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Journal Articles

CCL3 is a key mediator for the leukemogenic effect of Ptpn11 -activating mutations in the stem-cell microenvironment

Lei Dong, Hong Zheng, Cheng-Kui Qu
Journal: Blood
Blood (2017) 130 (12): 1471–1474.
https://doi.org/10.1182/blood-2017-06-791103
Published: 2017
Includes: Supplemental data
Journal Articles

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

Brief Report
Xia Liu, Hong Zheng, Wen-Mei Yu, Todd M. Cooper, Kevin D. Bunting, Cheng-Kui Qu
Journal: Blood
Blood (2015) 125 (10): 1562–1565.
https://doi.org/10.1182/blood-2014-04-568949
Published: 2015
Includes: Supplemental data
Journal Articles

Critical Role of Stat5 in the Maintenance of Leukemic Stem Cells in Ptpn11 -Associated Juvenile Myelomonocytic Leukemia

Wei Liu, Xia Liu, Wen-Mei Yu, Kevin D. Bunting, Cheng-Kui Qu
Journal: Blood
Blood (2014) 124 (21): 818.
https://doi.org/10.1182/blood.V124.21.818.818
Published: 2014
Journal Articles

Synergistic Cytotoxicity in Acute Myeloid Leukemia By Combined Treatment with Metformin and 6-Benzylthioinosine

Himalee S. Sabnis, Shweta Tripathi, Heath L Bradley, Wen-Mei Yu, William Tse, Cheng-Kui Qu, Kevin D. Bunting
Journal: Blood
Blood (2014) 124 (21): 3754.
https://doi.org/10.1182/blood.V124.21.3754.3754
Published: 2014
Journal Articles

Critical Role of the Gab2/PI3K/mTOR Pathway in the Pathogenesis of Ptpn11 (Shp2) Mutation-Induced Myeloproliferative Disease.

Wei Liu, Xia Liu, Cheng-Kui Qu
Journal: Blood
Blood (2012) 120 (21): 2856.
https://doi.org/10.1182/blood.V120.21.2856.2856
Published: 2012
Journal Articles

Disruption of Mitochondrial Phosphatase Ptpmt1 Induces Bioenergetic Stress and Differentiation Block in Hematopoietic Stem Cells

Wen-Mei Yu, Xia Liu, Jinhua Shen, Olga Jovanovic, Elena E. Pohl, Stanton L. Gerson, MD, Toren Finkel, Hal E. Broxmeyer, Ph.D., Cheng-Kui Qu
Journal: Blood
Blood (2012) 120 (21): 857.
https://doi.org/10.1182/blood.V120.21.857.857
Published: 2012
Journal Articles

Leukocyte Factor XII Mediates Inflammation and Its Deficiency Promotes Wound Healing

Evi Stavrou, MD, Matthew J. Fullana, Gretchen LaRusch, Cindy Yushin Chang, Chao Fang, Howard J. Meyerson, Cheng-Kui Qu, Wen-Mei Yu, Gary E. Wnek, Alvin H. Schmaier, MD
Journal: Blood
Blood (2012) 120 (21): 616.
https://doi.org/10.1182/blood.V120.21.616.616
Published: 2012
Journal Articles

Ex Vivo Expansion of SCID Leukemia-Initiating Cells Using NANEX Nanofiber Scaffold

Stephen L Fischer, PhD, Yukang Zhao, Cheng-Kui Qu, M.D., Ph.D., Ramasamy Sakthivel, PhD
Journal: Blood
Blood (2011) 118 (21): 4994.
https://doi.org/10.1182/blood.V118.21.4994.4994
Published: 2011
Journal Articles

Non-Lineage/Stage Restricted Effects of a Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn11 (Shp2) on Malignant Transformation of Hematopoietic Cells

Dan Xu, Xia Liu, Wen-Mei Yu, Howard J. Meyerson, Stanton L. Gerson, MD, Cheng-Kui Qu
Journal: Blood
Blood (2011) 118 (21): 392.
https://doi.org/10.1182/blood.V118.21.392.392
Published: 2011
Journal Articles

Factor XII Promotes Leukocyte Inflammation and Its Deficiency Results in Faster Wound Healing

Evi Stavrou, MD, Gretchen A. LaRusch, Matthew J. Fullana, Gary E. Wnek, Cheng-Kui Qu, Wen-Mei Yu, Howard J. Meyerson, Chao Fang, Nicholas P. Ziats, Alvin H. Schmaier, MD
Journal: Blood
Blood (2011) 118 (21): 368.
https://doi.org/10.1182/blood.V118.21.368.368
Published: 2011
Journal Articles

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, Cheng-Kui Qu
Journal: Blood
Blood (2010) 116 (18): 3611–3621.
https://doi.org/10.1182/blood-2010-01-265652
Published: 2010
Includes: Supplemental data
Journal Articles

Abnormal hematopoiesis in Gab2 mutant mice

Yi Zhang, Ernesto Diaz-Flores, Geqiang Li, Zhengqi Wang, Zizhen Kang, Eleonora Haviernikova, Sara Rowe, Cheng-Kui Qu, William Tse, Kevin M. Shannon, Kevin D. Bunting
Journal: Blood
Blood (2007) 110 (1): 116–124.
https://doi.org/10.1182/blood-2006-11-060707
Published: 2007
Includes: Supplemental data
Journal Articles

SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl

Jing Chen, Wen-Mei Yu, Hanako Daino, Hal E. Broxmeyer, Brian J. Druker, Cheng-Kui Qu
Journal: Blood
Blood (2006) 109 (2): 778–785.
https://doi.org/10.1182/blood-2006-04-019141
Published: 2006
Journal Articles

Effects of a Leukemia-Associated Gain-of-Function Mutation of SHP-2 Phosphatase on IL-3 Signaling.

Wen-Mei Yu, Hanako Daino, Jing Chen, Kevin D. Bunting, Cheng-Kui Qu
Journal: Blood
Blood (2005) 106 (11): 2285.
https://doi.org/10.1182/blood.V106.11.2285.2285
Published: 2005
Journal Articles

Immortalization of yolk sac–derived precursor cells

Brief Report
Wen-Mei Yu, Teresa S. Hawley, Robert G. Hawley, Cheng-Kui Qu
Journal: Blood
Blood (2002) 100 (10): 3828–3831.
https://doi.org/10.1182/blood-2002-03-0937
Published: 2002
Journal Articles

Role of the docking protein Gab2 in β 1 -integrin signaling pathway-mediated hematopoietic cell adhesion and migration

Wen-Mei Yu, Teresa S. Hawley, Robert G. Hawley, Cheng-Kui Qu
Journal: Blood
Blood (2002) 99 (7): 2351–2359.
https://doi.org/10.1182/blood.V99.7.2351
Published: 2002
Journal Articles

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

Cheng-Kui Qu, Suzanne Nguyen, Jianzhu Chen, Gen-Sheng Feng
Journal: Blood
Blood (2001) 97 (4): 911–914.
https://doi.org/10.1182/blood.V97.4.911
Published: 2001