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Hussein A Abbas
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Journal Articles

IL-9 secreted by leukemia stem cells induces Th1-skewed CD4 + T cells, which promote their expansion

Ramin Radpour, Cedric Simillion, Bofei Wang, Hussein A. Abbas, Carsten Riether, Adrian F. Ochsenbein
Journal: Blood
Blood (2024) 144 (8): 888–903.
https://doi.org/10.1182/blood.2024024000
Published: 2024
Includes: Supplemental data
Journal Articles

Venetoclax abrogates the prognostic impact of splicing factor gene mutations in newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Jayastu Senapati, Samuel Urrutia, Sanam Loghavi, Nicholas J. Short, Ghayas C. Issa, Abhishek Maiti, Hussein A. Abbas, Naval G. Daver, Naveen Pemmaraju, Sherry Pierce, Kelly S. Chien, Koji Sasaki, Tapan M. Kadia, Danielle E. Hammond, Gautam Borthakur, Keyur Patel, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (19): 1647–1657.
https://doi.org/10.1182/blood.2023020649
Published: 2023
Includes: Supplemental data
Journal Articles

Epigenetic Scarring Leads to Irreversible NK Cell Dysfunction in Myeloid Malignancies

Bijender Kumar, Anand Singh, Rafet Basar, Nadima Uprety, Ye Li, Huihui Fan, Mayra Shanley, Sunil Acharya, Mayela Carolina Mendt, Paul Lin, Alexander Biederstädt, Hind Rafei, Pinaki Banerjee, Vakul Mohanty, Hila Shaim, Merve Dede, Luciana Melo Garcia, Lucila Nassif Kerbauy, Ana K. Nunez Cortes, Qi Miao, Jinzhuang Dou, Francia Silva Reyes, Xingliang Guo, Mecit Kaplan, Sonny Ang, Xin Ru Jiang, Enli Liu, Bin Liu, Richard E. Champlin, Hagop Kantarjian, David Marin, Ken Chen, Hussein A Abbas, Elizabeth J. Shpall, Kunal Rai, Katayoun Rezvani, May Daher, MD
Journal: Blood
Blood (2023) 142 (Supplement 1): 2088.
https://doi.org/10.1182/blood-2023-187626
Published: 2023
Journal Articles

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Bofei Wang, Patrick K Reville, Fatima Z Jelloul, Poonam N Desai, Pamella Borges, Christopher Ly, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Nicole Vaugh, Natalia Baran, Qing Deng, Jairo Matthews, Preethi Gunaratne, Dinler A Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Y. Konopleva, Andy Futreal, Sean M. Post, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2796.
https://doi.org/10.1182/blood-2023-175010
Published: 2023
Journal Articles

Single-Cell Polyfunctional Proteomic Profiling Reveals Temporal and Niche Differences in CD4 and CD8 T Cells in Acute Myeloid Leukemia Following PD-1 Blockade Therapy

Jessica Lynn Root, Poonam N Desai, Patrick K Reville, Christopher Ly, Bofei Wang, Fatima Z Jelloul, Jing Zhou, Sean Gregory Mackay, Mansour Alfayez, Jairo Matthews, Sherry Pierce, Naval Daver, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1584.
https://doi.org/10.1182/blood-2023-188268
Published: 2023
Journal Articles

Single-Cell Characterization of TP53-Mutated AML Patients Treated with Frontline Azacitidine, Venetoclax, and Magrolimab Reveals Mechanisms of Response and Resistance

Poonam N Desai, Bofei Wang, Patrick K Reville, Fatima Z Jelloul, Pamella Borges, Jayastu Senapati, Micah Castillo, Preethi Gunaratne, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Guillermo Garcia-Manero, Naval Daver, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 64.
https://doi.org/10.1182/blood-2023-187307
Published: 2023
Journal Articles

Mutational and Cytogenetic Dynamics at Diagnosis and Relapse in Acute Myeloid Leukemia: Influence of Intensity and Type of Treatment

Alex Bataller, Hagop M. Kantarjian, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Nicholas J. Short, Musa Yilmaz, Ghayas C. Issa, Yesid Alvarado Valero, Guillermo Montalban-Bravo, Abhishek Maiti, Hussein A Abbas, Elias Jabbour, William G. Wierda, Guillermo Garcia-Manero, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 723.
https://doi.org/10.1182/blood-2023-179876
Published: 2023
Journal Articles

Phase Ib/2 Study of Oral Decitabine/Cedazuridine (ASTX727) and Venetoclax in Combination with the Targeted Mutant IDH1 Inhibitor Ivosidenib or the Targeted Mutant IDH2 Inhibitor Enasidenib: 2023 Update

