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Jacob Soumerai
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Journal Articles

ALK+ LBCL and PBL share a similar plasmablastic transcriptional identity but show divergent signaling dependencies and therapeutic vulnerabilities

Free
Jessica Duffy, Anna Rider, Derek Loneman, Devang Thakkar, Genna Mullen, Gail Newton, Raymond Alvarado, Bomin Ku, Shuze Wang, Veronica Russell, Yuxin Chen, James Townsend, Haley Martin, Shannon Harkins, Catherine Cho, Rex Au-Yeung, Amy Chadburn, Chee Leong Cheng, Magdalena Czader, Emily F. Mason, Andrew Evans, Yuri Fedoriw, Jean Koff, Kikkeri N Naresh, Sarah Ondrejka, Mette Pedersen, Jacob Soumerai, Christopher Ott, Wilfredo Garcia-Beltran, Sandeep Dave, Abner Louissaint
Journal: Blood
Blood (2025) 146 (Supplement 1): 51.
https://doi.org/10.1182/blood-2025-51
Published: 2025
Journal Articles

Preliminary safety and efficacy of boven (Zanubrutinib, Obinutuzumab, and Venetoclax) as frontline therapy for older patients with Mantle Cell Lymphoma

Free
Anita Kumar, Jacob Soumerai, Reem Karmali, Jeremy Abramson, Jeffrey Barnes, Bernadette Beatty, Jason Brecher, Philip Caron, Kenneth Carson, Maria Chabowska, Madelyn Coogan, Jayne Coyle, Kevin David, Meemanage De Zoysa, Ahmet Dogan, Zachary Epstein-Peterson, Paola Ghione, Cameron Gordan, Leo Gordon, Julie Haydu, Ephraim Hochberg, Patrick Connor Johnson, Ashlee Joseph, Akshata Kakolu, Alyssa Labarre, Carissa Laudati, Jennifer Lue, Shuo Ma, Rosalba Martignetti, Colette Owens, Olivia Maas, Joanna Mi, Rachel Nazzaro, James O'Grady, Jessica Pendleton, Gilles Salles, Venkatraman Seshan, Natalie Slupe, Pallawi Torka, Andrew Zelenetz
Journal: Blood
Blood (2025) 146 (Supplement 1): 888.
https://doi.org/10.1182/blood-2025-888
Published: 2025
Journal Articles

Frontline treatment of sonrotoclax (BGB-11417) and zanubrutinib for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) demonstrates high undetectable minimal residual disease (uMRD) rates with favorable tolerability: Updated data from BGB-11417-101, an ongoing phase 1/1b study

Free
Constantine Tam, Mary Ann Anderson, Masa Lasica, Emma Verner, Stephen Opat, Shuo Ma, Robert Weinkove, Raul Cordoba, Jacob Soumerai, Paolo Ghia, Sophie Leitch, David Westerman, Sheel Patel, Yiqian Fang, James Hilger, Remus Vezan, Chan Cheah
Journal: Blood
Blood (2025) 146 (Supplement 1): 3891.
https://doi.org/10.1182/blood-2025-3891
Published: 2025
Journal Articles

Zanubrutinib + obinutuzumab + sonrotoclax in patients with treatment-naive chronic lymphocytic leukemia/small lymphocytic lymphoma (TN CLL/SLL): Initial results from an ongoing phase 1/1b study, BGB-11417-101

Free
Jacob Soumerai, Stephen Opat, Chan Cheah, Mazyar Shadman, Emma Verner, Monica Tani, Marc Hoffmann, Lori Leslie, Shuo Ma, Yiqian Fang, Gabriel Man, Binghao Wu, Charity Henrich, Sheel Patel, Remus Vezan, Constantine Tam
Journal: Blood
Blood (2025) 146 (Supplement 1): 3890.
https://doi.org/10.1182/blood-2025-3890
Published: 2025
Journal Articles

Patterns, risk factors and management of CD19-directed chimeric antigen receptor T-cell therapy failure in CNS lymphoma

