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Michael A. Dengler
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Journal Articles

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Clinical Trials & Observations
Donia M. Moujalled, Fiona C. Brown, Chong Chyn Chua, Michael A. Dengler, Giovanna Pomilio, Natasha S. Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S. Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J. Herold, Guillaume Lessene, Jerry M. Adams, David C. S. Huang, Andrew W. Roberts, Piers Blombery, Andrew H. Wei
Journal: Blood
Blood (2023) 141 (6): 634–644.
https://doi.org/10.1182/blood.2022016090
Published: 2023
Includes: Supplemental data
Journal Articles

The Flavonoid Brusatol Induces Apoptosis in Aggressive Lymphoma Cells and Exhibits Synergistic Effect with Venetoclax

Marta M. Szmyra, Sandra Haingartner, Sonja Jantscher, Katrin Pansy, Barbara Uhl, Hildegard T. Greinix, Peter Neumeister, Eva Bernhart, Christine Beham-Schmid, Michael A. Dengler, Burkhard Klösch, Alexander J.A. Deutsch
Journal: Blood
Blood (2022) 140 (Supplement 1): 4945–4946.
https://doi.org/10.1182/blood-2022-166678
Published: 2022
Journal Articles

Clonal hematopoiesis, myeloid disorders and BAX -mutated myelopoiesis in patients receiving venetoclax for CLL

Clinical Trials & Observations
Piers Blombery, Thomas E. Lew, Michael A. Dengler, Ella R. Thompson, Victor S. Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka M. Handunnetti, Dennis A. Carney, David A. Westerman, Constantine S. Tam, Jerry M. Adams, Andrew H. Wei, David C. S. Huang, John F. Seymour, Andrew W. Roberts, Mary Ann Anderson
Journal: Blood
Blood (2022) 139 (8): 1198–1207.
https://doi.org/10.1182/blood.2021012775
Published: 2022
Includes: Supplemental data
Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X. Shi, Michael A. Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S. Anstee, Boris Reljić, Sarah S. Gabriel, Tirta M. Djajawi, Chris D. Riffkin, Brandon J. Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David A. Stroud, Ashish Bajel, Ruth M. Kluck, Steven W. Lane, Marie Schoumacher, Sébastien Banquet, Ian J. Majewski, Andreas Strasser, Andrew W. Roberts, David C. S. Huang, Fiona C. Brown, Gemma L. Kelly, Andrew H. Wei
Journal: Blood
Blood (2021) 137 (20): 2721–2735.
https://doi.org/10.1182/blood.2020010167
Published: 2021
Includes: Supplemental data
Journal Articles

BAX-Mutated Clonal Hematopoiesis in Patients on Long-Term Venetoclax for Relapsed/Refractory Chronic Lymphocytic Leukemia

Piers Blombery, MBBS, Ella R Thompson, PhD BSc, Xiangting Chen, PhD, Tamia Nguyen, Mary Ann Anderson, MBBS, PhD FRACP, FRCPA, David Alan Westerman, MBBS, FRCPA, FRACP, John F. Seymour, Constantine S. Tam, MBBS, MD, Michael A Dengler, PhD, David C.S. Huang, MBBS MRCP PhD, Andrew Wei, MBBS,PhD, Andrew W Roberts, MBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-137775
Published: 2020
Journal Articles

Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells

Simon Heine, MSc, Elisabeth Silkenstedt, MD, Michael A Dengler, PhD, Kleih Markus, MSc, German Ott, MD, Neus Giménez Carabaza, B.Pharm, Colomer Dolors, PhD, Heiko van der Kuip, PhD, Walter E. Aulitzky, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2811.
https://doi.org/10.1182/blood.V130.Suppl_1.2811.2811
Published: 2017
Journal Articles

The Phenotype High Noxa mRNA/Low NOXA Protein Levels Constitutes a Critical Achilles Heel Of Mantle Cell Lymphoma (MCL) Cells

Michael A. Dengler, Andrea Weilbacher, Matthias Gutekunst, Annette M. Staiger, Heike Horn, German Ott, MD, Heiko van der Kuip, Walter E. Aulitzky
Journal: Blood
Blood (2013) 122 (21): 644.
https://doi.org/10.1182/blood.V122.21.644.644
Published: 2013
Journal Articles

Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN)

Michael A. Dengler, Matthias Gutekunst, Stephanie Kopacz, Heike Horn, Ute Hofmann, Matthias Schwab, German Ott, MD, Heiko van der Kuip, Walter E. Aulitzky
Journal: Blood
Blood (2011) 118 (21): 1656.
https://doi.org/10.1182/blood.V118.21.1656.1656
Published: 2011
Journal Articles

Glucocorticoids Inhibit Cell Death Induced by Oncogenic Stress After Imatinib Withdrawal In TKI Resistant p190Bcr/Abl Overexpressing Cells

Michael A. Dengler, Annette M. Staiger, Ute Hofmann, Matthias Gutekunst, Heiko van der Kuip, Walter E. Aulitzky, MD
Journal: Blood
Blood (2010) 116 (21): 3150.
https://doi.org/10.1182/blood.V116.21.3150.3150
Published: 2010