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Silke Heising
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Journal Articles

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

Zoltan Nagy, Timo Vögtle, Mitchell J. Geer, Jun Mori, Silke Heising, Giada Di Nunzio, Ralph Gareus, Alexander Tarakhovsky, Arthur Weiss, Benjamin G. Neel, Guillaume E. Desanti, Alexandra Mazharian, Yotis A. Senis
Journal: Blood
Blood (2019) 133 (4): 331–343.
https://doi.org/10.1182/blood-2018-09-877787
Published: 2019
Includes: Supplemental data
Journal Articles

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Mitchell J. Geer, Johanna P. van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W. Smith, Silke Heising, Marijke J. E. Kuijpers, Bibian M. E. Tullemans, Gavin E. Jarvis, Johannes A. Eble, Mark Jeeves, Michael Overduin, Johan W. M. Heemskerk, Alexandra Mazharian, Yotis A. Senis
Journal: Blood
Blood (2018) 132 (13): 1413–1425.
https://doi.org/10.1182/blood-2017-10-802975
Published: 2018
Includes: Supplemental data
Journal Articles

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Inga Hofmann, Mitchell J. Geer, Timo Vögtle, Andrew Crispin, Dean R. Campagna, Alastair Barr, Monica L. Calicchio, Silke Heising, Johanna P. van Geffen, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Johannes A. Eble, Klaus Schmitz-Abe, Esther A. Obeng, Michael Douglas, Kathleen Freson, Corinne Pondarré, Rémi Favier, Gavin E. Jarvis, Kyriacos Markianos, Ernest Turro, Willem H. Ouwehand, Alexandra Mazharian, Mark D. Fleming, Yotis A. Senis
Journal: Blood
Blood (2018) 132 (13): 1399–1412.
https://doi.org/10.1182/blood-2017-08-802769
Published: 2018
Includes: Supplemental data
Journal Articles

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Jun Mori, Zoltan Nagy, Giada Di Nunzio, Christopher W. Smith, Mitchell J. Geer, Rashid Al Ghaithi, Johanna P. van Geffen, Silke Heising, Luke Boothman, Bibian M. E. Tullemans, Joao N. Correia, Louise Tee, Marijke J. E. Kuijpers, Paul Harrison, Johan W. M. Heemskerk, Gavin E. Jarvis, Alexander Tarakhovsky, Arthur Weiss, Alexandra Mazharian, Yotis A. Senis
Journal: Blood
Blood (2018) 131 (10): 1122–1144.
https://doi.org/10.1182/blood-2017-02-768077
Published: 2018
Includes: Multimedia, Supplemental data
Journal Articles

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Alexandra Mazharian, Jun Mori, Ying-Jie Wang, Silke Heising, Benjamin G. Neel, Steve P. Watson, Yotis A. Senis
Journal: Blood
Blood (2013) 121 (20): 4205–4220.
https://doi.org/10.1182/blood-2012-08-449272
Published: 2013
Includes: Multimedia, Supplemental data