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Journal Articles

MS-553 Therapy Inhibits BCR Signaling and Increases Survival Dependence on BCL-2 in BTK-Inhibitor Resistant CLL

Jyotsana Singh, John R. Sanchez II, Chaomei Liu, Bailey Slawin, Nitin Jain, William G. Wierda, Kai Zhang, Michael Niesman, James S. Blachly, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2023) 142 (Supplement 1): 2283.
https://doi.org/10.1182/blood-2023-189378
Published: 2023
Journal Articles

Enriched Signalling Pathways in Venetoclax-Relapsed Chronic Lymphocytic Leukemia (CLL) Cells and Targeting Using a Protac-Based Bcl-2/Bcl-Xl Degrader

Daisy Diaz Rohena, Arnau Peris Cuesta, Bailey Slawin, Janani Ravikrishnan, Chaomei Liu, Charmelle Williams, Wanyi Hu, Peiyi Zhang, Philip Thompson, William G. Wierda, Nitin Jain, Sachet Shukla, Guangrong Zheng, Daohong Zhou, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2023) 142 (Supplement 1): 4195.
https://doi.org/10.1182/blood-2023-188250
Published: 2023
Journal Articles

MS-553, a Selective PKC-ß Inhibitor Inhibits BCR Signaling and Synergizes with Venetoclax for the Treatment of High Risk CLL

Jyotsana Singh, Daisy Diaz Rohena, Chaomei Liu, Bailey Slawin, Janani Ravikrishnan, Nitin Jain, William G. Wierda, Kai Zhang, Michael Niesman, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2022) 140 (Supplement 1): 9857–9858.
https://doi.org/10.1182/blood-2022-168391
Published: 2022
Journal Articles

Targeting Venetoclax Resistant CLL Using a Protac-Based BCL-2/BCL-XL Degrader

Daisy Diaz Rohena, Bailey Slawin, Janani Ravikrishnan, Chaomei Liu, Wanyi Hu, Peiyi Zhang, Philip A. Thompson, William G. Wierda, Nitin Jain, Guangrong Zheng, Daohong Zhou, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2022) 140 (Supplement 1): 497–498.
https://doi.org/10.1182/blood-2022-168345
Published: 2022
Journal Articles

Targeting Venetoclax-Resistant CLL By Bcl-XL Degradation

Daisy Diaz Rohena, Janani Ravikrishnan, Chaomei Liu, Guangrong Zheng, Daohong Zhou, Peiyi Zhang, William G. Wierda, Nitin Jain, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2021) 138 (Supplement 1): 2252.
https://doi.org/10.1182/blood-2021-151982
Published: 2021
Journal Articles

Using HSP90 Inhibitors to Target DNA Repair Proteins in AML

Janani Ravikrishnan, BS, Tzung-Huei Lai, PhD, Shaneice Renee Mitchell, BS, Pei-Jung Wu, BS, Shelley Orwick, BS, Chaomei Liu, PhD, Jennifer A. Woyach, MD, Alice S. Mims, MD, William Plunkett, PhD, Vinay K Puduvalli, MD MBBS, John C. Byrd, MD, Rosa Lapalombella, PhD, Deepa Sampath, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5144.
https://doi.org/10.1182/blood-2018-99-116485
Published: 2018
Journal Articles

Targeting BTK through microRNA in chronic lymphocytic leukemia

Arianna Bottoni, Lara Rizzotto, Tzung-Huei Lai, Chaomei Liu, Lisa L. Smith, Rose Mantel, Sean Reiff, Dalia El-Gamal, Karilyn Larkin, Amy J. Johnson, Rosa Lapalombella, Amy Lehman, William Plunkett, John C. Byrd, James S. Blachly, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2016) 128 (26): 3101–3112.
https://doi.org/10.1182/blood-2016-07-727750
Published: 2016
Includes: Supplemental data
Journal Articles

Role of Histone Deacetylase-Mediated Gene Silencing in Chronic Lymphocytic Leukemia Progression

Lara Rizzotto, PhD, Arianna Bottoni, PhD, Tzung-Huei Lai, PhD, Chaomei Liu, BS, Pearlly S Yan, PhD, Hatice G Ozer, PhD, Rosa Lapalombella, PhD, Jennifer A. Woyach, MD, Christopher C Oakes, PhD, James S. Blachly, MD, Deepa Sampath, PhD
Journal: Blood
Blood (2016) 128 (22): 2705.
https://doi.org/10.1182/blood.V128.22.2705.2705
Published: 2016
Journal Articles

Histone Deacetylase Inhibitors Induce microRNAs Targeting BTK in Acute Myeloid Leukemia

Lara Rizzotto, PhD, Tzung-Huei Lai, PhD, Chaomei Liu, BS, Arianna Bottoni, PhD, Clara D. Bloomfield, MD, John C Byrd, MD, Deepa Sampath, PhD
Journal: Blood
Blood (2015) 126 (23): 1222.
https://doi.org/10.1182/blood.V126.23.1222.1222
Published: 2015
Journal Articles

Panobinostat, An Oral Pan-Histone Deacetylase (HDAC) Inhibitor Activates a Microrna Signature That Targets Rad51 To Attenuate Homologous DNA Repair and Sensitize AML Cells To Sapacitabine

Deepa Sampath, PhD, Alma Zecevic, PhD, Brett Ewald, PhD, Melanie Hayes, PhD, Chaomei Liu, BSc, Guido Marcucci, MD, William Plunkett, PhD
Journal: Blood
Blood (2013) 122 (21): 822.
https://doi.org/10.1182/blood.V122.21.822.822
Published: 2013
Journal Articles

Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia

Deepa Sampath, Chaomei Liu, Karthik Vasan, Melanie Sulda, Vinay K. Puduvalli, William G. Wierda, Michael J. Keating
Journal: Blood
Blood (2012) 119 (5): 1162–1172.
https://doi.org/10.1182/blood-2011-05-351510
Published: 2012
Includes: Supplemental data
Journal Articles

Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation

Deepa Sampath, George A. Calin, Vinay K. Puduvalli, Gopal Gopisetty, Cristian Taccioli, Chang-Gong Liu, Brett Ewald, Chaomei Liu, Michael J. Keating, William Plunkett
Journal: Blood
Blood (2009) 113 (16): 3744–3753.
https://doi.org/10.1182/blood-2008-09-178707
Published: 2009
Includes: Supplemental data