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Lorenzo Falchi
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Journal Articles

Zanubrutinib, Obinutuzumab, and Venetoclax for First-Line Treatment of Mantle Cell Lymphoma with a TP53 Mutation

Clinical Trials & Observations
Anita Kumar, Jacob D. Soumerai, Jeremy S Abramson, Jeffrey A. Barnes, Philip C Caron, Shalini Chhabra, Maria Chabowska, Ahmet Dogan, Lorenzo Falchi, Clare Grieve, J. Erika Haydu, Patrick Connor Johnson, Ashlee Joseph, Hailey Kelly, Alyssa Labarre, Jennifer K Lue, Rosalba Martignetti, Joanna Mi, Alison J Moskowitz, Colette N Owens, Sean Plummer, Madeline Puccio, Gilles A. Salles, Venkatraman E Seshan, Elizabeth Simkins, Natalie Slupe, Honglei Zhang, Andrew D. Zelenetz
Journal: Blood
Blood blood.2024025563.
https://doi.org/10.1182/blood.2024025563
Published: 2024
Includes: Supplemental data
Journal Articles

Consensus recommendations on the management of toxicity associated with CD3×CD20 bispecific antibody therapy

Jennifer L. Crombie, Tara Graff, Lorenzo Falchi, Yasmin H. Karimi, Rajat Bannerji, Loretta Nastoupil, Catherine Thieblemont, Renata Ursu, Nancy Bartlett, Victoria Nachar, Jonathan Weiss, Jane Osterson, Krish Patel, Joshua Brody, Jeremy S. Abramson, Matthew Lunning, Nirav N. Shah, Ayed Ayed, Manali Kamdar, Benjamin Parsons, Paolo Caimi, Ian Flinn, Alex Herrera, Jeffrey Sharman, Marshall McKenna, Philippe Armand, Brad Kahl, Sonali Smith, Andrew Zelenetz, Lihua Elizabeth Budde, Martin Hutchings, Tycel Phillips, Michael Dickinson
Journal: Blood
Blood (2024) 143 (16): 1565–1575.
https://doi.org/10.1182/blood.2023022432
Published: 2024
Journal Articles

Predicting Toxicities in Older Adults with Non-Hodgkin Lymphoma (NHL) Receiving Systemic Chemotherapy: A Prospective Geriatric Assessment (GA) Study

Pallawi Torka, Esther Drill, Nivetha Ganesan, Mayan Oliveros, Alexander P. Boardman, Philip Caron, Kevin A. David, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, Robert Stuver, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Paul A. Hamlin
Journal: Blood
Blood (2023) 142 (Supplement 1): 70.
https://doi.org/10.1182/blood-2023-188143
Published: 2023
Journal Articles

Glofitamab Monotherapy in Relapsed or Refractory Large B-Cell Lymphoma: Extended Follow-Up from a Pivotal Phase II Study and Subgroup Analyses in Patients with Prior Chimeric Antigen Receptor T-Cell Therapy and by Baseline Total Metabolic Tumor Volume

Martin Hutchings, Carmelo Carlo-Stella, Franck Morschhauser, Lorenzo Falchi, Emmanuel Bachy, Guillaume Cartron, Cyrus Khan, Monica Tani, Joaquin Martinez-Lopez, Nancy L. Bartlett, Antonio Salar, Joshua Brody, Sirpa Leppä, Pauline Baumlin, Estefania Mulvihill, James Relf, Yuying Xie, Derrick Kaufman, Linda Lundberg, Michael Dickinson
Journal: Blood
Blood (2023) 142 (Supplement 1): 433.
https://doi.org/10.1182/blood-2023-173951
Published: 2023
Journal Articles

Real-World Outcomes in Patients with Transformed Follicular Lymphoma Treated with CD19-Targeting CAR-T Therapy

