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Marina Y. Konopleva
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Journal Articles

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia

Carolin S. Escherich, Takaya Moriyama, Zhenhua Li, Yu-Chih Hsiao, Wenjian Yang, Yizhen Li, Noemi Reyes, Megan Walker, Amit Budhraja, Sheetal Bhatara, Ernesto Diaz-Flores, Wendy Stock, Elisabeth Paietta, Marina Y. Konopleva, Steven M. Kornblau, Mark R. Litzow, Hiroto Inaba, Ching-Hon Pui, Joseph T. Opferman, Mignon L. Loh, Jiyang Yu, Maureen M. O’Brien, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2025) 145 (11): 1182–1194.
https://doi.org/10.1182/blood.2024026085
Published: 2025
Includes: Supplemental data
Journal Articles

Venetoclax plus Daunorubicin and Cytarabine for Newly Diagnosed Acute Myeloid Leukemia: Results of a Phase 1b Study

Clinical Trials & Observations
Ioannis Mantzaris, Mendel Goldfinger, Matan Uriel, Aditi Shastri, Nishi Shah, Kira Gritsman, Noah Kornblum, Lauren C Shapiro, Alejandro Sica, Anne Munoz, Nicole Chambers, Aradhika Dhawan, Jhannine Alyssa Verceles, Karen Fehn, Balda Tirone, Lamisha Shah, Shaunmonique Clark, Chenxin Zhang, Mimi Y Kim, Dennis L Cooper, Amit Verma, Marina Y. Konopleva, Eric J Feldman
Journal: Blood
Blood blood.2024026700.
https://doi.org/10.1182/blood.2024026700
Published: 2025
Includes: Supplemental data
Journal Articles

The Prevalence and Mutational Spectrum of Clonal Hematopoiesis in Diverse Populations in New York City

Varun Gupta, Mariko Isshiki, Anna Skwarska, Kith Pradhan, Amit K. Verma, Marina Y. Konopleva, Aditi Shastri, Srilakshmi Raj
Journal: Blood
Blood (2023) 142 (Supplement 1): 5604.
https://doi.org/10.1182/blood-2023-180973
Published: 2023
Journal Articles

A Phase 2 Study of the Fully Oral Combination of ASTX727 (Decitabine/Cedazuridine) Plus Venetoclax for Older and/or Unfit Patients with Acute Myeloid Leukemia

Alexandre Bazinet, Guillermo Garcia-Manero, Nicholas J. Short, Yesid Alvarado Valero, Tareq Abuasab, Md Rabiul Islam, Kathryn Montalbano, Ghayas C. Issa, Abhishek Maiti, Musa Yilmaz, Nitin Jain, Lucia Masarova, Steven M. Kornblau, Elias Jabbour, Guillermo Montalban-Bravo, Sherry Pierce, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Marina Y. Konopleva, Hagop M. Kantarjian, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 833.
https://doi.org/10.1182/blood-2023-172658
Published: 2023
Journal Articles

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia

Abdullah Khasawneh, Faith Jessica Paran, Rieko Oyama, Abhishek Maiti, Hussein A Abbas, Bofei Wang, Poonam N Desai, Kala Hayes, Joe R Harman, Xiaoping Su, Courtney D. DiNardo, Michael Andreeff, Thomas A Milne, Marina Y. Konopleva, Yoko Tabe
Journal: Blood
Blood (2023) 142 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2023-180463
Published: 2023
Journal Articles

Venetoclax Synergizes with IMGN632, a Novel CD123-Targeting Antibody Conjugated to a DNA Alkylating Payload, By Suppressing DNA Damage Response and Potentiating Apoptosis in Acute Myeloid Leukemia in Vitro Models

Anna Skwarska, Vinitha Mary Kuruvilla, Qi Zhang, Sovira Chaudhry, Naval Daver, Krystal Watkins, Callum Mortimer Sloss, Patrick A. Zweidler-McKay, Deepa Sampath, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4155.
https://doi.org/10.1182/blood-2023-187018
Published: 2023
Journal Articles

Targeting BCL-XL with a Novel VHL-Based BCL-XL Degrader DT-2216 in Pre-Clinical JAK2 -Mutant AML Post-MPN Models

