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Journal Articles

Deciphering the Mechanisms of Osteoblast-Induced Resistance of Leukemic Stem Cell (LSC) in Ph+ CML: Role of PI3-Kinase, BRD4 and MYC and Development of Strategies to Overcome Osteoblast-Induced Resistance

Yueksel Filik, Karin Bauer, Barbara Peter, Emir Hadzijusufovic, Georg Greiner, Nadine Witzeneder, Gregor Hoermann, Karoline V. Gleixner, Wolfgang R. Sperr, Peter Valent

Blood (2021) 138 (Supplement 1): 1481.

https://doi.org/10.1182/blood-2021-152415

Published: 2021

Journal Articles

Phenotyping of Disease-Initiating CD34 + /CD38 ─ Stem Cells in BCR-ABL1 ─ MPN Reveals Expression of Multiple Cytokine Receptors and Resistance-Related Antigens

Blood (2020) 136 (Supplement 1): 53.

https://doi.org/10.1182/blood-2020-140477

Published: 2020

Journal Articles

BRD4 Degradation Is a Potent Approach to Block MYC Expression and to Overcome Multiple Forms of Stem Cell Resistance in Ph + CML

Barbara Peter, Gregor Eisenwort, Alexandra Keller, Karin Bauer, Daniela Berger, Irina Sadovnik, Gabriele Stefanzl, Gregor Hoermann, Dominik Wolf, Zdenek Racil, Jiří Mayer, Johannes Zuber, Wolfgang R. Sperr, Georg E. Winter, Michael Willmann, Thomas Rülicke, Peter Valent

Blood (2018) 132 (Supplement 1): 1722.

https://doi.org/10.1182/blood-2018-99-111126

Published: 2018

Journal Articles

Evaluation of Cell Surface Markers and Targets in Leukemic Stem Cells (LSC) Reveals Distinct Expression Profiles, Unique Drug Effects, and Specific Checkpoint Regulation in AML LSC and CML LSC

Irina Sadovnik, MSc, Harald Herrmann, MD, Katharina Blatt, MSc, PhD, Gregor Eisenwort, MD PhD, Niklas Mueller, MD, Gabriele Stefanzl, Gregor Hoermann, Susanne Herndlhofer, Karin Bauer, PhD, Barbara Peter, DVM, Rene Gaupmann, MD, Axel Schulenburg, MD, Wolfgang R. Sperr, MD, Peter Valent, MD

Blood (2016) 128 (22): 4234.

https://doi.org/10.1182/blood.V128.22.4234.4234

Published: 2016

Journal Articles

The Multi-Kinase Inhibitor DCC-2618 Inhibits Proliferation and Survival of Neoplastic Mast Cells and Other Cell Types Involved in Systemic Mastocytosis

Mathias A Schneeweiss, MD, Barbara Peter, DVM, Katharina Blatt, MSc,PhD, Daniela Berger, Gabriele Stefanzl, Emir Hadzijusufovic, DVM, Karoline V Gleixner, MD, Peter Valent, MD

Blood (2016) 128 (22): 1965.

https://doi.org/10.1182/blood.V128.22.1965.1965

Published: 2016

Journal Articles

Identification of the Epigenetic Reader BRD4 As a Novel Therapeutic Target in JAK2 V617F+ MPN Cells

Alexandra Keller, MSc, Barbara Peter, DVM, Johannes Zuber, MD PhD, Philipp Bernhard Staber, MD PhD, Peter Bettelheim, MD, Peter Valent, MD, Emir Hadzijusufovic, DVM

Blood (2015) 126 (23): 2829.

https://doi.org/10.1182/blood.V126.23.2829.2829

Published: 2015

Journal Articles

Identification of the Epigenetic Reader BRD4 As a Novel Potential Target in Ph+ CML

Barbara Peter, DVM, Gregor Eisenwort, Gabriele Stefanzl, Daniela Berger, Wolfgang R Sperr, MD, Johannes Zuber, MD PhD, Peter Valent, MD

Blood (2015) 126 (23): 1571.

https://doi.org/10.1182/blood.V126.23.1571.1571

Published: 2015

Journal Articles

Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia

Gregor Eisenwort, MD PhD, Barbara Peter, D.V.M., Katharina Blatt, MSc, PhD, Sabine Cerny-Reiterer, DVM, Gregor Hoermann, MD PhD, Irina Sadovnik, MSc, Martin Bilban, MD, Thomas Rülicke, D.V.M., Michael Willmann, D.V.M., Juliana Schwaab, MD, Andreas Reiter, MD, Wolfgang R Sperr, MD, Christine Mannhalter, PhD, Peter Valent, MD

Blood (2014) 124 (21): 817.

