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Journal Articles

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets

Caitlyn Vlasschaert, Taralynn Mack, J. Brett Heimlich, Abhishek Niroula, Md Mesbah Uddin, Joshua Weinstock, Brian Sharber, Alexander J. Silver, Yaomin Xu, Michael Savona, Christopher Gibson, Matthew B. Lanktree, Michael J. Rauh, Benjamin L. Ebert, Pradeep Natarajan, Siddhartha Jaiswal, Alexander G. Bick

Blood (2023) 141 (18): 2214–2223.

https://doi.org/10.1182/blood.2022018825

Published: 2023

Includes: Supplemental data

Journal Articles

Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia

Blood (2022) 140 (21): 2228–2247.

https://doi.org/10.1182/blood.2022015853

Published: 2022

Includes: Supplemental data

Journal Articles

Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia

Christine Chen, David Siegel, Martin Gutierrez, Meagan Jacoby, Craig C. Hofmeister, Nashat Gabrail, Rachid Baz, Morten Mau-Sorensen, Jesus G. Berdeja, Michael Savona, Lynn Savoie, Suzanne Trudel, Nuchanan Areethamsirikul, T. J. Unger, Tami Rashal, Tim Hanke, Michael Kauffman, Sharon Shacham, Donna Reece

Blood (2018) 131 (8): 855–863.

https://doi.org/10.1182/blood-2017-08-797886

Published: 2018

Includes: Supplemental data

Journal Articles

Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma

Blood (2017) 129 (24): 3175–3183.

https://doi.org/10.1182/blood-2016-11-750174

Published: 2017

Includes: Supplemental data

Journal Articles

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia

Ramiro Garzon, Michael Savona, Rachid Baz, Michael Andreeff, Nashat Gabrail, Martin Gutierrez, Lynn Savoie, Paul Morten Mau-Sorensen, Nina Wagner-Johnston, Karen Yee, Thaddeus J. Unger, Jean-Richard Saint-Martin, Robert Carlson, Tami Rashal, Trinayan Kashyap, Boris Klebanov, Sharon Shacham, Michael Kauffman, Richard Stone

Blood (2017) 129 (24): 3165–3174.

https://doi.org/10.1182/blood-2016-11-750158

Published: 2017

Includes: Supplemental data

Journal Articles

The DOT1L Inhibitor EPZ-5676: Safety and Activity in Relapsed/Refractory Patients with MLL-Rearranged Leukemia

Blood (2014) 124 (21): 387.

https://doi.org/10.1182/blood.V124.21.387.387

Published: 2014

Journal Articles

First Clinical Results of a Randomized Phase 2 Dose-Response Study of SGI-110, a Novel Subcutaneous (SC) Hypomethylating Agent (HMA), in 102 Patients with Intermediate (Int) or High Risk (HR) Myelodysplastic Syndromes (MDS) or Chronic Myelomonocytic Leukemia (CMML)

Blood (2014) 124 (21): 529.

https://doi.org/10.1182/blood.V124.21.529.529

Published: 2014

Journal Articles

In Vitro and in Vivo Quantification of Exportin-1 (XPO1) Occupancy By the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor in Multiple Myeloma, Acute Myeloid Leukemia, and Healthy PBMCs

Marsha Crochiere, PhD, Boris Klebanov, M.A., MsC, Erkan Baloglu, PhD, Ori Kalid, PhD, Trinayan Kashyap, MSc, William Senapedis, PhD, Diego del Alamo, BS, Tami Rashal, MD, Sharon Tamir, PhD, Dilara McCauley, PhD, Robert Carlson, PhD, Michael Savona, MD, Michael Kauffman, MD PhD, Sharon Shacham, PhDMBA, Yosef Landesman, PhD

Blood (2014) 124 (21): 5196.

https://doi.org/10.1182/blood.V124.21.5196.5196

Published: 2014

Journal Articles

Clinical Profile of Single-Agent Oprozomib in Patients (Pts) with Multiple Myeloma (MM): Updated Results from a Multicenter, Open-Label, Dose Escalation Phase 1b/2 Study

Ravi Vij, MBBS, MD, Michael Savona, MD, David S. Siegel, MD PhD, Jonathan L. Kaufman, MD, Ashraf Badros, MD, Irene M. Ghobrial, MD, Agne Paner, MD, Sundar Jagannath, MD, Andrzej Jakubowiak, MD PhD, Joseph R. Mikhael, MD, Prashant Kapoor, MD, Linda L. Neuman, MD MBA, Ju RueyJiuan Lee, PhD, Jesus G. Berdeja, MD

