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Journal Articles

Transient Differentiation-State Plasticity during Initiation of Pediatric Acute Lymphoblastic Leukemia

Vera M Poort, Rico Hagelaar, Mark van Roosmalen, Laurianne Trabut, Jessica G.C.A.M. Buijs-Gladdines, Diego Montiel González, Bram van Wijk, Jules P.P. Meijerink, Ruben Van Boxtel

Blood (2023) 142 (Supplement 1): 42.

https://doi.org/10.1182/blood-2023-188891

Published: 2023

Journal Articles

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Shunsuke Kimura, Petri Pölönen, Lindsey Montefiori, Kenneth Caldwell, Ilaria Iacobucci, Chelsey Chen, Anthony Brown, Katie Han, Yen-Chun Liu, Yunchao Chang, Zhongshan Cheng, Zhou Yinmei, Chun Shik Park, Sharnise Mitchell, Noemi Reyes, Allen Yeoh, Andishe Attarbaschi, Andrew Moore, Atsushi Manabe, Barbara Buldini, Kean Hui Chiew, Chi Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, Elisabeth Paietta, Franco Locatelli, Gabriele Escherich, Gao Qingsong, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A. de Groot-Kruseman, Jacob M. Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P.P. Meijerink, Junko Takita, Katarzyna Pawinska-Wasikowska, Kjeld Schmiegelow, Mariko Eguchi, Martin Schrappe, Martin Zimmermann, Masatoshi Takagi, Melissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Motohiro Kato, Orietta Spinelli, Pauline Mazilier, Paul G. Thomas, Riccardo Masetti, Rishi Sury Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Shuhong Shen, Sima Jeha, Steven M. Kornblau, Szymon Skoczen, Takako Miyamura, Tiffaney Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Zhaohui Gu, Kathryn G. Roberts, David T. Teachey, Kristine R Crews, Cheng Cheng, Jun J. Yang, Hiroto Inaba, Charles G. Mullighan

Blood (2023) 142 (Supplement 1): 845.

https://doi.org/10.1182/blood-2023-178688

Published: 2023

Journal Articles

Influence of Bisphosphonates or Recombinant Human Parathyroid Hormone on in Vitro Chemotherapy Sensitivity in Acute Lymphoblastic Leukemia Cells

Demi T.C. de Winter, Jenneke E. van Atteveld, Jessica G.C.A.M. Buijs-Gladdines, Rob Pieters, Sebastian J.C.M.M. Neggers, Jules P.P. Meijerink, Marry M. van den Heuvel-Eibrink

Blood (2021) 138 (Supplement 1): 4355.

https://doi.org/10.1182/blood-2021-152430

Published: 2021

Journal Articles

Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels By Recurrent CTCF inactivating Mutations in T Cell Acute Lymphoblastic Leukemia

Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen Van De Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried Van Eyndhoven, Max Jan Van Min, Roland P Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter De Laat, Jules P.P. Meijerink

Blood (2021) 138 (Supplement 1): 501.

https://doi.org/10.1182/blood-2021-152221

Published: 2021

Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinase Activities and Novel Treatment Combination Strategies

Valentina Cordo', MSc, Rico Hagelaar, Sander Piersma, Richard Goeij-de Haas, Thang V Pham, Jelle Dylus, Guido Zaman, PhD, Connie Jimenez, PhD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2020-139259

Published: 2020

Journal Articles

MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Zhongli Chen, MSc, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 1292.

https://doi.org/10.1182/blood-2019-124721

Published: 2019

Journal Articles

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Specific Kinase Activation Signatures That Can Predict Response to Targeted Therapy

Valentina Cordo', MSc, Rico Hagelaar, Sander Piersma, Thang V Pham, Connie Jimenez, PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 4649.

https://doi.org/10.1182/blood-2019-122898

Published: 2019

Journal Articles

The Clinical and Functional Relevance of the Transforming AKT E17K Mutation in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Izabela Mollova, BSc, Laura Graus, BSc, Frank L. Bos, PhD, Anne C. Rios, PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 3804.

https://doi.org/10.1182/blood-2019-124669

Published: 2019

Journal Articles

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

Kirsten Canté-Barrett, PhD, Laurent Holtzer, PhD, Henk van Ooijen, PhD, Rico Hagelaar, Valentina Cordo', MSc, Wim Verhaegh, PhD, Anja van de Stolpe, MD PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 4661.

https://doi.org/10.1182/blood-2019-122856

Published: 2019

Journal Articles

Identification of a Novel T-ALL Entity with NKX2-1/NKX2-2 Rearrangements

Blood (2010) 116 (21): 3139.

https://doi.org/10.1182/blood.V116.21.3139.3139

Published: 2010

Journal Articles

Clinical Relevance of NOTCH1 and FBXW7 Mutations in DCOG and COALL T-ALL Patient Cohorts.

Linda Zuurbier, Irene Homminga, Jessica Buijs-Gladdines, Valerie de Haas, MD, PhD, Martin Horstman, Rob Pieters, Jules P.P. Meijerink, PhD.

Blood (2009) 114 (22): 1603.

https://doi.org/10.1182/blood.V114.22.1603.1603

Published: 2009

Journal Articles

Oncogenic Transcriptional Programs Controlled by TLX1/HOX11 and TLX3/HOX11L2 in T-ALL.

