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Benjamin T. Kile
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Journal Articles

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. Carmichael, Jueqiong Wang, Thao Nguyen, Oluseyi Kolawole, Aissa Benyoucef, Charlotte De Mazière, Anna R. Milne, Sona Samuel, Kevin Gillinder, Soroor Hediyeh-zadeh, Anh N. Q. Vo, Yizhou Huang, Kathy Knezevic, William R. L. McInnes, Benjamin J. Shields, Helen Mitchell, Matthew E. Ritchie, Tim Lammens, Beatrice Lintermans, Pieter Van Vlierberghe, Nicholas C. Wong, Katharina Haigh, Julie A. I. Thoms, Emma Toulmin, David J. Curtis, Ethan P. Oxley, Ross A. Dickins, Dominik Beck, Andrew Perkins, Matthew P. McCormack, Melissa J. Davis, Geert Berx, Johannes Zuber, John E. Pimanda, Benjamin T. Kile, Steven Goossens, Jody J. Haigh
Journal: Blood
Blood (2020) 136 (8): 957–973.
https://doi.org/10.1182/blood.2019002548
Published: 2020
Includes: Supplemental data
Journal Articles

Platelet necrosis mediates ischemic stroke outcome in mice

Frederik Denorme, Bhanu Kanth Manne, Irina Portier, Alicia S. Eustes, Yasuhiro Kosaka, Benjamin T. Kile, Matthew T. Rondina, Robert A. Campbell
Journal: Blood
Blood (2020) 135 (6): 429–440.
https://doi.org/10.1182/blood.2019002124
Published: 2020
Includes: Supplemental data
Journal Articles

Shared roles for Scl and Lyl1 in murine platelet production and function

Sung K. Chiu, Stephanie L. Orive, Mitchell J. Moon, Jesslyn Saw, Sarah Ellis, Benjamin T. Kile, Yizhou Huang, Diego Chacon, John E. Pimanda, Dominik Beck, Justin R. Hamilton, Cedric S. Tremblay, David J. Curtis
Journal: Blood
Blood (2019) 134 (10): 826–835.
https://doi.org/10.1182/blood.2019896175
Published: 2019
Includes: Supplemental data
Journal Articles

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson
Journal: Blood
Blood (2018) 132 (2): 197–209.
https://doi.org/10.1182/blood-2017-11-816355
Published: 2018
Includes: Supplemental data
Journal Articles

Apoptosis in megakaryocytes and platelets: the life and death of a lineage

Kate McArthur, Stephane Chappaz, Benjamin T. Kile
Journal: Blood
Blood (2018) 131 (6): 605–610.
https://doi.org/10.1182/blood-2017-11-742684
Published: 2018
Journal Articles

The Genomic Landscape of Childhood and Adult Acute Erythroid Leukemia

Ilaria Iacobucci, PhD, Ji Wen, PhD, Manja Meggendorfer, PhD, Catherine Carmichael, John K Choi, MD, Katherine Masih, Yongjin Li, PhD, Debbie Payne, Daisuke Tomizawa, MD, PhD, Nobutaka Kiyokawa, MD PhD, Laura J. Janke, PhD, Thomas B. Alexander, MD MPH, Stanley Pounds, PhD, Lei Shi, PhD, Marcus Valentine, PhD, Giuseppe Basso, Franco Locatelli, MD, Shirley Kham Kow Yin, MD, Allen Yeoh Eng Juh, MD, Ries E Rhonda, Elliot Stieglitz, MD, Andrew Wei, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Richard D'Andrea, PhD, Benjamin T. Kile, Jinghui Zhang, PhD, Mignon L. Loh, MD, Soheil Meshinchi, MD PhD, Torsten Haferlach, MD, Charles Mullighan, MBBS, MSc, MD
Journal: Blood
Blood (2016) 128 (22): 39.
https://doi.org/10.1182/blood.V128.22.39.39
Published: 2016
Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Cecile Thirant, PhD, Cecile K Lopez, Cathy Ignacimouttou, M'Boyba Diop, Lou Le Mouël, MD, Clarisse Thiollier, MD PhD, Aurelie Siret, Philippe Dessen, Zakia Aid, Julie Riviere, PhD, Philippe Rameau, Celine Lefebvre, Mehdi Khaled, PhD, Guy Leverger, MD, Paola Fabiola Ballerini, MDPhD, Arnaud Petit, MD PhD, Hana Raslova, PhD, Catherine Carmichael, Benjamin T. Kile, PhD, Eric Soler, PhD, John Crispino, PhD, Christian Wichmann, MD, Camille Lobry, PhD, Francoise Pfumio, PhD, Juerg Schwaller, MD, Nathalie M. Droin, PhD, William Vainchenker, MD PhD, Olivier A. Bernard, PhD, Sebastien Malinge, PhD, Thomas Mercher, PhD
Journal: Blood
Blood (2016) 128 (22): 572.
https://doi.org/10.1182/blood.V128.22.572.572
Published: 2016
Journal Articles

