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Steven Goossens
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Journal Articles

A Dual Role of SOX11 Expression in the Formation of T-Cell Acute Lymphoblastic Leukemia in Mouse Models

André De Almeida, Sara T'Sas, Els Van Ammel, Pieter Van Vlierberghe, Tim Pieters, Steven Goossens
Journal: Blood
Blood (2023) 142 (Supplement 1): 1406.
https://doi.org/10.1182/blood-2023-179584
Published: 2023
Journal Articles

PDGFR-β As a New Therapeutic Target in T-Cell Acute Lymphoblastic Leukemia

Stien De Coninck, Renate De Smedt, Beatrice Lintermans, Steven Goossens, Pieter Van Vlierberghe
Journal: Blood
Blood (2022) 140 (Supplement 1): 11513–11514.
https://doi.org/10.1182/blood-2022-168556
Published: 2022
Journal Articles

SOX11 Functions As an Oncogene in Lmo2-Driven T-Cell Lymphoblastic Leukemia (T-ALL)

André De Almeida, Tim Pieters, Sara T'Sas, Steven Goossens, Pieter Van Vlierberghe
Journal: Blood
Blood (2021) 138 (Supplement 1): 1136.
https://doi.org/10.1182/blood-2021-149471
Published: 2021
Journal Articles

Aging of Preleukemic Thymocytes Drives CpG Island Hypermethylation in T-Cell Acute Lymphoblastic Leukemia

Juliette Roels, Morgan Thénoz, Bronisława Szarzyńska, Mattias Landfors, Stien De Coninck, Lisa Demoen, Lien Provez, Anna Kuchmiy, Steven Strubbe, Lindy Reunes, Tim Pieters, PhD, Filip Matthijssens, PhD, Wouter Van Loocke, Tim Lammens, PhD, Barbara De Moerloose, MD PhD, Marc R. Mansour, MD PhD, Utpal Dave, MD, Steven Goossens, PhD, David J. Curtis, MBBS,PhD, Tom Taghon, PhD, Małgorzata Dawidowska, PhD, Sofie Degerman, PhD, Pieter Van Vlierberghe, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-138501
Published: 2020
Journal Articles

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. Carmichael, Jueqiong Wang, Thao Nguyen, Oluseyi Kolawole, Aissa Benyoucef, Charlotte De Mazière, Anna R. Milne, Sona Samuel, Kevin Gillinder, Soroor Hediyeh-zadeh, Anh N. Q. Vo, Yizhou Huang, Kathy Knezevic, William R. L. McInnes, Benjamin J. Shields, Helen Mitchell, Matthew E. Ritchie, Tim Lammens, Beatrice Lintermans, Pieter Van Vlierberghe, Nicholas C. Wong, Katharina Haigh, Julie A. I. Thoms, Emma Toulmin, David J. Curtis, Ethan P. Oxley, Ross A. Dickins, Dominik Beck, Andrew Perkins, Matthew P. McCormack, Melissa J. Davis, Geert Berx, Johannes Zuber, John E. Pimanda, Benjamin T. Kile, Steven Goossens, Jody J. Haigh
Journal: Blood
Blood (2020) 136 (8): 957–973.
https://doi.org/10.1182/blood.2019002548
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Beatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Anne Uyttebroeck, Peter Vandenberghe, Roberta La Starza, Cristina Mecucci, Tim Lammens, Nadine Van Roy, Barbara De Moerloose, João T. Barata, Tom Taghon, Steven Goossens, Pieter Van Vlierberghe
Journal: Blood
Blood (2020) 135 (19): 1685–1695.
https://doi.org/10.1182/blood.2019003880
Published: 2020
Includes: Supplemental data
Journal Articles

ZEB2 and LMO2 Drive Immature T-Cell Lymphoblastic Leukemia Via Distinct Oncogenic Mechanisms

Steven Goossens, PhD, Jueqiong Wang, PhD, Cedric Tremblay, PhD, Pieter Van Vlierberghe, PhD, Geert Berx, PhD, Tom Taghon, PhD, Jody J Haigh, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3916.
https://doi.org/10.1182/blood-2018-99-111104
Published: 2018
Journal Articles

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Sara El Ashkar, Juerg Schwaller, Tim Pieters, Steven Goossens, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Sabine Juge, Nancy Boeckx, Alan Engelman, Pieter Van Vlierberghe, Zeger Debyser, Jan De Rijck
Journal: Blood
Blood (2018) 131 (1): 95–107.
https://doi.org/10.1182/blood-2017-05-786962
Published: 2018
Includes: Supplemental data
Journal Articles

Genetic Activation and Therapeutic Targeting of PIM1 in T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Renate De Smedt, MSc, Sofie Peirs, PhD, Julie Morscio, PhD, Juliette Roels, MSc, Steven Goossens, PhD, Aurore Touzart, MD, Anne Uyttebroeck, Nadine Van Roy, PhD, Tim Lammens, PhD, Lara Mussolin, PhD, Elizabeth Macyntire, MD PhD, Peter Vandenberghe, MD PhD, Pieter Van Vlierberghe, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1445.
https://doi.org/10.1182/blood.V130.Suppl_1.1445.1445
Published: 2017
Journal Articles

Novel oncogenic noncoding mutations in T-ALL

Steven Goossens, Pieter Van Vlierberghe
Journal: Blood
Blood (2017) 129 (24): 3140–3142.
https://doi.org/10.1182/blood-2017-04-773242
Published: 2017
Journal Articles