https://doi.org/10.1182/blood.V124.21.817.817

Published: 2014

Journal Articles

The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph + CML

Irina Sadovnik, M.Sc., Harald Herrmann, M.D., Sabine Cerny-Reiterer, D.V.M, Wolfgang Warsch, Ph.D., Andrea Hoelbl, Ph.D., Katharina Blatt, MSc, Ph.D., Barbara Peter, D.V.M., Gabriele Stefanzl, Msc, Gregor Hoermann, M.D., Ph.D., Susanne Herndlhofer, Berthold Streubel, M.D., Wolfgang R Sperr, M.D., Christine Mannhalter, Ph.D., Veronika Sexl, MD, Peter Valent

Blood (2013) 122 (21): 3979.

https://doi.org/10.1182/blood.V122.21.3979.3979

Published: 2013

Journal Articles

Effects of Ponatinib and Other Novel TKI On Growth, Survival, and Function of Neoplastic Eosinophils Carrying FIP1L1/Pdgfra

Irina Sadovnik, M.Sc., Peter Valent, MD, Els Lierman, PhD, Harald Herrmann, M.D., Barbara Peter, D.V.M., Verena Suppan, BSc, Gabriele Stefanzl, MSc, Winfried F Pickl, MD, Jan Cools, PhD, Peter Vandenberghe, MD, PhD

Blood (2012) 120 (21): 1760.

https://doi.org/10.1182/blood.V120.21.1760.1760

Published: 2012

Journal Articles

5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS- demethylation and FAS re-expression, and synergism with FAS-ligand

Viviane Ghanim, Harald Herrmann, Gerwin Heller, Barbara Peter, Emir Hadzijusufovic, Katharina Blatt, Karina Schuch, Sabine Cerny-Reiterer, Irina Mirkina, Heidrun Karlic, Winfried F. Pickl, Sabine Zöchbauer-Müller, Peter Valent

Blood (2012) 119 (18): 4242–4252.

https://doi.org/10.1182/blood-2011-09-382770

Published: 2012

Includes: Supplemental data

Journal Articles

5-Azacytidine and Decitabine Induce FAS Re-Expression, Exert Major Proapoptotic Effects, and Cooperate with the FAS Ligand in Producing Apoptosis in Neoplastic Human Mast Cells,

Viviane Ghanim, M.D., Harald Herrmann, MD, Emir Hadzijusufovic, DVM, Barbara Peter, D.V.M., Katharina Blatt, M.Sc., Karina Schuch, Sabine Cerny-Reiterer, D.V.M., Irina Mirkina, PhD, Gerwin Heller, PhD, Sabine Zöchbauer-Müller, MD, Heidrun Karlic, PhD, Winfried F Pickl, MD, Peter Valent, M.D.

Blood (2011) 118 (21): 3457.

https://doi.org/10.1182/blood.V118.21.3457.3457

Published: 2011

Journal Articles

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML,

Harald Herrmann, M.D., Katharina Blatt, M.Sc., Junwei Shi, Amy R. Rappaport, Karoline V. Gleixner, M.D., Sabine Cerny-Reiterer, D.V.M., Barbara Peter, D.V.M., Eric Wang, Wolfgang R. Sperr, M.D., James E. Bradner, MD, Scott W. Lowe, Ph.D., Christopher R. Vakoc, M.D., Ph.D., Johannes Zuber, M.D., Peter Valent, M.D.

Blood (2011) 118 (21): 3484.

https://doi.org/10.1182/blood.V118.21.3484.3484

Published: 2011

Journal Articles

Ponatinib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest and Apoptosis,

Karoline V. Gleixner, M.D., Katharina Blatt, M.Sc., Barbara Peter, D.V.M., Emir Hadzijusufovic, DVM, Peter Valent, M.D.

Blood (2011) 118 (21): 3497.

https://doi.org/10.1182/blood.V118.21.3497.3497

Published: 2011

Journal Articles

The Midostaurin (PKC412) Metabolite CGP52421 Shows Little Growth-Inhibitory Activity Against Against Neoplastic Mast Cells but Retains Inhibitory Effects on IgE-Dependent Activation and Histamine Release

Barbara Peter, D.V.M., Katharina Blatt, M.Sc., Gabriele Stefanzl, Emir Hadzijusufovic, DVM, Catherine Dutreix, Stefan H Gross, Johannes L Roesel, Peter Valent, M.D.

Blood (2011) 118 (21): 1417.

https://doi.org/10.1182/blood.V118.21.1417.1417

Published: 2011

Journal Articles

Identification of Basophils as Source of Hepatocyte Growth Factor (HGF) In CML: a Potential Trigger of Disease Acceleration.

Sabine Cerny-Reiterer, DVM, Karl J. Aichberger, MD, Harald Herrmann, MD, Gregor Hoermann, MD, Barbara Peter, MVM, Leonhard Muellauer, MD, Matthias Mayerhofer, MD, Peter Valent, MD

Blood (2010) 116 (21): 1202.

https://doi.org/10.1182/blood.V116.21.1202.1202

Published: 2010

Journal Articles

The Multi-Kinase/ABL Inhibitor R763/AS703569 Induces DNA Endoreduplication and Apoptosis In Imatinib-Resistant CML Cells and Synergizes with Nilotinib, Dasatinib, and the Plk-1 Inhibitor BI 2536, In Producing Growth Inhibition.

