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Michaela Prchal-Murphy
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Journal Articles

Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells

Isabella M. Mayer, Eszter Doma, Thorsten Klampfl, Michaela Prchal-Murphy, Sebastian Kollmann, Alessia Schirripa, Lisa Scheiblecker, Markus Zojer, Natalia Kunowska, Lea Gebrail, Lisa E. Shaw, Ulrike Mann, Alex Farr, Reinhard Grausenburger, Gerwin Heller, Eva Zebedin-Brandl, Matthias Farlik, Marcos Malumbres, Veronika Sexl, Karoline Kollmann
Journal: Blood
Blood (2024) 144 (2): 156–170.
https://doi.org/10.1182/blood.2023021985
Published: 2024
Includes: Supplemental data
Journal Articles

A STAT5B–CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

Sebastian Kollmann, Reinhard Grausenburger, Thorsten Klampfl, Michaela Prchal-Murphy, Klavdija Bastl, Hanja Pisa, Vanessa M. Knab, Tania Brandstoetter, Eszter Doma, Wolfgang R. Sperr, Sabine Lagger, Matthias Farlik, Richard Moriggl, Peter Valent, Florian Halbritter, Karoline Kollmann, Gerwin Heller, Barbara Maurer, Veronika Sexl
Journal: Blood
Blood (2021) 138 (23): 2347–2359.
https://doi.org/10.1182/blood.2021010980
Published: 2021
Includes: Supplemental data
Journal Articles

CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks

Iris Z. Uras, Barbara Maurer, Harini Nivarthi, Philipp Jodl, Karoline Kollmann, Michaela Prchal-Murphy, Jelena D. Milosevic Feenstra, Markus Zojer, Sabine Lagger, Reinhard Grausenburger, Beatrice Grabner, Raimund Holly, Anoop Kavirayani, Christoph Bock, Heinz Gisslinger, Peter Valent, Robert Kralovics, Veronika Sexl
Journal: Blood
Blood (2019) 133 (15): 1677–1690.
https://doi.org/10.1182/blood-2018-08-872648
Published: 2019
Includes: Supplemental data
Journal Articles

Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy

Clinical Trials & Observations
Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A. Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gregor Hoermann, Jean-Jacques Kiladjian, Thomas Kolbe, Christoph Kornauth, Maria-Theresa Krauth, Robert Kralovics, Leonhard Muellauer, Mathias Mueller, Michaela Prchal-Murphy, Eva Maria Putz, Emmanuel Raffoux, Ana-Iris Schiefer, Klaus Schmetterer, Christine Schneckenleithner, Ingrid Simonitsch-Klupp, Cathrin Skrabs, Wolfgang R. Sperr, Philipp Bernhard Staber, Birgit Strobl, Peter Valent, Ulrich Jaeger, Heinz Gisslinger, Veronika Sexl
Journal: Blood
Blood (2018) 132 (7): 694–706.
https://doi.org/10.1182/blood-2017-10-810739
Published: 2018
Includes: Supplemental data
Journal Articles

JAK2-Inhibitor Therapy Associated Lymphomas in Myelofibrosis: Distinct Clinico-Pathological Features Recapitulated in a Mouse Model

Sabrina Tripolt, PhD, Edit Anna Porpaczy, MD, Andrea Hoelbl-Kovacic, PhD, Bettina Gisslinger, Zsuzanna Bago-Horvath, PhD, Emilio Casanova, PhD, Thomas Decker, PhD, Daniela Fux, PhD, Gerwin Heller, MD, Harald Herkner, MD, Thomas Kolbe, PhD, Christoph Kornauth, MD, Mathias Mueller, PhD, Michaela Prchal-Murphy, PhD, Ana Iris Schiefer, MD, Christine Schneckenleithner, PhD, Cathrin Skrabs, MD, Wolfgang R. Sperr, MD, Philipp Bernhard Staber, MD PhD, Birgit Strobl, PhD, Peter Valent, MD, Ingrid Simonitsch-Klupp, MD, Gregor Hoermann, MD, Jean-Jacques Kiladjian, MD PhD, Robert Kralovics, PhD, Maria-Theresa Krauth, MD, Ulrich Jaeger, MD, Veronika Sexl, MD PhD, Heinz Gisslinger
Journal: Blood
Blood (2017) 130 (Supplement 1): 1643.
https://doi.org/10.1182/blood.V130.Suppl_1.1643.1643
Published: 2017
Journal Articles

Palbociclib treatment of FLT3 -ITD + AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6

Iris Z. Uras, Gina J. Walter, Ruth Scheicher, Florian Bellutti, Michaela Prchal-Murphy, Anca S. Tigan, Peter Valent, Florian H. Heidel, Stefan Kubicek, Claudia Scholl, Stefan Fröhling, Veronika Sexl
Journal: Blood
Blood (2016) 127 (23): 2890–2902.
https://doi.org/10.1182/blood-2015-11-683581
Published: 2016
Includes: Supplemental data
Journal Articles

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

Ruth Scheicher, Andrea Hoelbl-Kovacic, Florian Bellutti, Anca-Sarmiza Tigan, Michaela Prchal-Murphy, Gerwin Heller, Christine Schneckenleithner, María Salazar-Roa, Sabine Zöchbauer-Müller, Johannes Zuber, Marcos Malumbres, Karoline Kollmann, Veronika Sexl
Journal: Blood
Blood (2015) 125 (1): 90–101.
https://doi.org/10.1182/blood-2014-06-584417
Published: 2015
Includes: Supplemental data
Journal Articles

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis

Esther Rodríguez-Díez, Victor Quereda, Florian Bellutti, Michaela Prchal-Murphy, David Partida, Manuel Eguren, Karoline Kollmann, Marta Gómez de Cedrón, Pierre Dubus, Marta Cañamero, Dolores Martínez, Veronika Sexl, Marcos Malumbres
Journal: Blood
Blood (2014) 124 (15): 2380–2390.
https://doi.org/10.1182/blood-2014-02-555292
Published: 2014
Includes: Supplemental data