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Jennifer Woyach
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Journal Articles

The bromodomain and extra-terminal domain protein BRD4 promotes both self renewal and inflammation in TET2 mutated clonal hematopoiesis

Free
Alexander Marr, Madeline Halpin, Dominique Corbin, Britten Gordon, Somi Benrashid, Ethan Whipp, Mehdi Gharghabi, Jean Truxall, Olivia Cahn, Rathan Kumar, Parvarthi Ranganathan, Bethany Mundy-Bosse, Jennifer Woyach, Julia Cooper, Marina Beltrami Moreira, Jayanshu Jain, James Blachly, Uma Borate, Rosa Lapalombella, Nicole Grieselhuber
Journal: Blood
Blood (2025) 146 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2025-1398
Published: 2025
Journal Articles

Targeting BTKi-resistant CLL using the dual irreversible/reversible 4th generation BTK inhibitor rocbrutinib

Free
Britten Gordon, Lillian Cool, Elizabeth Muhowski, Lianbo Yu, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Jazmin Urrutia, Casey Leimbach, Naina Karnati, Serena Li Zhao, Sonam Sonam, Smita Kumari, Elizabeth Perry, Kerry Rogers, Adam Kittai, Seema Bhat, Aseel Alsouqi, Natarajan Muthusamy, John Byrd, Deepa Sampath, Rosa Lapalombella, Blake Peterson, Yi Chen, Stephen Anthony, Yu Chen, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 1532.
https://doi.org/10.1182/blood-2025-1532
Published: 2025
Journal Articles

Dysregulation of NF-kb and p73 signal axes in chronic lymphocytic leukemia with gain-of-function mutated p53

Free
Samon Benrashid, Britten Gordon, Andrew Mitchell, Alexander He, Tzung-Huei Lai, Shrilekha Misra, Shanmugapriya Thangavadivel, Kerry Rogers, Deepa Sampath, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 7405.
https://doi.org/10.1182/blood-2025-7405
Published: 2025
Journal Articles

Pirtobrutinib vs ibrutinib in treatment-naïve and relapsed/refractory CLL/SLL: Results from the first randomized phase III study comparing a non-covalent and covalent BTK inhibitor

Free
Jennifer Woyach, Lugui Qiu, Sebastian Grosicki, Tomasz Wrobel, Marcelo Capra, Jaroslaw Czyz, Shuhua Yi, Ki-Seong Eom, Anna Panovská, Wojciech Jurczak, Kamel Laribi, Lutz Jacobasch, Ross Baker, Richy Agajanian, Alejandro Berkovits, Muhit Özcan, Stephane Lepretre, Catherine Coombs, Paula Cramer, Katharine Lewis, Marisa Hill, Katherine Bao, Yuanyuan Bian, Amy Ruppert Stark, Ching Ching Leow, William Wierda
Journal: Blood
Blood (2025) 146 (Supplement 1): 683.
https://doi.org/10.1182/blood-2025-683
Published: 2025
Journal Articles

Pirtobrutinib outcomes in second-line (2L) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) after first-line (1L) cBTKi therapy: A pooled analysis from the BRUIN LOXO-BTK-18001 and BRUIN CLL-321 studies

Free
Toby Eyre, Matthew S Davids, Jeff Sharman, Paul Barr, Catherine Coombs, Wojciech Jurczak, Koji Izutsu, Meghan Thompson, William Wierda, Ying (denise) Wang, Marisa Hill, Donald Tsai, Ching Ching Leow, Sarang Abhyankar, Paolo Ghia, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 5670.
https://doi.org/10.1182/blood-2025-5670
Published: 2025
Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL): Final update from the Phase 1/2 BRUIN study

Free
Michael Wang, Jonathon Cohen, Nirav Shah, Wojciech Jurczak, Pier Luigi Zinzani, Chan Cheah, Chaitra Ujjani, Youngil Koh, Won Seog Kim, Sunita Dwivedy Nasta, Ian Flinn, Benoit Tessoulin, Shuo Ma, Alvaro Alencar, David Lewis, Jennifer Woyach, Kami Maddocks, Krish Patel, Yucai Wang, Joanna Rhodes, Constantine Tam, John Seymour, Hirokazu Nagai, Julie Vose, Bita Fakhri, Marc Hoffmann, Francisco Hernandez-Ilizaliturri, Andrew Zelenetz, Anita Kumar, Talha Munir, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Lindsey Roeker, Toby Eyre
Journal: Blood
Blood (2025) 146 (Supplement 1): 665.
https://doi.org/10.1182/blood-2025-665
Published: 2025
Journal Articles

Updates of R/R CLL with prior exposure to Bruton's tyrosine kinase (BTK) inhibitor and/or bcl-2 inhibitor in the Phase 1 trial of LP-168 (Rocbrutinib), a novel COVALENT and non-COVALENT BTK inhibitor

