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Alexander Marr
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Journal Articles

Targeting BTKi-resistant CLL using the dual irreversible/reversible 4th generation BTK inhibitor rocbrutinib

Free
Britten Gordon, Lillian Cool, Elizabeth Muhowski, Lianbo Yu, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Jazmin Urrutia, Casey Leimbach, Naina Karnati, Serena Li Zhao, Sonam Sonam, Smita Kumari, Elizabeth Perry, Kerry Rogers, Adam Kittai, Seema Bhat, Aseel Alsouqi, Natarajan Muthusamy, John Byrd, Deepa Sampath, Rosa Lapalombella, Blake Peterson, Yi Chen, Stephen Anthony, Yu Chen, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 1532.
https://doi.org/10.1182/blood-2025-1532
Published: 2025
Journal Articles

The bromodomain and extra-terminal domain protein BRD4 promotes both self renewal and inflammation in TET2 mutated clonal hematopoiesis

Free
Alexander Marr, Madeline Halpin, Dominique Corbin, Britten Gordon, Somi Benrashid, Ethan Whipp, Mehdi Gharghabi, Jean Truxall, Olivia Cahn, Rathan Kumar, Parvarthi Ranganathan, Bethany Mundy-Bosse, Jennifer Woyach, Julia Cooper, Marina Beltrami Moreira, Jayanshu Jain, James Blachly, Uma Borate, Rosa Lapalombella, Nicole Grieselhuber
Journal: Blood
Blood (2025) 146 (Supplement 1): 1398.
https://doi.org/10.1182/blood-2025-1398
Published: 2025
Journal Articles

Brd4 Inhibition Abrogates Inflammation and Self-Renewal in a Murine Model of Tet2 Mutated Clonal Hematopoiesis

Free
Alexander Marr, Madeline Halpin, Dominique Corbin, Britten Gordon, Samon Benrashid, Ethan C. Whipp, Mehdi Gharghabi, Jean Truxall, Olivia Cahn, Kristin L Koenig, Karilyn T. Larkin, Jennifer A. Woyach, Rosa Lapalombella, Nicole R. Grieselhuber
Journal: Blood
Blood (2023) 142 (Supplement 1): 4070.
https://doi.org/10.1182/blood-2023-179237
Published: 2023
Journal Articles

The PKC-β Inhibitor MS-553 Displays Preclinical Efficacy in BTK Inhibitor Resistant Chronic Lymphocytic Leukemia

Free
Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Shanmugapriya Thangavadivel, Samon Benrashid, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Nicole R. Grieselhuber, Kerry A Rogers, James S. Blachly, Adam S Kittai, Seema A Bhat, John C. Byrd, Michael Niesman, Kai Zhang, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2260.
https://doi.org/10.1182/blood-2023-182024
Published: 2023
Journal Articles

Targeting Covalent and Non-Covalent Btki-Resistant CLL Using the Dual Irreversible/Reversible 4 th Generation BTK Inhibitor LP-168

Free
Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Kerry A Rogers, Adam S Kittai, Seema A Bhat, John C. Byrd, Deepa Sampath, Rosa Lapalombella, Weiguo Han, Neil E. Kay, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 416.
https://doi.org/10.1182/blood-2023-178259
Published: 2023
Journal Articles

The Multi-CDK Inhibitor Dinaciclib Shows Synergistic Activity with the BET Inhibitor PLX51107 and Reverses BET Resistance through Inhibition of Canonical Wnt Signaling in Acute Myeloid Leukemia (AML)

Free
Alexander Marr, Soumendrakrishna Karmahapatra, Dominique Corbin, Yerdanos Asemelash, Steven Sher, Shaneice Renee Mitchell, Bonnie K Harrington, Shelley Orwick, Larry Beaver, Ronni Wasmuth, Virginia Goettl, Alice S. Mims, Karilyn T. Larkin, Sumithira Vasu, Meixiao Long, James S. Blachly, Ramiro Garzon, John C. Byrd, Rosa Lapalombella, Nicole Grieselhuber
Journal: Blood
Blood (2022) 140 (Supplement 1): 3075–3076.
https://doi.org/10.1182/blood-2022-160277
Published: 2022