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Rachel Thijssen
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Journal Articles

Venetoclax Dose Escalation Rapidly Activates a BAFF/BCL-2 Survival Axis in Chronic Lymphocytic Leukemia

Meng-Xiao Luo, Tania Tan, Marie Trussart, Annika Poch, Minh-Hanh Thi Nguyen, Terence P. Speed, Damien G Hicks, Esther Bandala-Sanchez, Hongke Peng, Stephane Chappaz, Charlotte Slade, Daniel T Utzschneider, Rachel M Koldej, David Ritchie, Andreas Strasser, Rachel Thijssen, Matthew E Ritchie, Constantine Si Lun Tam, Geoffrey J Lindeman, David Ching Siang Huang, Professor, Thomas E Lew, Mary Ann Anderson, Andrew W Roberts, Charis E Teh, Daniel H D Gray
Journal: Blood
Blood blood.2024024341.
https://doi.org/10.1182/blood.2024024341
Published: 2024
Includes: Supplemental data
Journal Articles

Venetoclax Has Potent Efficacy in NPM1 mutated AML with Acquired Resistance Associated with Either Perturbed Pro-Survival Signalling or NPM1 wild-Type Populations

Chong Chyn Chua, Natasha Anstee, Christoffer Flensburg, Charis Teh, Adam Ivey, Noorul Amin, Rachel Thijssen, Stefan K. Bohlander, Purvi M. Kakadia, Zhen Xu, Chun Yew Fong, Stephen Ting, Sun Loo, Ing Soo Tiong, Daniel Gray, Shaun Fleming, Nadia Davidson, Andrew W. Roberts, Ian Majewski, Andrew H. Wei, Fiona C. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 423.
https://doi.org/10.1182/blood-2023-185321
Published: 2023
Journal Articles

Depletion of the Mitochondrial E3 Ligase MARCH5 Induces Synthetic Lethality to BCL2 Inhibitor (Venetoclax) Therapy in Cell Lines Representative of Diverse Blood Cancers

Thomas E Lew, Mark Van Delft, Chris Riffkin, Georgiou Angela, Christine White, Yin Yuan, Jahja Michelle, Mary Ann Anderson, Rachel Thijssen, David C.S. Huang, Mark A Dawson, Andrew W. Roberts
Journal: Blood
Blood (2023) 142 (Supplement 1): 415.
https://doi.org/10.1182/blood-2023-184392
Published: 2023
Journal Articles

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L. Garnham, Jafar S. Jabbari, Hongke Peng, Thomas E. Lew, Charis E. Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M. Djajawi, Constantine S. Tam, John F. Seymour, Piers Blombery, Daniel H.D. Gray, Ian J. Majewski, Matthew E. Ritchie, Andrew W. Roberts, David C.S. Huang
Journal: Blood
Blood (2022) 140 (20): 2127–2141.
https://doi.org/10.1182/blood.2022016040
Published: 2022
Includes: Supplemental data
Journal Articles

Overcoming resistance hurdles

Rachel Thijssen
Journal: Blood
Blood (2022) 139 (6): 804–805.
https://doi.org/10.1182/blood.2021014430
Published: 2022
Journal Articles

Deep Profiling of Chronic Lymphocytic Leukaemia (CLL) and Healthy Immune Cells By Mass Cytometry Resolves Impacts of Venetoclax Pressure

Charis E Teh, Tania Tan, Marie Trussart, Mengxiao Luo, Rachel Thijssen, Andrew W Roberts, David C.S. Huang, Terence Speed, Mary Ann Anderson, Daniel Gray
Journal: Blood
Blood (2021) 138 (Supplement 1): 3710.
https://doi.org/10.1182/blood-2021-149938
Published: 2021
Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X. Shi, Michael A. Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S. Anstee, Boris Reljić, Sarah S. Gabriel, Tirta M. Djajawi, Chris D. Riffkin, Brandon J. Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David A. Stroud, Ashish Bajel, Ruth M. Kluck, Steven W. Lane, Marie Schoumacher, Sébastien Banquet, Ian J. Majewski, Andreas Strasser, Andrew W. Roberts, David C. S. Huang, Fiona C. Brown, Gemma L. Kelly, Andrew H. Wei
Journal: Blood
Blood (2021) 137 (20): 2721–2735.
https://doi.org/10.1182/blood.2020010167
Published: 2021
Includes: Supplemental data
Journal Articles

High Clonal Complexity of Resistance Mechanisms Occurring at Progression after Single-Agent Targeted Therapy Strategies in Chronic Lymphocytic Leukemia

Ella R Thompson, PhD BSc, Tamia Nguyen, Yamuna Kankanige, PhD, Mary Ann Anderson, MBBS, PhD FRACP, FRCPA, Sasanka M. Handunnetti, MBBS, FRACP, FRCPA, Rachel Thijssen, PhD, Paul Sung-Hao Yeh, MBBS, FRCPA, FRACP, Constantine S. Tam, MBBS, MD, John F. Seymour, Andrew W Roberts, MBBS, David Alan Westerman, MBBS, FRCPA, FRACP, Piers Blombery, MBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–16.
https://doi.org/10.1182/blood-2020-137411
Published: 2020
Journal Articles

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

Piers Blombery, Ella R. Thompson, Tamia Nguyen, Richard W. Birkinshaw, Jia-nan Gong, Xiangting Chen, Michelle McBean, Rachel Thijssen, Thomas Conway, Mary Ann Anderson, John F. Seymour, David A. Westerman, Peter E. Czabotar, David C. S. Huang, Andrew W. Roberts
Journal: Blood
Blood (2020) 135 (10): 773–777.
https://doi.org/10.1182/blood.2019004205
Published: 2020
Includes: Supplemental data
Journal Articles

