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Journal Articles

Unique Long Non-Coding RNA Expression Signature in ETV6/RUNX1-Driven B-Cell Precursor Acute Lymphoblastic Leukemia

Farzaneh Ghazavi, Barbara De Moerloose, MD, Wouter Van Loocke, Annelynn Wallaert, Alina Ferster, Marleen Bakkus, PhD, Genevieve Plat, MD, Eric Delabesse, PharmD, PhD, Anne Uyttebroeck, Filip Van Nieuwerburgh, PharmD, Prof, Dieter Deforce, PharmD, Prof, Nadine van Roy, MD Prof, Frank Speleman, Prof, Yves Benoit, Tim Lammens, Pieter van Vlierberghe, Prof
Journal: Blood
Blood (2016) 128 (22): 3920.
https://doi.org/10.1182/blood.V128.22.3920.3920
Published: 2016
Journal Articles

RPPA-Based Protein Profiling Reveals Enhanced PI3K/AKT/mTOR Signaling in ETV6/RUNX1-Positive Acute Lymphoblastic Leukemia Patients with Low CD200 Expression

Farzaneh Ghazavi, Valentina Serafin, PhD, Pieter Rondou, PhD, Tim Lammens, Frank Speleman, Prof, Benedetta Accordi, PhD, Barbara De Moerloose, MD, Pieter Van Vlierberghe, Prof
Journal: Blood
Blood (2016) 128 (22): 890.
https://doi.org/10.1182/blood.V128.22.890.890
Published: 2016
Journal Articles

Impact of Age and Treatment Group in Childhood High Hyperdiploid Low Risk B-Cell Acute Lymphoblastic Leukemia (ALL): Results of the CLG-EORTC 58951 Study

Laura Clement, Stefan Suciu, PhD, Isabelle Luquet, MD, Alina Ferster, MD PhD, Karima Yakouben, MD, Anne Uytterbroeck, Catherine Paillard, MD PhD, Nicolas Sirvent, Vitor Costa, Barbara De Moerloose, MD, Francoise Mazingue, Emmanuel Plouvier, MD, Martine Munzer, Maryline Poirée, Odile Minckes, MD, Frédéric Millot, MD, Dominique Plantaz, Caroline Piette, Frank Speleman, Prof, Hélène Cavé, Jutte VanderWerff-tenBossch, Pierre Simon Rohrlich, MDPhD, Yves Bertrand, Yves Benoit, Geneviève Plat
Journal: Blood
Blood (2016) 128 (22): 1743.
https://doi.org/10.1182/blood.V128.22.1743.1743
Published: 2016
Journal Articles

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Hetty H. Helsmoortel, Silvia Bresolin, Tim Lammens, Hélène Cavé, Peter Noellke, Aurélie Caye, Farzaneh Ghazavi, Andrica de Vries, Henrik Hasle, Veerle Labarque, Riccardo Masetti, Jan Stary, Marry M. van den Heuvel-Eibrink, Jan Philippé, Nadine Van Roy, Yves Benoit, Frank Speleman, Charlotte Niemeyer, Christian Flotho, Giuseppe Basso, Geertruy te Kronnie, Pieter Van Vlierberghe, Barbara De Moerloose
Journal: Blood
Blood (2016) 127 (9): 1163–1172.
https://doi.org/10.1182/blood-2015-09-667808
Published: 2016
Includes: Supplemental data
Journal Articles

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der Meulen, Viraj Sanghvi, Konstantinos Mavrakis, Kaat Durinck, Fang Fang, Filip Matthijssens, Pieter Rondou, Monica Rosen, Tim Pieters, Peter Vandenberghe, Eric Delabesse, Tim Lammens, Barbara De Moerloose, Björn Menten, Nadine Van Roy, Bruno Verhasselt, Bruce Poppe, Yves Benoit, Tom Taghon, Ari M. Melnick, Frank Speleman, Hans-Guido Wendel, Pieter Van Vlierberghe
Journal: Blood
Blood (2015) 125 (1): 13–21.
https://doi.org/10.1182/blood-2014-05-577270
Published: 2015
Includes: Supplemental data
Journal Articles

