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Journal Articles

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Julie A. I. Thoms, Peter Truong, Shruthi Subramanian, Kathy Knezevic, Gregory Harvey, Yizhou Huang, Janith A. Seneviratne, Daniel R. Carter, Swapna Joshi, Joanna Skhinas, Diego Chacon, Anushi Shah, Ineke de Jong, Dominik Beck, Berthold Göttgens, Jonas Larsson, Jason W. H. Wong, Fabio Zanini, John E. Pimanda

Blood (2021) 138 (16): 1441–1455.

https://doi.org/10.1182/blood.2020009707

Published: 2021

Includes: Supplemental data

Journal Articles

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Blood (2020) 136 (8): 957–973.

https://doi.org/10.1182/blood.2019002548

Published: 2020

Includes: Supplemental data

Journal Articles

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

Blood (2016) 128 (15): 1928–1939.

https://doi.org/10.1182/blood-2016-02-697870

Published: 2016

Includes: Supplemental data

Journal Articles

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML

Blood (2015) 126 (23): 710.

https://doi.org/10.1182/blood.V126.23.710.710

Published: 2015

Journal Articles

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms, Nurul A. Yakob, Jason W. H. Wong, Kathy Knezevic, John E. Pimanda, Richard B. Lock

Blood (2015) 125 (2): 273–283.

https://doi.org/10.1182/blood-2014-05-576470

Published: 2015

Includes: Supplemental data

Journal Articles

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

Liat Goldberg, Marloes R. Tijssen, Yehudit Birger, Rebecca L. Hannah, Sarah J. Kinston, Judith Schütte, Dominik Beck, Kathy Knezevic, Ginette Schiby, Jasmine Jacob-Hirsch, Anat Biran, Yoel Kloog, Guido Marcucci, Clara D. Bloomfield, Peter D. Aplan, John E. Pimanda, Berthold Göttgens, Shai Izraeli

Blood (2013) 122 (15): 2694–2703.

https://doi.org/10.1182/blood-2013-01-477133

Published: 2013

Includes: Supplemental data

Journal Articles

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

Dominik Beck, Julie A. I. Thoms, Dilmi Perera, Judith Schütte, Ashwin Unnikrishnan, Kathy Knezevic, Sarah J. Kinston, Nicola K. Wilson, Tracey A. O’Brien, Berthold Göttgens, Jason W. H. Wong, John E. Pimanda

Blood (2013) 122 (14): e12–e22.

https://doi.org/10.1182/blood-2013-03-490425

Published: 2013

Includes: Supplemental data

Journal Articles

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

Blood (2013) 121 (12): 2289–2300.

https://doi.org/10.1182/blood-2012-07-446120

Published: 2013

Includes: Supplemental data

Journal Articles

Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia

Blood (2012) 120 (21): 3525.

https://doi.org/10.1182/blood.V120.21.3525.3525

Published: 2012

Journal Articles

Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells

Ashu Kumari, Laura A Richards, Georg Jonquieres, Kathy Knezevic, BSc (Hons), Rosemary O'Brien, Christine E Napier, Jonathon Marks-Bluth, Hilda Pickett, John E Pimanda, MD, PhD, Karen L MacKenzie

Blood (2012) 120 (21): 980.

https://doi.org/10.1182/blood.V120.21.980.980

Published: 2012

Journal Articles

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

Julie A. I. Thoms, Yehudit Birger, Sam Foster, Kathy Knezevic, Yael Kirschenbaum, Vashe Chandrakanthan, Georg Jonquieres, Dominik Spensberger, Jason W. Wong, S. Helen Oram, Sarah J. Kinston, Yoram Groner, Richard Lock, Karen L. MacKenzie, Berthold Göttgens, Shai Izraeli, John E. Pimanda

Blood (2011) 117 (26): 7079–7089.

https://doi.org/10.1182/blood-2010-12-317990

Published: 2011

Includes: Supplemental data

Journal Articles

Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors

Josette-Renée Landry, Nicolas Bonadies, Sarah Kinston, Kathy Knezevic, Nicola K. Wilson, S. Helen Oram, Mary Janes, Sandie Piltz, Michelle Hammett, Jacinta Carter, Tina Hamilton, Ian J. Donaldson, Georges Lacaud, Jonathan Frampton, George Follows, Valerie Kouskoff, Berthold Göttgens

