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Marco J. Herold
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Journal Articles

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Clinical Trials & Observations
Donia M. Moujalled, Fiona C. Brown, Chong Chyn Chua, Michael A. Dengler, Giovanna Pomilio, Natasha S. Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S. Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J. Herold, Guillaume Lessene, Jerry M. Adams, David C. S. Huang, Andrew W. Roberts, Piers Blombery, Andrew H. Wei
Journal: Blood
Blood (2023) 141 (6): 634–644.
https://doi.org/10.1182/blood.2022016090
Published: 2023
Includes: Supplemental data
Journal Articles

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

Victoria Y Ling, Sebastien Jacquelin, Jasmin Straube, Rohit Haldar, Yashaswini Janardhanan, Leanne T Cooper, Claudia Bruedigam, Emily Cooper, William Godfrey, Siok-Keen Tey, Lars Bullinger, Marco J Herold, Jonathan Baell, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2021) 138 (Supplement 1): 2241.
https://doi.org/10.1182/blood-2021-148379
Published: 2021
Journal Articles

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Donia M Moujalled, PhD, Fiona C Brown, PhD, Giovanna Pomilio, Natasha S Anstee, PhD, Veronique Litalien, Ella R Thompson, PhD BSc, Thomas Morley, Sarah MacRaild, Chong C Chua, MBBS, BMedSc, SéBastien Banquet, PhD, Maia Chanrion, Ana-Leticia Maragno, PhD, Marie Schoumacher, Marco J Herold, PhD, Guillaume Lessene, PhD, Olivier Geneste, PhD, David C.S. Huang, MBBS MRCP PhD, Andrew W Roberts, MBBS, Piers Blombery, MBBS, Andrew Wei, MBBS,PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-136872
Published: 2020
Journal Articles

Loss of IRF4 Results in Multiple Myeloma Cell Apoptosis through the Transcriptional up-Regulation of the BH3-Only Proteins Bmf and BIM

Pasquale L. Fedele, MBBS PhDFRACP FRCPA, Yang Liao, PhD, Jianan Gong, PhD, Mark van Delft, PhD, Michael S.Y. Low, MBBS PhDFRACP FRCPA, Lin Tai, PhD, Marco J Herold, PhD, Julie Tellier, PhD, George Grigoriadis, MBBS PhDFRACP FRCPA, David C.S. Huang, MBBS MRCP PhD, Wei Shi, PhD, Stephen Nutt, PhD, Simon Willis, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3103.
https://doi.org/10.1182/blood-2019-126417
Published: 2019
Journal Articles

Identification of Genetic Pathways Controlling Resistance to Standard Combination Chemotherapy in Acute Myeloid Leukemia

Victoria Y Ling, MBBS, William Godfrey, Sebastien Jacquelin, PhD, Jasmin Straube, PhD, Leanne T Cooper, Claudia Bruedigam, PhD, Siok-Keen Tey, MBBS PhDFRACP FRCPA, Lars Bullinger, MD, Marco J Herold, Megan Bywater, PhD, Steven W. Lane, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2771.
https://doi.org/10.1182/blood-2018-99-115729
Published: 2018
Journal Articles

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas Strasser, Grant Dewson, Gemma L. Kelly, Marco J. Herold
Journal: Blood
Blood (2018) 132 (15): 1573–1583.
https://doi.org/10.1182/blood-2018-06-859405
Published: 2018
Includes: Supplemental data
Journal Articles

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Brandon J Aubrey, MBBS, FRACP, FRCPA, Ana Janic, PhD, Yunshun Chen, PhD, Gordon K Smyth, PhD, Andrew J Kueh, PhD, Stephen Wilcox, PhD, Margs S Brennan, Lin Tai, Daniel HD Gray, PhD, Charis Teh, PhD, Ann Lin, Catherine Chang, Lorraine A O'Reilly, PhD, Marco J Herold, PhD, Andreas Strasser, MSc, PhD FAA, Gemma L Kelly, PhD
Journal: Blood
Blood (2016) 128 (22): 1545.
https://doi.org/10.1182/blood.V128.22.1545.1545
Published: 2016
Journal Articles

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D. Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C. S. Huang
Journal: Blood
Blood (2016) 128 (14): 1834–1844.
https://doi.org/10.1182/blood-2016-03-704908
Published: 2016
Includes: Supplemental data
Journal Articles

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

Eleonora Ottina, Francesca Grespi, Denise Tischner, Claudia Soratroi, Stephan Geley, Andreas Ploner, Holger M. Reichardt, Andreas Villunger, Marco J. Herold
Journal: Blood
Blood (2012) 119 (25): 6032–6042.
https://doi.org/10.1182/blood-2011-12-399089
Published: 2012
Includes: Supplemental data
Journal Articles

Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Lina Happo, Mark S. Cragg, Belinda Phipson, Jon M. Haga, Elisa S. Jansen, Marco J. Herold, Grant Dewson, Ewa M. Michalak, Cassandra J. Vandenberg, Gordon K. Smyth, Andreas Strasser, Suzanne Cory, Clare L. Scott
Journal: Blood
Blood (2010) 116 (24): 5256–5267.
https://doi.org/10.1182/blood-2010-04-280818
Published: 2010
Includes: Supplemental data