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Daniel Starczynowski
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Journal Articles

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Free
Ted Getz, Kelly Pugh, Andrew Brunner, Jan Philipp Bewersdorf, Amy DeZern, Tariq Kewan, Uma Borate, Uwe Platzbecker, Mikkael Sekeres, Andrew Wei, Shahram Kordasti, Rena Buckstein, Gail Roboz, Michael Savona, Sanam Loghavi, Robert Hasserjian, Pierre Fenaux, David Sallman, Christopher Hourigan, Matteo Della Porta, Stephen Nimer, Richard Little, Valeria Santini, Fabio Efficace, Justin Taylor, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami Komrokji, Elizabeth Griffiths, Peter Greenberg, Mina Xu, Zhuoer Xie, Rafael Bejar, Guillermo Sanz, Mrinal Patnaik, Maria E. Figueroa, Hetty Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval Daver, Jane Churpek, Ravi Majeti, John Bennett, Alan List, Adrian Mosquera Orgueira, Klaus Metzeler, Francesc Sole, Lisa Pleyer, Arjan Van de Loosdrecht, Thomas Cluzeau, David Steensma, Ghulam Mufti, Lionel Ades, Luca Lanino, Yazan Madanat, Anne Sophie Kubasch, Marie Sebert, R. Coleman Lindsley, Katharina S. Götze, Carmelo Gurnari, Yasushi Miyazaki, Aref Al-Kali, Abdulraheem Yacoub, Bing Li, Ioannis Kotsianidis, Maximilian Stahl, Amer Zeidan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3852.
https://doi.org/10.1182/blood-2025-3852
Published: 2025
Journal Articles

FLT3-F691L confers kinase-independent resistance via Grb2-dependent MAPK signaling in AML

Free
LaQuita Jones, Akhtar Khadaroo, Riya Tiwari, Kwangmin Choi, Mike Adam, Mark Wunderlich, Cody Stillwell, Christina Sexton, William Seibel, Greg Tawa, Scott Hoyt, Craig Thomas, Daniel Starczynowski
Journal: Blood
Blood (2025) 146 (Supplement 1): 5049.
https://doi.org/10.1182/blood-2025-5049
Published: 2025
Journal Articles

RAS G12 and Q61 codon mutations confer distinct disease characteristics in Acute Myeloid Leukemia and exhibit differential response to RAS(ON) inhibitor RMC-7977.

Free
Annabelle Anandappa, Vidushi Trivedi, Megan Bones, Jahnavi Raval, Rachel Hefner, Ashley Wooten, Robert Bowman, Ross Levine, Daniel Starczynowski, Linde Miles
Journal: Blood
Blood (2025) 146 (Supplement 1): 3229.
https://doi.org/10.1182/blood-2025-3229
Published: 2025
Journal Articles

Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement

Open Access
Clinical Trials & Observations
Uma Borate, Kelly Pugh, Allyson Waller, Rina Li Welkie, Ying Huang, Jan Philipp Bewersdorf, Maximilian Stahl, Amy E. DeZern, Uwe Platzbecker, Mikkael A. Sekeres, Andrew H. Wei, Rena J. Buckstein, Gail J. Roboz, Michael R. Savona, Sanam Loghavi, Robert P. Hasserjian, Pierre Fenaux, David A. Sallman, Christopher S. Hourigan, Matteo Giovanni Della Porta, Stephen Nimer, Richard F. Little, Valeria Santini, Fabio Efficace, Justin Taylor, Guillermo Garcia-Manero, Olatoyosi Odenike, Tae Kon Kim, Stephanie Halene, Rami S. Komrokji, Elizabeth A. Griffiths, Peter L. Greenberg, Mina L. Xu, Zhuoer Xie, Rafael Bejar, Guillermo F. Sanz, Mrinal M. Patnaik, Maria Figueroa, Hetty E. Carraway, Omar Abdel-Wahab, Daniel Starczynowski, Eric Padron, Jacqueline Boultwood, Steven Gore, Naval G. Daver, Jane E. Churpek, Ravindra Majeti, John M. Bennett, Alan F. List, Andrew M. Brunner, Amer M. Zeidan
Journal: Blood
Blood (2025) 145 (13): 1369–1381.
https://doi.org/10.1182/blood.2023023717
Published: 2025
Includes: Supplemental data
Journal Articles

