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Journal Articles

Zanubrutinib, Obinutuzumab, and Venetoclax for First-Line Treatment of Mantle Cell Lymphoma with a TP53 Mutation

Clinical Trials & Observations
Anita Kumar, Jacob D. Soumerai, Jeremy S Abramson, Jeffrey A. Barnes, Philip C Caron, Shalini Chhabra, Maria Chabowska, Ahmet Dogan, Lorenzo Falchi, Clare Grieve, J. Erika Haydu, Patrick Connor Johnson, Ashlee Joseph, Hailey Kelly, Alyssa Labarre, Jennifer K Lue, Rosalba Martignetti, Joanna Mi, Alison J Moskowitz, Colette N Owens, Sean Plummer, Madeline Puccio, Gilles A. Salles, Venkatraman E Seshan, Elizabeth Simkins, Natalie Slupe, Honglei Zhang, Andrew D. Zelenetz
Journal: Blood
Blood blood.2024025563.
https://doi.org/10.1182/blood.2024025563
Published: 2024
Includes: Supplemental data
Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) Patients with Prior cBTKi: Safety and Efficacy Including High-Risk Subgroup Analyses from the Phase 1/2 BRUIN Study

Jonathon B. Cohen, Nirav N. Shah, Wojciech Jurczak, Pier Luigi Zinzani, Chan Y. Cheah, Toby A. Eyre, Chaitra S Ujjani, Youngil Koh, Won Seog Kim, Sunita D. Nasta, Ian W. Flinn, Benoit Tessoulin, Shuo Ma, Alvaro J. Alencar, David Lewis, Jennifer A. Woyach, Kami J. Maddocks, Krish Patel, Yucai Wang, Joanna M. Rhodes, Constantine S. Tam, John F. Seymour, Hirokazu Nagai, Julie M. Vose, Bita Fakhri, Marc S. Hoffmann, Francisco J. Hernandez-Ilizaliturri, Andrew D. Zelenetz, Anita Kumar, Talha Munir, Donald E. Tsai, Minna Balbas, Bin Liu, Amy S. Ruppert, Bastien Nguyen, Lindsey E. Roeker, Michael L. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 981.
https://doi.org/10.1182/blood-2023-181627
Published: 2023
Journal Articles

Infectious Complications in Patients with Relapsed or Refractory (R/R) Non-Hodgkin's Lymphoma (NHL) Treated with the Anti-CD20xCD3 Bispecific Antibody (BsAb) Mosunetuzumab

Zainab Shahid, Michelle Okwali, Ashlee Joseph, Susan K. Seo, Jennifer Kimberly Lue, Alexander P. Boardman, Philip Caron, Kevin A. David, Zachary D. Epstein-Peterson, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Alison Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Lorenzo Falchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4403.
https://doi.org/10.1182/blood-2023-187911
Published: 2023
Journal Articles

Predicted Functional Consequences of TP53 Alterations and Prognosis in TP53 -Mutated Mantle Cell Lymphoma

Manik Uppal, Erel Joffe, Kurt S. Bantilan, Gilles Salles, Jacob Soumerai, Andrew D. Zelenetz, Anita Kumar
Journal: Blood
Blood (2023) 142 (Supplement 1): 3006.
https://doi.org/10.1182/blood-2023-187599
Published: 2023
Journal Articles

A Phase 2 Study of Minimal Residual Disease (MRD)-Adapted Front Line Venetoclax and Obinutuzumab in Fit Patients with Chronic Lymphocytic Leukemia (CLL): Effect of Obinutuzumab on Tumor Lysis Syndrome (TLS) Risk and Safety of Outpatient Venetoclax Dose Escalation

Lindsey E. Roeker, Andrew D. Zelenetz, Jae H. Park, Andriy Derkach, Mark Blaine Geyer, Prioty Islam, Lorenzo Falchi, Maria Lia Palomba, Anita Kumar, Gilles Salles, Jennifer Kimberly Lue, Aaron D. Goldberg, Bita Fakhri, Catherine C. Coombs, Victoria Falco, Gail Panton, Dianna Tyznar, Dhara Soni, Lauren Nogan, Sonia Lebowitz, Katherine Blesie, Monica Shah, Sarah Court, Christopher E. Jensen, Anthony R. Mato, Meghan C. Thompson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4657.
https://doi.org/10.1182/blood-2023-181661
Published: 2023
Journal Articles

