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Journal Articles

Randomized, Active-Control Phase 3 Study of Four-Factor Prothrombin Complex Concentrate Versus Frozen Plasma in Bleeding Adult Cardiac Surgery Patients

Keyvan Karkouti, Jeannie Callum, Kenichi Tanaka, Deep Grewal, Cristina Solomon, Sigurd Knaub, Sylvia Werner, Jerrold H Levy

Blood (2023) 142 (Supplement 1): 5515.

https://doi.org/10.1182/blood-2023-186539

Published: 2023

Journal Articles

Updated Protocol for the Phase 3, Randomized, Double-Blinded Lex-210 Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Factor Xa Inhibitor Therapy

Ravindra Sarode, Stephan Maack, Cristina Solomon, Sigurd Knaub, Gita Pezeshki, Sam Schulman

Blood (2023) 142 (Supplement 1): 1256.

https://doi.org/10.1182/blood-2023-188990

Published: 2023

Journal Articles

Atenativ, a Plasma-Derived Antithrombin Concentrate, Used in Patients with Congenital Antithrombin Deficiency Undergoing Surgery or Parturition: Study Description (NCT04918173)

Craig M. Kessler, Claudio Sandoval, Martina Jansen, Cristina Solomon, Sigurd Knaub, Michael D Tarantino

Blood (2022) 140 (Supplement 1): 8548–8549.

https://doi.org/10.1182/blood-2022-166246

Published: 2022

Journal Articles

The Nupower Study: Nuwiq for Perioperative Management of Patients with Haemophilia a on Emicizumab Regular Prophylaxis

Sylvia Werner, Sigurd Knaub

Blood (2022) 140 (Supplement 1): 5625–5626.

https://doi.org/10.1182/blood-2022-156401

Published: 2022

Journal Articles

Nuwiq Dosing and Outcomes in the Management of Women/Girls with Haemophilia a Needing FVIII Treatment for Surgery - an International, Open-Label, Non-Controlled Study (NuDIMENSION)

Johannes Oldenburg, Natascha Marquardt, Martina Jansen, Sigurd Knaub

Blood (2022) 140 (Supplement 1): 11323–11324.

https://doi.org/10.1182/blood-2022-156405

Published: 2022

Journal Articles

Efficacy and Safety of Prophylaxis with a Plasma-Derived Von Willebrand Factor/ Factor VIII Concentrate in Previously Treated Patients with Von Willebrand Disease

Robert F. Sidonio, Jr., Ana Boban, Leonid Dubey, Adlette Inati, Csongor Kiss, Toshko Lissitchkov, Dzmitry Novik, Elina Peteva, Ali T. Taher, Margarita Arkadevna Timofeeva, Kateryna V. Vilchevska, Vladimir Vdovin, Sylvia Werner, Sigurd Knaub, Claudia Khayat

Blood (2022) 140 (Supplement 1): 8438–8439.

https://doi.org/10.1182/blood-2022-162358

Published: 2022

Journal Articles

A Phase 3, Randomized, Double-Blinded Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Direct Oral Anticoagulant Therapy with Factor Xa Inhibitor: The Lex-210 Study

Ravi Sarode, Stephan Maack, Cristina Solomon, Sigurd Knaub, Sam Schulman

Blood (2021) 138 (Supplement 1): 3235.

https://doi.org/10.1182/blood-2021-152697

Published: 2021

Journal Articles

Prospective, Phase III Study of the Efficacy, Safety, and Pharmacokinetics of a Human Antithrombin III Concentrate in Congenital Antithrombin Deficiency during Surgery or Childbirth

Bruce A. Schwartz, Cristina Solomon, Sigurd Knaub, Craig M. Kessler

Blood (2021) 138 (Supplement 1): 3238.

https://doi.org/10.1182/blood-2021-152594

Published: 2021

Journal Articles

Safety and Efficacy of Fibrinogen Concentrate in Congenital Fibrinogen Deficiency: A Post-Marketing Observational Study

Bruce A. Schwartz, PhD, Flora Peyvandi, MD PhD, Cristina Solomon, Sigurd Knaub, Balazs Toth

Blood (2019) 134 (Supplement_1): 4971.