Alfredo Rivas-Delgado, Efrat Luttwak, Esther Drill, Ilan Goldstein, Ivan Landego, Ana Alarcon Tomas, Allison Parascondola, Amethyst Saldia, Philip Caron, Parastoo B. Dahi, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paul A. Hamlin, William Johnson, Anita Kumar, Richard J. Lin, Jennifer Kimberly Lue, Colette Owens, Ariela Noy, Michael Scordo, Ahmet Dogan, Venkatraman Seshan, Andrew D. Zelenetz, Miguel-Angel Perales, Roni Shouval, Maria Lia Palomba, Gunjan L. Shah, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 4888.
https://doi.org/10.1182/blood-2023-187379
Published: 2023
Journal Articles

Distinct Patterns of CD4+ and CD8+ T-Cell Clonal Expansion Enable Broad Clinical Responses to Pembrolizumab + GVD in Patients with Relapsed Hodgkin Lymphoma

Beatriz Wills, Jahan Rahman, Nivetha Ganesan, Gunjan L. Shah, Ariela Noy, Heiko Schoder, Joachim Yahalom, Anita Kumar, Lorenzo Falchi, Paul A. Hamlin, Maria Lia Palomba, William Johnson, Andrew M. Intlekofer, Philip Caron, Theresa Davey, Helen Hancock, Natasha Galasso, Brittney Munayirji, Ya Hui Lin, Alayna Santarosa, Ellie Casper, Georgio Pongas, Andrew D. Zelenetz, Craig H. Moskowitz, Gilles Salles, Santosha A Vardhana, Alison Moskowitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1623.
https://doi.org/10.1182/blood-2023-185083
Published: 2023
Journal Articles

Glofitamab (Glofit) Plus R-CHOP Has a Favorable Safety Profile and Induces High Response Rates in Patients with Previously Untreated (1L) Large B-Cell Lymphoma (LBCL) Defined As High Risk By Circulating Tumor DNA (ctDNA) Dynamics: Preliminary Safety and Efficacy Results

Lorenzo Falchi, Fabrice Jardin, Corinne Haioun, Tomasz Wrobel, Judit Mészáros Joergensen, Mariana Bastos-Oreiro, Eric Mou, Joaquin Martinez-Lopez, L. Elizabeth Budde, Nancy L. Bartlett, Jan M. Zaucha, Alejandro Martin Garcia-Sancho, Rutanshu Shah, Nathan Rees, Ron McCord, Alexandra Bazeos, Maneesh Tandon, Michelle Doral, Ethan Troy-Barnes, Marcel Nijland
Journal: Blood
Blood (2023) 142 (Supplement 1): 858.
https://doi.org/10.1182/blood-2023-173953
Published: 2023
Journal Articles

Real-Life Experience with Lenalidomide Plus Anti-CD20 Antibodies for the Treatment of Patients (pts) with Relapsed/Refractory (R/R) Indolent Non-Hodgkin Lymphoma (iNHL)

Giulio Cassanello, Alfredo Rivas-Delgado, Alejandro Luna De Abia, Magdalena Corona, Efrat Luttwak, Michelle Okwali, Irem Isgor, Pallavi Galera, Alexander P. Boardman, Philip Caron, Kevin A. David, Zachary D. Epstein-Peterson, Paola Ghione, Paul A. Hamlin, Jennifer Kimberly Lue, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Alison Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Lorenzo Falchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1686.
https://doi.org/10.1182/blood-2023-187783
Published: 2023
Journal Articles

A Multicenter Phase 2 Trial of Zanubrutinib, Obinutuzumab, and Venetoclax (BOVen) in Patients with Treatment-Naïve, TP53 -Mutant Mantle Cell Lymphoma

Anita Kumar, Jacob Soumerai, Jeremy S. Abramson, Jeffrey A. Barnes, Philip Caron, Maria Chabowska, Mary Devlin, Ahmet Dogan, Lorenzo Falchi, Rayna N. Garcia, Clare Grieve, Emma Haskell, Julie E. Haydu, Patrick Connor Johnson, Ashlee Joseph, Hailey E. Kelly, Alyssa Labarre, Emerald D Littlejohn, Jennifer Kimberly Lue, Joanna Mi, Rosalba Martignetti, Grace McCambridge, Alison Moskowitz, Colette Owens, Sean F. Plummer, Madeline G. Puccio, Gilles Salles, Venkatraman Seshan, Natalie Slupe, Andrew D. Zelenetz
Journal: Blood
Blood (2023) 142 (Supplement 1): 738.
https://doi.org/10.1182/blood-2023-180069
Published: 2023
Journal Articles