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Jesse W. Rowley, Stéphane Chappaz, Aurélie Corduan, Mark M. W. Chong, Robert Campbell, Amanda Khoury, Bhanu Kanth Manne, Jeremy G. T. Wurtzel, James V. Michael, Lawrence E. Goldfinger, Michele M. Mumaw, Marvin T. Nieman, Benjamin T. Kile, Patrick Provost, Andrew S. Weyrich
Journal: Blood
Blood (2016) 127 (14): 1743–1751.
https://doi.org/10.1182/blood-2015-07-661371
Published: 2016
Includes: Supplemental data
Journal Articles

Extended Platelet In Vivo Survival Results in Exhausted Platelets

Irina Pleines, Marion Lebois, Amanda E.-L. Au, Rachael M. Lane, Katya J. Henley, Jason Corbin, Ping Cannon, Kate E Jarman, Sarah Ellis, Shaun P Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson
Journal: Blood
Blood (2015) 126 (23): 416.
https://doi.org/10.1182/blood.V126.23.416.416
Published: 2015
Journal Articles

Regulation of Platelet Lifespan in the Presence and Absence of TPO Signaling

Marion Lebois, Mark R. Dowling, Philip D. Hodgkin, Benjamin T. Kile, Warren S. Alexander, Emma C. Josefsson
Journal: Blood
Blood (2015) 126 (23): 11.
https://doi.org/10.1182/blood.V126.23.11.11
Published: 2015
Journal Articles

Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans

Irina Pleines, PhD, Joanne Woods, PhD, Ernest Turro, PhD, Nicola Foad, PhD, Stephane Chappaz, PhD, Rachael M. Lane, Harriet Manning, Galina Schevzov, PhD, Sarah K Westbury, Andrew D Mumford, Remi Favier, MD, Peter Gunning, PhD, Willem H. Ouwehand, MDPhDFRCPath FMedSci #, Marloes R Tijssen, PhD, Benjamin T Kile, PhD
Journal: Blood
Blood (2014) 124 (21): 571.
https://doi.org/10.1182/blood.V124.21.571.571
Published: 2014
Journal Articles

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

Brief Report
Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben, Emma C. Josefsson, Lachlan W. Whitehead, Kelly L. Rogers, Anna Liakhovitskaia, Gordon K. Smyth, Benjamin T. Kile, Alexander Medvinsky, Warren S. Alexander, Douglas J. Hilton, Samir Taoudi
Journal: Blood
Blood (2014) 124 (17): 2725–2729.
https://doi.org/10.1182/blood-2014-02-559468
Published: 2014
Includes: Supplemental data
Journal Articles

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Zhi-Jian Liu, Karin M. Hoffmeister, Zhongbo Hu, Donald E. Mager, Sihem Ait-Oudhia, Marlyse A. Debrincat, Irina Pleines, Emma C. Josefsson, Benjamin T. Kile, Joseph Italiano, Jr, Haley Ramsey, Renata Grozovsky, Peter Veng-Pedersen, Chaitanya Chavda, Martha Sola-Visner
Journal: Blood
Blood (2014) 123 (22): 3381–3389.
https://doi.org/10.1182/blood-2013-06-508200
Published: 2014
Includes: Supplemental data
Journal Articles

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263)