The Zymogen Form of Caspase-1 Is Required to Finetune Excessive Cell-Intrinsic Inflammation in Myelodysplastic Syndromes

Free
Emma E. Uible, Kathleen Hueneman, Lyndsey C. Bolanos, Kwangmin Choi, William Seibel, Daniel Starczynowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 4572.
https://doi.org/10.1182/blood-2024-207548
Published: 2024
Journal Articles

Characterization of E1 Ligase Dependencies in a Mutant- UBA1 Human Cell Model Reveals UBA6 As a Novel Therapeutic Target in Vexas Syndrome

Free
Courtnee A. Clough, Claire Cunningham, Sophia Philbrook, Daniel Starczynowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 4049.
https://doi.org/10.1182/blood-2024-207451
Published: 2024
Journal Articles

Single-Cell Multi-Omic Analysis of KMT2A -Rearranged Pediatric Acute Leukemia Clonal Evolution

Free
Morgan Drucker, Dalia Dhingra, Mark Wunderlich, John Perentesis, Daniel Starczynowski, Robert L. Bowman, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 66.
https://doi.org/10.1182/blood-2024-202590
Published: 2024
Journal Articles

MYD88 Is Mutated in Clonal Hematopoiesis and Drives Altered Immune Cell Populations

Free
Jennifer Yeung, Sophia Philbrook, Kwangmin Choi, Kathleen Hueneman, Erin K. Hertlein, John C. Byrd, Daniel Starczynowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 2663.
https://doi.org/10.1182/blood-2024-208279
Published: 2024
Journal Articles

Codon-Specific Differences in RAS Mutations in AML and Differential Response to Therapeutic Agents

Free
Annabelle J Anandappa, Vidushi Trivedi, Tiffany Merlinsky, Nicole Delgaudio, Emily Guzzardi, Ashley Wooten, Daniel Starczynowski, Robert L. Bowman, Ross Levine, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 2713.
https://doi.org/10.1182/blood-2024-205218
Published: 2024
Journal Articles

Momelotinib Is a Highly Potent Inhibitor of FLT3-Mutant AML

Free
Mohammad Azhar, Zachary Kincaid, Meenu Kesarwani, Mark Wunderlich, Tahir Latif, Daniel Starczynowski, Mohammad Azam
Journal: Blood
Blood (2021) 138 (Supplement 1): 206.
https://doi.org/10.1182/blood-2021-148822
Published: 2021
Journal Articles

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Free
Leya Y Schwartz, Gaurav S Choudhary, Nandini Ramachandra, Srabani Sahu, Shanisha Gordon, Bruce Ruggeri, Diane Heiser, Peggy Scherle, Daniel Starczynowski, Amit Verma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2021-148494
Published: 2021
Journal Articles

Heterozygous Mutations in DDX41 Cause Erythroid Progenitor Cell Defects

Free
Timothy M Chlon, Emily Stepanchick, Analise Sulentic, Kathleen Hueneman, Daniel Starczynowski
Journal: Blood
Blood (2021) 138 (Supplement 1): 148.
https://doi.org/10.1182/blood-2021-153544
Published: 2021
Journal Articles

The Inherited MDS Gene DDX41 Is Essential for Ribosomal RNA Processing through Regulation of Snorna Biogenesis

Free
Timothy M Chlon, PhD, Emily Stepanchick, Daniel Starczynowski, PhD, Kathleen Hueneman
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
https://doi.org/10.1182/blood-2020-143222
Published: 2020
Journal Articles