Response to Mosunetuzumab in Patients with B-Cell Lymphomas Relapsed or Refractory after CAR-T Cell Therapy Is Associated with Changes in Lymphocyte Counts

Elise A. Chong, Elicia Penuel, Nancy L. Bartlett, Francesc Bosch, L. Elizabeth Budde, Keith Fay, Ian W. Flinn, Andre Goy, Anita Kumar, Rachel Lundberg, Ellen B. Napier, Loretta J. Nastoupil, Mazyar Shadman, Michael C. Wei, Mei Wu, Shen Yin, Emeline R. Chong, Stephen J. Schuster
Journal: Blood
Blood (2023) 142 (Supplement 1): 1752.
https://doi.org/10.1182/blood-2023-190201
Published: 2023
Journal Articles

Responses and Outcomes after Second-Line Therapy in Transplant-Eligible Patients with DLBCL Relapse over 1 Year after First-Line Therapy

David A Qualls, Gunjan L. Shah, Roni Shouval, Philip Caron, Kevin A. David, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Oscar Boutros Lahoud, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Maria Lia Palomba, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Michelle Okwali, Parastoo Bahrami Dahi, Michael Scordo, Richard J. Lin, Miguel-Angel Perales, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 4970.
https://doi.org/10.1182/blood-2023-182733
Published: 2023
Journal Articles

Potent CD8+ T-Cell Proliferation and Effector Differentiation Following Subcutaneous (SC) Mosunetuzumab Administration in Patients with Untreated, High Tumor-Burden Follicular Lymphoma (FL)

Lorenzo Falchi, Ya-Hui Lin, Lauren Melendez, Paola Ghione, Colette Owens, Paul A. Hamlin, Jennifer Kimberly Lue, Zachary D. Epstein-Peterson, Anita Kumar, Maria Lia Palomba, Pallawi Torka, Michelle Okwali, Alexandra Ferreira Lopes, Anastasia Martinova, Lauren Wood, Clare Grieve, Walter Ramos Amador, Andrew D. Zelenetz, Gilles Salles, Santosha A Vardhana
Journal: Blood
Blood (2023) 142 (Supplement 1): 6116.
https://doi.org/10.1182/blood-2023-189638
Published: 2023
Journal Articles

Predicting Toxicities in Older Adults with Non-Hodgkin Lymphoma (NHL) Receiving Systemic Chemotherapy: A Prospective Geriatric Assessment (GA) Study

Pallawi Torka, Esther Drill, Nivetha Ganesan, Mayan Oliveros, Alexander P. Boardman, Philip Caron, Kevin A. David, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, Robert Stuver, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Paul A. Hamlin
Journal: Blood
Blood (2023) 142 (Supplement 1): 70.
https://doi.org/10.1182/blood-2023-188143
Published: 2023
Journal Articles

Multicenter Study of Mantle Cell Lymphoma Outcomes Following First-Line Bendamustine-Rituximab and Second-Line Bruton's Tyrosine Kinase Inhibitor Therapy

Yucai Wang, Melissa C. Larson, Steven R. Hwang, Anita Kumar, Ashlee Joseph, Brian T. Hill, Taylor R. Brooks, David A. Bond, Kami J. Maddocks, Alexey Danilov, Christine McCarthy, Jia Ruan, Imran A. Nizamuddin, Brad S. Kahl, Natalie S. Grover, Nazneen B. Khan, Evguenia Ouchveridze, Aung M. Tun, Philip Young, Craig A. Portell, Zoey I. Harris, Javier L. Munoz, Patrick M. Reagan, Georgio Pongas, Izidore S. Lossos, Christine E. Ryan, Reid W. Merryman, Firas Baidoun, Muhamad Alhaj Moustafa, Drew Gerber, Sabarish R. Ayyappan, Brian K. Link, Arash Velayati, Irl Brian Greenwell, Lauren G Banaszak, Priyanka A Pophali, Anthony C. Stack, Marcus R. Messmer, Mayur Narkhede, Amitkumar N. Mehta, Preetesh Jain, Michael L. Wang, Tamara K. Moyo, Nilanjan Ghosh, Rahul S. Bhansali, Stefan K. Barta, Manali K. Kamdar, Jacob Anna, Alexander V. Stanisic, Reem Karmali, Laveniya Kugathasan, Diego Villa, Matthew J. Maurer, James R. Cerhan, Jonathon B. Cohen, Peter Martin
Journal: Blood
Blood (2023) 142 (Supplement 1): 300.
https://doi.org/10.1182/blood-2023-182942
Published: 2023
Journal Articles

