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Kristine R Crews
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Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Shunsuke Kimura, Petri Pölönen, Lindsey Montefiori, Kenneth Caldwell, Ilaria Iacobucci, Chelsey Chen, Anthony Brown, Katie Han, Yen-Chun Liu, Yunchao Chang, Zhongshan Cheng, Zhou Yinmei, Chun Shik Park, Sharnise Mitchell, Noemi Reyes, Allen Yeoh, Andishe Attarbaschi, Andrew Moore, Atsushi Manabe, Barbara Buldini, Kean Hui Chiew, Chi Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, Elisabeth Paietta, Franco Locatelli, Gabriele Escherich, Gao Qingsong, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A. de Groot-Kruseman, Jacob M. Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P.P. Meijerink, Junko Takita, Katarzyna Pawinska-Wasikowska, Kjeld Schmiegelow, Mariko Eguchi, Martin Schrappe, Martin Zimmermann, Masatoshi Takagi, Melissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Motohiro Kato, Orietta Spinelli, Pauline Mazilier, Paul G. Thomas, Riccardo Masetti, Rishi Sury Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Shuhong Shen, Sima Jeha, Steven M. Kornblau, Szymon Skoczen, Takako Miyamura, Tiffaney Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Zhaohui Gu, Kathryn G. Roberts, David T. Teachey, Kristine R Crews, Cheng Cheng, Jun J. Yang, Hiroto Inaba, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (Supplement 1): 845.
https://doi.org/10.1182/blood-2023-178688
Published: 2023
Journal Articles

Zegocractin to Reduce the Severity of Asparaginase Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia: Results of the Phase 1 Portion of the Crspa Study

Seth E. Karol, Haitao Pan, Zhou Yinmei, Jeffrey E. Rubnitz, Nickhill Bhakta, Sima Jeha, Mary V. Relling, Kristine R Crews, John C Panetta, Cara Morin, Cheng Cheng, Ching-Hon Pui, Hiroto Inaba, M Beth McCarville
Journal: Blood
Blood (2023) 142 (Supplement 1): 2837.
https://doi.org/10.1182/blood-2023-188357
Published: 2023
Journal Articles

Genetic and Epigenetic Cis -Regulatory Disruptions Impacting the Canonical Wnt Signaling Repressor TLE1 Gene Promote Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia

Brennan P. Bergeron, Jonathan D. Diedrich, Yang Zhang, Kelly R. Barnett, Qian Dong, Daniel Ferguson, Robert J Autry, Wenjian Yang, Baranda S Hansen, Colton A Smith, Kristine R. Crews, Yiping Fan, Ching-Hon Pui, Shondra Miller, Mary V. Relling, Jun J. Yang, Chunliang Li, William E. Evans, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 8838–8839.
https://doi.org/10.1182/blood-2022-166973
Published: 2022
Journal Articles

Pharmacotypes across the Genomic Landscape of Pediatric Acute Lymphoblastic Leukemia and Impact on Treatment Response

Shawn Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. Crews, Kathryn G Roberts, Sima Jeha, Cheng Cheng, Seth E. Karol, Mary V. Relling, Gary Rosner, Hiroto Inaba, Charles G. Mullighan, Ching-Hon Pui, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 1730–1731.
https://doi.org/10.1182/blood-2022-156699
Published: 2022
Journal Articles

Epigenetic Fine Mapping and Functional Dissection of Inherited Non-Coding Variation Impacting the Pharmacogenomics of Acute Lymphoblastic Leukemia Treatment

Kashi Raj Bhattarai, Kelly R. Barnett, Robert J. Mobley, Daniel C. Ferguson, Jonathan D. Diedrich, Brennan P. Bergeron, Wenjian Yang, Kristine R. Crews, Wendy Stock, Elisabeth Paietta, Steven M. Kornblau, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Cheng Cheng, Mary V. Relling, William E. Evans, Jun J.J. Yang, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 3027–3028.
https://doi.org/10.1182/blood-2022-167419
Published: 2022
Journal Articles

Chromatin Accessibility Landscapes of B-Cell Acute Lymphoblastic Leukemia Identify Extensive Epigenomic Reprogramming and Heterogeneity Among Subtypes

Kelly R. Barnett, Jonathan D. Diedrich, Brennan P. Bergeron, Wenjian Yang, Kristine R. Crews, Wendy Stock, Elisabeth Paietta, Steven M. Kornblau, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, William E. Evans, Jun J.J. Yang, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 5907–5908.
https://doi.org/10.1182/blood-2022-166528
Published: 2022
Journal Articles

