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Journal Articles

The PKC-β Inhibitor MS-553 Displays Preclinical Efficacy in BTK Inhibitor Resistant Chronic Lymphocytic Leukemia

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Shanmugapriya Thangavadivel, Samon Benrashid, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Nicole R. Grieselhuber, Kerry A Rogers, James S. Blachly, Adam S Kittai, Seema A Bhat, John C. Byrd, Michael Niesman, Kai Zhang, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2260.
https://doi.org/10.1182/blood-2023-182024
Published: 2023
Journal Articles

MS-553 Therapy Inhibits BCR Signaling and Increases Survival Dependence on BCL-2 in BTK-Inhibitor Resistant CLL

Jyotsana Singh, John R. Sanchez II, Chaomei Liu, Bailey Slawin, Nitin Jain, William G. Wierda, Kai Zhang, Michael Niesman, James S. Blachly, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2023) 142 (Supplement 1): 2283.
https://doi.org/10.1182/blood-2023-189378
Published: 2023
Journal Articles

Initial Results from a Phase 1/2 Dose Escalation and Expansion Study Evaluating MS-553, a Novel and Selective PKCβ Inhibitor, in Patients with CLL/SLL

James S. Blachly, Deborah M. Stephens, J Christine Ye, Nicole Lamanna, Nitin Jain, Michael Niesman, Kai Zhang, Jennifer A. Woyach
Journal: Blood
Blood (2022) 140 (Supplement 1): 2324–2325.
https://doi.org/10.1182/blood-2022-171203
Published: 2022
Journal Articles

MS-553, a Selective PKC-ß Inhibitor Inhibits BCR Signaling and Synergizes with Venetoclax for the Treatment of High Risk CLL

Jyotsana Singh, Daisy Diaz Rohena, Chaomei Liu, Bailey Slawin, Janani Ravikrishnan, Nitin Jain, William G. Wierda, Kai Zhang, Michael Niesman, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2022) 140 (Supplement 1): 9857–9858.
https://doi.org/10.1182/blood-2022-168391
Published: 2022
Journal Articles

Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Clinical Trials & Observations
Xinyi Xia, Kening Li, Lingxiang Wu, Zhihua Wang, Mengyan Zhu, Bin Huang, Jie Li, Ziyu Wang, Wei Wu, Min Wu, Wanlin Li, Lu Li, Yun Cai, Bakwatanisa Bosco, Aifang Zhong, Xiong Liu, Tangfeng Lv, Zhenhua Gan, Guang Chen, Yunhu Pan, Caidong Liu, Kai Zhang, Xiaoli Xu, Changjun Wang, Qianghu Wang
Journal: Blood
Blood (2020) 136 (6): 755–759.
https://doi.org/10.1182/blood.2020007079
Published: 2020
Includes: Supplemental data
Journal Articles

The Protein Kinase C Inhibitor MS-553 for the Treatment of Chronic Lymphocytic Leukemia

Elizabeth M. Muhowski, Amy M. Lehman, M.A.S, Sean D. Reiff, PhD, Janani Ravikrishnan, Rose Mantel, Shrilekha Misra, Michael Niesman, PhD, Kai Zhang, MD, James S. Blachly, MD, Deepa Sampath, PhD, John C. Byrd, MD, Jennifer Woyach, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2077.
https://doi.org/10.1182/blood-2019-128871
Published: 2019