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Marina Y. Konopleva
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Journal Articles

Efficacy of a Novel BCL-xL Degrader, DT2216, in Preclinical Models of JAK2-mutated Post-MPN AML

Open Access
Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P Papapetrou, Kapil N Bhalla, Daohong Zhou, Adam J. Mead, Raajit K. Rampal, Jeffrey W. Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Y. Konopleva
Journal: Blood
Blood blood.2024027117.
https://doi.org/10.1182/blood.2024027117
Published: 2025
Includes: Supplemental data
Journal Articles

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia

Available to Purchase
Carolin S. Escherich, Takaya Moriyama, Zhenhua Li, Yu-Chih Hsiao, Wenjian Yang, Yizhen Li, Noemi Reyes, Megan Walker, Amit Budhraja, Sheetal Bhatara, Ernesto Diaz-Flores, Wendy Stock, Elisabeth Paietta, Marina Y. Konopleva, Steven M. Kornblau, Mark R. Litzow, Hiroto Inaba, Ching-Hon Pui, Joseph T. Opferman, Mignon L. Loh, Jiyang Yu, Maureen M. O’Brien, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2025) 145 (11): 1182–1194.
https://doi.org/10.1182/blood.2024026085
Published: 2025
Includes: Supplemental data
Journal Articles

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia

Free
Abdullah Khasawneh, Faith Jessica Paran, Rieko Oyama, Abhishek Maiti, Hussein A Abbas, Bofei Wang, Poonam N Desai, Kala Hayes, Joe R Harman, Xiaoping Su, Courtney D. DiNardo, Michael Andreeff, Thomas A Milne, Marina Y. Konopleva, Yoko Tabe
Journal: Blood
Blood (2023) 142 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2023-180463
Published: 2023
Journal Articles

Venetoclax Synergizes with IMGN632, a Novel CD123-Targeting Antibody Conjugated to a DNA Alkylating Payload, By Suppressing DNA Damage Response and Potentiating Apoptosis in Acute Myeloid Leukemia in Vitro Models

Free
Anna Skwarska, Vinitha Mary Kuruvilla, Qi Zhang, Sovira Chaudhry, Naval Daver, Krystal Watkins, Callum Mortimer Sloss, Patrick A. Zweidler-McKay, Deepa Sampath, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4155.
https://doi.org/10.1182/blood-2023-187018
Published: 2023
Journal Articles

Targeting BCL-XL with a Novel VHL-Based BCL-XL Degrader DT-2216 in Pre-Clinical JAK2 -Mutant AML Post-MPN Models

Free
Zhe WANG, Qi Zhang, Anna Skwarska, Cassandra L. Ramage, Guangrong Zheng, Kira Gritsman, Kapil N. Bhalla, Naveen Pemmaraju, Daohong Zhou, Jeffrey W Tyner, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4154.
https://doi.org/10.1182/blood-2023-178813
Published: 2023
Journal Articles

A Study Evaluating Financial Toxicity Amongst Hematologic Malignancy Patients in the Bronx

Free
Lemchukwu Amaeshi, Alex Sisto, Lauren Laufer, Kateryna Fedorov, Rosmi Mathew, David Levitz, Ioannis Mantzaris, Noah Kornblum, Mendel Goldfinger, Alejandro Sica, Dennis L Cooper, Marina Y. Konopleva, Bruce Rapkin, Amit Verma, Aditi Shastri, Nishi Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 7397.
https://doi.org/10.1182/blood-2023-188024
Published: 2023
Journal Articles

A Phase I, Single-Arm, Open Label, Dose Escalation, Multicenter Study of Off-the-Shelf Natural Killer (NK) Cells (SAR445419) in Patients with Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)

Free
Marina Y. Konopleva, Vijaya Raj Bhatt, Ioannis Mantzaris, Abhishek Maiti, Krishna Gundabolu, Kyle Jensen, Jolie Schafer, Gu Mi, Agata Drewniak, Heidi Krenz, Rao Saleem, Giovanni Abbadessa, Naval Daver
Journal: Blood
Blood (2023) 142 (Supplement 1): 5972.
https://doi.org/10.1182/blood-2023-174030
Published: 2023
Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Free
Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

Phase II Trial of 10-Day ASTX727 (Decitabine/Cedazuridine) with Venetoclax for Relapsed or Refractory Acute Myeloid Leukemia

