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Journal Articles

“Ring-form” megakaryocytic dysplasia in STAG2 -mutated myelodysplastic neoplasm

Pratik Q. Deb, Wenbin Xiao
Journal: Blood
Blood (2024) 143 (21): 2218.
https://doi.org/10.1182/blood.2024024069
Published: 2024
Journal Articles

Polytypic B-Cells, B-Cell Lymphoproliferative Disorders/Lymphomas, and Neoplastic T-Cells Divergently Differentiate from TET2 -/ DNMT3A -Mutated Clonal Hematopoiesis in Patients with Follicular Helper T-Cell Lymphomas/Lymphoproliferative Disorders

Natasha Lewis, Kseniya Petrova-Drus, Rohan Sardana, Qi Gao, Shenon Sethi, Wenbin Xiao, Mikhail Roshal, Jeeyeon Baik, Himanshu Bhurtel, Alison Moskowitz, Steven M. Horwitz, Ahmet Dogan
Journal: Blood
Blood (2023) 142 (Supplement 1): 849.
https://doi.org/10.1182/blood-2023-187320
Published: 2023
Journal Articles

Precision Lineage Deconvolution in Mixed Phenotype Acute Leukemia Using Cite-Seq Derived Hematopoietic Stages Identifies Lineage Dynamics Associated with Treatment Response

Deepika Dilip, Pallavi Galera, David Nemirovsky, Morgan Lallo, Kamal Menghrajani, Andriy Derkach, Ross L Levine, Richard Koche, Wenbin Xiao, Jacob Glass
Journal: Blood
Blood (2023) 142 (Supplement 1): 4324.
https://doi.org/10.1182/blood-2023-188871
Published: 2023
Journal Articles

Cumulative Incidence of Myeloid Neoplasms in Patients with Nodal T-Follicular Helper Cell Lymphoma

Robert Stuver, Nivetha Ganesan, Ahmet Dogan, Zachary D. Epstein-Peterson, Paola Ghione, William Johnson, Natasha Lewis, Alison Moskowitz, Gunjan L. Shah, Michael Scordo, Wenbin Xiao, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 4438.
https://doi.org/10.1182/blood-2023-182272
Published: 2023
Journal Articles

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis

Andrew J. Dunbar, Dongjoo Kim, Min Lu, Mirko Farina, Robert L. Bowman, Julie L. Yang, Young Park, Abdul Karzai, Wenbin Xiao, Zach Zaroogian, Kavi O’Connor, Shoron Mowla, Francesca Gobbo, Paola Verachi, Fabrizio Martelli, Giuseppe Sarli, Lijuan Xia, Nada Elmansy, Maria Kleppe, Zhuo Chen, Yang Xiao, Erin McGovern, Jenna Snyder, Aishwarya Krishnan, Corrine Hill, Keith Cordner, Anouar Zouak, Mohamed E. Salama, Jayden Yohai, Eric Tucker, Jonathan Chen, Jing Zhou, Timothy McConnell, Anna R. Migliaccio, Richard Koche, Raajit Rampal, Rong Fan, Ross L. Levine, Ronald Hoffman
Journal: Blood
Blood (2023) 141 (20): 2508–2519.
https://doi.org/10.1182/blood.2022015418
Published: 2023
Includes: Supplemental data
Journal Articles

Primary thymic marginal zone lymphoma with amyloidosis

Krasimira A. Rozenova, Wenbin Xiao
Journal: Blood
Blood (2023) 141 (12): 1494.
https://doi.org/10.1182/blood.2022019001
Published: 2023
Journal Articles

Single Cell Genotypic and Phenotypic Analysis of Measurable Residual Disease in Acute Myeloid Leukemia

Troy Robinson, Robert L. Bowman, Sonali Persaud, Ying Liu, Qi Gao, Jing-Ping Zhang, Xiaotian Sun, Adam Sciambi, Aaron Llanso, Christopher Famulare, Aaron D Goldberg, Ahmet Dogan, Mikhail Roshal, Ross L. Levine, Wenbin Xiao
Journal: Blood
Blood (2022) 140 (Supplement 1): 2275–2277.
https://doi.org/10.1182/blood-2022-166501
Published: 2022
Journal Articles

