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Alexandra Schurer
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Journal Articles

Investigating ribosome biogenesis in AML identifies MYB-binding protein 1A (MYBBP1A) as an essential regulator of leukemia cells

Free
Phuong To, Bertina Dragunaite, Pedro Casado, Quang-Anh Hoang, Emilie Alard, Lauren Harrison-Oakes, Anthony Velleca, Keith Woodley, Louie van de Lagemaat, Thomas Rohwetter, Alexandra Schurer, Mandy Chan, Salma Noorzai, Ly Vu, Alex Radzisheuskaya, Paolo Gallipoli, Ana Rio-Machin, Kamil Kranc, Faraz Mardakheh, Benjamin Towler, Pedro Cutillas, Michael Kharas, Diu Nguyen
Journal: Blood
Blood (2025) 146 (Supplement 1): 990.
https://doi.org/10.1182/blood-2025-990
Published: 2025
Journal Articles

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated Acute Myeloid Leukemia

Free
Alexandra Schurer, Humaira Ilyas, Maxim Maron, Subray Hegde, Melissa Leyden, Irene Roy, Rotila Hyka, Lucas Dada, Jeffrey Shabanowitz, Donald Hunt, Ellen Angeles, Victor Morell, Benjamin Lorton, Shira Glushakow-Smith, Daniel Borger, Yuxuan Wang, Linde Miles, Roger Belizaire, Seiya Kitamura, Kira Gritsman, David Shechter
Journal: Blood
Blood (2025) 146 (Supplement 1): 869.
https://doi.org/10.1182/blood-2025-869
Published: 2025
Journal Articles

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2 -mutated post-MPN AML

Open Access
Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P. Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J. Mead, Raajit K. Rampal, Jeffrey W. Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2025) 146 (3): 341–355.
https://doi.org/10.1182/blood.2024027117
Published: 2025
Includes: Supplemental data
Journal Articles

Differential Requirements for the RON Ligand Binding and Kinase Domains in Myeloproliferative Neoplasms

Free
Alexandra Schurer, Lindsay Gurska, Yuxuan Wang, Allison Montoya, Swati Goel, Kira Gritsman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1751.
https://doi.org/10.1182/blood-2024-210545
Published: 2024
Journal Articles

Efficacy of a Novel BCL-XL Degrader, DT2216, in Preclinical Models of Post-Myeloproliferative Neoplasm Secondary AML

Free
Zhe Wang, Anna Skwarska, Gowri Poigailwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini Papapetrou, Kapil N. Bhalla, Daohong Zhou, Adam J Mead, Raajit Rampal, Jeffrey W Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2024) 144 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2024-194031
Published: 2024
Journal Articles

Dual IKZF2 and CK1α Degrader Targets Acute Myeloid Leukemia Cells

Free
Sun Mi Park, David Miyamoto, Grace Han, Mandy Chan, Nicole Curnutt, Nathan Tran, Anthony Velleca, Jun Hyun Kim, Alexandra Schurer, Kathryn Chang, Christina M Woo, Michael G Kharas
Journal: Blood
Blood (2022) 140 (Supplement 1): 675–676.
https://doi.org/10.1182/blood-2022-167678
Published: 2022
Journal Articles

RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality

Free
Florisela Herrejon Chavez, Paolo Cifani, Alli Pine, Karen L Chu, Ersilia Barin, Alexandra Schurer, Hanzhi Luo, Diu T.T. Nguyen, Alex Kentsis, Christina Leslie, Michael G Kharas, Ly P Vu
Journal: Blood
Blood (2021) 138 (Supplement 1): 296.
https://doi.org/10.1182/blood-2021-147575
Published: 2021
Journal Articles

Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

Free
Diu T.T. Nguyen, DPhil, Camila Prieto, PhD, Zhaoqi Liu, PhD, Justin Wheat, Alexendar Perez, Saroj Gourkanti, BA, Timothy Chou, BS, Ersilia Barin, Arthur Chow, BS, James Taggart, BA, Katerina Hoskova, Meera Dhodapkar, Alexandra Schurer, BS, Trevor Stephen Barlowe, BA, Ly Vu, PhD, Christina Leslie, PhD, Ulrich G. Steidl, MDPhD, Raul Rabadan, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
https://doi.org/10.1182/blood-2020-142229
Published: 2020
Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Free
Gerard Minuesa Dinares, PhD, Steven K. Albanese, BS, Arthur Chow, BA, Alexandra Schurer, BS, Sun Mi Park, PhD, Christina Z. Rotsides, PhD, James Taggart, BS, Andrea Rizzi, BS, Levi N. Naden, PhD, Timothy Chou, BS, Saroj Gourkanti, BA, Daniel Cappel, PhD, Maria C. Passarelli, BS, Lauren Fairchild, PhD, Carolina Adura, PhD, Joseph Fraser Glickman, MSPH, PhD, Jessica Schulman, Christopher Famulare, MS, Minal Patel, BA, Joseph K. Eibl, PhD, Gregory M. Ross, PhD, Derek Tan, PhD, Christina Leslie, PhD, Thijs Beuming, PhD, Yehuda Goldgur, PhD, John D. Chodera, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 428.
https://doi.org/10.1182/blood-2018-99-118745
Published: 2018
Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Free
Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 883.
https://doi.org/10.1182/blood-2018-99-112543
Published: 2018
Journal Articles

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

Free
Yuanming Cheng, PhD, Hanzhi Luo, PhD, Franco Izzo, PhD, Brian F Pickering, PhD, Ly P Vu, PhD, Alexandra Schurer, BS, Saroj Gourkanti, BA, Samie R. Jaffrey, MD PhD, Dan A. Landau, MD PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 327.
https://doi.org/10.1182/blood-2018-99-117191
Published: 2018