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Gerwin Heller
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Journal Articles

Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells

Isabella M. Mayer, Eszter Doma, Thorsten Klampfl, Michaela Prchal-Murphy, Sebastian Kollmann, Alessia Schirripa, Lisa Scheiblecker, Markus Zojer, Natalia Kunowska, Lea Gebrail, Lisa E. Shaw, Ulrike Mann, Alex Farr, Reinhard Grausenburger, Gerwin Heller, Eva Zebedin-Brandl, Matthias Farlik, Marcos Malumbres, Veronika Sexl, Karoline Kollmann
Journal: Blood
Blood (2024) 144 (2): 156–170.
https://doi.org/10.1182/blood.2023021985
Published: 2024
Includes: Supplemental data
Journal Articles

Distinct Subtypes of Chemotherapy-Resistant Systemic ALK-Positive Anaplastic Large Cell Lymphoma Demonstrate Long-Term Complete Remissions to Imatinib

Alexander Pichler, Christoph Kornauth, Ines Garces De Los Fayos Alonso, Lukas Kazianka, Arne Zibat, Luca Mologni, Halima Alachram, Tea Pemovska, Gerwin Heller, Richard Greil, Lukas Kenner, Ulrich Jaeger, Philipp Bernhard Staber
Journal: Blood
Blood (2023) 142 (Supplement 1): 1691.
https://doi.org/10.1182/blood-2023-188835
Published: 2023
Journal Articles

A STAT5B–CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

Sebastian Kollmann, Reinhard Grausenburger, Thorsten Klampfl, Michaela Prchal-Murphy, Klavdija Bastl, Hanja Pisa, Vanessa M. Knab, Tania Brandstoetter, Eszter Doma, Wolfgang R. Sperr, Sabine Lagger, Matthias Farlik, Richard Moriggl, Peter Valent, Florian Halbritter, Karoline Kollmann, Gerwin Heller, Barbara Maurer, Veronika Sexl
Journal: Blood
Blood (2021) 138 (23): 2347–2359.
https://doi.org/10.1182/blood.2021010980
Published: 2021
Includes: Supplemental data
Journal Articles

Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Bon Q. Trinh, Simone Ummarino, Yanzhou Zhang, Alexander K. Ebralidze, Mahmoud A. Bassal, Tuan M. Nguyen, Gerwin Heller, Rory Coffey, Danielle E. Tenen, Emiel van der Kouwe, Emiliano Fabiani, Carmelo Gurnari, Chan-Shuo Wu, Vladimir Espinosa Angarica, Henry Yang, Sisi Chen, Hong Zhang, Abby R. Thurm, Francisco Marchi, Elena Levantini, Philipp B. Staber, Pu Zhang, Maria Teresa Voso, Pier Paolo Pandolfi, Susumu S. Kobayashi, Li Chai, Annalisa Di Ruscio, Daniel G. Tenen
Journal: Blood
Blood (2021) 138 (15): 1331–1344.
https://doi.org/10.1182/blood.2020007920
Published: 2021
Includes: Supplemental data
Journal Articles

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Emiel van der Kouwe, PharmD, Gerwin Heller, PhD, Akos Czibere, MD, Lucio H. Castilla, PhD, Ruud Delwel, PhD, Annalisa Di Ruscio, MD PhD, Alexander Ebralidze, PhD, Maurizio Forte, MSc, Lukas Kazianka, MD, Christoph Kornauth, Trang Le, BSc, Karin Lind, MSc, Ines Barbosa, PhD, Alexander Pichler, MD, John Pulikkan, PhD, Ann-Sofie Schmolke, MD, Heinz Sill, MD, Wolfgang R. Sperr, MD, Andreas Spittler, MD, Bon Q. Trinh, PhD, Peter Valent, MD, Katrina Vanura, PhD, Robert Welner, PhD, Johannes Zuber, PhD, Daniel G. Tenen, MD, Philipp B. Staber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-140776
Published: 2020
Journal Articles

Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy

Clinical Trials & Observations
Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A. Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gregor Hoermann, Jean-Jacques Kiladjian, Thomas Kolbe, Christoph Kornauth, Maria-Theresa Krauth, Robert Kralovics, Leonhard Muellauer, Mathias Mueller, Michaela Prchal-Murphy, Eva Maria Putz, Emmanuel Raffoux, Ana-Iris Schiefer, Klaus Schmetterer, Christine Schneckenleithner, Ingrid Simonitsch-Klupp, Cathrin Skrabs, Wolfgang R. Sperr, Philipp Bernhard Staber, Birgit Strobl, Peter Valent, Ulrich Jaeger, Heinz Gisslinger, Veronika Sexl
Journal: Blood
Blood (2018) 132 (7): 694–706.
https://doi.org/10.1182/blood-2017-10-810739
Published: 2018
Includes: Supplemental data
Journal Articles