Brentuximab Vedotin-Based Regimens for Older Patients with Newly Diagnosed Classical Hodgkin Lymphoma -Real World Experience

Efrat Luttwak, Nivetha Ganesan, Alexander P. Boardman, Philip Caron, Kevin A. David, Alfredo Rivas-Delgado, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Jennifer Kimberly Lue, Ariela Noy, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Alison Moskowitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3059.
https://doi.org/10.1182/blood-2023-189617
Published: 2023
Journal Articles

Real-World Outcomes in Patients with Transformed Follicular Lymphoma Treated with CD19-Targeting CAR-T Therapy

Alfredo Rivas-Delgado, Efrat Luttwak, Esther Drill, Ilan Goldstein, Ivan Landego, Ana Alarcon Tomas, Allison Parascondola, Amethyst Saldia, Philip Caron, Parastoo B. Dahi, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paul A. Hamlin, William Johnson, Anita Kumar, Richard J. Lin, Jennifer Kimberly Lue, Colette Owens, Ariela Noy, Michael Scordo, Ahmet Dogan, Venkatraman Seshan, Andrew D. Zelenetz, Miguel-Angel Perales, Roni Shouval, Maria Lia Palomba, Gunjan L. Shah, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 4888.
https://doi.org/10.1182/blood-2023-187379
Published: 2023
Journal Articles

Real-Life Experience with Lenalidomide Plus Anti-CD20 Antibodies for the Treatment of Patients (pts) with Relapsed/Refractory (R/R) Indolent Non-Hodgkin Lymphoma (iNHL)

Giulio Cassanello, Alfredo Rivas-Delgado, Alejandro Luna De Abia, Magdalena Corona, Efrat Luttwak, Michelle Okwali, Irem Isgor, Pallavi Galera, Alexander P. Boardman, Philip Caron, Kevin A. David, Zachary D. Epstein-Peterson, Paola Ghione, Paul A. Hamlin, Jennifer Kimberly Lue, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Alison Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles, Lorenzo Falchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1686.
https://doi.org/10.1182/blood-2023-187783
Published: 2023
Journal Articles

A Multicenter Phase 2 Trial of Zanubrutinib, Obinutuzumab, and Venetoclax (BOVen) in Patients with Treatment-Naïve, TP53 -Mutant Mantle Cell Lymphoma

Anita Kumar, Jacob Soumerai, Jeremy S. Abramson, Jeffrey A. Barnes, Philip Caron, Maria Chabowska, Mary Devlin, Ahmet Dogan, Lorenzo Falchi, Rayna N. Garcia, Clare Grieve, Emma Haskell, Julie E. Haydu, Patrick Connor Johnson, Ashlee Joseph, Hailey E. Kelly, Alyssa Labarre, Emerald D Littlejohn, Jennifer Kimberly Lue, Joanna Mi, Rosalba Martignetti, Grace McCambridge, Alison Moskowitz, Colette Owens, Sean F. Plummer, Madeline G. Puccio, Gilles Salles, Venkatraman Seshan, Natalie Slupe, Andrew D. Zelenetz
Journal: Blood
Blood (2023) 142 (Supplement 1): 738.
https://doi.org/10.1182/blood-2023-180069
Published: 2023
Journal Articles

Distinct Patterns of CD4+ and CD8+ T-Cell Clonal Expansion Enable Broad Clinical Responses to Pembrolizumab + GVD in Patients with Relapsed Hodgkin Lymphoma