Free
Leon D. Kaulen, Philipp Karschnia, Sofia Doubrovinskaia, Jeremy Abramson, Jacob Soumerai, Maria Martinez-Lage, Julie Haydu, Ganesh Shankar, Chirayu Patel, Bryan D. Choi, Jeffrey Barnes, Areej El-Jawahri, Ephraim Hochberg, Patrick Connor Johnson, Wolfgang Wick, Marcela Maus, Yi-Bin Chen, Matthew Frigault, Jorg Dietrich
Journal: Blood
Blood (2025) 146 (Supplement 1): 5493.
https://doi.org/10.1182/blood-2025-5493
Published: 2025
Journal Articles

Superior real-world outcomes of lisocabtagene maraleucel in chronic lymphocytic leukemia

Free
Jennifer Huang, Jenna Voutsinas, Niranjan Khaire, Vincenzo Pizzuti, Leyla Shune, Matthew Lei, Rodrigo Fonseca, Mohammad Ammad Ud Din, Alan Skarbnik, Agrima Mian, Sushma Bharadwaj, Aseel Alsouqi, Bret Wankel, Graham Wehmeyer, Joseph Lukowski, Alexey Danilov, Tanya Siddiqi, Meghan Thompson, Michael Scordo, Stephanie Franco, Deborah Stephens, Chaitra Ujjani, Ryan Lynch, Jordan Gauthier, William Wierda, Paul Barr, Adam Kittai, Jonah Shulman, Matthew Lunning, Kerry Rogers, Bita Fakhri, Brian Hill, Javier Pinilla-Ibarz, Talal Hilal, Jacob Soumerai, Manali Kamdar, Qian Wu, Nitin Jain, Mazyar Shadman
Journal: Blood
Blood (2025) 146 (Supplement 1): 798.
https://doi.org/10.1182/blood-2025-798
Published: 2025
Journal Articles

Post-treatment outcomes of TP53-mutant Mantle Cell Lymphoma patients treated with frontline zanubrutinib, obinutuzumab, and venetoclax (BOVen): Durable responses in patients who achieve complete remissions with undetectable MRD

Free
Sean Healton, Jacob Soumerai, Jeffrey Barnes, Jason Brecher, Philip Caron, Shalini Chhabra, Maria Chabowska, Ahmet Dogan, Lorenzo Falchi, Clare Grieve, Erika Haydu, Patrick Connor Johnson, Ashlee Joseph, Alyssa Labarre, Jennifer Lue, Rosalba Martignetti, Joanna Mi, Alison Moskowitz, Colette Owens, Sean Plummer, Madeline Puccio, Venkatraman Seshan, Elizabeth Simkins, Natalie Slupe, Honglei Zhang, Gilles Salles, Andrew Zelenetz, Anita Kumar
Journal: Blood
Blood (2025) 146 (Supplement 1): 3569.
https://doi.org/10.1182/blood-2025-3569
Published: 2025
Journal Articles

MRD-guided therapy of sonrotoclax (BGB-11417) + obinutuzumab (O) in patients with treatment-naive CLL: Initial results from an ongoing phase 1/1b study, BGB-11417-101

Free
Marc Hoffmann, Shuo Ma, Herbert Eradat, Constantine Tam, Masa Lasica, Paul Hampel, Emma Verner, Lori Leslie, Christopher D'Angelo, Jacob Soumerai, Mazyar Shadman, Chan Cheah, Monica Tani, Yiqian Fang, Binghao Wu, Gabriel Man, Sheel Patel, Remus Vezan, Stephen Opat
Journal: Blood
Blood (2025) 146 (Supplement 1): 793.
https://doi.org/10.1182/blood-2025-793
Published: 2025
Journal Articles

Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a  TP53 mutation

Available to Purchase
Clinical Trials & Observations
Anita Kumar, Jacob Soumerai, Jeremy S. Abramson, Jeffrey A. Barnes, Philip Caron, Shalini Chhabra, Maria Chabowska, Ahmet Dogan, Lorenzo Falchi, Clare Grieve, J. Erika Haydu, Patrick Connor Johnson, Ashlee Joseph, Hailey E. Kelly, Alyssa Labarre, Jennifer Kimberly Lue, Rosalba Martignetti, Joanna Mi, Alison Moskowitz, Colette Owens, Sean Plummer, Madeline Puccio, Gilles Salles, Venkatraman Seshan, Elizabeth Simkins, Natalie Slupe, Honglei Zhang, Andrew D. Zelenetz
Journal: Blood
Blood (2025) 145 (5): 497–507.
https://doi.org/10.1182/blood.2024025563
Published: 2025
Includes: Supplemental data
Journal Articles

Infection Outcomes and Hypogammaglobulinemia in Patients with Chronic Lymphocytic Leukemia Treated with Immunoglobulin Replacement Therapy

Free
Jacob Soumerai, Thais Gift, Zaid Yousif, Raj Desai, Lynn Huynh, Gregory Belsky, Mei Sheng Duh, Marie Sanchirico
Journal: Blood
Blood (2023) 142 (Supplement 1): 3280.
https://doi.org/10.1182/blood-2023-179458
Published: 2023
Journal Articles

A Multicenter Phase 2 Trial of Zanubrutinib, Obinutuzumab, and Venetoclax (BOVen) in Patients with Treatment-Naïve, TP53 -Mutant Mantle Cell Lymphoma

Free
Anita Kumar, Jacob Soumerai, Jeremy S. Abramson, Jeffrey A. Barnes, Philip Caron, Maria Chabowska, Mary Devlin, Ahmet Dogan, Lorenzo Falchi, Rayna N. Garcia, Clare Grieve, Emma Haskell, Julie E. Haydu, Patrick Connor Johnson, Ashlee Joseph, Hailey E. Kelly, Alyssa Labarre, Emerald D Littlejohn, Jennifer Kimberly Lue, Joanna Mi, Rosalba Martignetti, Grace McCambridge, Alison Moskowitz, Colette Owens, Sean F. Plummer, Madeline G. Puccio, Gilles Salles, Venkatraman Seshan, Natalie Slupe, Andrew D. Zelenetz
Journal: Blood
Blood (2023) 142 (Supplement 1): 738.
https://doi.org/10.1182/blood-2023-180069
Published: 2023
Journal Articles

Lisocabtagene Maraleucel (liso-cel) in R/R CLL/SLL: 24-Month Median Follow-up of TRANSCEND CLL 004

Free
Tanya Siddiqi, David G Maloney, Saad S. Kenderian, Danielle M Brander, Kathleen Dorritie, Jacob Soumerai, Peter A Riedell, Nirav N. Shah, Rajneesh Nath, Bita Fakhri, Deborah M. Stephens, Shuo Ma, Tatyana Feldman, Scott R. Solomon, Stephen J. Schuster, Serena K. Perna, Sherilyn A. Tuazon, San-San Ou, Neha Rane, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 330.
https://doi.org/10.1182/blood-2023-179529
Published: 2023
Journal Articles

Infection Outcomes and Hypogammaglobulinemia in Patients with Non-Hodgkin Lymphoma Treated with Immunoglobulin Replacement Therapy

Free
Jacob Soumerai, Zaid Yousif, Thais Gift, Raj Desai, Lynn Huynh, Caitlin Haven, Mei Sheng Duh, Marie Sanchirico
Journal: Blood
Blood (2023) 142 (Supplement 1): 3040.
https://doi.org/10.1182/blood-2023-187068
Published: 2023
Journal Articles

Combination Treatment with Sonrotoclax (BGB-11417), a Second-Generation BCL2 Inhibitor, and Zanubrutinib, a Bruton Tyrosine Kinase (BTK) Inhibitor, Is Well Tolerated and Achieves Deep Responses in Patients with Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (TN-CLL/SLL): Data from an Ongoing Phase 1/2 Study