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven Goossens, Sofie Peirs, Wouter Van Loocke, Jueqiong Wang, Mina Takawy, Filip Matthijssens, Stefan E. Sonderegger, Katharina Haigh, Thao Nguyen, Niels Vandamme, Magdaline Costa, Catherine Carmichael, Filip Van Nieuwerburgh, Dieter Deforce, Oded Kleifeld, David J. Curtis, Geert Berx, Pieter Van Vlierberghe, Jody J. Haigh
Journal: Blood
Blood (2017) 129 (8): 981–990.
https://doi.org/10.1182/blood-2016-06-721191
Published: 2017
Includes: Supplemental data
Journal Articles

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Jin Li, Tamara Riedt, Steven Goossens, Carmen Carrillo García, Sabrina Szczepanski, Maria Brandes, Tim Pieters, Linne Dobrosch, Ines Gütgemann, Natalie Farla, Enrico Radaelli, Paco Hulpiau, Nikhil Mallela, Holger Fröhlich, Roberta La Starza, Caterina Matteucci, Tong Chen, Peter Brossart, Cristina Mecucci, Danny Huylebroeck, Jody J. Haigh, Viktor Janzen
Journal: Blood
Blood (2017) 129 (4): 460–472.
https://doi.org/10.1182/blood-2016-05-714659
Published: 2017
Includes: Supplemental data
Journal Articles

Oncogenic ZEB2 Activation Drives Sensitivity Towards LSD1 Inhibition in T-Cell Acute Lymphoblastic Leukemia

Steven Goossens, PhD, Sofie Peirs, MSc, Geert Berx, PhD, Pieter Van Vlierberghe, PhD, Jody J. Haigh, PhD
Journal: Blood
Blood (2016) 128 (22): 4027.
https://doi.org/10.1182/blood.V128.22.4027.4027
Published: 2016
Journal Articles

The EMT Modulator SNAI1 Drives AML Development Via Its Interaction with the Chromatin Modulator LSD1

Catherine L Carmichael, PhD, Steven Goossens, PhD, Jueqiong Wang, PhD, Thao Nguyen, PhD, Katharina Haigh, Geert Berx, PhD, Benjamin Kile, PhD, Jody J Haigh, PhD
Journal: Blood
Blood (2016) 128 (22): 2688.
https://doi.org/10.1182/blood.V128.22.2688.2688
Published: 2016
Journal Articles

Cyclin D2 Overexpression Recapitulates Mantle Cell Lymphoma in Mice

Tim Pieters, PhD, Steven Goossens, PhD, Sara T'Sas, Geert Berx, PhD, Jody J. Haigh, PhD, Pieter Van Vlierberghe, Prof
Journal: Blood
Blood (2016) 128 (22): 1748.
https://doi.org/10.1182/blood.V128.22.1748.1748
Published: 2016
Journal Articles

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie Peirs, Filip Matthijssens, Steven Goossens, Inge Van de Walle, Katia Ruggero, Charles E. de Bock, Sandrine Degryse, Kirsten Canté-Barrett, Delphine Briot, Emmanuelle Clappier, Tim Lammens, Barbara De Moerloose, Yves Benoit, Bruce Poppe, Jules P. Meijerink, Jan Cools, Jean Soulier, Terence H. Rabbitts, Tom Taghon, Frank Speleman, Pieter Van Vlierberghe
Journal: Blood
Blood (2014) 124 (25): 3738–3747.
https://doi.org/10.1182/blood-2014-05-574566
Published: 2014
Includes: Supplemental data
Journal Articles

Zeb2-Defficiency in the Adult Murine Hematopoietic Precursor Cells Leads to Differentiation Defects in Multiple Hematopoietic Lineages and a Myeloproliferative-Like Phenotype

Tamara Riedt, Steven Goossens, PhD, Ines Gütgemann, MD, Carmen Carrillo-Garcia, PhD, Hichem D Gallala, PhD, Holger Fröhlich, PhD, Peter Brossart, MD, Dany Huylebroeck, PhD, Jody J Haigh, PhD, Viktor Janzen, MD
Journal: Blood
Blood (2012) 120 (21): 1199.
https://doi.org/10.1182/blood.V120.21.1199.1199
Published: 2012
Journal Articles

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Steven Goossens, Viktor Janzen, Sonia Bartunkova, Tomomasa Yokomizo, Benjamin Drogat, Mihaela Crisan, Katharina Haigh, Eve Seuntjens, Lieve Umans, Tamara Riedt, Pieter Bogaert, Lieven Haenebalcke, Geert Berx, Elaine Dzierzak, Danny Huylebroeck, Jody J. Haigh
Journal: Blood
Blood (2011) 117 (21): 5620–5630.
https://doi.org/10.1182/blood-2010-08-300236
Published: 2011
Includes: Supplemental data
Journal Articles

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin Drogat, Joanna Kalucka, Laura Gutiérrez, Hamida Hammad, Steven Goossens, Morvarid Farhang Ghahremani, Sonia Bartunkova, Katharina Haigh, Kim Deswarte, Omar Nyabi, Michael Naessens, Napoleone Ferrara, Ursula Klingmüller, Bart N. Lambrecht, Andras Nagy, Sjaak Philipsen, Jody J. Haigh
Journal: Blood
Blood (2010) 116 (12): 2141–2151.
https://doi.org/10.1182/blood-2010-01-264143
Published: 2010
Includes: Supplemental data