Beatriz Wills, Jahan Rahman, Nivetha Ganesan, Gunjan L. Shah, Ariela Noy, Heiko Schoder, Joachim Yahalom, Anita Kumar, Lorenzo Falchi, Paul A. Hamlin, Maria Lia Palomba, William Johnson, Andrew M. Intlekofer, Philip Caron, Theresa Davey, Helen Hancock, Natasha Galasso, Brittney Munayirji, Ya Hui Lin, Alayna Santarosa, Ellie Casper, Georgio Pongas, Andrew D. Zelenetz, Craig H. Moskowitz, Gilles Salles, Santosha A Vardhana, Alison Moskowitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1623.
https://doi.org/10.1182/blood-2023-185083
Published: 2023
Journal Articles

Clinical Characteristics and Outcomes of Limited Stage High Grade B-Cell Lymphoma with MYC/BCL2 and/or BCL6 Rearrangements: A Single Center Experience

Jennifer Kimberly Lue, Efrat Luttwak, Philip Caron, Alexander P. Boardman, Kevin A. David, Alfredo Rivas-Delgado, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Alison Moskowitz, Ariela Noy, Maria Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Yanming Zhang, Pallavi Galera, Ahmet Dogan, Umut Aypar, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 3129.
https://doi.org/10.1182/blood-2023-173562
Published: 2023
Journal Articles

Outcomes in Mantle Cell Lymphoma with Central Nervous System Involvement - a Dual Center Study

Nicole McLaughlin, Ashlee Joseph, Yucai Wang, Levi D. Pederson, Susan M. Geyer, Thomas E. Witzig, Andrew D. Zelenetz, J. C. C Villasboas, Michael Scordo, Paul A. Hamlin, N. Nora Bennani, Ariela Noy, Gita Thanarajasingam, Grzegorz S. Nowakowski, Luis Porrata, Carrie Thompson, Ivana Micallef, Patrick B Johnston, Thomas M. Habermann, Stephen M Ansell, Anita Kumar, Jonas Paludo
Journal: Blood
Blood (2023) 142 (Supplement 1): 1670.
https://doi.org/10.1182/blood-2023-174701
Published: 2023
Journal Articles

Ruxolitinib Promotes Clinical Responses in Large Granular Lymphocytic Leukemia Via Suppression of JAK/STAT-Dependent Inflammatory Cascades

Alison Moskowitz, Jahan Rahman, Nivetha Ganesan, Kelly Hannigan, Katie Ksanznak, Hadassah Bitton, Ya-Hui Lin, Theresa Davey, Helen Hancock, Leslie Perez, Tayler Miller, Jamila Brutus, Ahmet Dogan, Mark Blaine Geyer, Eric Jacobsen, Anita Kumar, Jonathan Moreira, Jae H. Park, Meghan C. Thompson, Pallawi Torka, Andrew D. Zelenetz, Santosha A Vardhana, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 183.
https://doi.org/10.1182/blood-2023-181922
Published: 2023
Journal Articles

Impact of Early Histological Transformation on Survival in Patients with Follicular Lymphoma

Efrat Luttwak, Annie Qiu, Michelle Okwali, Alfredo Rivas-Delgado, Irem Isgor, Alexander P. Boardman, Philip Caron, Kevin A. David, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William Johnson, Anita Kumar, Jennifer Kimberly Lue, Alison Moskowitz, Ariela Noy, Pallavi Galera, M. Lia Palomba, Robert Stuver, Pallawi Torka, Santosha A Vardhana, Andrew D. Zelenetz, Heiko Schoder, Joachim Yahalom, Ahmet Dogan, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 3023.
https://doi.org/10.1182/blood-2023-190325
Published: 2023
Journal Articles

Subcutaneous (SC) Mosunetuzumab (mosun) As First-Line Therapy for Patients (pts) with High Tumor-Burden Follicular Lymphoma (FL): First Results of a Multicenter Phase 2 Study

Lorenzo Falchi, Michelle Okwali, Paola Ghione, Colette Owens, Paul A. Hamlin, Jennifer Kimberly Lue, Zachary D. Epstein-Peterson, Maria Lia Palomba, Anita Kumar, Pallawi Torka, Lori A. Leslie, Alexandra Ferreira Lopes, Anastasia Martinova, Lauren Wood, Clare Grieve, Walter Ramos Amador, Santosha A Vardhana, Andrew D. Zelenetz, Gilles Salles
Journal: Blood
Blood (2023) 142 (Supplement 1): 604.
https://doi.org/10.1182/blood-2023-179906
Published: 2023