Free
Constantine S. Tam, Mary Ann Anderson, Masa Lasica, Emma Verner, Stephen S. Opat, Shuo Ma, Robert Weinkove, Raul Cordoba, Jacob Soumerai, Paolo Ghia, Sophie Leitch, James Hilger, Yiqian Fang, David Simpson, Haiyi Guo, Chan Yoon Cheah
Journal: Blood
Blood (2023) 142 (Supplement 1): 327.
https://doi.org/10.1182/blood-2023-179541
Published: 2023
Journal Articles

Predicted Functional Consequences of TP53 Alterations and Prognosis in TP53 -Mutated Mantle Cell Lymphoma

Free
Manik Uppal, Erel Joffe, Kurt S. Bantilan, Gilles Salles, Jacob Soumerai, Andrew D. Zelenetz, Anita Kumar
Journal: Blood
Blood (2023) 142 (Supplement 1): 3006.
https://doi.org/10.1182/blood-2023-187599
Published: 2023
Journal Articles

Cholesterol Regulation and Statin Therapy in Patients with Waldenstrom's Macroglobulinemia.

Free
Thea Ioakimidis, MS, Christopher J Patterson, Zachary Hunter, Jacob Soumerai, Robert Manning, Diane L. Warren, Irene Ghobrial, M.D., Patricia Sheehy, NP, Steven Treon, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 4789.
https://doi.org/10.1182/blood.V114.22.4789.4789
Published: 2009
Journal Articles

Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia

Free
Xavier Leleu, Lian Xu, Xiaoying Jia, Antonio Sacco, Mena Farag, Zachary R. Hunter, Anne-Sophie Moreau, Hai T. Ngo, Evdoxia Hatjiharissi, Allen W. Ho, Daniel D. Santos, Sofia Adamia, Kelly O'Connor, Bryan Ciccarelli, Jacob Soumerai, Robert J. Manning, Christopher J. Patterson, Aldo M. Roccaro, Irene M. Ghobrial, Steven P. Treon
Journal: Blood
Blood (2009) 113 (3): 626–634.
https://doi.org/10.1182/blood-2007-10-116848
Published: 2009
Journal Articles

Phase II Trial of the mTOR Inhibitor RAD001 in Relapsed and/or Refractory Waldenstrom Macroglobulinemia: The Dana Farber Cancer Institute Experience.

Free
Irene M. Ghobrial, M.D., Stacey Chuma, RN, Amy Sam, Renee Leduc, Marybeth Nelson, PA, Kelly O’Connor, Brianna Harris, Jacob Soumerai, Diane Warren, Eric Jacobsen, MD, Daniel DeAngelo, MD, PhD, Kenneth C. Anderson, MD, Paul G. Richardson, MD, Thomas E. Witzig, MD, Steven P. Treon, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1011.
https://doi.org/10.1182/blood.V112.11.1011.1011
Published: 2008
Journal Articles

Long Term Responses to Fludarabine and Rituximab in Waldenstrom’s Macroglobulinemia

Free
Steven Treon, MD, PhD, Andrew Branagan, Leukothea Ioakimidis, PhD, Jacob Soumerai, Christopher Patterson, MD, Parveen Wasi, MD, FRCP(C), Christos Emmanouilides, MD, PhD, Stanley R. Frankel, MD, T. Andrew Lister, MD, Pierre Morel, MD, Jeffrey Matous, MD, Stephanie A. Gregory, MD, Eva K. Kimby, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3057.
https://doi.org/10.1182/blood.V112.11.3057.3057
Published: 2008
Journal Articles

Comparative Outcomes Following CP-R, CVP-R and CHOP-R in Patients with Waldenstrom’s Macroglobulinemia.

Free
Leukothea Ioakimidis, PhD, Christopher Patterson, MD, Jacob Soumerai, Robert Manning, Patricia Sheehy, NP, Steven Treon, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2011.
https://doi.org/10.1182/blood.V112.11.2011.2011
Published: 2008