Mapping the Glucocorticoid Gene Regulatory Network and Alterations That Contribute to Steroid Resistance in Childhood Acute Lymphoblastic Leukemia

Brennan P. Bergeron, Jonathan Diedrich, Yang Zhang, Qian Dong, Daniel Ferguson, Robert J Autry, Wenjian Yang, Baranda S Hansen, Kristine R. Crews, Ching-Hon Pui, Yiping Fan, Shondra M. Pruett-Miller, Mary V. Relling, Jun J. Yang, Chunliang Li, William E. Evans, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 674.
https://doi.org/10.1182/blood-2021-153002
Published: 2021
Journal Articles

Chromatin Accessibility Landscapes of Acute Lymphoblastic Leukemia

Kelly R. Barnett, Jonathan D. Diedrich, Brennan P. Bergeron, Wenjian Yang, Kristine R. Crews, Wendy Stock, Elisabeth M. Paietta, Steven M. Kornblau, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, William E. Evans, Jun J. Yang, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 2215.
https://doi.org/10.1182/blood-2021-150676
Published: 2021
Journal Articles

Amino Acid Stress Response Genes Promote L-Asparaginase Resistance in Pediatric Acute Lymphoblastic Leukemia

Daniel Ferguson, J. Robert McCorkle, Qian Dong, Erik Bonten, Wenjian Yang, Brennan P. Bergeron, Robert J Autry, Jonathan Diedrich, Yoshihiro Gocho, Richa Bajpai, Kristine R. Crews, Shondra M. Pruett-Miller, Kathryn G Roberts, Wendy Stock, Charles G. Mullighan, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Jun J. Yang, Mary V. Relling, William E. Evans, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2021-152940
Published: 2021
Journal Articles

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Kathryn G. Roberts, PhD, Samuel W. Brady, PhD, Zhaohui Gu, PhD, Lei Shi, PhD, Stanley Pounds, PhD, Deqing Pei, MS, Cheng Cheng, PhD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Chunxu Qu, PhD, Ashley Hill, BS, Xiaotu Ma, Lei Wei, PhD, Sasi Arunachalam, PhD, Kohei Hagiwara, MD, Yangling Liu, Diane Flasch, Yu Liu, PhD, Matthew Parker, PhD, Xiaolong Chen, PhD, Yongjin Li, PhD, Yiping Fan, PhD, Robert Michael, PhD, Michael Rusch, BS, Mark Wilkinson, Scott Foy, PhD, Dale Hedges, PhD, Scott Newman, PhD, Xin Zhou, PhD, Jian Wang, Shalini C. Reshmi, PhD, Julie M. Gastier-Foster, PhD, Patee Gesuwan, Malcolm A Smith, MD PhD, Daniela S. Gerhard, PhD, Naomi Winick, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Eric Larsen, MD, Elizabeth A. Raetz, MD, Michael J. Borowitz, MD PhD, Brent L Wood, MD PhD, William L. Carroll, MD, Patrick A. Zweidler-McKay, MD PhD, Karen R. Rabin, MD PhD, Leonard A. Mattano, MD, Kelly Maloney, MD, Stuart S. Winter, MD, Michael J. Burke, MD, Wanda L. Salzer, MD, Kimberly P. Dunsmore, Anne Angiolillo, MD, Kristine R Crews, PharmD, James R. Downing, MD, Sima Jeha, MD, William E. Evans, PharmD, Ching-Hon Pui, MD, Jun J. Yang, PhD, Mary V. Relling, PharmD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 649.
https://doi.org/10.1182/blood-2019-124881
Published: 2019
Journal Articles

Pegaspargase Allergic Reactions Are Related to Anti-Pegaspargase Antibodies and to Intensity of Intrathecal Therapy

Yiwei Liu, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Lauren Thompson, Anisha Dash, Jacob Counts, May Chung, Alejandro R Molinelli, PhD, Deqing Pei, MS, Nancy M Kornegay, Erik A Springer, John C Panetta, PhD, Kristine R Crews, PharmD, Hope Swanson, PharmD, Cheng Cheng, PhD, Seth E Karol, MD, William E. Evans, PharmD, Hiroto Inaba, MD, Ching-Hon Pui, MD, Sima Jeha, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2697.
https://doi.org/10.1182/blood-2018-99-110141
Published: 2018
Journal Articles