Free
Abhishek Maiti, Courtney D. DiNardo, Maro Ohanian, Naval Daver, Gautam Borthakur, Kelly S. Chien, Ghayas C. Issa, Koichi Takahashi, Lucia Masarova, Yesid Alvarado Valero, Elias Jabbour, William G. Wierda, Nicholas J. Short, Melissa MacFarland, Allison Pike, Tapan M. Kadia, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4289.
https://doi.org/10.1182/blood-2023-182901
Published: 2023
Journal Articles

Phase Ib/2 Study of Oral Decitabine/Cedazuridine (ASTX727) and Venetoclax in Combination with the Targeted Mutant IDH1 Inhibitor Ivosidenib or the Targeted Mutant IDH2 Inhibitor Enasidenib: 2023 Update

Free
Himachandana Atluri, Jillian Mullin, Koichi Takahashi, Sanam Loghavi, Abhishek Maiti, Koji Sasaki, Naval Daver, Yesid Alvarado Valero, Naveen Pemmaraju, Gautam Borthakur, Danielle E. Hammond, Kelly S. Chien, Alessandra Ferrajoli, Nicholas J. Short, Hussein A Abbas, Elias Jabbour, Michael Andreeff, Farhad Ravandi, Rebecca S.S. Tidwell, Xuemei Wang, Marina Y. Konopleva, Guillermo Garcia-Manero, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 968.
https://doi.org/10.1182/blood-2023-182944
Published: 2023
Journal Articles

Nelarabine (NEL), Pegylated Asparginase (PEG) and Venetoclax (VEN) Incorporated to HCVAD Chemotherapy in the Frontline Treatment of Adult Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-ALL/T-LBL)

Free
Jayastu Senapati, Hagop M. Kantarjian, Elias Jabbour, Rodrick Babakhanlou, Tapan M. Kadia, Gautam Borthakur, Marina Y. Konopleva, William G. Wierda, Jan A. Burger, Ghayas C. Issa, Abhishek Maiti, Hayley S. Balkin, Mary Kelly, Rebecca Garris, Alessandra Ferrajoli, Guillermo Garcia-Manero, Yesid Alvarado Valero, Partow Kebriaei, Nicholas J. Short, Nitin Jain, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 963.
https://doi.org/10.1182/blood-2023-179562
Published: 2023
Journal Articles

N/KRAS -Mutant AML LSCs Originate from Committed Myelomonocytic Progenitors and Drive Clinical Resistance to Venetoclax

Free
Junya Sango, Saul Carcamo, Nataly Cruz-Rodriguez, Maria Sirenko, Abhishek Maiti, Malgorzata Olszewska, Tiansu Wang, Gulay Bengu Ulukaya, Lewis Tomalin, Emmanuel Olivier, Manon Jaud, Ronan Chaligne, Hager Mansour, Deniz Demircioglu, Dan A. Landau, Elli Papaemmanuil, Courtney D. DiNardo, Dan Hasson, Marina Y. Konopleva, Eirini Papapetrou
Journal: Blood
Blood (2023) 142 (Supplement 1): 403.
https://doi.org/10.1182/blood-2023-187695
Published: 2023
Journal Articles

Dual-Targeting CD33/CD123 NANOBODY ® T Cell Engager Targeting Leukemia Blasts and Stem/Progenitor Cells in Relapsed AML

Free
Zhihong Zeng, Annelies Roobrouck, Geert Deschamps, Helene Bonnevaux, Stephane Guerif, Veronique De Brabandere, Amara Céline, Eline Jonckheere, Angela Virone-Oddos, Marielle Chiron, Melissa Dullaers, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2023-186012
Published: 2023
Journal Articles

Single-Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms

Free
Yi June Kim, Zongrui Li, Abhishek Maiti, Tomoyuki Tanaka, Hidetaka Uryu, Ken Furudate, Kala Hayes, Naval Daver, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Nicholas J. Short, Maro Ohanian, Gautam Borthakur, Nitin Jain, Ghayas C. Issa, Lucia Masarova, Steven M. Kornblau, William G. Wierda, Sanam Loghavi, Sa A. Wang, Guillermo Garcia-Manero, Hagop Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva, Koichi Takahashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2931.
https://doi.org/10.1182/blood-2023-190400
Published: 2023
Journal Articles