JAK2-Inhibitor Therapy Associated Lymphomas in Myelofibrosis: Distinct Clinico-Pathological Features Recapitulated in a Mouse Model

Sabrina Tripolt, PhD, Edit Anna Porpaczy, MD, Andrea Hoelbl-Kovacic, PhD, Bettina Gisslinger, Zsuzanna Bago-Horvath, PhD, Emilio Casanova, PhD, Thomas Decker, PhD, Daniela Fux, PhD, Gerwin Heller, MD, Harald Herkner, MD, Thomas Kolbe, PhD, Christoph Kornauth, MD, Mathias Mueller, PhD, Michaela Prchal-Murphy, PhD, Ana Iris Schiefer, MD, Christine Schneckenleithner, PhD, Cathrin Skrabs, MD, Wolfgang R. Sperr, MD, Philipp Bernhard Staber, MD PhD, Birgit Strobl, PhD, Peter Valent, MD, Ingrid Simonitsch-Klupp, MD, Gregor Hoermann, MD, Jean-Jacques Kiladjian, MD PhD, Robert Kralovics, PhD, Maria-Theresa Krauth, MD, Ulrich Jaeger, MD, Veronika Sexl, MD PhD, Heinz Gisslinger
Journal: Blood
Blood (2017) 130 (Supplement 1): 1643.
https://doi.org/10.1182/blood.V130.Suppl_1.1643.1643
Published: 2017
Journal Articles

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

Ruth Scheicher, Andrea Hoelbl-Kovacic, Florian Bellutti, Anca-Sarmiza Tigan, Michaela Prchal-Murphy, Gerwin Heller, Christine Schneckenleithner, María Salazar-Roa, Sabine Zöchbauer-Müller, Johannes Zuber, Marcos Malumbres, Karoline Kollmann, Veronika Sexl
Journal: Blood
Blood (2015) 125 (1): 90–101.
https://doi.org/10.1182/blood-2014-06-584417
Published: 2015
Includes: Supplemental data
Journal Articles

Next Generation Sequencing Identifies DNA Methylation Patterns Indicative of Disease Progression in Ph + CML

Gerwin Heller, PhD, Thais Topakian, Corinna Altenberger, MSc, Sabine Cerny-Reiterer, Dr., Barbara Ziegler, Paul Datlinger, MSc, Christoph Bock, PhD, Christine Mannhalter, PhD, Gregor Hörmann, MD PhD, Wolfgang R Sperr, MD, Christoph C Zielinski, MD, Peter Valent, MD, Sabine Zöchbauer-Müller, MD
Journal: Blood
Blood (2014) 124 (21): 4526.
https://doi.org/10.1182/blood.V124.21.4526.4526
Published: 2014
Journal Articles

5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS- demethylation and FAS re-expression, and synergism with FAS-ligand

Viviane Ghanim, Harald Herrmann, Gerwin Heller, Barbara Peter, Emir Hadzijusufovic, Katharina Blatt, Karina Schuch, Sabine Cerny-Reiterer, Irina Mirkina, Heidrun Karlic, Winfried F. Pickl, Sabine Zöchbauer-Müller, Peter Valent
Journal: Blood
Blood (2012) 119 (18): 4242–4252.
https://doi.org/10.1182/blood-2011-09-382770
Published: 2012
Includes: Supplemental data
Journal Articles

5-Azacytidine and Decitabine Induce FAS Re-Expression, Exert Major Proapoptotic Effects, and Cooperate with the FAS Ligand in Producing Apoptosis in Neoplastic Human Mast Cells,

Viviane Ghanim, M.D., Harald Herrmann, MD, Emir Hadzijusufovic, DVM, Barbara Peter, D.V.M., Katharina Blatt, M.Sc., Karina Schuch, Sabine Cerny-Reiterer, D.V.M., Irina Mirkina, PhD, Gerwin Heller, PhD, Sabine Zöchbauer-Müller, MD, Heidrun Karlic, PhD, Winfried F Pickl, MD, Peter Valent, M.D.
Journal: Blood
Blood (2011) 118 (21): 3457.
https://doi.org/10.1182/blood.V118.21.3457.3457
Published: 2011
Journal Articles

c-JUN promotes BCR-ABL–induced lymphoid leukemia by inhibiting methylation of the 5′ region of Cdk6

Karoline Kollmann, Gerwin Heller, Rene Georg Ott, Ruth Scheicher, Eva Zebedin-Brandl, Christine Schneckenleithner, Olivia Simma, Wolfgang Warsch, Eva Eckelhart, Andrea Hoelbl, Martin Bilban, Sabine Zöchbauer-Müller, Marcos Malumbres, Veronika Sexl
Journal: Blood
Blood (2011) 117 (15): 4065–4075.
https://doi.org/10.1182/blood-2010-07-299644
Published: 2011
Includes: Supplemental data