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Journal Articles

Unique Roles for Grb2-Associated Binding (Gab) Adaptors in Hematopoietic Stem Cell Homeostasis and Repopulation

Zhengqi Wang, PhD, Gen-sheng Feng, PhD, Kevin D. Bunting, PhD

Blood (2017) 130 (Supplement 1): 2431.

https://doi.org/10.1182/blood.V130.Suppl_1.2431.2431

Published: 2017

Journal Articles

Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function

XingJun Li, MD PhD, Charles Goodwin, BS, Zhenyun Yang, Sarah C Nabinger, PhD, Briana Richine, Gordon Chan, Helmut Hanenberg, Hiroaki Ohnishi, MD, Takashi Matozaki, MD PhD, Jamel El Benna, Gen-Sheng Feng, PhD, Benjamin Neel, MD PhD, Rebecca J. Chan, MD PhD

Blood (2014) 124 (21): 1397.

https://doi.org/10.1182/blood.V124.21.1397.1397

Published: 2014

Journal Articles

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Sarah C Nabinger, PhD, Xing Jun Li, MD, PhD, Baskar Ramdas, Ph.D., Yantao He, PhD, Xian Zhang, Ph.D., Briana Richine, Joshua Bowling, Seiji Fukuda, MD, PhD, Shreevrat Goenka, Ph.D., Ziyue Liu, Ph.D., Gen-Sheng Feng, PhD, Menggang Yu, Ph.D., George Sandusky, MD, H. Scott Boswell, MD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2012) 120 (21): 2420.

https://doi.org/10.1182/blood.V120.21.2420.2420

Published: 2012

Journal Articles

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Blood (2012) 120 (13): 2669–2678.

https://doi.org/10.1182/blood-2011-08-375873

Published: 2012

Includes: Supplemental data

Journal Articles

Negative effects of GM-CSF signaling in a murine model of t(8;21)–induced leukemia

Shinobu Matsuura, Ming Yan, Miao-Chia Lo, Eun-Young Ahn, Stephanie Weng, David Dangoor, Mahan Matin, Tsunehito Higashi, Gen-Sheng Feng, Dong-Er Zhang

Blood (2012) 119 (13): 3155–3163.

https://doi.org/10.1182/blood-2011-04-350694

Published: 2012

Includes: Supplemental data

Journal Articles

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Peilin Ma, MD, PhD, Raghuveer Mali, Ph.D., Li-Fan Zeng, PhD, Holly Martin, Baskar Ramdas, Ph.D., Yantao He, PhD, Emily Sims, Joydeep Ghosh, Ph.D, Sarah C Nabinger, Shuo Li, Veerendra Munugalavadla, PhD, Anindya Chatterjee, PhD, George Sandusky, MD, Andrew Craig, PhD, Kevin D. Bunting, PhD, Gen-Sheng Feng, Rebecca J. Chan, MD, PhD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD

Blood (2011) 118 (21): 868.

https://doi.org/10.1182/blood.V118.21.868.868

Published: 2011

Journal Articles

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

Muneyoshi Futami, Quan-sheng Zhu, Zakary L. Whichard, Ling Xia, Yuehai Ke, Benjamin G. Neel, Gen-Sheng Feng, Seth J. Corey

Blood (2011) 118 (4): 1077–1086.

https://doi.org/10.1182/blood-2009-12-261636

Published: 2011

Journal Articles

Kit-Shp2- Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

Helen He Zhu, Kaihong Ji, Nazilla Alderson, Zhao He, Shuangwei Li, Wen Liu, Dong-Er Zhang, Linheng Li, Gen-Sheng Feng

Blood (2011) 117 (20): 5350–5361.

https://doi.org/10.1182/blood-2011-01-333476

Published: 2011

Includes: Supplemental data

Journal Articles

Tyrosine Phosphorylation of Runx1 In Megakaryocytes by Src Family Kinases

Hui Huang, Zachary Waldon, Gordon Chan, Helen Zhu, Hanno Steen, Gen-Sheng Feng, Benjamin Neel, Alan Cantor

Blood (2010) 116 (21): 742.

https://doi.org/10.1182/blood.V116.21.742.742

Published: 2010

Journal Articles

The G-CSF Receptor Requires Gab2-Mediated Recruitment of the Tyrosine Phosphatase Shp2 to Promote Lyn-Dependent Proliferation.