Blood (2009) 113 (23): 5783–5792.

https://doi.org/10.1182/blood-2008-11-187757

Published: 2009

Includes: Supplemental data

Journal Articles

Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code

John E. Pimanda, Wan Y. I. Chan, Nicola K. Wilson, Aileen M. Smith, Sarah Kinston, Kathy Knezevic, Mary E. Janes, Josette-Renée Landry, Anja Kolb-Kokocinski, Jonathan Frampton, David Tannahill, Katrin Ottersbach, George A. Follows, Georges Lacaud, Valerie Kouskoff, Berthold Göttgens

Blood (2008) 112 (12): 4512–4522.

https://doi.org/10.1182/blood-2008-05-157560

Published: 2008

Includes: Supplemental data

Journal Articles

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver

Josette-Renée Landry, Sarah Kinston, Kathy Knezevic, Marella F.T.R. de Bruijn, Nicola Wilson, Wade T. Nottingham, Michael Peitz, Frank Edenhofer, John E. Pimanda, Katrin Ottersbach, Berthold Göttgens

Blood (2008) 111 (6): 3005–3014.

https://doi.org/10.1182/blood-2007-07-098830

Published: 2008

Includes: Supplemental data

Journal Articles

Genome-Wide Computational Screen for Blood Stem Cell Enhancers Integrates RUNX1 and the BMP Signaling Pathway into the SCL Transcriptional Network.

John E. Pimanda, FRACP, FRCPA, PhD, Ian J. Donaldson, PhD, Marella F. Bruijn, PhD, Sarah J. Kinston, BSc, Kathy Knezevic, BSc, Liz Huckle, BSc, Sandie Piltz, Josette-Renee Landry, PhD, Anthony R. Green, FRCP, FRCPath, PhD, David Tannahill, PhD, Berthold Gottgens, PhD

Blood (2006) 108 (11): 4196.

https://doi.org/10.1182/blood.V108.11.4196.4196

Published: 2006

Journal Articles

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl –/– phenotype

Wan Y. I. Chan, George A. Follows, Georges Lacaud, John E. Pimanda, Josette-Renee Landry, Sarah Kinston, Kathy Knezevic, Sandie Piltz, Ian J. Donaldson, Laure Gambardella, Fred Sablitzky, Anthony R. Green, Valerie Kouskoff, Berthold Göttgens

Blood (2006) 109 (5): 1908–1916.

https://doi.org/10.1182/blood-2006-05-023226

Published: 2006

Includes: Supplemental data

Journal Articles

Transcriptional Regulation of the LMO2 T-Cell Leukaemia Oncogene.

Josette-Renée Landry, Sarah Kinston, Kathy Knezevic, Anthony R. Green, Berthold Göttgens

Blood (2005) 106 (11): 2728.

https://doi.org/10.1182/blood.V106.11.2728.2728

Published: 2005

Journal Articles

Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells

Josette-Renée Landry, Sarah Kinston, Kathy Knezevic, Ian J. Donaldson, Anthony R. Green, Berthold Göttgens

Blood (2005) 106 (8): 2680–2687.

https://doi.org/10.1182/blood-2004-12-4755

Published: 2005

Includes: Supplemental data

Journal Articles

Genome-Wide Identification of Cis-Regulatory Sequences Controlling Blood and Endothelial Development.

Berthold Göttgens, Ian J. Donaldson, Michael Chapman, Sarah Kinston, Josette Renée Landry, Kathy Knezevic, Sandie Piltz, Noel Buckley, Anthony Green

Blood (2004) 104 (11): 1616.

https://doi.org/10.1182/blood.V104.11.1616.1616

Published: 2004

NARROW

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia

Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors

Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver

Genome-Wide Computational Screen for Blood Stem Cell Enhancers Integrates RUNX1 and the BMP Signaling Pathway into the SCL Transcriptional Network.

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl –/– phenotype

Transcriptional Regulation of the LMO2 T-Cell Leukaemia Oncogene.

Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells

Genome-Wide Identification of Cis-Regulatory Sequences Controlling Blood and Endothelial Development.

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American Society of Hematology

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American Society of Hematology

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