Blood (2014) 124 (21): 34.

https://doi.org/10.1182/blood.V124.21.34.34

Published: 2014

Journal Articles

Novel Selective Orally Bioavailable Small Molecule PAK4 Allosteric Modulators (PAMs) Display Anti-Tumor Activity in Vitro and in Vivo in Hematological Malignancies

William Senapedis, PhD, Ryan George, PhD, Dilara McCauley, PhD, Joel Ellis, PhD, Marsha Crochiere, PhD, Michael Savona, MD, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Erkan Baloglu, PhD

Blood (2014) 124 (21): 2208.

https://doi.org/10.1182/blood.V124.21.2208.2208

Published: 2014

Journal Articles

Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML)

Blood (2013) 122 (21): 1440.

https://doi.org/10.1182/blood.V122.21.1440.1440

Published: 2013

Journal Articles

A Single-Arm, Open-Label, Multi-Center Phase I/II Study Of The Combination Of Panobinostat and Carfilzomib In Patients (pts) With Relapsed Or Relapse/Refractory Multiple Myeloma (MM)

Jesus Berdeja, MD, Michael Savona, MD, Joseph R Mace, MD, Lowell Hart, MD, James Essell, MD, Rami Owera, MD, Edward Arrowsmith, MD, MPH, Ian Flinn, MD, PhD

Blood (2013) 122 (21): 1937.

https://doi.org/10.1182/blood.V122.21.1937.1937

Published: 2013

Journal Articles

Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM)

Blood (2013) 122 (21): 1942.

https://doi.org/10.1182/blood.V122.21.1942.1942

Published: 2013

Journal Articles

Single-Arm, Open-Label, Multicenter Study Of Deep Molecular Response (MR 4.5 ) With Nilotinib In Adult Patients (pts) With Newly Diagnosed Philadelphia Chromosome–Positive Chronic Myeloid Leukemia In Chronic Phase (CML-CP): ENESTnext Study Update

Michael Mauro, MD, Jerald Radich, MD, Jorge E. Cortes, MD, Shaker Dakhil, MD, Christopher Keir, MD, Sandy Yi, Martha Wadleigh, MD, Vivian G. Oehler, MD, Thomas Ervin, MD, Stuart Goldberg, MD, Michael Savona, MD, FACP

Blood (2013) 122 (21): 4015.

https://doi.org/10.1182/blood.V122.21.4015.4015

Published: 2013

Journal Articles

Array-Based Comparative Genomic Hybridization (aCGH) In Myelofibrosis Reveals Divergent Genetic Copy Number Alterations Among Patients With Post-Essential Thrombocythemia-Myelofibrosis/Post-Polycythemia Rubra Vera-Myelofibrosis (PET-MF and PPV-MF) and Patients With Idiopathic Myelofibrosis

Michael Savona, MD, Zeqiang Ma, PhD, Laura DeBusk, PhD, Pranil Chandra, DO, Shile Liang, PhD, R. Seth Cooper, MD, Eric Raefsky, MD, Victor Gian, MD, Richard Hockett, MD, Jesus Berdeja, MD, P. Alan Lennon, PhD

Blood (2013) 122 (21): 5266.

https://doi.org/10.1182/blood.V122.21.5266.5266

Published: 2013

Journal Articles

Clinical Profile Of Single-Agent Modified-Release Oprozomib Tablets In Patients (Pts) With Hematologic Malignancies: Updated Results From a Multicenter, Open-Label, Dose Escalation Phase 1b/2 Study

Irene M. Ghobrial, MD, Jonathan L. Kaufman, MD, David S. Siegel, MD, PhD, Ravi Vij, MD, Ashraf Badros, MD, Linda Neuman, MD, Hansen Wong, PhD, Janet Anderl, MS, Michael Savona, MD

Blood (2013) 122 (21): 3184.

https://doi.org/10.1182/blood.V122.21.3184.3184

Published: 2013

Journal Articles

Bendamustine, Bortezomib and Dexamethasone (BBD) As First-Line Treatment Of Patients (Pts) With Multiple Myeloma Who Are Not Candidates For High Dose Chemotherapy

Jesus Berdeja, MD, Michael Savona, MD, Luis Chu, MD, James Essell, MD, Patrick Murphy, MD, Todd Bauer, MD, Eric Raefsky, MD, Ralph V. Boccia, MD, Ian Flinn, MD, PhD

