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Betty Lamothe
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Journal Articles

Safety and efficacy of the mutant calreticulin-specific monoclonal antibody INCA033989 as monotherapy or in combination with ruxolitinib in patients (pts) with myelofibrosis (MF): Preliminary results from dose escalation of two global Phase 1 studies

Free
John Mascarenhas, Haifa Kathrin Al-Ali, Vikas Gupta, Haris Ali, Francesca Palandri, Professor Francesco Passamonti, Raajit Rampal, Aaron Gerds, Tania Jain, Sanjay Mohan, Steffen Koschmieder, Caroline McNamara, Andrew Perkins, Bethan Psaila, Vincent Ribrag, William Shomali, Rosa Ayala Diaz, Mikkel Helleberg Dorff, Claire Harrison, Stephen Oh, Frank Stegelmann, Alessandro Maria Vannucchi, Abdulraheem Yacoub, Jason Gotlib, Jyoti Nangalia, Chenwei Tian, Betty Lamothe, Erin Crowgey, Tatiana Zinger, Evan Braunstein, David Ross
Journal: Blood
Blood (2025) 146 (Supplement 1): 484.
https://doi.org/10.1182/blood-2025-484
Published: 2025
Journal Articles

Safety and efficacy of INCA033989, a novel first in class mutant calreticulin-specific monoclonal antibody, in patients with essential thrombocythemia

Free
Vikas Gupta, John Mascarenhas, Haris Ali, David Ross, Abdulraheem Yacoub, Tania Jain, Lynette Chee, Aaron Gerds, Jean-Jacques Kiladjian, Ruben Mesa, William Shomali, Makoto Yoshimitsu, Rosa Ayala Diaz, Chi-Joan How, Steffen Koschmieder, Caroline McNamara, Yosuke Nakaya, Francesca Palandri, Professor Francesco Passamonti, Andrew Perkins, Bethan Psaila, Raajit Rampal, Natasha Szuber, Frank Stegelmann, Alessandro Maria Vannucchi, Hiroki Yamaguchi, Jason Gotlib, Jyoti Nangalia, Chenwei Tian, Betty Lamothe, Erin Crowgey, Tatiana Zinger, Evan Braunstein, Claire Harrison
Journal: Blood
Blood (2025) 146 (Supplement 1): 1024.
https://doi.org/10.1182/blood-2025-1024
Published: 2025
Journal Articles

Molecular characterization of patients (pts) with myeloproliferative neoplasms treated with INCA033989 demonstrates selective targeting of CALR mutant hematopoietic cells

Free
Bethan Psaila, Jyoti Nangalia, Jason Gotlib, Claire Harrison, John Mascarenhas, Erin Crowgey, Betty Lamothe, Chenwei Tian, Evan Braunstein, Steffen Koschmieder
Journal: Blood
Blood (2025) 146 (Supplement 1): 71.
https://doi.org/10.1182/blood-2025-71
Published: 2025
Journal Articles

The activin receptor-like kinase-2 inhibitor zilurgisertib (INCB000928) as monotherapy or with ruxolitinib in patients with anemia due to myelofibrosis: Phase 1/2 study final results

Free
Prithviraj Bose, Stephen Oh, Anthony Hunter, Francesca Palandri, Haris Ali, Paola Guglielmelli, Vikas Gupta, Tomoki Ito, Jean-Jacques Kiladjian, Taizo Shimomura, Andrew Sochacki, Masahiro Takeuchi, Francoise Boyer, Jason Gotlib, Ellen Ritchie, Michael Savona, Yi Cui, Jill Harrison, Betty Lamothe, Amanda McBride, Sanjay Mohan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3795.
https://doi.org/10.1182/blood-2025-3795
Published: 2025
Journal Articles

Phase 1/2 Study of the Activin Receptor-like Kinase-2 Inhibitor Zilurgisertib (INCB000928, LIMBER-104) As Monotherapy or with Ruxolitinib in Patients with Anemia Due to Myelofibrosis

Free
Sanjay Mohan, Stephen Oh, Jean-Jacques Kiladjian, Masahiro Takeuchi, Jason Gotlib, Ellen K. Ritchie, Taizo Shimomura, Paola Guglielmelli, Anthony M. Hunter, Francesca Palandri, Francoise Boyer, Alessandro Rambaldi, Takehiko Mori, Tomoki Ito, Betty Lamothe, Yan-Ou Yang, Yi Cui, Francis Seguy, Amanda McBride, Prithviraj Bose
Journal: Blood
Blood (2023) 142 (Supplement 1): 624.
https://doi.org/10.1182/blood-2023-179291
Published: 2023
Journal Articles

A Phase 1/2 Study of INCB000928 As Monotherapy or Combined with Ruxolitinib (RUX) in Patients (Pts) with Anemia Due to Myelofibrosis (MF)

Free
Sanjay R Mohan, Stephen T Oh, Haris Ali, Anthony M. Hunter, Francesca Palandri, Betty Lamothe, Yi Cui, Francis Seguy, Amanda McBride, Michael Robert Savona, Jean-Jacques Kiladjian, Srdan Verstovsek
Journal: Blood
Blood (2022) 140 (Supplement 1): 3943–3944.
https://doi.org/10.1182/blood-2022-169210
Published: 2022
Journal Articles

Proteasome inhibitor carfilzomib complements ibrutinib’s action in chronic lymphocytic leukemia

Free
Clinical Trials & Observations
Betty Lamothe, Fabiola Cervantes-Gomez, Mariela Sivina, William G. Wierda, Michael J. Keating, Varsha Gandhi
Journal: Blood
Blood (2015) 125 (2): 407–410.
https://doi.org/10.1182/blood-2014-07-585364
Published: 2015