Karoline V. Gleixner, Harald Herrmann, Barbara Peter, Katharina Blatt, Karina Schuch, Winfried F Pickl, Christian Sillaber, Peter Valent

Blood (2010) 116 (21): 3394.

https://doi.org/10.1182/blood.V116.21.3394.3394

Published: 2010

Journal Articles

Establishment of a Novel Canine Mastocytoma Cell Line, NI-1: a Model for Studying Resistance Against KIT Tyrosine Kinase Inhibitors In Canine Neoplastic Mast Cells

Emir Hadzijusufovic, Barbara Peter, Harald Herrmann, Karina Schuch, Tuddow Thaiwong, Vilma Yuzbasiyan-Gurkan, Thomas Rülicke, Winfried Pickl, Michael Willmann, Peter Valent, M.D.

Blood (2010) 116 (21): 4936.

https://doi.org/10.1182/blood.V116.21.4936.4936

Published: 2010

Journal Articles

The Aurora-Kinase Inhibitor R763/AS703569 Exerts Major Growth-Inhibitory and Apoptosis-Inducing Effects on Neoplastic Mast Cells

Barbara Peter, MVM, Harald Herrmann, MD, Karoline V. Gleixner, MD, Emir Hadzijusufovic, MVM, Sylvia Laffer, PhD, Karina Schuch, Winfried Pickl, MD, Samantha M. Sarno, PhD, Michael Willmann, DVM, Peter Valent, MD

Blood (2010) 116 (21): 3972.

https://doi.org/10.1182/blood.V116.21.3972.3972

Published: 2010

Journal Articles

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs

Karl J. Aichberger, Karoline V. Gleixner, Irina Mirkina, Sabine Cerny-Reiterer, Barbara Peter, Veronika Ferenc, Michael Kneidinger, Christian Baumgartner, Matthias Mayerhofer, Alexander Gruze, Winfried F. Pickl, Christian Sillaber, Peter Valent

Blood (2009) 114 (26): 5342–5351.

https://doi.org/10.1182/blood-2008-08-175190

Published: 2009

NARROW

Deciphering the Mechanisms of Osteoblast-Induced Resistance of Leukemic Stem Cell (LSC) in Ph+ CML: Role of PI3-Kinase, BRD4 and MYC and Development of Strategies to Overcome Osteoblast-Induced Resistance

Phenotyping of Disease-Initiating CD34 + /CD38 ─ Stem Cells in BCR-ABL1 ─ MPN Reveals Expression of Multiple Cytokine Receptors and Resistance-Related Antigens

BRD4 Degradation Is a Potent Approach to Block MYC Expression and to Overcome Multiple Forms of Stem Cell Resistance in Ph + CML

Evaluation of Cell Surface Markers and Targets in Leukemic Stem Cells (LSC) Reveals Distinct Expression Profiles, Unique Drug Effects, and Specific Checkpoint Regulation in AML LSC and CML LSC

The Multi-Kinase Inhibitor DCC-2618 Inhibits Proliferation and Survival of Neoplastic Mast Cells and Other Cell Types Involved in Systemic Mastocytosis

Identification of the Epigenetic Reader BRD4 As a Novel Therapeutic Target in JAK2 V617F+ MPN Cells

Identification of the Epigenetic Reader BRD4 As a Novel Potential Target in Ph+ CML

Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia

The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph + CML

Effects of Ponatinib and Other Novel TKI On Growth, Survival, and Function of Neoplastic Eosinophils Carrying FIP1L1/Pdgfra

5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS- demethylation and FAS re-expression, and synergism with FAS-ligand

5-Azacytidine and Decitabine Induce FAS Re-Expression, Exert Major Proapoptotic Effects, and Cooperate with the FAS Ligand in Producing Apoptosis in Neoplastic Human Mast Cells,

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML,

Ponatinib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest and Apoptosis,

The Midostaurin (PKC412) Metabolite CGP52421 Shows Little Growth-Inhibitory Activity Against Against Neoplastic Mast Cells but Retains Inhibitory Effects on IgE-Dependent Activation and Histamine Release

Identification of Basophils as Source of Hepatocyte Growth Factor (HGF) In CML: a Potential Trigger of Disease Acceleration.

The Multi-Kinase/ABL Inhibitor R763/AS703569 Induces DNA Endoreduplication and Apoptosis In Imatinib-Resistant CML Cells and Synergizes with Nilotinib, Dasatinib, and the Plk-1 Inhibitor BI 2536, In Producing Growth Inhibition.

Establishment of a Novel Canine Mastocytoma Cell Line, NI-1: a Model for Studying Resistance Against KIT Tyrosine Kinase Inhibitors In Canine Neoplastic Mast Cells

The Aurora-Kinase Inhibitor R763/AS703569 Exerts Major Growth-Inhibitory and Apoptosis-Inducing Effects on Neoplastic Mast Cells

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs

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