Free
Jennifer Woyach, Danielle Brander, Boyu Hu, Kerry Rogers, Zulfa Omer, Emily Curran, Deborah Stephens, Andrea Sitlinger, Yi Chen, Stephen Anthony, Yu Chen, Kewei Shang, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 87.
https://doi.org/10.1182/blood-2025-87
Published: 2025
Journal Articles

A phase II multi-institutional Study evaluating the safety and efficacy of the combination of lisocabtagene maraleucel and zanubrutinib in patients with richter transformation

Free
Aseel Alsouqi, Ying Huang, Lindsey Rike, Lillian Dweik, Swetha Hinton, Mollie Moran, Mark Reid, Corinne Hoffman, Cara Grantier, Margaret Lucas, Amneet Bajwa, Seema Bhat, Michael Grever, Kerry Rogers, Harsh Shah, Jennifer Woyach, Adam Kittai
Journal: Blood
Blood (2025) 146 (Supplement 1): 1953.
https://doi.org/10.1182/blood-2025-1953
Published: 2025
Journal Articles

Anti-CD19 chimeric antigen receptor T-cell therapy for patients with non-Hodgkin's lymphoma and concurrent autoimmune disease

Free
Zachary Braunstein, Eric McLaughlin, Timothy Voorhees, Jiasheng Wang, Evandro Bezerra, David Bond, Audrey Sigmund, Robert Baiocchi, Yun Choi, John Reneau, Yazeed Sawalha, Kami Maddocks, Walter Hanel, Lapo Alinari, Beth Christian, Kerry Rogers, Seema Bhat, Jisna Paul, Ali Ajam, Judith Lin, Gabriela Sanchez-Petitto, Polina Shindiapina, Sarah Wall, Jennifer Woyach, Wael Jarjour, Sumithira Vasu, Marcos de Lima, Jonathan Brammer, Alexa Meara, Nathan Denlinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 1935.
https://doi.org/10.1182/blood-2025-1935
Published: 2025
Journal Articles

Concurrent loss of TP53 and CDKN2A with tetraploidy predicts richter transformation and poor prognosis in chronic lymphocytic leukemia

Free
Anthony Mansour, Ying Huang, Samon Benrashid, Samantha Teierle, Sydney Fobare, Shrilekha Misra, Aseel Alsouqi, Michael Grever, Gerard Lozanski, Matthew Avenarius, Joie Olayiwola, Mollie Moran, Margaret Lucas, Swetha Hinton, Cara Grantier, Corinne Hoffman, Mark Reid, Kerry Rogers, Seema Bhat, Jennifer Woyach, Cecelia Miller
Journal: Blood
Blood (2025) 146 (Supplement 1): 2133.
https://doi.org/10.1182/blood-2025-2133
Published: 2025
Journal Articles

Pirtobrutinib in post-cbtki CLL/SLL: Final update from the Phase 1/2 BRUIN study with more than 5 years follow-up

Free
William Wierda, Jennifer Brown, Paolo Ghia, Lindsey Roeker, Krish Patel, Toby Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine Tam, John Seymour, Benoit Tessoulin, Nirav Shah, Chaitra Ujjani, Bita Fakhri, Catherine Coombs, Ian Flinn, Manish Patel, Sunita Dwivedy Nasta, Jonathon Cohen, Alvaro Alencar, Chan Cheah, Shuo Ma, Joanna Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Österborg, Koji Izutsu, Noriko Fukuhara, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Wojciech Jurczak, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 2115.
https://doi.org/10.1182/blood-2025-2115
Published: 2025
Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Waldenström macroglobulinemia (WM): Up to 5 years of follow-up from the Phase 1/2 BRUIN study

Free
Chan Cheah, Manish Patel, Toby Eyre, Wojciech Jurczak, David Lewis, Thomas Gastinne, Shuo Ma, Jonathon Cohen, Krish Patel, Jennifer Brown, Lydia Scarfo, Talha Munir, Ewa Lech-Maranda, Marc Hoffmann, Chaitra Ujjani, Bita Fakhri, Michael Wang, Koji Izutsu, Hirokazu Nagai, Constantine Tam, Joanna Rhodes, Julie Vose, Matthew McKinney, James Gerson, Minal Barve, Bryone Kuss, Youngil Koh, Aisling Barrett, Steven Treon, Jorge Castillo, John Seymour, Amy Ruppert Stark, Samuel McNeely, Richard Walgren, Donald Tsai, Katherine Bao, Binoj Chandrasekharan Nair, Jennifer Woyach, Lia Palomba
Journal: Blood
Blood (2025) 146 (Supplement 1): 226.
https://doi.org/10.1182/blood-2025-226
Published: 2025
Journal Articles

Venetoclax enhances T cell fitness and CAR T-cell manufacturing potential in chronic lymphocytic leukemia (CLL)