The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Emily R Finch, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Nancy M Kornegay, John C Panetta, PhD, Kristine R Crews, PharmD, Alejandro R Molinelli, PhD, Cheng Cheng, PhD, Deqing Pei, MS, Laura B. Ramsey, PhD, Seth E Karol, MD, Hiroto Inaba, MD, John T. Sandlund, MD, Monika Metzger, MD, William E. Evans, PharmD, Sima Jeha, MD, Ching-Hon Pui, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2665.
https://doi.org/10.1182/blood-2018-99-117093
Published: 2018
Journal Articles

Risk Score Generated from Ara-C Metabolic Pathway Predicts Leukemic Cell Intracellular Ara-CTP Levels in AML-97 Pediatric Patients

Abdelrahman Elsayed, BSc, MSc, Kristine R Crews, PharmD, Xueyuan Cao, PhD, Jeffrey E Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder Lamba, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2666.
https://doi.org/10.1182/blood.V130.Suppl_1.2666.2666
Published: 2017
Journal Articles

Genome-Wide Association Study (GWAS) Identifies SNPs in GPR56 and IGF1R Predictive of Leukemic Cell In Vitro cytarabine Sensitivity in Pediatric AML

Salma Bargal, BSPharm, Roya Rafiee, PhD, Kristine R Crews, PharmD, Xueyuan Cao, PhD, Jeffrey E Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder Lamba, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1426.
https://doi.org/10.1182/blood.V130.Suppl_1.1426.1426
Published: 2017
Journal Articles

a Phase I Trial of Bendamustine in Combination with Clofarabine and Etoposide in Pediatric Patients with Relapsed or Refractory Hematologic Malignancies

Sima Jeha, MD, Monika L. Metzger, MD, Kristine R Crews, PhD, Patrick Campbell, MD PhD, Raul C. Ribeiro, MD, Cheng Cheng, PhD, Melissa Peyton, RN, Carl Panetta, PhD, Jun Yang, PhD, Ching-Hon Pui, MD, Deepa Bhojwani, MD
Journal: Blood
Blood (2016) 128 (22): 1628.
https://doi.org/10.1182/blood.V128.22.1628.1628
Published: 2016
Journal Articles

Asparaginase May Affect Mercaptopurine Tolerability in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia

Chengcheng Liu, PhD, Deqing Pei, Cheng Cheng, PhD, Jun J Yang, PhD, Kristine R Crews, PhD, John C Panetta, PhD, Xiangjun DeMeter, Sima Jeha, MD, John Sandlund, MD, Raul C. Ribeiro, MD, Jeffrey E Rubnitz, MD PhD, Monika L. Metzger, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2016) 128 (22): 179.
https://doi.org/10.1182/blood.V128.22.179.179
Published: 2016
Journal Articles

6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study

Clinical Trials & Observations
Smita Bhatia, Wendy Landier, Lindsey Hageman, Heeyoung Kim, Yanjun Chen, Kristine R. Crews, William E. Evans, Bruce Bostrom, Jacqueline Casillas, David S. Dickens, Kelly W. Maloney, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey, F. Lennie Wong, Mary V. Relling
Journal: Blood
Blood (2014) 124 (15): 2345–2353.
https://doi.org/10.1182/blood-2014-01-552166
Published: 2014
Includes: Supplemental data
Journal Articles

Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients

Eric R. Gamazon, Jatinder K. Lamba, Stanley Pounds, Amy L. Stark, Heather E. Wheeler, Xueyuan Cao, Hae K. Im, Amit K. Mitra, Jeffrey E. Rubnitz, Raul C. Ribeiro, Susana Raimondi, Dario Campana, Kristine R. Crews, Shan S. Wong, Marleen Welsh, Imge Hulur, Lidija Gorsic, Christine M. Hartford, Wei Zhang, Nancy J. Cox, M. Eileen Dolan
Journal: Blood
Blood (2013) 121 (21): 4366–4376.
https://doi.org/10.1182/blood-2012-10-464149
Published: 2013
Includes: Supplemental data
Journal Articles

A Genome-Wide Approach Identifies Variations in the Aspartate Metabolism Pathway That Are Associated with Asparaginase Sensitivity

Shih-Hsiang Chen, MD, Wenjian Yang, PhD, Yiping Fang, PhD, Gabriele Stocco, PhD, Kristine R. Crews, PharmD, Ching-Hon Pui, MD, William E. Evans, Pharm.D, Mary V. Relling, Pharm.D
Journal: Blood
Blood (2008) 112 (11): 213.
https://doi.org/10.1182/blood.V112.11.213.213
Published: 2008