Zhe WANG, Qi Zhang, Anna Skwarska, Cassandra L. Ramage, Guangrong Zheng, Kira Gritsman, Kapil N. Bhalla, Naveen Pemmaraju, Daohong Zhou, Jeffrey W Tyner, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4154.
https://doi.org/10.1182/blood-2023-178813
Published: 2023
Journal Articles

A Study Evaluating Financial Toxicity Amongst Hematologic Malignancy Patients in the Bronx

Lemchukwu Amaeshi, Alex Sisto, Lauren Laufer, Kateryna Fedorov, Rosmi Mathew, David Levitz, Ioannis Mantzaris, Noah Kornblum, Mendel Goldfinger, Alejandro Sica, Dennis L Cooper, Marina Y. Konopleva, Bruce Rapkin, Amit Verma, Aditi Shastri, Nishi Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 7397.
https://doi.org/10.1182/blood-2023-188024
Published: 2023
Journal Articles

A Phase I, Single-Arm, Open Label, Dose Escalation, Multicenter Study of Off-the-Shelf Natural Killer (NK) Cells (SAR445419) in Patients with Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)

Marina Y. Konopleva, Vijaya Raj Bhatt, Ioannis Mantzaris, Abhishek Maiti, Krishna Gundabolu, Kyle Jensen, Jolie Schafer, Gu Mi, Agata Drewniak, Heidi Krenz, Rao Saleem, Giovanni Abbadessa, Naval Daver
Journal: Blood
Blood (2023) 142 (Supplement 1): 5972.
https://doi.org/10.1182/blood-2023-174030
Published: 2023
Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

Phase II Trial of 10-Day ASTX727 (Decitabine/Cedazuridine) with Venetoclax for Relapsed or Refractory Acute Myeloid Leukemia

Abhishek Maiti, Courtney D. DiNardo, Maro Ohanian, Naval Daver, Gautam Borthakur, Kelly S. Chien, Ghayas C. Issa, Koichi Takahashi, Lucia Masarova, Yesid Alvarado Valero, Elias Jabbour, William G. Wierda, Nicholas J. Short, Melissa MacFarland, Allison Pike, Tapan M. Kadia, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4289.
https://doi.org/10.1182/blood-2023-182901
Published: 2023
Journal Articles

Phase Ib/2 Study of Oral Decitabine/Cedazuridine (ASTX727) and Venetoclax in Combination with the Targeted Mutant IDH1 Inhibitor Ivosidenib or the Targeted Mutant IDH2 Inhibitor Enasidenib: 2023 Update

Himachandana Atluri, Jillian Mullin, Koichi Takahashi, Sanam Loghavi, Abhishek Maiti, Koji Sasaki, Naval Daver, Yesid Alvarado Valero, Naveen Pemmaraju, Gautam Borthakur, Danielle E. Hammond, Kelly S. Chien, Alessandra Ferrajoli, Nicholas J. Short, Hussein A Abbas, Elias Jabbour, Michael Andreeff, Farhad Ravandi, Rebecca S.S. Tidwell, Xuemei Wang, Marina Y. Konopleva, Guillermo Garcia-Manero, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 968.
https://doi.org/10.1182/blood-2023-182944
Published: 2023
Journal Articles

Nelarabine (NEL), Pegylated Asparginase (PEG) and Venetoclax (VEN) Incorporated to HCVAD Chemotherapy in the Frontline Treatment of Adult Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-ALL/T-LBL)

Jayastu Senapati, Hagop M. Kantarjian, Elias Jabbour, Rodrick Babakhanlou, Tapan M. Kadia, Gautam Borthakur, Marina Y. Konopleva, William G. Wierda, Jan A. Burger, Ghayas C. Issa, Abhishek Maiti, Hayley S. Balkin, Mary Kelly, Rebecca Garris, Alessandra Ferrajoli, Guillermo Garcia-Manero, Yesid Alvarado Valero, Partow Kebriaei, Nicholas J. Short, Nitin Jain, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 963.
https://doi.org/10.1182/blood-2023-179562
Published: 2023
Journal Articles

N/KRAS -Mutant AML LSCs Originate from Committed Myelomonocytic Progenitors and Drive Clinical Resistance to Venetoclax