Targeted Sequencing of 7 Genes Can Help Reduce Pathologic Misclassification of MDS

Free
Johannes B Goll, MSc, Travis L Jensen, BS, R. Coleman Lindsley, MD PhD, Rafael Bejar, MD PhD, Jason Walker, Robert Fulton, MS, Gregory A. Abel, MD MPH, Tareq Al Baghdadi, MD, H. Joachim Deeg, MD, Amy E. DeZern, MD, Benjamin L. Ebert, MDPhD, James M. Foran, MD, Edward J. Gorak, DO,MBA,MS, Steven D. Gore, MD, Rami Komrokji, MD, Jane Jijun Liu, MD, Jaroslaw P. Maciejewski, MD PhD, Eric Padron, MD, Wael Saber, MD MS, Daniel Starczynowski, PhD, Myron Waclawiw, PhD, Steffanie H. Wilson, PhD, Donnie Hebert, PhD, Harrison Reed, MSc, Nancy L. DiFronzo, PhD, Mikkael A. Sekeres, MD MS, Alexandra M. Harrington, MDMT(ASCP), Steven H. Kroft, MD, Ling Zhang, MD, Matthew J. Walter, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-140317
Published: 2020
Journal Articles

Innate Immune Signal Pathway Activation Induced By Combined Loss of Del(5q) MDS Genes, Tifab and Mir-146a, Accelerates Hematopoietic Stem Cell Exhaustion Driven By Chronic Exposure to a TLR Ligands

Free
Tomoya Muto, MD PhD, Melinda Varney, PhD, Callum Walker, MSc, Lyndsey Bolanos, BSc, Kathleen Hueneman, BSc, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1674.
https://doi.org/10.1182/blood.V130.Suppl_1.1674.1674
Published: 2017
Journal Articles

Splicesome Mutant MDS and AML Cells Activate Innate Immune Signaling By Regulating the Expression of Therapeutically Targetable IRAK4 Isoforms

Free
Molly A Smith, Gaurav Choudhary, PhD, Andrea Pellagatti, PhD, Kwangmin Choi, PhD, Tushar Damodar Bhagat, PhD, Nathan Salomonis, PhD, Matthew J. Walter, MD, Kakajan Komurov, Maria Elena S Sampson, Shanisha Gordon, Dagny Von Ahrens, Kith Pradhan, PhD, Ulrich G. Steidl, MDPhD, Robert Booher, PhD, Jacqueline Boultwood, PhD, Amit Verma, MD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 785.
https://doi.org/10.1182/blood.V130.Suppl_1.785.785
Published: 2017
Journal Articles

Tifab Deficiency Protects Against Stress-Induced Bone Marrow Failure at the Expense of Pre-Leukemic Selection

Free
Madeline Niederkorn, BS, Melinda Varney, PhD, Ken Greis, PhD, Ruhikanta A. Meetei, PhD, Kwangmin Choi, PhD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2960.
https://doi.org/10.1182/blood.V130.Suppl_1.2960.2960
Published: 2017
Journal Articles

Ubiquitin Editing of a Spliceosome Auxiliary Factor By TRAF6 Links Chronic TLR Signaling with Hematopoietic Defects and Myelodysplasia

Free
Jing Fang, MD, PhD, Lyndsey Bolanos, BSc, Kwang-Min Choi, PhD, Xiaona Liu, Ms, Susanne Christie, Shailaja Akunuru, PhD, Rupali Kumar, PhD, Ken Greis, PhD, Peter Stoilov, PhD, Marie-Dominique Filippi, PhD, Jaroslaw P. Maciejewski, MD PhD, Guillermo Garcia-Manero, MD, Matthew Weirauch, PhD, Nathan Salomonis, PhD, Hartmut Geiger, PhD, Yi Zheng, PhD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2015) 126 (23): 143.
https://doi.org/10.1182/blood.V126.23.143.143
Published: 2015