maria Sol Cruz, MD, Kay Decker, Eva M.K. Zetterberg, MD PhD, Sylvia Werner, Mariko Hashimoto, Sigurd Knaub, George M. Rodgers, MD PhD

Blood (2018) 132 (Supplement 1): 1182.

https://doi.org/10.1182/blood-2018-99-118069

Published: 2018

Journal Articles

Inactivation of Zika Virus By Solvent/Detergent Treatment or Pasteurization

Torben Schmidt, Denis Kuehnel, Sebastian Mueller, Alexander Pichotta, Kai Uwe Radomski, Andreas Volk, Sigurd Knaub

Blood (2016) 128 (22): 2630.

https://doi.org/10.1182/blood.V128.22.2630.2630

Published: 2016

Journal Articles

Observational Study on Safety and Efficacy of Factor Replacement Therapy in the Management of Von Willebrand Disease Patients - Results from an Ongoing Study with a VWF/FVIII Concentrate

Hassan M. Yaish, Kate Khair, Mario von Depka, Maria Sol Cruz, Sylvia Werner, Sigurd Knaub, George M. Rodgers

Blood (2016) 128 (22): 4968.

https://doi.org/10.1182/blood.V128.22.4968.4968

Published: 2016

Journal Articles

Efficacy of Human Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and to Prevent Bleeding during and after Surgery in Subjects with Congenital Fibrinogen Deficiency

Bruce A. Schwartz, PhD, Cecil Ross, MD, Bella Madan, MD, Toshko Jelev Lissitchkov, MD, Mehran Karimi, MD, Sigurd Knaub, Flora Peyvandi, MD PhD

Blood (2016) 128 (22): 1404.

https://doi.org/10.1182/blood.V128.22.1404.1404

Published: 2016

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C1-INH and atiii inhibit vaso-occlusion and vascular inflammation in sickle cell disease mice

Prothrombin complex concentrate in managing direct oral anticoagulant (DOAC)-associated bleeding and real-world use in vitamin k antagonist (VKA)-associated bleeding: The ongoing lex-210 and lex-212 studies

Fibrinogen concentrate versus cryoprecipitate for bleeding in cardiac surgery patients stratified by surgery risk in the phase 3 fibres Study

Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Cardiac Surgery Patients: Protocol Update for an Ongoing Phase 3, Double-Blind, Placebo-Controlled, Multicenter Study

Updated Protocol for the Phase 3, Randomized, Double-Blinded Lex-210 Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Factor Xa Inhibitor Therapy

Randomized, Active-Control Phase 3 Study of Four-Factor Prothrombin Complex Concentrate Versus Frozen Plasma in Bleeding Adult Cardiac Surgery Patients

Nuwiq Dosing and Outcomes in the Management of Women/Girls with Haemophilia a Needing FVIII Treatment for Surgery - an International, Open-Label, Non-Controlled Study (NuDIMENSION)

The Nupower Study: Nuwiq for Perioperative Management of Patients with Haemophilia a on Emicizumab Regular Prophylaxis

Efficacy and Safety of Prophylaxis with a Plasma-Derived Von Willebrand Factor/ Factor VIII Concentrate in Previously Treated Patients with Von Willebrand Disease

Atenativ, a Plasma-Derived Antithrombin Concentrate, Used in Patients with Congenital Antithrombin Deficiency Undergoing Surgery or Parturition: Study Description (NCT04918173)

A Phase 3, Randomized, Double-Blinded Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Direct Oral Anticoagulant Therapy with Factor Xa Inhibitor: The Lex-210 Study

Prospective, Phase III Study of the Efficacy, Safety, and Pharmacokinetics of a Human Antithrombin III Concentrate in Congenital Antithrombin Deficiency during Surgery or Childbirth

Safety and Efficacy of Fibrinogen Concentrate in Congenital Fibrinogen Deficiency: A Post-Marketing Observational Study

Efficacy and Pharmacokinetics of a New Fibrinogen Concentrate in Treating Acute Bleeding in Adolescent Patients with Congenital Fibrinogen Deficiency

Fibrinogen Concentrate Vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study

Efficacy and Safety of Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and for Surgical Prophylaxis in Subjects with Congenital Fibrinogen Deficiency — a Phase 3 Study

Final Results from a Non-Interventional Safety and Efficacy Study of a VWF/FVIII Concentrate (wilate ® ) in Patients with Von Willebrand Disease

Inactivation of Zika Virus By Solvent/Detergent Treatment or Pasteurization

Observational Study on Safety and Efficacy of Factor Replacement Therapy in the Management of Von Willebrand Disease Patients - Results from an Ongoing Study with a VWF/FVIII Concentrate

Efficacy of Human Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and to Prevent Bleeding during and after Surgery in Subjects with Congenital Fibrinogen Deficiency

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