Free
Arun Arunachalam, Beatriz Coutinho De Oliveira, Celine Gregoire, Ziran Zhao, Lily Simpson-Heavey, John Molina, Arnon Kater, Fleur Peters, Adrian Wiestner, Jennifer Woyach, J. Joseph Melenhorst
Journal: Blood
Blood (2025) 146 (Supplement 1): 2322.
https://doi.org/10.1182/blood-2025-2322
Published: 2025
Journal Articles

Safety and efficacy of transposon, BAFF-ligand directed chimeric antigen receptor T cells (LMY-920) with pre-apheresis obinutuzumab for patients with Relapsed/Refractory chronic lymphocytic leukemia and small lymphocytic lymphoma

Free
Paolo Caimi, Leland Metheny, Lapo Alinari, Changchun Deng, Matthew Spear, Jeff Liter, Branden Moriarity, Beau Webber, Jennifer Woyach, Brian Hill, J. Joseph Melenhorst
Journal: Blood
Blood (2025) 146 (Supplement 1): 4177.
https://doi.org/10.1182/blood-2025-4177
Published: 2025
Journal Articles

Ventricular arrhythmias and sudden death events following acalabrutinib initiation

Free
Clinical Trials & Observations Brief Report
Seema A. Bhat, John Gambril, Leylah Azali, Sunnia T. Chen, Lindsay Rosen, Marilly Palettas, Tracy E. Wiczer, Sujay Kalathoor, Qiuhong Zhao, Kerry A. Rogers, Adam Kittai, Michael Grever, Farrukh Awan, Patrick Ruz, John C. Byrd, Jennifer Woyach, Daniel Addison
Journal: Blood
Blood (2022) 140 (20): 2142–2145.
https://doi.org/10.1182/blood.2022016953
Published: 2022
Includes: Supplemental data
Journal Articles

Resistance to Acalabrutinib in CLL Is Mediated Primarily By BTK Mutations

Free
Jennifer Woyach, MD, Ying Huang, MS, MA, Kerry Rogers, Seema A. Bhat, MD, Michael R. Grever, MD, Arletta Lozanski, Tzyy-Jye Doong, James S. Blachly, MD, Gerard Lozanski, MD, Dan Jones, MD PhD, John C. Byrd, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 504.
https://doi.org/10.1182/blood-2019-127674
Published: 2019
Journal Articles

The Protein Kinase C Inhibitor MS-553 for the Treatment of Chronic Lymphocytic Leukemia

Free
Elizabeth M. Muhowski, Amy M. Lehman, M.A.S, Sean D. Reiff, PhD, Janani Ravikrishnan, Rose Mantel, Shrilekha Misra, Michael Niesman, PhD, Kai Zhang, MD, James S. Blachly, MD, Deepa Sampath, PhD, John C. Byrd, MD, Jennifer Woyach, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2077.
https://doi.org/10.1182/blood-2019-128871
Published: 2019
Journal Articles

Selinexor Combined with Ibrutinib Demonstrates Tolerability and Efficacy in Advanced B-Cell Malignancies: A Phase I Study

Free
Deborah M. Stephens, DO, Ying Huang, MS, MA, Akwasi Agyeman, Amy S. Ruppert, MAS, PhD, Boyu Hu, MD, Natalie Turner, APRN, Renee Vadeboncoeur, MSN, APRN, Kerry A Rogers, MD, Seema A. Bhat, MD, Basem M. William, MRCP,MD, Samantha Jaglowski, MDMPH, Hank Lockman, Martha Glenn, MD, Rosa Lapalombella, PhD, John C. Byrd, MD, Jennifer Woyach, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4310.
https://doi.org/10.1182/blood-2019-124544
Published: 2019
Journal Articles

Role of Mutant p53 in the Progression of Chronic Lymphocytic Leukemia

Free
Janani Ravikrishnan, Tzung-Huei Lai, PhD DVM, Elizabeth Muhowski, Lindsey Brinton, PhD, Katie Williams, MS, Alexandria Thompson, James S. Blachly, MD, Hatice Gulcin Ozer, PhD, John C. Byrd, MD, Rosa Lapalombella, PhD, Jennifer Woyach, MD, Deepa Sampath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2526.
https://doi.org/10.1182/blood-2019-128574
Published: 2019
Journal Articles

Rapid Dose Escalation of Venetoclax in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Previously Treated with B-Cell Receptor Inhibitor Therapy

Free
Kristin Koenig, MD, Emily Dotson, PharmD, Shane Sheredy, Seema A. Bhat, MD, John C. Byrd, MD, Tracy Wiczer, Jennifer Woyach, MD, Farrukh T. Awan, MD, Kerry A. Rogers, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3045.
https://doi.org/10.1182/blood-2019-124538
Published: 2019