https://doi.org/10.1182/blood-2019-129891

Published: 2019

Journal Articles

Efficacy and Pharmacokinetics of a New Fibrinogen Concentrate in Treating Acute Bleeding in Adolescent Patients with Congenital Fibrinogen Deficiency

Flora Peyvandi, MD PhD, Bruce A. Schwartz, Sigurd Knaub

Blood (2018) 132 (Supplement 1): 2501.

https://doi.org/10.1182/blood-2018-99-116572

Published: 2018

Journal Articles

Fibrinogen Concentrate Vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study

Ashok Roy, Nigel Sargant, Savita Rangarajan, Sue Alves, John Bell, Sophia Stanford, Cristina Solomon, Irina Kruzhkova, Sigurd Knaub, Faheez Mohamed

Blood (2018) 132 (Supplement 1): 2549.

https://doi.org/10.1182/blood-2018-99-118145

Published: 2018

Journal Articles

Efficacy and Safety of Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and for Surgical Prophylaxis in Subjects with Congenital Fibrinogen Deficiency — a Phase 3 Study

Flora Peyvandi, MD PhD, Bruce A. Schwartz, Sigurd Knaub

Blood (2018) 132 (Supplement 1): 2502.

https://doi.org/10.1182/blood-2018-99-116440

Published: 2018

Journal Articles

Final Results from a Non-Interventional Safety and Efficacy Study of a VWF/FVIII Concentrate (wilate ® ) in Patients with Von Willebrand Disease

Hassan M. Yaish, MD, Maria Sol Cruz, MD, Kay Decker, Eva M.K. Zetterberg, MD PhD, Sylvia Werner, Mariko Hashimoto, Sigurd Knaub, George M. Rodgers, MD PhD

Blood (2018) 132 (Supplement 1): 1182.

https://doi.org/10.1182/blood-2018-99-118069

Published: 2018

Journal Articles

Efficacy of Human Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and to Prevent Bleeding during and after Surgery in Subjects with Congenital Fibrinogen Deficiency

Bruce A. Schwartz, PhD, Cecil Ross, MD, Bella Madan, MD, Toshko Jelev Lissitchkov, MD, Mehran Karimi, MD, Sigurd Knaub, Flora Peyvandi, MD PhD

Blood (2016) 128 (22): 1404.

https://doi.org/10.1182/blood.V128.22.1404.1404

Published: 2016

Journal Articles

Thrombin Generation and Bleeding Phenotype during Personalized Prophylaxis with Recombinant Human FVIII in Previously Treated Patients with Severe Hemophilia A

Yesim G. Dargaud, MDPhD, Robert Klamroth, Luminita Rusen, MD, Jerzy Windyga, MD, Johann Bichler, PhD, Sigurd Knaub, Claude Negrier, MD

Blood (2016) 128 (22): 1410.

https://doi.org/10.1182/blood.V128.22.1410.1410

Published: 2016

Journal Articles

Observational Study on Safety and Efficacy of Factor Replacement Therapy in the Management of Von Willebrand Disease Patients - Results from an Ongoing Study with a VWF/FVIII Concentrate

Hassan M. Yaish, Kate Khair, Mario von Depka, Maria Sol Cruz, Sylvia Werner, Sigurd Knaub, George M. Rodgers

Blood (2016) 128 (22): 4968.

https://doi.org/10.1182/blood.V128.22.4968.4968

Published: 2016

Journal Articles

Inactivation of Zika Virus By Solvent/Detergent Treatment or Pasteurization

Torben Schmidt, Denis Kuehnel, Sebastian Mueller, Alexander Pichotta, Kai Uwe Radomski, Andreas Volk, Sigurd Knaub

Blood (2016) 128 (22): 2630.

https://doi.org/10.1182/blood.V128.22.2630.2630

Published: 2016

Journal Articles

Personalized Prophylaxis with Human-Cl Recombinant FVIII in HA Patients

Robert Klamroth, Toshko Lissitchkov, MD, Luminita Rusen, Olaf Walter, MD MBA, Johann Bichler, PhD, K John Pasi, Andreas Tiede, MD PhD, Sigurd Knaub, PhD

Blood (2015) 126 (23): 547.

