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Sovira Chaudhry
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Journal Articles

Pre-clinical efficacy of FLT3/BRAF targeting with novel dual inhibitor PHI3 in FLT3/RAS co-mutated AML

Free
Shikhar Sharma, Anna Skwarska, Evangelia Matenoglou, Sovira Chaudhry, Murugan Selvam, Catherine Smith, Pamela Sung, Eunice Wang, Donald Small, Evripidis Gavathiotis, Marina Konopleva
Journal: Blood
Blood (2025) 146 (Supplement 1): 5062.
https://doi.org/10.1182/blood-2025-5062
Published: 2025
Journal Articles

EB2023 primes mitochondria for BCL2 dependence and induces pyroptotic cell death via AMPK signaling and the unfolded protein response

Free
Matthew Villaume, Michael Davidson, Anna Skwarska, Maria Arrate, Liana Valin, Sovira Chaudhry, Benjamin Reisman, Ming Jiang, Andrew Monteith, Haley Ramsey, Sarah Olmstead, Agnieszka Gorska, Brent Ferrell, Brian Bachmann, Marina Konopleva, Michael Savona
Journal: Blood
Blood (2025) 146 (Supplement 1): 637.
https://doi.org/10.1182/blood-2025-637
Published: 2025
Journal Articles

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2 -mutated post-MPN AML

Open Access
Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P. Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J. Mead, Raajit K. Rampal, Jeffrey W. Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2025) 146 (3): 341–355.
https://doi.org/10.1182/blood.2024027117
Published: 2025
Includes: Supplemental data
Journal Articles

Targeting PERK Arm of Unfolded Protein Response Helps to Eliminate Therapy-Induced Residual Senescent-like Acute Myeloid Leukemia Cells

Free
Gowri Poigaialwar, Sumiko Takao, Sovira Chaudhry, Laura K. Schmalbrock, Varun Gupta, Alex Kentsis, Julio A. Aguirre-Ghiso, Marina Konopleva, Maria S. Sosa, Anna Skwarska
Journal: Blood
Blood (2024) 144 (Supplement 1): 4137.
https://doi.org/10.1182/blood-2024-203451
Published: 2024
Journal Articles

Efficacy of a Novel BCL-XL Degrader, DT2216, in Preclinical Models of Post-Myeloproliferative Neoplasm Secondary AML

Free
Zhe Wang, Anna Skwarska, Gowri Poigailwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini Papapetrou, Kapil N. Bhalla, Daohong Zhou, Adam J Mead, Raajit Rampal, Jeffrey W Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2024) 144 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2024-194031
Published: 2024
Journal Articles

Venetoclax Synergizes with IMGN632, a Novel CD123-Targeting Antibody Conjugated to a DNA Alkylating Payload, By Suppressing DNA Damage Response and Potentiating Apoptosis in Acute Myeloid Leukemia in Vitro Models

Free
Anna Skwarska, Vinitha Mary Kuruvilla, Qi Zhang, Sovira Chaudhry, Naval Daver, Krystal Watkins, Callum Mortimer Sloss, Patrick A. Zweidler-McKay, Deepa Sampath, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4155.
https://doi.org/10.1182/blood-2023-187018
Published: 2023