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Journal Articles

Expression Levels of the TERT Gene Can be Used to Risk Stratify Aplastic Anemia Patients: Study in an Indian Cohort

Arati Khanna-Gupta, PhD, Durga Sarvepalli, Snigdha Majumder, Coral Karunakaran, Malini Manoharan, Shilpa Sudesh, Varun Bafna, Chirantan Bose, Ravi Gupta, K.S. Natraj, Sharat Damodar, MBBS, MD DM, Arkasubhra Ghosh, PhD

Blood (2017) 130 (Supplement 1): 4963.

https://doi.org/10.1182/blood.V130.Suppl_1.4963.4963

Published: 2017

Journal Articles

Retrospective Next Generation DNA Sequencing Analysis in Patients with Hemophagocytic Lymphohistiocytosis (HLH) Highlights Genetic Variants Associated with Secondary/Late-Onset Disease

Meeta Sunil, Chirantan Bose, Coral Karunakaran, Sunil Bhat, MBBS, MD, Nita Radhakrishnan, Srisha Rani, Sakthivel Murugan SM, Sharat Damodar, MBBS, MD DM, Ravi Gupta, Rohit Gupta, Mukesh Manharlal Desai, MBBS,MD, Arati Khanna-Gupta, PhD

Blood (2017) 130 (Supplement 1): 2286.

https://doi.org/10.1182/blood.V130.Suppl_1.2286.2286

Published: 2017

Journal Articles

Mutations in the Telomerase Complex and Expression Levels of the TERT Gene Determine Severity and Outcome of Disease in Aplastic Anemia Patients

Arati Khanna-Gupta, MSc, PhD, Durga Sarvepalli, PhD, Snigdha Majumder, M.Tech, Coral Karunakaran, PhD, Malini Manoharan, PhD, Shilpa Prabhu, MBBS, MD, Varun Bafna, III, MBBS,DNB, Sakthivel Murugan SM, PhD, Chirantan Bose, MD(Path), Ravi Gupta, PhD, Nataraj KS, MD DM, Sharat Damodar, MD DM, Arkasubhra Ghosh, PhD

Blood (2016) 128 (22): 1502.

https://doi.org/10.1182/blood.V128.22.1502.1502

Published: 2016

Journal Articles

Predicting Response to Immunosuppressive Therapy in Patients with Acquired Aplastic Anemiausing EGFR and TWIST1 Expression Levels

Sharat Damodar, MD DM, Varun Bafna, MBBS, MD, Arati Khanna-Gupta, MSc, PhD, Shilpa Prabhu, MBBS, MD, Nataraj KS, MD DM, Durga Sarvepalli, PhD, Snigdha Majumder, M.Tech, Coral Karunakaran, PhD, Malini Manoharan, PhD, Sakthivel Murugan, Chirantan Bose, MD(Path), Ravi Gupta, PhD, Arkasubhra Ghosh, PhD

Blood (2016) 128 (22): 5076.

https://doi.org/10.1182/blood.V128.22.5076.5076

Published: 2016

Journal Articles

Haploinsufficiency of NPM1 in AML Derived NPM1 Mutant (NPMc+) Expressing Cells Contributes to Aberrant C/EBPα Activity

Kathryn Czepiel, BS, Kelly Nichol, BS, Mason Tippy, Nirmalee Abayasekara, MS, Jaclyn Lee, BS, Ethan Wajswol, BS, Anjali Khanna, MBBS, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2014) 124 (21): 2188.

https://doi.org/10.1182/blood.V124.21.2188.2188

Published: 2014

Journal Articles

Mutant Nucleophosmin 1(NPMc+) Mislocalizes The p40 Isoform Of The Master Myeloid Transcriptional Regulator C/EBPα To The Cytoplasm: Implications In AML

Nirmalee Abayasekara, MS, Czepiel Kathryn, BS, Lee Jaclyn, BS, Anjali Khanna, MBBS, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2013) 122 (21): 1417.

https://doi.org/10.1182/blood.V122.21.1417.1417

Published: 2013

Journal Articles

L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner

Nirmalee Abayasekara, MS, Anupama Narla, Slater Hurst, BS, Hong Sun, MD, Maria Virgilio, Elspeth Payne, Benjamin L. Ebert, MD, PhD, A. Thomas Look, M.D., Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2012) 120 (21): 1257.