Quantitative Cytogenetic Analysis with karyoParser Allows for More Precise Identification of Disease Biology, Clonal Evolution, and Etiology of Relapse in Acute Myeloid Leukemia

Deepika Dilip, Andriy Derkach, Kamal Menghrajani, Aaron D Goldberg, Hannah May, Virginia M. Klimek, Pallavi K Galera, Wenbin Xiao, Yanming Zhang, Olivier Elemento, Ross L. Levine, Jacob L Glass
Journal: Blood
Blood (2022) 140 (Supplement 1): 9119–9121.
https://doi.org/10.1182/blood-2022-170847
Published: 2022
Journal Articles

Jak2 V617F Reversible Activation Shows an Essential Requirement for Jak2 V617F in Myeloproliferative Neoplasms (MPNs)

Andrew Dunbar, Robert L. Bowman, Young Park, Franco Izzo, Robert M. Myers, Abdul Karzai, Won Jun Kim, Inés Fernández Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Max Brodsky, Mirko Farina, Louise Cai, Sheng F Cai, Benjamin Wang, Wenbin An, Julie Yang, Shoron Mowla, Shira E. Eisman, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D Viny, Richard Koche, Dan A. Landau, Ross L. Levine
Journal: Blood
Blood (2022) 140 (Supplement 1): 803–804.
https://doi.org/10.1182/blood-2022-164827
Published: 2022
Journal Articles

Erythroid and Megakaryocytic Differentiation Program in JAK2 -Mutated Acute Myeloid Leukemia with or without Antecedent Myeloproliferative Neoplasm

Ying Liu, Shenon Sethi, Richard Koche, Qi Gao, Deepika Dilip, Jacob L Glass, Pallavi K Galera, Sonali Persaud, Tanmay Mishra, Xiaotian Sun, Dory Londono, Robert Cimera, Menglei Zhu, Christopher Famulare, Jeeyeon Baik, Himanshu Bhurtel, Maria E. Arcila, Ahmet Dogan, Ross L. Levine, Yanming Zhang, Mikhail Roshal, Raajit K Rampal, Wenbin Xiao
Journal: Blood
Blood (2022) 140 (Supplement 1): 9160–9162.
https://doi.org/10.1182/blood-2022-169215
Published: 2022
Journal Articles

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation

Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Journal: Blood
Blood (2022) 139 (25): 3630–3646.
https://doi.org/10.1182/blood.2021014465
Published: 2022
Includes: Supplemental data
Journal Articles

Clinical and Genomic Characterization of Secondary Acute Myeloid Leukemia with Mixed Phenotype

Pallavi Galera, Alexander Chan, Andriy Derkach, Ying Liu, Jeeyeon Baik, Christopher Famulare, Allison Sigler, Maria E. Arcila, Douglas A Mata, Ahmet Dogan, Martin S. Tallman, Ross L. Levine, Yanming Zhang, Mikhail Roshal, Jacob L Glass, Wenbin Xiao
Journal: Blood
Blood (2021) 138 (Supplement 1): 687.
https://doi.org/10.1182/blood-2021-151263
Published: 2021
Journal Articles

Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Robert L. Bowman, Tanmay Mishra, Shira E. Eisman, Louise Cai, Wenbin Xiao, Michael R. Waarts, Pablo Sanchez Vela, Inés Fernández-Maestre, Isabelle S. Csete, Chad R. Potts, Matthew T. Jenkins, Linde A. Miles, Jennifer J. Trowbridge, Paul Brent Ferrell, Jr., Ross L. Levine
Journal: Blood
Blood (2021) 138 (Supplement 1): 2220.
https://doi.org/10.1182/blood-2021-149846
Published: 2021
Journal Articles

The BMP/SMAD Pathway Is a Key Mediator of Leukemic Transformation of TP53-Mutant Post-MPN AML