Jianlin Qiao, Simone M. Schoenwaelder, Kylie D. Mason, Huy Tran, Amanda K. Davis, Zane S. Kaplan, Shaun P. Jackson, Benjamin T. Kile, Robert K. Andrews, Andrew W. Roberts, Elizabeth E. Gardiner
Journal: Blood
Blood (2013) 121 (8): 1479–1481.
https://doi.org/10.1182/blood-2012-12-467415
Published: 2013
Journal Articles

Bacteria differentially induce degradation of Bcl-x L , a survival protein, by human platelets

Bjoern F. Kraemer, Robert A. Campbell, Hansjörg Schwertz, Zechariah G. Franks, Adriana Vieira de Abreu, Katharina Grundler, Benjamin T. Kile, Bijaya K. Dhakal, Matthew T. Rondina, Walter H. A. Kahr, Matthew A. Mulvey, Robert C. Blaylock, Guy A. Zimmerman, Andrew S. Weyrich
Journal: Blood
Blood (2012) 120 (25): 5014–5020.
https://doi.org/10.1182/blood-2012-04-420661
Published: 2012
Includes: Supplemental data
Journal Articles

Radioulnar Synostosis-Hematology (RUS-H) Syndrome: Description of the New Syndrome and Comparison to Similar Syndromes

Evangelista E Jessie, BA, Mary M. Ruisi, MD, Daniel Green, MD, Rachel Burt, PhD, Jaclyn Davis, MD, Regina A. Macatangay, MD, Farid Boulad, MD, Shivani Shah, MBBS, Brenda Oiyemhonlan, MD, MPH, MHSA, Benjamin T. Kile, PhD, James B Bussel, MD
Journal: Blood
Blood (2012) 120 (21): 1100.
https://doi.org/10.1182/blood.V120.21.1100.1100
Published: 2012
Journal Articles

Hematopoietic Overexpression of the ETS Family Transcription Factor Erg, or the Oncogenic Fusion Protein TLS-ERG, Induces Erythro-Megakaryocytic Leukemia

Catherine L Carmichael, PhD, Donald Metcalf, Katya J. Henley, Elizabeth A Kruse, PhD, Ladina Di Rago, Sandra Mifsud, Jian Zhong Tang, PhD, Warren S. Alexander, Benjamin T. Kile
Journal: Blood
Blood (2012) 120 (21): 1283.
https://doi.org/10.1182/blood.V120.21.1283.1283
Published: 2012
Journal Articles

Platelet Production Occurs Independently of Both the Intrinsic and Extrinsic Apoptosis Pathways

Emma C. Josefsson, Deborah L. Burnett, Marlyse A. Debrincat, Katya J. Henley, Rachael M. Lane, Marion Lebois, Lorraine A. O'Reilly, Marc Pellegrini, Simon P. Preston, Ben A. Croker, Donald Metcalf, Andreas Strasser, Benjamin T. Kile
Journal: Blood
Blood (2012) 120 (21): 389.
https://doi.org/10.1182/blood.V120.21.389.389
Published: 2012
Journal Articles

A Novel DNM2 Mutation Displaying Embryonic Lethality and Impaired Transferrin Uptake Identified in a Mouse ENU Mutagenesis Screen for Genes Perturbing Erythropoiesis

Fiona C Brown, BSc, Michael Collett, BSc, Phillip J Robinson, PhD, James C Whisstock, PhD, Douglas J. Hilton, Benjamin T. Kile, Stephen M Jane, FRACP, FRCPA, MBBS, PhD, David J. Curtis, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 608.
https://doi.org/10.1182/blood.V120.21.608.608
Published: 2012
Journal Articles

Activation of the NLRP1 Inflammasome Induces the Pyroptotic Death of Hematopoietic Progenitor Cells

Seth L. Masters, Mordechay Gerlic, Donald Metcalf, Simon P. Preston, Marc Pellegrini, Joanne A. O'Donnell, Kate McArthur, Tracey M. Baldwin, Stephane Chevrier, Cameron J. Nowell, Louise H. Cengia, Katya J. Henley, Janelle E. Collinge, Daniel L. Kastner, Lionel Feigenbaum, Douglas J. Hilton, Warren S. Alexander, Ben A. Croker, Benjamin T. Kile
Journal: Blood
Blood (2012) 120 (21): 1213.
https://doi.org/10.1182/blood.V120.21.1213.1213
Published: 2012