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Gordon K. Smyth
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Journal Articles

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

Yuqing Yang, Andrew J. Kueh, Zoe L. Grant, Waruni Abeysekera, Alexandra L. Garnham, Stephen Wilcox, Craig D. Hyland, Ladina Di Rago, Don Metcalf, Warren S. Alexander, Leigh Coultas, Gordon K. Smyth, Anne K. Voss, Tim Thomas
Journal: Blood
Blood (2022) 139 (6): 845–858.
https://doi.org/10.1182/blood.2021013954
Published: 2022
Includes: Supplemental data
Journal Articles

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M. McRae, Alexandra L. Garnham, Yifang Hu, Matthew T. Witkowski, Mark A. Corbett, Mathew P. Dixon, Rose E. May, Bilal N. Sheikh, William Chiang, Andrew J. Kueh, Tan A. Nguyen, Kevin Man, Renee Gloury, Brandon J. Aubrey, Antonia Policheni, Ladina Di Rago, Warren S. Alexander, Daniel H. D. Gray, Andreas Strasser, Edwin D. Hawkins, Stephen Wilcox, Jozef Gécz, Axel Kallies, Matthew P. McCormack, Gordon K. Smyth, Anne K. Voss, Tim Thomas
Journal: Blood
Blood (2019) 133 (16): 1729–1741.
https://doi.org/10.1182/blood-2018-07-860726
Published: 2019
Includes: Supplemental data
Journal Articles

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Reema Jain, Julie M. Sheridan, Antonia Policheni, Melanie Heinlein, Luke C. Gandolfo, Grant Dewson, Gordon K. Smyth, Stephen N. Sansom, Nai Yang Fu, Jane E. Visvader, Georg A. Holländer, Andreas Strasser, Daniel H. D. Gray
Journal: Blood
Blood (2017) 130 (23): 2504–2515.
https://doi.org/10.1182/blood-2017-03-771576
Published: 2017
Includes: Supplemental data
Journal Articles

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Brandon J Aubrey, MBBS, FRACP, FRCPA, Ana Janic, PhD, Yunshun Chen, PhD, Gordon K Smyth, PhD, Andrew J Kueh, PhD, Stephen Wilcox, PhD, Margs S Brennan, Lin Tai, Daniel HD Gray, PhD, Charis Teh, PhD, Ann Lin, Catherine Chang, Lorraine A O'Reilly, PhD, Marco J Herold, PhD, Andreas Strasser, MSc, PhD FAA, Gemma L Kelly, PhD
Journal: Blood
Blood (2016) 128 (22): 1545.
https://doi.org/10.1182/blood.V128.22.1545.1545
Published: 2016
Journal Articles

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

Bilal N. Sheikh, Stanley C. W. Lee, Farrah El-Saafin, Hannah K. Vanyai, Yifang Hu, Swee Heng Milon Pang, Stephanie Grabow, Andreas Strasser, Stephen L. Nutt, Warren S. Alexander, Gordon K. Smyth, Anne K. Voss, Tim Thomas
Journal: Blood
Blood (2015) 125 (12): 1910–1921.
https://doi.org/10.1182/blood-2014-08-594655
Published: 2015
Includes: Supplemental data
Journal Articles

Reversible Tumor Suppression By Ikzf1/Ikaros in Mouse Models of BCR-ABL1+ B-ALL

Matthew T Witkowski, Yifang Hu, Luisa Cimmino, PhD, Mark D McKenzie, PhD, Grace J Liu, Gordon K Smyth, PhD, Ross A Dickins, PhD
Journal: Blood
Blood (2014) 124 (21): 288.
https://doi.org/10.1182/blood.V124.21.288.288
Published: 2014
Journal Articles

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

Brief Report
Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben, Emma C. Josefsson, Lachlan W. Whitehead, Kelly L. Rogers, Anna Liakhovitskaia, Gordon K. Smyth, Benjamin T. Kile, Alexander Medvinsky, Warren S. Alexander, Douglas J. Hilton, Samir Taoudi
Journal: Blood
Blood (2014) 124 (17): 2725–2729.
https://doi.org/10.1182/blood-2014-02-559468
Published: 2014
Includes: Supplemental data
Journal Articles

Polycomb repressive complex 2 (PRC2) suppresses Eμ- myc lymphoma

Stanley C. W. Lee, Belinda Phipson, Craig D. Hyland, Huei San Leong, Rhys S. Allan, Aaron Lun, Douglas J. Hilton, Stephen L. Nutt, Marnie E. Blewitt, Gordon K. Smyth, Warren S. Alexander, Ian J. Majewski
Journal: Blood
Blood (2013) 122 (15): 2654–2663.
https://doi.org/10.1182/blood-2013-02-484055
Published: 2013
Includes: Supplemental data
Journal Articles

Mechanisms of Tumor Suppression by the Hematopoietic Transcription Factor PU.1.

