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Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X. Shi, