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Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

Enriched Signalling Pathways in Venetoclax-Relapsed Chronic Lymphocytic Leukemia (CLL) Cells and Targeting Using a Protac-Based Bcl-2/Bcl-Xl Degrader

Daisy Diaz Rohena, Arnau Peris Cuesta, Bailey Slawin, Janani Ravikrishnan, Chaomei Liu, Charmelle Williams, Wanyi Hu, Peiyi Zhang, Philip Thompson, William G. Wierda, Nitin Jain, Sachet Shukla, Guangrong Zheng, Daohong Zhou, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2023) 142 (Supplement 1): 4195.
https://doi.org/10.1182/blood-2023-188250
Published: 2023
Journal Articles

Ibrutinib induces durable remissions in treatment-naïve patients with CLL and 17p deletion and/or TP53 mutations

Clinical Trials & Observations
Mariela Sivina, Ekaterina Kim, William G. Wierda, Alessandra Ferrajoli, Nitin Jain, Philip Thompson, Hagop Kantarjian, Michael Keating, Jan A. Burger
Journal: Blood
Blood (2021) 138 (24): 2589–2592.
https://doi.org/10.1182/blood.2021012315
Published: 2021
Includes: Supplemental data
Journal Articles

Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia

Clinical Trials & Observations
Jan A. Burger, Mariela Sivina, Nitin Jain, Ekaterina Kim, Tapan Kadia, Zeev Estrov, Graciela M. Nogueras-Gonzalez, Xuelin Huang, Jeffrey Jorgensen, Jianling Li, Mei Cheng, Fong Clow, Maro Ohanian, Michael Andreeff, Thomas Mathew, Philip Thompson, Hagop Kantarjian, Susan O’Brien, William G. Wierda, Alessandra Ferrajoli, Michael J. Keating
Journal: Blood
Blood (2019) 133 (10): 1011–1019.
https://doi.org/10.1182/blood-2018-10-879429
Published: 2019
Includes: Supplemental data
Journal Articles

Clinical implications of cancer gene mutations in patients with chronic lymphocytic leukemia treated with lenalidomide

Clinical Trials & Observations
Koichi Takahashi, Boyu Hu, Feng Wang, Yuanqing Yan, Ekaterina Kim, Candida Vitale, Keyur P. Patel, Paolo Strati, Curtis Gumbs, Latasha Little, Samantha Tippen, Xingzhi Song, Jianhua Zhang, Nitin Jain, Philip Thompson, Guillermo Garcia-Manero, Hagop Kantarjian, Zeev Estrov, Kim-Anh Do, Michael Keating, Jan A. Burger, William G. Wierda, P. Andrew Futreal, Alessandra Ferrajoli
Journal: Blood
Blood (2018) 131 (16): 1820–1832.
https://doi.org/10.1182/blood-2017-11-817296
Published: 2018
Includes: Supplemental data
Journal Articles

Ruxolitinib Reduces Cytokine/Chemokine Levels and Improves Fatigue and Chronic Lymphocytic Leukemia (CLL)-Related Symptoms in CLL Patients Not Requiring Systemic Therapy

Preetesh Jain, MBBS,MDDM,PhD, Michael J. Keating, MD, Charles Cleeland, Sarah Renner, Huang Xuelin, Graciela Nogueras Gonzalez, David M. Harris, William Wierda, MD PhD, Courtney DiNardo, MD, Naveen Pemmaraju, Nitin Jain, MD, Philip Thompson, MBBS, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Hagop M. Kantarjian, MD, Srdan Verstovsek, MD, Zeev Estrov, MD
Journal: Blood
Blood (2015) 126 (23): 2943.
https://doi.org/10.1182/blood.V126.23.2943.2943
Published: 2015
Journal Articles

Stimulation of the B-Cell Receptor (BCR) Induces Successive Activation of STAT3 and Nuclear Factor-Kappa-B in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Alessandra Ferrajoli, MD, Jan A Burger, MD PhD, Philip Thompson, MBBS, Nitin Jain, MD, William Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD
Journal: Blood
Blood (2015) 126 (23): 4125.
https://doi.org/10.1182/blood.V126.23.4125.4125
Published: 2015
Journal Articles

P300 Acetylates STAT3 and Increases Its Constitutive Transcriptional Activity in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Alessandra Ferrajoli, MD, Jan A Burger, MD PhD, Philip Thompson, MBBS, Nitin Jain, MD, William Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD
Journal: Blood
Blood (2015) 126 (23): 4143.
https://doi.org/10.1182/blood.V126.23.4143.4143
Published: 2015
Journal Articles

The CXCR4/STAT3/IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia (CLL) and Can be Modulated By Lenalidomide

Hila Shaim, MD, Zeev Estrov, MD, Takuya Sekine, Kayo Kondo, PhD, Peter P. Ruvolo, PhD, Philip Thompson, MBBS, Anushruti Sarvaria, MS, Muharrem Muftuoglu, Nobuhiko Imahashi, MD PhD, Enli Liu, MD MS, Catherine Sobieski, William Wierda, MD PhD, Michael J. Keating, MD, Nina Shah, MD, Chitra M. Hosing, MD, Abdullah Alsuliman, Rafet Basar, MD, Alessandra Ferrajoli, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1709.
https://doi.org/10.1182/blood.V126.23.1709.1709
Published: 2015
Journal Articles

Ibrutinib Can Modulate the T Cell Response in Chronic Lymphocytic Leukemia By Reducing PD1/PDL1 Interactions

Kayo Kondo, PhD, Jan A. Burger, MD PhD, Keating Micheal, MD, Jamie Tran, Muharrem Muftuoglu, May Daher, Hila Shaim, MD, Philip Thompson, MBBS, Nobuhiko Imahashi, MD PhD, Abdullah Alsuliman, William Wierda, MD PhD, Enli Liu, MD MS, Elizabeth J. Shpall, MD, Katayoun Rezvani, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1737.
https://doi.org/10.1182/blood.V126.23.1737.1737
Published: 2015