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie Peirs, Filip Matthijssens, Steven Goossens, Inge Van de Walle, Katia Ruggero, Charles E. de Bock, Sandrine Degryse, Kirsten Canté-Barrett, Delphine Briot, Emmanuelle Clappier, Tim Lammens, Barbara De Moerloose, Yves Benoit, Bruce Poppe, Jules P. Meijerink, Jan Cools, Jean Soulier, Terence H. Rabbitts, Tom Taghon, Frank Speleman, Pieter Van Vlierberghe
Journal: Blood
Blood (2014) 124 (25): 3738–3747.
https://doi.org/10.1182/blood-2014-05-574566
Published: 2014
Includes: Supplemental data
Journal Articles

Transcriptional Antagonism Between the Cooperative Oncogenes TLX1 and NOTCH1 in T-Cell Acute Lymphoblastic Leukemia

Kaat Durinck, Wouter Vanloocke, Joni Van der Meulen, Inge van de Walle, Pieter Rondou, PhD, Charles De Bock, Bruno Verhasselt, Bruce Graham Poppe, MD PhD, Jan Cools, PhD, Jean Soulier, MD PhD, Tom Taghon, PhD, Frank Speleman, Pieter Van Vlierberghe
Journal: Blood
Blood (2014) 124 (21): 3588.
https://doi.org/10.1182/blood.V124.21.3588.3588
Published: 2014
Journal Articles

Prognostic Relevance of CD200 /Btla Deletions in Pediatric Precursor-B Cell Acute Lymphoblastic Leukemia Treated According to the EORTC-CLG 58951 Protocol

Farzaneh Ghazavi, Tim Lammens, Emmanuelle Clappier, Stefan Suciu, Aurélie Caye, Samira Zegrari, Marleen Bakkus, Nathalie Grardel, Yves Benoit, Yves Bertrand, Odile Minckes, Vitor Costa, Alina Ferster, Françoise Mazingue, Geneviève Plat, Emmanuel Plouvier, Marilyne Poirée, Anne Uyttebroeck, Jutte Van der Werff Ten Bosch, Hetty Helsmoortel, Magali Meul, Nadine Van Roy, Jan Philippé, Frank Speleman, Hélène Cavé, Pieter Van Vlierberghe, Barbara De Moerloose
Journal: Blood
Blood (2014) 124 (21): 2394.
https://doi.org/10.1182/blood.V124.21.2394.2394
Published: 2014
Journal Articles

The NOTCH1 Driven Long Non-Coding RNA Repertoire in T-Cell Acute Lymphoblastic Leukemia

Annelynn Wallaert, Kaat Durinck, Pieter Rondou, PhD, Inge van de Walle, Wouter Vanloocke, Pieter-Jan Volders, Suzanne Vanhauwaert, Ellen Geerdens, Maté Ongenaert, Nadine Van Roy, Bruce Graham Poppe, MD PhD, Yves Benoit, Jan Cools, PhD, Jo Vandesompele, PhD, Jean Soulier, MD PhD, Pieter Van Vlierberghe, Tom Taghon, PhD, Frank Speleman
Journal: Blood
Blood (2014) 124 (21): 900.
https://doi.org/10.1182/blood.V124.21.900.900
Published: 2014
Journal Articles

Expanding The TLX1-Regulome In T Cell Acute Lymphoblastic Leukemia Towards Long Non-Coding RNAs

Kaat Durinck, Joni Van der Meulen, Maté Ongenaert, Pieter-Jan Volders, Annelynn Wallaert, Nadine Van Roy, PhD, Yves Benoit, Bruce Poppe, MD, Pieter Mestdagh, PhD, Jo Vandesompele, PhD, Pieter Rondou, PhD, Jean Soulier, MD, PhD, Pieter Van Vlierberghe, Frank Speleman, PhD
Journal: Blood
Blood (2013) 122 (21): 813.
https://doi.org/10.1182/blood.V122.21.813.813
Published: 2013
Journal Articles

Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results

Clinical Trials & Observations
Nicole Dastugue, Stefan Suciu, Geneviève Plat, Frank Speleman, Hélène Cavé, Sandrine Girard, Marleen Bakkus, Marie Pierre Pagès, Karima Yakouben, Brigitte Nelken, Anne Uyttebroeck, Carine Gervais, Patrick Lutz, Manuel R. Teixeira, Pierre Heimann, Alice Ferster, Pierre Rohrlich, Marie Agnès Collonge, Martine Munzer, Isabelle Luquet, Patrick Boutard, Nicolas Sirvent, Matthias Karrasch, Yves Bertrand, Yves Benoit
Journal: Blood
Blood (2013) 121 (13): 2415–2423.
https://doi.org/10.1182/blood-2012-06-437681
Published: 2013
Includes: Supplemental data
Journal Articles

Regulatory Networks Governed by MicroRNAs in T-ALL Oncogenesis and Normal T-Cell Development

Joni Van der Meulen, Evelien Mets, Pieter Mestdagh, PhD, Peter Pipelers, Tom Taghon, PhD, David Camacho Trujillo, PhD, David Avran, Gert Van Peer, Nadine Van Roy, PhD, Olivier Thas, PhD, Yves Benoit, MD, Jo Vandesompele, PhD, Bruce Poppe, MD, Pieter Van Vlierberghe, PhD, Pieter Rondou, PhD, Jean Soulier, MD, Frank Speleman, PhD
Journal: Blood
Blood (2011) 118 (21): 1366.
https://doi.org/10.1182/blood.V118.21.1366.1366
Published: 2011
Journal Articles

In Childhood B-Lineage Acute Lymphoblastic Leukemia (B-ALL) with Hyperdiploidy >50 Chromosomes, Patients with 58 to 66 Chromosomes Have 99% EFS At 6-Year Follow-up: Results of the EORTC CLG 58951 Trial

Nicole Dastugue, Stefan Suciu, Geneviève Plat, Frank Speleman, PhD, Hélène Cavé, Sandrine Girard, Emmanuelle Delabesse, Marie Pierre Pagès, Karima Yakouben, Brigitte Nelken, Francoise Mazingue, MD, Anne Hagemeijer, Anne Uyttebroeck, Carine Gervais, MD, Patrick Lutz, Manuel Teixera, Lucilia Norton, Pierre Heimann, Alina Ferster, Ghislaine Plessis, Patrick Boutard, Marie Agnès Collonge, Pierre Rohrlich, MD, PhD, Isabelle Luquet, MD, PhD, Martine Munzer, Nicolas Sirvent, Dominique Plantaz, Christian Herens, Claire Hoyoux, Matthias Karrasch, Yves Bertrand, Yves Benoit, MD
Journal: Blood
Blood (2011) 118 (21): 565.
https://doi.org/10.1182/blood.V118.21.565.565
Published: 2011
Journal Articles

BCL11B Mutations In T-Cell Acute Lymphoblastic Leukemia

Kim De Keersmaecker, PhD, Pedro Jose Real, PhD, Giusy Della Gatta, PhD, Teresa Palomero, PhD, Maria Luisa Sulis, MD, Valeria Tosello, PhD, Pieter Van Vlierberghe, PhD, Kelly Barnes, Mireia Castillo, MD, Xavier Sole, PhD, Michael Hadler, Jack Lenz, PhD, Peter Aplan, MD, Michelle Kelliher, PhD, Barbara L. Kee, PhD, Pier Paolo Pandolfi, MD, PhD, Dietmar Kappes, PhD, Fotini Gounari, PhD, Howard Petrie, PhD, Joni Van der Meulen, Frank Speleman, PhD, Elisabeth Paietta, PhD, Janis Racevskis, Martin Tallman, MD, Jacob M. Rowe, MD, Jean Soulier, MD, PhD, David Avran, Hélène Cavé, MD, Nicole Dastugue, MD, Susana C. Raimondi, PhD, Jules Meijerink, PhD, Carlos Cordon-Cardo, MD, PhD, Andrea Califano, PhD, Adolfo Ferrando, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 471.
https://doi.org/10.1182/blood.V116.21.471.471
Published: 2010
Journal Articles

Downregulation of MiR-449a Is Essential for the Survival of EVI1 Positive Leukemic Cells through Modulation of NOTCH1 and BCL2 .