https://doi.org/10.1182/blood.V120.21.1257.1257

Published: 2012

Journal Articles

L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

Elspeth M. Payne, Maria Virgilio, Anupama Narla, Hong Sun, Michelle Levine, Barry H. Paw, Nancy Berliner, A. Thomas Look, Benjamin L. Ebert, Arati Khanna-Gupta

Blood (2012) 120 (11): 2214–2224.

https://doi.org/10.1182/blood-2011-10-382986

Published: 2012

Includes: Supplemental data

Journal Articles

L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway

Maria Virgilio, Elspeth Payne, MB, ChB, Ph.D, Anupama Narla, MD, Hong Sun, MD, Barry H. Paw, M.D., Ph.D., Thomas Look, MD, Benjamin L. Ebert, MD, D.Phil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2011) 118 (21): 970.

https://doi.org/10.1182/blood.V118.21.970.970

Published: 2011

Journal Articles

Upregulation of eIF4E in Nucleophosmin 1 (NPM1) Haploinsufficient Cells Alters CCAAT Enhancer Binding Protein Alpha (C/EBPα) Activity: Implications for MDS and AML

Nirmalee Abayasekara, MS, Michelle Levine, BS, Niccolo Bolli, MD, Hong Sun, MD, Matthew Silver, BS, Navid Nia, Paolo Sportoletti, MD, Pier Paolo Pandolfi, MD, PhD, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2011) 118 (21): 2432.

https://doi.org/10.1182/blood.V118.21.2432.2432

Published: 2011

Journal Articles

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML

Elspeth M. Payne, Niccolò Bolli, Jennifer Rhodes, Omar I. Abdel-Wahab, Ross Levine, Cyrus V. Hedvat, Richard Stone, Arati Khanna-Gupta, Hong Sun, John P. Kanki, Hanna T. Gazda, Alan H. Beggs, Finbarr E. Cotter, A. Thomas Look

Blood (2011) 118 (4): 903–915.

https://doi.org/10.1182/blood-2010-11-318022

Published: 2011

Includes: Multimedia, Supplemental data

Journal Articles

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

Shilpee Dutt, Anupama Narla, Katherine Lin, Ann Mullally, Nirmalee Abayasekara, Christine Megerdichian, Frederick H. Wilson, Treeve Currie, Arati Khanna-Gupta, Nancy Berliner, Jeffery L. Kutok, Benjamin L. Ebert

Blood (2011) 117 (9): 2567–2576.

https://doi.org/10.1182/blood-2010-07-295238

Published: 2011

Includes: Supplemental data

Journal Articles

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Maria Virgilio, Elspeth Payne, MBChB, Anupama Narla, MD, Hong Sun, MD, Barry Paw, M.D., Ph.D., A. Thomas Look, MD, Benjamin L. Ebert, MD, DPhil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2010) 116 (21): 195.

https://doi.org/10.1182/blood.V116.21.195.195

Published: 2010

Journal Articles

Both p53-Dependent and -Independent Pathways Contribute to Erythroid Dysplasia in a Zebrafish Model for Diamond Blackfan Anemia.

Elspeth Payne, MBChB, BSc, MRCP, Hong Sun, Barry H. Paw, M.D., Ph.D., A. Thomas Look, MD, Arati Khanna-Gupta, PhD

Blood (2009) 114 (22): 177.

https://doi.org/10.1182/blood.V114.22.177.177

Published: 2009

Journal Articles

Nucleophosmin Is Required for Macrophage Function and Maturation.

Paolo Sportoletti, MD, John G Clohessy, Luisa Riccardi, MD, Arati Khanna-Gupta, PhD, Jian Chen, Nancy Berliner, MD, Pier Paolo Pandolfi, MD, PhD

Blood (2009) 114 (22): 238.

https://doi.org/10.1182/blood.V114.22.238.238

Published: 2009

Journal Articles

Nucleophosmin-1 Interacts with CCAAT Enhancer Binding Protein Alpha (C/EBPα) to Facilitate Granulocyte Maturation: Implications in MDS and AML.