Muneyoshi Futami, MD, PhD, Quan-Sheng Zhu, MD, PhD, Gen-Sheng Feng, Benjamin Neel, MD, PhD, Seth J. Corey, MD

Blood (2010) 116 (21): 1555.

https://doi.org/10.1182/blood.V116.21.1555.1555

Published: 2010

Journal Articles

Coordinated Regulation of Embryonic and Adult Hematopoietic Stem Cell Activity by PTPN11 /Shp2.

Helen He Zhu, Kaihong Ji, Nazilla Alderson, Zhao He, Shuangwei Li, Linheng Li, PhD, Gen-Sheng Feng

Blood (2010) 116 (21): 2630.

https://doi.org/10.1182/blood.V116.21.2630.2630

Published: 2010

Journal Articles

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

Sarah C Nabinger, Yantao He, Fuqin Yin, Xian Zhang, Linda Senbanjo, Seiji Fukuda, MD, PhD, Menggang Yu, Gen-Sheng Feng, Zhong-Yin Zhang, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2009) 114 (22): 827.

https://doi.org/10.1182/blood.V114.22.827.827

Published: 2009

Journal Articles

A Noval Stat3 Binding Site in Gab2 Mediates Hematopoietic Transformation by Friend Erythroleukemia Virus.

Shuang Ni, MD, Jie Xu, B.S., Hami Teal, Ph.D, Gen-Sheng Feng, Ph.D, Robert F. Paulson, Ph. D, Pamela H. Correll, Ph. D

Blood (2006) 108 (11): 465.

https://doi.org/10.1182/blood.V108.11.465.465

Published: 2006

Journal Articles

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Rebecca J. Chan, Gen-Sheng Feng

Blood (2006) 109 (3): 862–867.

https://doi.org/10.1182/blood-2006-07-028829

Published: 2006

Includes: Supplemental data

Journal Articles

Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

Rongzhen Xu, Yingzi Yu, Shu Zheng, Xiaoying Zhao, Qinghua Dong, Zhiwen He, Yun Liang, Qinghua Lu, Yongmin Fang, Xiaoxian Gan, Xiaohua Xu, Suzhan Zhang, Qi Dong, Xiaohong Zhang, Gen-Sheng Feng

Blood (2005) 106 (9): 3142–3149.

https://doi.org/10.1182/blood-2004-10-4057

Published: 2005

Journal Articles

Mutated SHP and AML in leukemias

Gen-Sheng Feng

Blood (2004) 103 (6): 1982–1983.

https://doi.org/10.1182/blood-2004-01-0060

Published: 2004

Journal Articles

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

Rebecca J. Chan, Scott A. Johnson, Yanjun Li, Mervin C. Yoder, Gen-Sheng Feng

Blood (2003) 102 (6): 2074–2080.

https://doi.org/10.1182/blood-2003-04-1171

Published: 2003

Journal Articles

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

Cheng-Kui Qu, Suzanne Nguyen, Jianzhu Chen, Gen-Sheng Feng

Blood (2001) 97 (4): 911–914.

https://doi.org/10.1182/blood.V97.4.911

Published: 2001

NARROW

Unique Roles for Grb2-Associated Binding (Gab) Adaptors in Hematopoietic Stem Cell Homeostasis and Repopulation

Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Negative effects of GM-CSF signaling in a murine model of t(8;21)–induced leukemia

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

Kit-Shp2- Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

Tyrosine Phosphorylation of Runx1 In Megakaryocytes by Src Family Kinases

The G-CSF Receptor Requires Gab2-Mediated Recruitment of the Tyrosine Phosphatase Shp2 to Promote Lyn-Dependent Proliferation.

Coordinated Regulation of Embryonic and Adult Hematopoietic Stem Cell Activity by PTPN11 /Shp2.

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

A Noval Stat3 Binding Site in Gab2 Mediates Hematopoietic Transformation by Friend Erythroleukemia Virus.

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

Mutated SHP and AML in leukemias

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

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American Society of Hematology

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ASH Publications

American Society of Hematology

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