Impact of Early Histological Transformation on Survival in Patients with Follicular Lymphoma

Efrat Luttwak, Annie Qiu, Michelle Okwali, Alfredo Rivas-Delgado, Irem Isgor, Alexander P. Boardman, Philip Caron, Kevin A. David, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Pallavi Galera, M. Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Heiko Schoder, Joachim Yahalom, Ahmet Dogan, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 3023.
https://doi.org/10.1182/blood-2023-190325
Published: 2023
Journal Articles

EPCORE FL-1: Phase 3 Trial of Subcutaneous Epcoritamab with Rituximab and Lenalidomide (R 2 ) Vs R 2 Alone in Patients with Relapsed or Refractory Follicular Lymphoma

Lorenzo Falchi, Franck Morschhauser, Kim Linton, Huiqiang Huang, Faith Galderisi, Syed Quadri, Lingmin Zeng, Daniela Hoehn, John F. Seymour
Journal: Blood
Blood (2023) 142 (Supplement 1): 3053.
https://doi.org/10.1182/blood-2023-180092
Published: 2023
Journal Articles

Subcutaneous (SC) Mosunetuzumab (mosun) As First-Line Therapy for Patients (pts) with High Tumor-Burden Follicular Lymphoma (FL): First Results of a Multicenter Phase 2 Study

Lorenzo Falchi, Michelle Okwali, Paola Ghione, Colette Owens, Paul A. Hamlin, Jennifer Kimberly Lue, Zachary D. Epstein-Peterson, Maria Lia Palomba, Anita Kumar, Pallawi Torka, Lori A. Leslie, Alexandra Ferreira Lopes, Anastasia Martinova, Lauren Wood, Clare Grieve, Walter Ramos Amador, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 604.
https://doi.org/10.1182/blood-2023-179906
Published: 2023
Journal Articles

Infectious Complications in Patients with Relapsed or Refractory (R/R) Non-Hodgkin's Lymphoma (NHL) Treated with the Anti-CD20xCD3 Bispecific Antibody (BsAb) Mosunetuzumab

Zainab Shahid, Michelle Okwali, Ashlee Joseph, Susan K. Seo, Jennifer Kimberly Lue, Alexander P. Boardman, Philip Caron, Kevin A. David, Zachary D. Epstein-Peterson, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Alison Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Lorenzo Falchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4403.
https://doi.org/10.1182/blood-2023-187911
Published: 2023
Journal Articles

A Phase 2 Study of Minimal Residual Disease (MRD)-Adapted Front Line Venetoclax and Obinutuzumab in Fit Patients with Chronic Lymphocytic Leukemia (CLL): Effect of Obinutuzumab on Tumor Lysis Syndrome (TLS) Risk and Safety of Outpatient Venetoclax Dose Escalation

Lindsey E. Roeker, Andrew D. Zelenetz, Jae H. Park, Andriy Derkach, Mark Blaine Geyer, Prioty Islam, Lorenzo Falchi, Maria Lia Palomba, Anita Kumar, Gilles Salles, Jennifer Kimberly Lue, Aaron D. Goldberg, Bita Fakhri, Catherine C. Coombs, Victoria Falco, Gail Panton, Dianna Tyznar, Dhara Soni, Lauren Nogan, Sonia Lebowitz, Katherine Blesie, Monica Shah, Sarah Court, Christopher E. Jensen, Anthony R. Mato, Meghan C. Thompson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4657.
https://doi.org/10.1182/blood-2023-181661
Published: 2023
Journal Articles

CNS Radiotherapy As Bridging Prior to CAR T-Cell Therapy for Non-Hodgkin B-Cell Lymphoma