Blood (2013) 122 (21): 3193.

https://doi.org/10.1182/blood.V122.21.3193.3193

Published: 2013

Journal Articles

A Phase I Dose Escalation Study Of TGR-1202, a Novel PI3K-δ Inhibitor, For Patients With Relapsed Or Refractory Hematologic Malignancies

Michael Savona, MD, Martin Gutierrez, MD, Mark Lanasa, MD, PhD, Changchun Deng, MD, PhD, John Kuhn, PharmD, Lauren Sade, Hari Miskin, MS, Peter Sportelli, Swaroop Vakkalanka, PhD, Manish Patel, MD

Blood (2013) 122 (21): 4373.

https://doi.org/10.1182/blood.V122.21.4373.4373

Published: 2013

Journal Articles

An Open-Label, Phase II Study Of The JAK1 Inhibitor INCB039110 In Patients With Myelofibrosis

John Mascarenhas, MD, Moshe Talpaz, MD, Vikas Gupta, MD, FRCP, FRCPath, Michael Savona, MD, FACP, Paul Coughlin, FRACP, PhD, Elliott Winton, MD, Deborah Hunter, PhD, Bijoyesh Mookerjee, MD, FACP, Lance Leopold, MD, Jason Clark, PhD, Peter O'Neill, MBA, CCRP, Ronald Hoffman, MD, Srdan Verstovsek, MD, PhD

Blood (2013) 122 (21): 663.

https://doi.org/10.1182/blood.V122.21.663.663

Published: 2013

Journal Articles

Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

Blood (2013) 122 (21): 90.

https://doi.org/10.1182/blood.V122.21.90.90

Published: 2013

NARROW

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets

Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia

Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia

Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia

The DOT1L Inhibitor EPZ-5676: Safety and Activity in Relapsed/Refractory Patients with MLL-Rearranged Leukemia

First Clinical Results of a Randomized Phase 2 Dose-Response Study of SGI-110, a Novel Subcutaneous (SC) Hypomethylating Agent (HMA), in 102 Patients with Intermediate (Int) or High Risk (HR) Myelodysplastic Syndromes (MDS) or Chronic Myelomonocytic Leukemia (CMML)

In Vitro and in Vivo Quantification of Exportin-1 (XPO1) Occupancy By the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor in Multiple Myeloma, Acute Myeloid Leukemia, and Healthy PBMCs

Clinical Profile of Single-Agent Oprozomib in Patients (Pts) with Multiple Myeloma (MM): Updated Results from a Multicenter, Open-Label, Dose Escalation Phase 1b/2 Study

Novel Selective Orally Bioavailable Small Molecule PAK4 Allosteric Modulators (PAMs) Display Anti-Tumor Activity in Vitro and in Vivo in Hematological Malignancies

Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML)

A Single-Arm, Open-Label, Multi-Center Phase I/II Study Of The Combination Of Panobinostat and Carfilzomib In Patients (pts) With Relapsed Or Relapse/Refractory Multiple Myeloma (MM)

Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM)

Single-Arm, Open-Label, Multicenter Study Of Deep Molecular Response (MR 4.5 ) With Nilotinib In Adult Patients (pts) With Newly Diagnosed Philadelphia Chromosome–Positive Chronic Myeloid Leukemia In Chronic Phase (CML-CP): ENESTnext Study Update

Array-Based Comparative Genomic Hybridization (aCGH) In Myelofibrosis Reveals Divergent Genetic Copy Number Alterations Among Patients With Post-Essential Thrombocythemia-Myelofibrosis/Post-Polycythemia Rubra Vera-Myelofibrosis (PET-MF and PPV-MF) and Patients With Idiopathic Myelofibrosis

Clinical Profile Of Single-Agent Modified-Release Oprozomib Tablets In Patients (Pts) With Hematologic Malignancies: Updated Results From a Multicenter, Open-Label, Dose Escalation Phase 1b/2 Study

Bendamustine, Bortezomib and Dexamethasone (BBD) As First-Line Treatment Of Patients (Pts) With Multiple Myeloma Who Are Not Candidates For High Dose Chemotherapy

A Phase I Dose Escalation Study Of TGR-1202, a Novel PI3K-δ Inhibitor, For Patients With Relapsed Or Refractory Hematologic Malignancies

An Open-Label, Phase II Study Of The JAK1 Inhibitor INCB039110 In Patients With Myelofibrosis

Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

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American Society of Hematology

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American Society of Hematology

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