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Journal Articles

Pathogenic Mechanisms of DDX41 Mutations in the Development of Myeloid Malignancies

Ayana Kon, Masahiro Marshall Nakagawa, Keisuke Kataoka, Nobuyuki Kakiuchi, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa

Blood (2023) 142 (Supplement 1): 952.

https://doi.org/10.1182/blood-2023-184519

Published: 2023

Journal Articles

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Blood (2022) 140 (Supplement 1): 4022–4023.

https://doi.org/10.1182/blood-2022-158748

Published: 2022

Journal Articles

Functional Roles of DDX41 Mutations in the Development of Myeloid Malignancies

Ayana Kon, Masahiro Marshall Nakagawa, Keisuke Kataoka, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa

Blood (2021) 138 (Supplement 1): 150.

https://doi.org/10.1182/blood-2021-152269

Published: 2021

Journal Articles

CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo

Ari Itoh-Nakadai, PhD, Yoriko Saito, MD, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Takehisa Matsumoto, PhD, Masashi Matsuda, PhD, Takashi Watanabe, PhD, Mikako Shirouzu, Osamu Ohara, PhD, Haruhiko Koseki, MD PhD, Leonard Shultz, PhD, Fumihiko Ishikawa, MDPhD

Blood (2020) 136 (Supplement 1): 35–36.

https://doi.org/10.1182/blood-2020-142228

Published: 2020

Journal Articles

Functional Characterization of Compound DDX41 Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies

Ayana Kon, MD PhD, Masahiro Marshall Nakagawa, MDPhD, Ryosaku Inagaki, MSc, Keisuke Kataoka, MD PhD, Hideki Makishima, MD PhD, Yotaro Ochi, MD, Manabu Nakayama, PhD, Haruhiko Koseki, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD

Blood (2020) 136 (Supplement 1): 21–22.

https://doi.org/10.1182/blood-2020-143318

Published: 2020

Journal Articles

Variant Pcgf-PRC1 Regulates Susceptibility of PRC2 Mediated H3K27me3 to Safeguard B Cell Fate of Hematopoietic Stem/Progenitor Cells

Junichiro Takano, MD, Yaeko Nakajima-Takagi, PhD, Shinsuke Ito, PhD, Haruhiko Koseki, MD PhD, Atsushi Iwama, MD PhD, Tomokatsu Ikawa, PhD

Blood (2019) 134 (Supplement_1): 3717.

https://doi.org/10.1182/blood-2019-129518

Published: 2019

Journal Articles

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Shiro Tara, Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Tomoyuki Tanaka, Daisuke Shinoda, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Ichiro Manabe, Hirotaka Matsui, Haruhiko Koseki, Vivian J. Bardwell, Atsushi Iwama

Blood (2018) 132 (23): 2470–2483.

https://doi.org/10.1182/blood-2018-01-827964

Published: 2018

Includes: Supplemental data

Journal Articles

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Yusuke Isshiki, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 2597.

https://doi.org/10.1182/blood-2018-99-117831

Published: 2018

Journal Articles

Biological Characterization of the U2af1 S34F Mutation in the Pathogenesis of Myelodysplasia

Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Masahiro Nakagawa, MD PhD, Keisuke Kataoka, MD PhD, Masashi Sanada, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Seishi Ogawa, MD PhD

Blood (2018) 132 (Supplement 1): 3080.

https://doi.org/10.1182/blood-2018-99-117453

Published: 2018

Journal Articles

Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development

Raksha Shrestha, MD, DiMM, Maie Koichiro, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Olivier Bernard, Hirotaka Matsui, MD PhD, Yaeko Nakajima-Takagi, PhD, Takayasu Kato, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD, Shigeru Chiba, MD PhD

Blood (2018) 132 (Supplement 1): 1330.

https://doi.org/10.1182/blood-2018-99-112352

Published: 2018

Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 100.

https://doi.org/10.1182/blood-2018-99-117741

Published: 2018

Journal Articles

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Gloria Jih, PhD, Jennifer Chase, PhD, Yile Zhou, MD PhD, Ann Friedman, BS, Xiaomin Feng, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Kenichi Nishioka, PhD, Gang Huang, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 1270.

https://doi.org/10.1182/blood-2018-99-117367

Published: 2018

Journal Articles

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells

Haruko Shima, Emi Takamatsu-Ichihara, Mika Shino, Kazutsune Yamagata, Takuo Katsumoto, Yukiko Aikawa, Shuhei Fujita, Haruhiko Koseki, Issay Kitabayashi

Blood (2018) 131 (16): 1833–1845.

https://doi.org/10.1182/blood-2017-05-787226

Published: 2018

Includes: Supplemental data

Journal Articles

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice

Ayana Kon, Satoshi Yamazaki, Yasuhito Nannya, Keisuke Kataoka, Yasunori Ota, Masahiro Marshall Nakagawa, Kenichi Yoshida, Yusuke Shiozawa, Maiko Morita, Tetsuichi Yoshizato, Masashi Sanada, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa

Blood (2018) 131 (6): 621–635.

https://doi.org/10.1182/blood-2017-01-762393

Published: 2018

Includes: Supplemental data

Journal Articles

Stag2 regulates Hematopoietic Differentiation and Self-Renewal

Yotaro Ochi, MD, Ayana Kon, MD PhD, Kenichi Yoshida, MD PhD, Keisuke Kataoka, Masahiro Marshall Nakagawa, Hideki Makishima, MD,PhD,FACP., Manabu Nakayama, Haruhiko Koseki, Akifumi Takaori-Kondo, MD PhD, Seishi Ogawa, MD PhD

Blood (2017) 130 (Supplement 1): 790.

https://doi.org/10.1182/blood.V130.Suppl_1.790.790

Published: 2017

Journal Articles

Srsf2 P95H Mutation Causes Impaired Stem Cell Repopulation and Hematopoietic Differentiation in Mice

Ayana Kon, MD PhD, Satoshi Yamazaki, PhD, Yasunori Ota, MD PhD, Keisuke Kataoka, MD PhD, Yusuke Shiozawa, MD, Maiko Morita, MS, Tetsuichi Yoshizato, MD, Masashi Sanada, MD PhD, Kenichi Yoshida, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Hiromitsu Nakauchi, MD PhD, Seishi Ogawa, MD PhD

Blood (2015) 126 (23): 1649.

https://doi.org/10.1182/blood.V126.23.1649.1649

Published: 2015

Journal Articles

Role of the Polycomb Gene Bcor in Hematopoiesis

Tomoyuki Tanaka, MD, Yaeko Nakajima-Takagi, PhD, Sha Si, Atsunori Saraya, MS, Sone Hirohito, MDPhD, Haruhiko Koseki, MD PhD, Atsushi Iwama, MD, PhD

Blood (2014) 124 (21): 4312.

https://doi.org/10.1182/blood.V124.21.4312.4312

Published: 2014

Journal Articles

Histone Acetylation Mediated by Brd1 Is Crucial for Cd8 Gene Activation during Early Thymocyte Development

Yuta Mishima, PhD, Changshan Wang, PhD, Satoru Miyagi, PhD, Atsunori Saraya, MS, Hiroyuki Hosokawa, PhD, Naoto Yamaguchi, PhD, Toshinori Nakayama, MD PhD, Haruhiko Koseki, MD PhD, Ichiro Taniuchi, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 1576.

https://doi.org/10.1182/blood.V124.21.1576.1576

Published: 2014

Journal Articles

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

Changshan Wang, Goro Sashida, Atsunori Saraya, Reiko Ishiga, Shuhei Koide, Motohiko Oshima, Kyoichi Isono, Haruhiko Koseki, Atsushi Iwama

Blood (2014) 123 (21): 3336–3343.

https://doi.org/10.1182/blood-2013-12-544544

Published: 2014

Includes: Supplemental data

Journal Articles

Role Of Sf3b1 On Hematopoiesis

Manabu Matsunawa, MD, Ryo Yamamoto, MD, PhD, Masashi Sanada, MD, Aiko Sato, PhD, Yusuke Shiozawa, MD, Kenichi Yoshida, MD, Yasunobu Nagata, MD, Ayana Kon, MD, Tetsuichi Yoshizato, MD, Makoto Otsu, MD, PhD, Kyoichi Isono, Haruhiko Koseki, MD, PhD, Hiromitsu Nakauchi, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2013) 122 (21): 600.

https://doi.org/10.1182/blood.V122.21.600.600

Published: 2013

NARROW

Pathogenic Mechanisms of DDX41 Mutations in the Development of Myeloid Malignancies

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Functional Roles of DDX41 Mutations in the Development of Myeloid Malignancies

CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo

Functional Characterization of Compound DDX41 Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies

Variant Pcgf-PRC1 Regulates Susceptibility of PRC2 Mediated H3K27me3 to Safeguard B Cell Fate of Hematopoietic Stem/Progenitor Cells

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Biological Characterization of the U2af1 S34F Mutation in the Pathogenesis of Myelodysplasia

Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice

Stag2 regulates Hematopoietic Differentiation and Self-Renewal

Srsf2 P95H Mutation Causes Impaired Stem Cell Repopulation and Hematopoietic Differentiation in Mice

Role of the Polycomb Gene Bcor in Hematopoiesis

Histone Acetylation Mediated by Brd1 Is Crucial for Cd8 Gene Activation during Early Thymocyte Development

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

Role Of Sf3b1 On Hematopoiesis

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American Society of Hematology

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American Society of Hematology

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