Mark D McKenzie, Luisa Cimmino, Yifang Hu, Ladina Di Rago, Sandra Mifsud, Donald Metcalf, Gordon K Smyth, Ross Dickins
Journal: Blood
Blood (2012) 120 (21): 2432.
https://doi.org/10.1182/blood.V120.21.2432.2432
Published: 2012
Journal Articles

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

Ashley P. Ng, Stephen J. Loughran, Donald Metcalf, Craig D. Hyland, Carolyn A. de Graaf, Yifang Hu, Gordon K. Smyth, Douglas J. Hilton, Benjamin T. Kile, Warren S. Alexander
Journal: Blood
Blood (2011) 118 (9): 2454–2461.
https://doi.org/10.1182/blood-2011-03-344739
Published: 2011
Includes: Supplemental data
Journal Articles

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

François-Xavier Hubert, Sarah A. Kinkel, Gayle M. Davey, Belinda Phipson, Scott N. Mueller, Adrian Liston, Anna I. Proietto, Ping Z. F. Cannon, Simon Forehan, Gordon K. Smyth, Li Wu, Christopher C. Goodnow, Francis R. Carbone, Hamish S. Scott, William R. Heath
Journal: Blood
Blood (2011) 118 (9): 2462–2472.
https://doi.org/10.1182/blood-2010-06-286393
Published: 2011
Includes: Supplemental data
Journal Articles

Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Lina Happo, Mark S. Cragg, Belinda Phipson, Jon M. Haga, Elisa S. Jansen, Marco J. Herold, Grant Dewson, Ewa M. Michalak, Cassandra J. Vandenberg, Gordon K. Smyth, Andreas Strasser, Suzanne Cory, Clare L. Scott
Journal: Blood
Blood (2010) 116 (24): 5256–5267.
https://doi.org/10.1182/blood-2010-04-280818
Published: 2010
Includes: Supplemental data
Journal Articles

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

Ian J. Majewski, Matthew E. Ritchie, Belinda Phipson, Jason Corbin, Miha Pakusch, Anja Ebert, Meinrad Busslinger, Haruhiko Koseki, Yifang Hu, Gordon K. Smyth, Warren S. Alexander, Douglas J. Hilton, Marnie E. Blewitt
Journal: Blood
Blood (2010) 116 (5): 731–739.
https://doi.org/10.1182/blood-2009-12-260760
Published: 2010
Includes: Supplemental data
Journal Articles

Platelets Play a Protective Role in Erythrocytic Stage Malaria Infection.

Simon J. Foote, MBBS, BMedSci, PhD, Brendan J. McMorran, Karen E. Drysdale, Carolyn de Graaf, Gordon K. Smyth, Warren S. Alexander, PhD
Journal: Blood
Blood (2009) 114 (22): MRG-1.
https://doi.org/10.1182/blood.V114.22.MRG-1.MRG-1
Published: 2009
Journal Articles

Blimp1 is limiting for transformation in a mouse plasmacytoma model

Kathy D'Costa, Dianne Emslie, Donald Metcalf, Gordon K. Smyth, Alexander Karnowski, Axel Kallies, Stephen L. Nutt, Lynn M. Corcoran
Journal: Blood
Blood (2009) 113 (23): 5911–5919.
https://doi.org/10.1182/blood-2008-08-172866
Published: 2009
Includes: Supplemental data
Journal Articles

The molecular signature of CD8 + T cells undergoing deletional tolerance

Ian A. Parish, Sudha Rao, Gordon K. Smyth, Torsten Juelich, Gareth S. Denyer, Gayle M. Davey, Andreas Strasser, William R. Heath
Journal: Blood
Blood (2009) 113 (19): 4575–4585.
https://doi.org/10.1182/blood-2008-10-185223
Published: 2009
Includes: Supplemental data