“Dose-Dense” Mini-Hyper-CVD, Inotuzumab Ozogamicin and Blinatumomab Achieves High Rates of Rapid MRD-Negativity in Patients with Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis

Free
Trevor Jamison, Hagop M. Kantarjian, Shilpa Paul, Branko Cuglievan, David McCall, Nitin Jain, Fadi G. Haddad, Kayleigh R. Marx, Caitlin R Rausch, J. Michael Savoy, Lewis Nasr, Cedric Nasnas, Marianne Zoghbi, Rebecca Garris, Farhad Ravandi, Marina Y. Konopleva, Elias Jabbour, Nicholas J. Short
Journal: Blood
Blood (2023) 142 (Supplement 1): 1508.
https://doi.org/10.1182/blood-2023-188530
Published: 2023
Journal Articles

Patient Characteristics and Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Free
Muzaffar H. Qazilbash, Hina N. Khan, Denái R. Milton, Oren Pasvolsky, Mark R. Tanner, Uday R. Popat, Partow Kebriaei, Chitra Hosing, Issa F. Khouri, Katayoun Rezvani, Yago Nieto, Betul Oran, Samer A. Srour, Neeraj Y. Saini, Amanda L. Olson, Sairah Ahmed, Gheath Alatrash, Gabriela Rondon, Marina Y. Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Qaiser Bashir, Naveen Pemmaraju
Journal: Blood
Blood (2023) 142 (Supplement 1): 4988.
https://doi.org/10.1182/blood-2023-181031
Published: 2023
Journal Articles

Updated Results from a Phase II Study of Hyper-CVAD, with or without Inotuzumab Ozogamicin, and Sequential Blinatumomab in Patients with Newly Diagnosed B-Cell Acute Lymphoblastic Leukemia

Free
Daniel Nguyen, Hagop M. Kantarjian, Nicholas J. Short, Nitin Jain, Fadi G. Haddad, Musa Yilmaz, Alessandra Ferrajoli, Tapan M. Kadia, Yesid Alvarado Valero, Abhishek Maiti, Cedric Nasnas, Lewis Nasr, Rebecca Garris, Marina Y. Konopleva, Farhad Ravandi, Elias Jabbour
Journal: Blood
Blood (2023) 142 (Supplement 1): 4245.
https://doi.org/10.1182/blood-2023-190902
Published: 2023
Journal Articles

Results of Phase I/II Study of Azacitidine in Combination with Quizartinib for Patients with Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms with FLT3 or CBL Mutations

Free
Guillermo Montalban-Bravo, Elias Jabbour, Kelly S. Chien, Danielle E. Hammond, Nicholas J. Short, Farhad Ravandi, Marina Y. Konopleva, Gautam Borthakur, Naval Daver, Rashmi Kanagal-Shamanna, Wei Qiao, Xuelin Huang, Heather Schneider, Meghan Anne Meyer, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 3238.
https://doi.org/10.1182/blood-2023-178115
Published: 2023
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 5-Year Follow-up Data

Free
Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jayastu Senapati, Jan A. Burger, Gautam Borthakur, Mahesh Swaminathan, Koichi Takahashi, Zeev Estrov, Marina Y. Konopleva, Koji Sasaki, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Elias Jabbour, Courtney D. DiNardo, Yesid Alvarado Valero, Musa Yilmaz, Prithviraj Bose, Maro Ohanian, Rashmi Kanagal-Shamanna, Keyur Patel, Jeffrey L. Jorgensen, Sa A. Wang, Sameh Nassar, Naveen Garg, Hyunsoo Hwang, Xuemei Wang, Nichole Cruz, Ana Ayala, William Plunkett, Hagop M. Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4635.
https://doi.org/10.1182/blood-2023-189711
Published: 2023
Journal Articles

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Free
Natalia Baran, Lina Han, Lucille Stuani, Antonio Cavazos, Laurie Cooper, Cassandra L. Ramage, Vinitha MARY Kuruvilla, Qi Zhang, Marie Sabtier, Emeline Boet, Jason P Gay, Ninping Feng, Venkata Lokesh Battula, Emeline Chu-Van, Florence Castelli, Martin Carroll, Sergej Naumovich Konoplev, Beenu Thakral, Naval Daver, Joseph R Marszalek, Yubin Ge, Michael Andreeff, Jean-Emmanuel Sarry, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2952.
https://doi.org/10.1182/blood-2023-186514
Published: 2023