An De Weer, Pieter Mestdagh, Katleen De Preter, Joni Van der Meulen, Pieter Van Vlierberghe, Tom Van Maerken, Nadine Van Roy, Marta Jeison, Isaac Yaniv, Barbara Cauwelier, Lucien Noens, Hélène-Antoine Poirel, Peter Vandenberghe, Frédéric Lambert, Anne De Paepe, Torsten Konrad, Rotraud Wieser, Maria García Sánchez, Maria Odero, Bruno Verhasselt, Jan Philippé, Jo Vandesompele, Nicole Dastugue, Bruce Poppe, Frank Speleman
Journal: Blood
Blood (2009) 114 (22): 361.
https://doi.org/10.1182/blood.V114.22.361.361
Published: 2009
Journal Articles

Prognostic Significance of NOTCH1 and FBXW7 Mutations in Childhood T-Cell Acute Lymphoblastic Leukemia (T-ALL): Results From the EORTC Children Leukemia Group.

Emmanuelle Clappier, Sandra Collette, Nathalie Grardel, Sandrine Girard, Lydia Suarez, Ghislaine Brunie, Sophie Kaltenbach, Karima Yakouben, Françoise Mazingue, Alain Robert, Patrick Boutard, Dominique Plantaz, Pierre-Simon Rohrlich, Claude Preudhomme, Frank Speleman, Jacques Otten, Nicole Dastugue, Stefan Suciu, Yves Benoit, Yves Bertrand, Hélène Cavé
Journal: Blood
Blood (2009) 114 (22): 909.
https://doi.org/10.1182/blood.V114.22.909.909
Published: 2009
Journal Articles

Comparison of miRNA Profiles of Microdissected Hodgkin/Reed-Sternberg Cells and Hodgkin Cell Lines Versus CD77+ B-Cells Reveals a Distinct Subset of Differentially Expressed miRNAs

Bruce Poppe, Pieter Van Vlierberghe, Pieter Mestdagh, Tom Feys, An De Weer, Pascale De Paepe, MD, PhD, Kathleen Lambein, Katleen De Preter, Nadine Van Roy, MD, PhD, Jo Vandesompele, Bruno Verhasselt, Frank Speleman
Journal: Blood
Blood (2008) 112 (11): 4488.
https://doi.org/10.1182/blood.V112.11.4488.4488
Published: 2008
Journal Articles

MicroRNA Profiling of EVI1 Deregulated Myeloid Leukemia

An De Weer, Bruce Poppe, Pieter Mestdagh, Katleen De Preter, Pieter Van Vlierberghe, Barbara Cauwelier, Nadine Van Roy, Bruno Verhasselt, Jo Vandesompele, Nicole Dastugue, Frank Speleman
Journal: Blood
Blood (2008) 112 (11): 5322.
https://doi.org/10.1182/blood.V112.11.5322.5322
Published: 2008
Journal Articles

Improved Detection of Chromosomal Abnormalities in CLL by Conventional Cytogenetics Using CpG Oligonucleotide and Interleukin-2 Stimulation. A Belgian Multicentric Study

Natalie Put, MD, Katrina Rack, PhD, Nadine Van Roy, MD, PhD, Jeanne-Marie Libouton, Pascal Vannuffel, PhD, Daniel Sartenaer, Geneviève Ameye, Frank Speleman, PhD, Hélène A Poirel, MD, PhD, Peter Vandenberghe, MD, PhD, Lucienne Michaux, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3118.
https://doi.org/10.1182/blood.V112.11.3118.3118
Published: 2008
Journal Articles

MicroRNA signatures in Genetic Subtypes of T-Cell Acute Lymphoblastic Leukemia.

Pieter Van Vlierberghe, Bruce Poppe, Nadine Van Roy, MD, PhD, Tom Taghon, PhD, Jean Plum, MD, PhD, Barbara Cauwelier, Dominik L.D. Selleslag, MD, Pierre Heimann, Peter Vandenberghe, Nicole Dastugue, Eric Delabesse, PhD, Carine Gervais, Marie-Jose Gregoire, Marie-Joelle Mozzicconacci, Christine Lefebvre, Jules P.P. Meijerink, Jessica Buijs-Gladdines, Barbara De Moerloose, Yves Benoit, Frank Speleman
Journal: Blood
Blood (2008) 112 (11): 3360.
https://doi.org/10.1182/blood.V112.11.3360.3360
Published: 2008