Bing Li, Wenbin An, Hua Wang, Aishwarya Krishnan, Shoron Mowla, Timour Baslan, Richard Koche, Wenbin Xiao, Scott Lowe, Ross L. Levine, Raajit Rampal
Journal: Blood
Blood (2021) 138 (Supplement 1): 626.
https://doi.org/10.1182/blood-2021-152036
Published: 2021
Journal Articles

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 -mutated acute myeloid leukemia

Wenbin Xiao, Alexander Chan, Michael R. Waarts, Tanmay Mishra, Ying Liu, Sheng F. Cai, Jinjuan Yao, Qi Gao, Robert L. Bowman, Richard P. Koche, Isabelle S. Csete, Nicole L. DelGaudio, Andriy Derkach, Jeeyeon Baik, Sophia Yanis, Christopher A. Famulare, Minal Patel, Maria E. Arcila, Maximilian Stahl, Raajit K. Rampal, Martin S. Tallman, Yanming Zhang, Ahmet Dogan, Aaron D. Goldberg, Mikhail Roshal, Ross L. Levine
Journal: Blood
Blood (2021) 137 (10): 1377–1391.
https://doi.org/10.1182/blood.2020007897
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Outcomes of Acute Myeloid Leukemia Patients Bridged to Allogeneic Stem Cell Transplant By Venetoclax Combination Therapy

Maximilian Stahl, MD, Kamal Menghrajani, MD, Andriy Derkach, PhD, Susan DeWolf, MD, Josel D Ruiz, MPH, Doris M Ponce, MD, Brian C. Shaffer, MD, Roni Tamari, MD, James W. Young, MD, Juliet Barker, MBBS, Ann A. Jakubowski, MDPhD, Boglarka Gyurkocza, MD, Alexander Chan, Wenbin Xiao, MD PhD, Jacob L Glass, MDPhD, Amber C. King, PharmD, BCOP, Sheng F Cai, MDPhD, Anthony Daniyan, MD, Christopher Famulare, MS, Bernadette M. Cuello, BSN, MSN, NP, RN, Troy Z. Horvat, PharmD, BCOP, Eytan M. Stein, MD, Mikhail Roshal, MD PhD, Sergio Giralt, MD, Miguel-Angel Perales, MD, Christina Cho, MD, Martin S. Tallman, MD, Aaron D Goldberg, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137749
Published: 2020
Journal Articles

Immunophenotypic Lineage Assessment By Multiparameter Flow Cytometry Provides More Precise MDS Prognosis

Ikenna Onyekwere, BS, Julie Perilla Garcia, BS, MS, Kamal Menghrajani, MD, Alexander Chan, MD, Christopher Famulare, MS, Minal A Patel, MPH, John Philip, BA, MS, Martin S. Tallman, MD, Virginia M. Klimek, MD, Ross L. Levine, MD, Wenbin Xiao, MD PhD, Jacob L Glass, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-143154
Published: 2020
Journal Articles

Venetoclax Therapy for Relapsed and Treatment Refractory AML: Clinical Outcomes and Molecular Predictors

Maximilian Stahl, MD, Kamal Menghrajani, MD, Andriy Derkach, PhD, Alexander Chan, MD, Wenbin Xiao, MD PhD, Jacob L Glass, MDPhD, Amber C. King, PharmD, BCOP, Anthony Daniyan, MD, Christopher Famulare, MS, Bernadette M. Cuello, BSN, MSN, NP, RN, Omar Abdel-Wahab, MD, Ross L. Levine, MD, Aaron D Viny, MDMS, Eytan M. Stein, MD, Mikhail Roshal, MD PhD, Martin S. Tallman, MD, Aaron D Goldberg, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-137815
Published: 2020
Journal Articles

LSD1 Inhibitor CPI-482 Shows Efficacy and Prolongs Survival in Mouse Models of AML and Post-MPN AML in the Context of Constitutive JAK-STAT Pathway Activation

Raajit K. Rampal, MD PhD, John P. McGrath, PhD, Aishwarya Krishnan, BS, Bing Li, MD, Wenbin Xiao, MD PhD, David Nikom, Jing Wang, PhD, Ross L. Levine, MD, Patrick Trojer, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50–51.
https://doi.org/10.1182/blood-2020-140186
Published: 2020
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019