Arati Khanna-Gupta, PhD, Jian Chen, Matthew Silver, BS, Hong Sun, Nirmalee Abayasekara, MS, Stephanie Halene, MD, Paolo Sportoletti, MD, Pier Paolo Pandolfi, MD, PhD, Nancy Berliner, MD

Blood (2009) 114 (22): 2768.

https://doi.org/10.1182/blood.V114.22.2768.2768

Published: 2009

Journal Articles

Generation of a Factor Dependent Myeloid Cell Line from Nucleophosmin-1 Heterozygous (NPM-1+/−) Mouse Bone Marrow as a Model for 5q- MDS

Arati Khanna-Gupta, PhD, Hong Sun, Jian Chen, Stephanie Halene, MD, Paolo Sportoletti, MD, Pier Paolo Pandolfi, MD, PhD, Nancy Berliner

Blood (2008) 112 (11): 852.

https://doi.org/10.1182/blood.V112.11.852.852

Published: 2008

Journal Articles

Post-Translational Modification and Differential Protein Binding Partners of CCAAT Enhancer Binding Protein Alpha (C/EBPα) p42 Versus p30 May Contribute to Aberrant C/EBPα Activity in Acute Leukemia

Matthew Silver, BS, Nirmalee Abayasekara, MS, Dylan Perry, Hong Sun, Nancy Berliner, Arati Khanna-Gupta, PhD

Blood (2008) 112 (11): 3577.

https://doi.org/10.1182/blood.V112.11.3577.3577

Published: 2008

Journal Articles

Differential Transactivation Activities of Sumoylated CCAAT Enhancer Binding Protein alpha (C/EBPα) p42 Versus p30 May Contribute in Part, to Aberrant C/EBPα Activity in Acute Leukemias.

Arati Khanna-Gupta, PhD, Matthew Silver, B.S., William Hankey, M.Phil, Hong Sun, MD, Nancy Berliner, MD

Blood (2007) 110 (11): 1231.

https://doi.org/10.1182/blood.V110.11.1231.1231

Published: 2007

Journal Articles

ATRA: Finding targeted APL therapy targets

Arati Khanna-Gupta, Nancy Berliner

Blood (2007) 110 (2): 476–477.

https://doi.org/10.1182/blood-2007-04-086348

Published: 2007

NARROW

Expression Levels of the TERT Gene Can be Used to Risk Stratify Aplastic Anemia Patients: Study in an Indian Cohort

Retrospective Next Generation DNA Sequencing Analysis in Patients with Hemophagocytic Lymphohistiocytosis (HLH) Highlights Genetic Variants Associated with Secondary/Late-Onset Disease

Mutations in the Telomerase Complex and Expression Levels of the TERT Gene Determine Severity and Outcome of Disease in Aplastic Anemia Patients

Predicting Response to Immunosuppressive Therapy in Patients with Acquired Aplastic Anemiausing EGFR and TWIST1 Expression Levels

Haploinsufficiency of NPM1 in AML Derived NPM1 Mutant (NPMc+) Expressing Cells Contributes to Aberrant C/EBPα Activity

Mutant Nucleophosmin 1(NPMc+) Mislocalizes The p40 Isoform Of The Master Myeloid Transcriptional Regulator C/EBPα To The Cytoplasm: Implications In AML

L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner

L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway

Upregulation of eIF4E in Nucleophosmin 1 (NPM1) Haploinsufficient Cells Alters CCAAT Enhancer Binding Protein Alpha (C/EBPα) Activity: Implications for MDS and AML

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Both p53-Dependent and -Independent Pathways Contribute to Erythroid Dysplasia in a Zebrafish Model for Diamond Blackfan Anemia.

Nucleophosmin Is Required for Macrophage Function and Maturation.

Nucleophosmin-1 Interacts with CCAAT Enhancer Binding Protein Alpha (C/EBPα) to Facilitate Granulocyte Maturation: Implications in MDS and AML.

Generation of a Factor Dependent Myeloid Cell Line from Nucleophosmin-1 Heterozygous (NPM-1+/−) Mouse Bone Marrow as a Model for 5q- MDS

Post-Translational Modification and Differential Protein Binding Partners of CCAAT Enhancer Binding Protein Alpha (C/EBPα) p42 Versus p30 May Contribute to Aberrant C/EBPα Activity in Acute Leukemia

Differential Transactivation Activities of Sumoylated CCAAT Enhancer Binding Protein alpha (C/EBPα) p42 Versus p30 May Contribute in Part, to Aberrant C/EBPα Activity in Acute Leukemias.

ATRA: Finding targeted APL therapy targets

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American Society of Hematology

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