Gustav Cederquist, Javin Schefflein, Sean M. Devlin, Harper Hubbeling, Kathryn Tringale, Gunjan L. Shah, Ana Alarcon Tomas, Roni Shouval, Carla Hajj, Beatrice Fregonese, Parastoo B. Dahi, Richard J. Lin, Maria Lia Palomba, Miguel-Angel Perales, Gilles Salles, Lorenzo Falchi, Christian Grommes, Michael Scordo, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2023) 142 (Supplement 1): 4491.
https://doi.org/10.1182/blood-2023-190326
Published: 2023
Journal Articles

Responses and Outcomes after Second-Line Therapy in Transplant-Eligible Patients with DLBCL Relapse over 1 Year after First-Line Therapy

David A Qualls, Gunjan L. Shah, Roni Shouval, Philip Caron, Kevin A. David, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Oscar Boutros Lahoud, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Maria Lia Palomba, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Michelle Okwali, Parastoo Bahrami Dahi, Michael Scordo, Richard J. Lin, Miguel-Angel Perales, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 4970.
https://doi.org/10.1182/blood-2023-182733
Published: 2023
Journal Articles

Potent CD8+ T-Cell Proliferation and Effector Differentiation Following Subcutaneous (SC) Mosunetuzumab Administration in Patients with Untreated, High Tumor-Burden Follicular Lymphoma (FL)

Lorenzo Falchi, Ya-Hui Lin, Lauren Melendez, Paola Ghione, Colette Owens, Paul A. Hamlin, Jennifer Kimberly Lue, Zachary D. Epstein-Peterson, Anita Kumar, Maria Lia Palomba, Pallawi Torka, Michelle Okwali, Alexandra Ferreira Lopes, Anastasia Martinova, Lauren Wood, Clare Grieve, Walter Ramos Amador, Andrew D. Zelenetz, Gilles Salles, Santosha A Vardhana
Journal: Blood
Blood (2023) 142 (Supplement 1): 6116.
https://doi.org/10.1182/blood-2023-189638
Published: 2023
Journal Articles

Clinical Characteristics and Outcomes of Limited Stage High Grade B-Cell Lymphoma with MYC/BCL2 and/or BCL6 Rearrangements: A Single Center Experience

Jennifer Kimberly Lue, Efrat Luttwak, Philip Caron, Alexander P. Boardman, Kevin A. David, Alfredo Rivas-Delgado, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Alison Moskowitz, Ariela Noy, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Yanming Zhang, Pallavi Galera, Ahmet Dogan, Umut Aypar, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 3129.
https://doi.org/10.1182/blood-2023-173562
Published: 2023
Journal Articles

Radiotherapy As an Effective Bridge for Relapsed/Refractory Secondary CNS Lymphoma

Gustav Cederquist, Kathryn Tringale, Carla Hajj, Harper Hubbeling, Jennifer Ma, Alexandra Dreyfuss, Beatrice Fregonese, Gilles Salles, Christian Grommes, Michael Scordo, Lorenzo Falchi, Joachim Yahalom, Brandon S. Imber
Journal: Blood
Blood (2023) 142 (Supplement 1): 1759.
https://doi.org/10.1182/blood-2023-190236
Published: 2023
Journal Articles

Dexamethasone is Associated with a Lower Incidence and Severity of Cytokine Release Syndrome Compared with Other Corticosteroid Regimens When Given as Premedication for Glofitamab Monotherapy in Patients with Relapsed/Refractory (R/R) Large B-Cell Lymphoma (LBCL)

Lorenzo Falchi, Carmelo Carlo-Stella, Franck Morschhauser, Michael Dickinson, Emmanuel Bachy, Guillaume Cartron, Cyrus Khan, Monica Tani, Joaquin Martinez-Lopez, Nancy L. Bartlett, Antonio Salar, Joshua Brody, Sirpa Leppä, Aurelien Berthier, Martine Kallemeijn, James Relf, Saibah Chohan, Linda Lundberg, Martin Hutchings
Journal: Blood
Blood (2023) 142 (Supplement 1): 3130.
https://doi.org/10.1182/blood-2023-173949
Published: 2023