https://doi.org/10.1182/blood.V126.23.547.547

Published: 2015

Journal Articles

Pharmacokinetic (PK) Comparison of Two Fibrinogen Concentrates in Patients with Congenital Fibrinogen Deficiency: Final Analysis

Cecil Ross, MD, Savita Rangarajan, Mehran Karimi, MD, Bruce A. Schwartz, PhD, Sigurd Knaub, PhD, Flora Peyvandi, MD PhD

Blood (2015) 126 (23): 4680.

https://doi.org/10.1182/blood.V126.23.4680.4680

Published: 2015

Journal Articles

Pharmacokinetic (PK) Comparison of Two Fibrinogen Concentrates for the Treatment of Congenital Fibrinogen Deficiency

Bruce A. Schwartz, PhD, Savita Rangarajan, MBBS, FRCP, FRCPath, Flora Peyvandi, Mehran Karimi, MD, Sigurd Knaub, PhD

Blood (2014) 124 (21): 2817.

https://doi.org/10.1182/blood.V124.21.2817.2817

Published: 2014

NARROW

Randomized, Active-Control Phase 3 Study of Four-Factor Prothrombin Complex Concentrate Versus Frozen Plasma in Bleeding Adult Cardiac Surgery Patients

Updated Protocol for the Phase 3, Randomized, Double-Blinded Lex-210 Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Factor Xa Inhibitor Therapy

Atenativ, a Plasma-Derived Antithrombin Concentrate, Used in Patients with Congenital Antithrombin Deficiency Undergoing Surgery or Parturition: Study Description (NCT04918173)

The Nupower Study: Nuwiq for Perioperative Management of Patients with Haemophilia a on Emicizumab Regular Prophylaxis

Nuwiq Dosing and Outcomes in the Management of Women/Girls with Haemophilia a Needing FVIII Treatment for Surgery - an International, Open-Label, Non-Controlled Study (NuDIMENSION)

Efficacy and Safety of Prophylaxis with a Plasma-Derived Von Willebrand Factor/ Factor VIII Concentrate in Previously Treated Patients with Von Willebrand Disease

A Phase 3, Randomized, Double-Blinded Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Direct Oral Anticoagulant Therapy with Factor Xa Inhibitor: The Lex-210 Study

Prospective, Phase III Study of the Efficacy, Safety, and Pharmacokinetics of a Human Antithrombin III Concentrate in Congenital Antithrombin Deficiency during Surgery or Childbirth

Safety and Efficacy of Fibrinogen Concentrate in Congenital Fibrinogen Deficiency: A Post-Marketing Observational Study

Efficacy and Pharmacokinetics of a New Fibrinogen Concentrate in Treating Acute Bleeding in Adolescent Patients with Congenital Fibrinogen Deficiency

Fibrinogen Concentrate Vs Cryoprecipitate in Pseudomyxoma Peritonei Surgery: Interim Results from a Prospective, Randomized, Controlled Phase 2 Study

Efficacy and Safety of Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and for Surgical Prophylaxis in Subjects with Congenital Fibrinogen Deficiency — a Phase 3 Study

Final Results from a Non-Interventional Safety and Efficacy Study of a VWF/FVIII Concentrate (wilate ® ) in Patients with Von Willebrand Disease

Efficacy of Human Fibrinogen Concentrate for on-Demand Treatment of Acute Bleeding and to Prevent Bleeding during and after Surgery in Subjects with Congenital Fibrinogen Deficiency

Thrombin Generation and Bleeding Phenotype during Personalized Prophylaxis with Recombinant Human FVIII in Previously Treated Patients with Severe Hemophilia A

Observational Study on Safety and Efficacy of Factor Replacement Therapy in the Management of Von Willebrand Disease Patients - Results from an Ongoing Study with a VWF/FVIII Concentrate

Inactivation of Zika Virus By Solvent/Detergent Treatment or Pasteurization

Personalized Prophylaxis with Human-Cl Recombinant FVIII in HA Patients

Pharmacokinetic (PK) Comparison of Two Fibrinogen Concentrates in Patients with Congenital Fibrinogen Deficiency: Final Analysis

Pharmacokinetic (PK) Comparison of Two Fibrinogen Concentrates for the Treatment of Congenital Fibrinogen Deficiency

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American Society of Hematology

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American Society of Hematology

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