Himachandana Atluri, Jillian Mullin, Koichi Takahashi, Sanam Loghavi, Abhishek Maiti, Koji Sasaki, Naval Daver, Yesid Alvarado Valero, Naveen Pemmaraju, Gautam Borthakur, Danielle E. Hammond, Kelly S. Chien, Alessandra Ferrajoli, Nicholas J. Short, Hussein A Abbas, Elias Jabbour, Michael Andreeff, Farhad Ravandi, Rebecca S.S. Tidwell, Xuemei Wang, Marina Y. Konopleva, Guillermo Garcia-Manero, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 968.
https://doi.org/10.1182/blood-2023-182944
Published: 2023
Journal Articles

Characterizing Inferred Functional and Phenotypical States of Newly Diagnosed Acute Myeloid Leukemia from Single Cell Transcriptomic Profiling

Bofei Wang, Christopher Ly, Enes Dasdemir, Fatima Z Jelloul, Poonam N Desai, Pamella Borges, Jessica Lynn Root, Guilin Tang, Preethi Gunaratne, Sreyashi Basu, Sonali Jindal, Yulong Chen, Khalida M Wani, Alexander J Lazar, Padmanee Sharma, Patrick K Reville, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2938.
https://doi.org/10.1182/blood-2023-178345
Published: 2023
Journal Articles

Patterns of Relapse in Patients with Acute Myeloid Leukemia (AML) Treated with Venetoclax-Containing Regimens

Naszrin Arani, Emmanuel Almanza, Alex Bataller, Courtney D. DiNardo, Farhad Ravandi, Naval Daver, Naveen Pemmaraju, Musa Yilmaz, Abhishek Maiti, Patrick K Reville, Sanam Loghavi, Hussein A Abbas, Guillermo Garcia-Manero, Nicholas J. Short, Hagop M. Kantarjian, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4236.
https://doi.org/10.1182/blood-2023-191181
Published: 2023
Journal Articles

Cladribine-Based Chemotherapy for Patients with Secondary Acute Myeloid Leukemia (AML) Arising after Myeloproliferative Neoplasms (MPNs)

Lucia Masarova, Hagop M. Kantarjian, Naveen Pemmaraju, Hussein A Abbas, Prithviraj Bose, Mahesh Swaminathan, Sherry Pierce, Koji Sasaki, Musa Yilmaz, Nicholas J. Short, Naval Daver, Gautam Borthakur, Guillermo Garcia-Manero, Maro Ohanian, Kapil N. Bhalla, Courtney D. DiNardo, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4264.
https://doi.org/10.1182/blood-2023-187968
Published: 2023
Journal Articles

Poor Outcome of Patients with Acute Myeloid Leukemia in First Relapse Underscores the Need for Effective Initial Treatment

Alex Bataller, Hagop M. Kantarjian, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Nicholas J. Short, Musa Yilmaz, Ghayas C. Issa, Yesid Alvarado Valero, Guillermo Montalban-Bravo, Abhishek Maiti, Hussein A Abbas, Elias Jabbour, William G. Wierda, Guillermo Garcia-Manero, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1480.
https://doi.org/10.1182/blood-2023-179245
Published: 2023
Journal Articles

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia

Abdullah Khasawneh, Faith Jessica Paran, Rieko Oyama, Abhishek Maiti, Hussein A Abbas, Bofei Wang, Poonam N Desai, Kala Hayes, Joe R Harman, Xiaoping Su, Courtney D. DiNardo, Michael Andreeff, Thomas A Milne, Marina Y. Konopleva, Yoko Tabe
Journal: Blood
Blood (2023) 142 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2023-180463
Published: 2023
Journal Articles

Phase I/II Study of Azacitidine (AZA) with Venetoclax (VEN) and Magrolimab (Magro) in Patients (pts) with Newly Diagnosed (ND) Older/Unfit or High-Risk Acute Myeloid Leukemia (AML) and Relapsed/Refractory (R/R) AML

Naval Daver, Jayastu Senapati, Abhishek Maiti, Sanam Loghavi, Tapan M. Kadia, Courtney D. DiNardo, Naveen Pemmaraju, Elias Jabbour, Guillermo Montalban-Bravo, Guilin Tang, Koji Sasaki, Gautam Borthakur, Musa Yilmaz, Joie Alvarez, Sherry A. Pierce, Graciela M. Nogueras González, Jing Ning, Ghayas C. Issa, Michael Andreeff, Hussein A Abbas, Farhad Ravandi, Guillermo Garcia-Manero, Hagop Kantarjian
Journal: Blood
Blood (2022) 140 (Supplement 1): 141–144.
https://doi.org/10.1182/blood-2022-170188
Published: 2022
Journal Articles