Giusy Della Gatta, PhD, Teresa Palomero, PhD, Maria Luisa Sulis, MD, Xavier Solé, PhD, Wei Keat Lim, PhD, Kim De Keersmaecker, PhD, Pedro Jose Real Luna, PhD, Valeria Tosello, PhD, Fotini Gounari, PhD, Barbara Kee, PhD, Jack Lenz, PhD, Michelle Kelliher, PhD, Peter D. Aplan, MD, Jules P.P. Meijerink, PhD., Andrea Califano, PhD, Adolfo Ferrando

Blood (2009) 114 (22): 676.

https://doi.org/10.1182/blood.V114.22.676.676

Published: 2009

Journal Articles

Expression of Mir-196b Is Not Exclusively MLL -Driven but Especially Linked to Activation of HOXA Genes in Children with Acute Lymphoblastic Leukemia.

Diana Schotte, Ellen Lange-Turenhout, Dominique JPM Stumpel, Ronald W. Stam, Ph.D., Jessica Buijs-Gladdines, Jules P.P. Meijerink, PhD., Rob Pieters, Ph.D., Prof., Monique L. Den Boer, PhD

Blood (2009) 114 (22): 580.

https://doi.org/10.1182/blood.V114.22.580.580

Published: 2009

Journal Articles

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Irene Homminga, MD, Michel C. Zwaan, MD, PhD, Amel Seghouani, MD, Chantal Y. Manz, PhD, Shanta Bantia, PhD, Wilco Smits, Rob Pieters, MD, PhD, Jules P.P. Meijerink, PhD

Blood (2009) 114 (22): 2038.

https://doi.org/10.1182/blood.V114.22.2038.2038

Published: 2009

Journal Articles

Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Maria Kleppe, Idoya Lahortiga, PhD, Tiama El Chaar, Kim De Keersmaecker, PhD, Nicole Mentens, Carlos Graux, MD, PhD, Katrien Van Roosbroeck, Adolfo A. Ferrando, MD, PhD, Anton W Langerak, PhD, Jules P.P. Meijerink, PhD, Francois Sigaux, MD, Torsten Haferlach, MD, Iwona Wlodarska, PhD, Peter Vandenberghe, MD, PhD, Jean Soulier, MD, PhD, Jan Cools, PhD

Blood (2009) 114 (22): 141.

https://doi.org/10.1182/blood.V114.22.141.141

Published: 2009

Journal Articles

Inhibition of NOTCH1 Signaling and Glucocorticoid Therapy in T-ALL

Pedro Jose Real, PhD, Valeria Tosello, PhD, Teresa Palomero, PhD, Mireia Castillo, MD, Catherine Sawai, Maria Luisa Sulis, MD, Jules P.P. Meijerink, Giuseppe Basso, MD, Iannis Aifantis, PhD, MSC, Carlos Cordon-Cardo, MD, Adolfo A. Ferrando, MD, PhD

Blood (2008) 112 (11): 298.

https://doi.org/10.1182/blood.V112.11.298.298

Published: 2008

Journal Articles

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX- 1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia Cells.

Irene Homminga, MD, Christian M Zwaan, MD, PhD, Chantal Y. Manz, PhD, Shanta Bantia, PhD, Cynthia Parker, Jessica Buijs-Gladdines, Wilco Smits, Martin A. Horstmann, MD, Rob Pieters, MD, PhD, Jules P.P. Meijerink, MSc, PhD

Blood (2008) 112 (11): 1925.

https://doi.org/10.1182/blood.V112.11.1925.1925

Published: 2008

Journal Articles

MicroRNA signatures in Genetic Subtypes of T-Cell Acute Lymphoblastic Leukemia.

Blood (2008) 112 (11): 3360.

https://doi.org/10.1182/blood.V112.11.3360.3360

Published: 2008

Journal Articles

Poor Survival of CD34 Positive and CD13/33 Positive Patients in Pediatric T-Cell Acute Lymphoblastic Leukemia Is Not Explained by Expression of Multidrug Resistance Genes.

Martine van Grotel, MSc, Max M. van Noesel, MD,PhD, M.M. Van Den Heuvel, MD,PhD, Rob Pieters, MD,PhD, Jules P.P. Meijerink, PhD

Blood (2007) 110 (11): 4219.

https://doi.org/10.1182/blood.V110.11.4219.4219

Published: 2007

NARROW

Transient Differentiation-State Plasticity during Initiation of Pediatric Acute Lymphoblastic Leukemia

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Influence of Bisphosphonates or Recombinant Human Parathyroid Hormone on in Vitro Chemotherapy Sensitivity in Acute Lymphoblastic Leukemia Cells

Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels By Recurrent CTCF inactivating Mutations in T Cell Acute Lymphoblastic Leukemia

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinase Activities and Novel Treatment Combination Strategies

MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Specific Kinase Activation Signatures That Can Predict Response to Targeted Therapy

The Clinical and Functional Relevance of the Transforming AKT E17K Mutation in T-ALL

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients

Identification of a Novel T-ALL Entity with NKX2-1/NKX2-2 Rearrangements

Clinical Relevance of NOTCH1 and FBXW7 Mutations in DCOG and COALL T-ALL Patient Cohorts.

Oncogenic Transcriptional Programs Controlled by TLX1/HOX11 and TLX3/HOX11L2 in T-ALL.

Expression of Mir-196b Is Not Exclusively MLL -Driven but Especially Linked to Activation of HOXA Genes in Children with Acute Lymphoblastic Leukemia.

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Inhibition of NOTCH1 Signaling and Glucocorticoid Therapy in T-ALL

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX- 1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia Cells.

MicroRNA signatures in Genetic Subtypes of T-Cell Acute Lymphoblastic Leukemia.

Poor Survival of CD34 Positive and CD13/33 Positive Patients in Pediatric T-Cell Acute Lymphoblastic Leukemia Is Not Explained by Expression of Multidrug Resistance Genes.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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