Detection of Multiple Recurrent Novel BCL2 Mutations Co-Occurring with BCL2 Gly101Val in Patients with Chronic Lymphocytic Leukemia on Long Term Venetoclax

Piers Blombery, MBBS, Ella Thompson, PhD BSc, Tamia Nguyen, Xiangting Chen, PhD, Michelle McBean, Richard W Birkinshaw, PhD, Peter E Czabotar, PhD, Rachel Thijssen, Mary Ann Anderson, MBBS, PhD FRACP, FRCPA, John F. Seymour, MBBS, PhD FRACP, David Alan Westerman, MBBS, FRCPA, FRACP, David C.S. Huang, MBBS MRCP PhD, Andrew W. Roberts, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 171.
https://doi.org/10.1182/blood-2019-125457
Published: 2019
Journal Articles

Cross-Talk between Cytokine and NF-ĸb Signaling in the CLL Microenvironment Can Affect Sensitivity for Venetoclax

Marco Haselager, MSc, Rachel Thijssen, Arnon P. Kater, Eric Eldering
Journal: Blood
Blood (2019) 134 (Supplement_1): 5449.
https://doi.org/10.1182/blood-2019-126788
Published: 2019
Journal Articles

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, MBBS, Mary Ann Anderson, FRACP, FRCPA, MBBS, Jianan Gong, PhD, Rachel Thijssen, Richard W Birkinshaw, PhD, Ella Thompson, PhD, Charis E Teh, PhD, Tamia Nguyen, Zhen Xu, PhD, Christoffer Flensburg, PhD, Thomas Lew, MBBS, Ian Majewski, PhD, Daniel Gray, David Alan Westerman, MBBS, FRCPA, FRACP, Constantine S. Tam, MBBS (Hons), MD FRACP, FRCPA, John F. Seymour, MBBS, PhD, Peter E Czabotar, PhD, David Huang, Andrew W. Roberts, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): LBA-7.
https://doi.org/10.1182/blood-2018-120761
Published: 2018
Journal Articles

Cross-Talk between Cytokine and NF-ĸB Signaling in the CLL Microenvironment Can Affect Sensitivity for Venetoclax

Rachel Thijssen, Marco Haselager, Elaine Willmore, Simon Mackay, Arnon P. Kater, MD, Eric Eldering
Journal: Blood
Blood (2017) 130 (Supplement 1): 4306.
https://doi.org/10.1182/blood.V130.Suppl_1.4306.4306
Published: 2017
Journal Articles

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia

Rachel Thijssen, Johanna ter Burg, Brett Garrick, Gregor G. W. van Bochove, Jennifer R. Brown, Stacey M. Fernandes, María Solé Rodríguez, Jean-Marie Michot, Michael Hallek, Barbara Eichhorst, Hans Christian Reinhardt, Johanna Bendell, Ingrid A. M. Derks, Roel J. W. van Kampen, Kristen Hege, Marie José Kersten, Torsten Trowe, Ellen H. Filvaroff, Eric Eldering, Arnon P. Kater
Journal: Blood
Blood (2016) 128 (4): 574–583.
https://doi.org/10.1182/blood-2016-02-700328
Published: 2016
Includes: Supplemental data
Journal Articles

Targeting BCR-Independent Proliferation of CLL Cells

Slinger Erik, PhD, Arnon P. Kater, MD PhD, Rachel Thijssen, MSc, Eric Eldering, PhD
Journal: Blood
Blood (2015) 126 (23): 2916.
https://doi.org/10.1182/blood.V126.23.2916.2916
Published: 2015
Journal Articles

Combined Inhibition of Phosphatidylinositol 3-Kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic Lymphocytic Leukemia Cells Blocks Survival, Adhesion and Proliferation

Rachel Thijssen, Gregor van Bochove, Martin FM de Rooij, Johanna ter Burg, Marcel Spaargaren, PhD, Coumaran Egile, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4691.
https://doi.org/10.1182/blood.V124.21.4691.4691
Published: 2014
Journal Articles

Combined Inhibition of mTOR and DNA-PK Blocks Survival, Adhesion, Proliferation and Chemoresistance in Primary Chronic Lymphocytic Leukemia (CLL) Cells

Rachel Thijssen, Gregor van Bochove, Ingrid AM Derks, Johanna ter Burg, Martin FM de Rooij, Marcel Spaargaren, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1981.
https://doi.org/10.1182/blood.V124.21.1981.1981
Published: 2014
Journal Articles

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Rachel Thijssen, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Katinka Weller, Hermen S Overkleeft, Marinus H.J. Van Oers, MD, PhD, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD
Journal: Blood
Blood (2013) 122 (21): 4188.
https://doi.org/10.1182/blood.V122.21.4188.4188
Published: 2013
Journal Articles

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

Maria Fernanda Pascutti, Margot Jak, Jacqueline M. Tromp, Ingrid A. M. Derks, Ester B. M. Remmerswaal, Rachel Thijssen, Martijn H. A. van Attekum, Gregor G. van Bochove, Dieuwertje M. Luijks, Steven T. Pals, René A. W. van Lier, Arnon P. Kater, Marinus H. J. van Oers, Eric Eldering
Journal: Blood
Blood (2013) 122 (17): 3010–3019.
https://doi.org/10.1182/blood-2012-11-467670
Published: 2013
Includes: Supplemental data