Clinical Outcomes and Impact of Therapeutic Intervention in Patients (pts) with Acute Myeloid Leukemia (AML) with Recurrence of Measurable Residual Disease (MRD) after Achievement of MRD-Negative Remission

Walid Macaron, Farhad Ravandi, Tapan M. Kadia, Courtney D. DiNardo, Ghayas C. Issa, Naval Daver, Sa A Wang, Jeffrey L. Jorgensen, Keyur Patel, Sanam Loghavi, Marina Konopleva, Musa Yilmaz, Elias Jabbour, Abhishek Maiti, Hussein A Abbas, Elizabeth J Shpall, Uday R Popat, Gheath Alatrash, Sherry A. Pierce, Hagop Kantarjian, Nicholas Short
Journal: Blood
Blood (2022) 140 (Supplement 1): 543–545.
https://doi.org/10.1182/blood-2022-156955
Published: 2022
Journal Articles

Venetoclax Combined with Cladribine, Idarubicin, Cytarabine (CLIA) As Induction Therapy in Patients with Newly Diagnosed Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome

Patrick K Reville, Hagop Kantarjian, Gautam Borthakur, Musa Yilmaz, Naval Daver, Nicholas Short, Courtney D. DiNardo, Steven M. Kornblau, Naveen Pemmaraju, Nitin Jain, Yesid Alvarado, Prithviraj Bose, Elias Jabbour, Kelly S. Chien, Hussein A Abbas, Lucia Masarova, Sa A Wang, Rebecca S. S Tidwell, Michael Andreeff, Guillermo Garcia-Manero, Marina Konopleva, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2022) 140 (Supplement 1): 1702–1704.
https://doi.org/10.1182/blood-2022-167931
Published: 2022
Journal Articles

Single Cell RNA-Seq Reveals Intra-Tumoral Heterogeneity Relevant to Differentiation States and Outcomes Among Newly Diagnosed Acute Myeloid Leukemia Patients

Bofei Wang, Fatima Zahra Jelloul, Pamella Borges, Poonam Desai, Guilin Tang, Marina Konopleva, Natalia Baran, Michael R Green, Qing Deng, Naval Daver, Andy Futreal, Dapeng Hao, Hussein A Abbas
Journal: Blood
Blood (2022) 140 (Supplement 1): 6272–6273.
https://doi.org/10.1182/blood-2022-167527
Published: 2022
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation in Older Patients with Acute Myeloid Leukemia: Analysis of Outcomes and Contemporary Trends Spanning 10 Years

Alexandre Bazinet, Hagop Kantarjian, Naszrin Arani, Uday R. Popat, Courtney D. DiNardo, Naval Daver, Musa Yilmaz, Hussein A. Abbas, Nicholas Short, Ghayas C. Issa, Elias Jabbour, Sherry A. Pierce, Julianne Chen, Ricky Garcia, Marina Konopleva, Guillermo Garcia-Manero, Amin M. Alousi, Elizabeth J. Shpall, Richard E. Champlin, Gautam Borthakur, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2022) 140 (Supplement 1): 4872–4875.
https://doi.org/10.1182/blood-2022-162962
Published: 2022
Journal Articles

Short Telomere Syndromes and Inherited Predisposition to Bone Marrow Diseases: The MDACC Experience

Alex Bataller, Yoheved Gerstein, Naveen Pemmaraju, Danielle Hammond, Hussein A. Abbas, Ghayas C. Issa, Koichi Takahashi, Tapan M. Kadia, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2022) 140 (Supplement 1): 11463–11465.
https://doi.org/10.1182/blood-2022-164954
Published: 2022
Journal Articles

Clinical and Molecular Profiling of AML Patients with Chromosome 7 or 7q Deletions Incontext of TP53 Alterations and Venetoclax Treatment

Hussein A Abbas, Edward Ayoub, Hanxiao Sun, Rashmi Kanagal-Shamanna, Nicholas Short, Ghayas C. Issa, Musa Yilmaz, Sherry A. Pierce, Daniel Rivera, Brent Cham, Shane Wing, Ziyi Li, Danielle Hammond, Elias Jabbour, Gautam Borthakur, Guillermo Garcia-Manero, Michael Andreeff, Naval Daver, Tapan M. Kadia, Marina Konopleva, Courtney D. DiNardo, Farhad Ravandi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6064–6066.
https://doi.org/10.1182/blood-2022-170458
Published: 2022