Junya Sango, Saul Carcamo, Nataly Cruz-Rodriguez, Maria Sirenko, Abhishek Maiti, Malgorzata Olszewska, Tiansu Wang, Gulay Bengu Ulukaya, Lewis Tomalin, Emmanuel Olivier, Manon Jaud, Ronan Chaligne, Hager Mansour, Deniz Demircioglu, Dan A. Landau, Elli Papaemmanuil, Courtney D. DiNardo, Dan Hasson, Marina Y. Konopleva, Eirini Papapetrou
Journal: Blood
Blood (2023) 142 (Supplement 1): 403.
https://doi.org/10.1182/blood-2023-187695
Published: 2023
Journal Articles

Dual-Targeting CD33/CD123 NANOBODY ® T Cell Engager Targeting Leukemia Blasts and Stem/Progenitor Cells in Relapsed AML

Zhihong Zeng, Annelies Roobrouck, Geert Deschamps, Helene Bonnevaux, Stephane Guerif, Veronique De Brabandere, Amara Céline, Eline Jonckheere, Angela Virone-Oddos, Marielle Chiron, Melissa Dullaers, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2023-186012
Published: 2023
Journal Articles

Single-Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms

Yi June Kim, Zongrui Li, Abhishek Maiti, Tomoyuki Tanaka, Hidetaka Uryu, Ken Furudate, Kala Hayes, Naval Daver, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Nicholas J. Short, Maro Ohanian, Gautam Borthakur, Nitin Jain, Ghayas C. Issa, Lucia Masarova, Steven M. Kornblau, William G. Wierda, Sanam Loghavi, Sa A. Wang, Guillermo Garcia-Manero, Hagop Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva, Koichi Takahashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2931.
https://doi.org/10.1182/blood-2023-190400
Published: 2023
Journal Articles

“Dose-Dense” Mini-Hyper-CVD, Inotuzumab Ozogamicin and Blinatumomab Achieves High Rates of Rapid MRD-Negativity in Patients with Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis

Trevor Jamison, Hagop M. Kantarjian, Shilpa Paul, Branko Cuglievan, David McCall, Nitin Jain, Fadi G. Haddad, Kayleigh R. Marx, Caitlin R Rausch, J. Michael Savoy, Lewis Nasr, Cedric Nasnas, Marianne Zoghbi, Rebecca Garris, Farhad Ravandi, Marina Y. Konopleva, Elias Jabbour, Nicholas J. Short
Journal: Blood
Blood (2023) 142 (Supplement 1): 1508.
https://doi.org/10.1182/blood-2023-188530
Published: 2023
Journal Articles

Patient Characteristics and Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Muzaffar H. Qazilbash, Hina N. Khan, Denái R. Milton, Oren Pasvolsky, Mark R. Tanner, Uday R. Popat, Partow Kebriaei, Chitra Hosing, Issa F. Khouri, Katayoun Rezvani, Yago Nieto, Betul Oran, Samer A. Srour, Neeraj Y. Saini, Amanda L. Olson, Sairah Ahmed, Gheath Alatrash, Gabriela Rondon, Marina Y. Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Qaiser Bashir, Naveen Pemmaraju
Journal: Blood
Blood (2023) 142 (Supplement 1): 4988.
https://doi.org/10.1182/blood-2023-181031
Published: 2023
Journal Articles

Updated Results from a Phase II Study of Hyper-CVAD, with or without Inotuzumab Ozogamicin, and Sequential Blinatumomab in Patients with Newly Diagnosed B-Cell Acute Lymphoblastic Leukemia

Daniel Nguyen, Hagop M. Kantarjian, Nicholas J. Short, Nitin Jain, Fadi G. Haddad, Musa Yilmaz, Alessandra Ferrajoli, Tapan M. Kadia, Yesid Alvarado Valero, Abhishek Maiti, Cedric Nasnas, Lewis Nasr, Rebecca Garris, Marina Y. Konopleva, Farhad Ravandi, Elias Jabbour
Journal: Blood
Blood (2023) 142 (Supplement 1): 4245.
https://doi.org/10.1182/blood-2023-190902
Published: 2023
Journal Articles

Results of Phase I/II Study of Azacitidine in Combination with Quizartinib for Patients with Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms with FLT3 or CBL Mutations

Guillermo Montalban-Bravo, Elias Jabbour, Kelly S. Chien, Danielle E. Hammond, Nicholas J. Short, Farhad Ravandi, Marina Y. Konopleva, Gautam Borthakur, Naval Daver, Rashmi Kanagal-Shamanna, Wei Qiao, Xuelin Huang, Heather Schneider, Meghan Anne Meyer, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 3238.
https://doi.org/10.1182/blood-2023-178115
Published: 2023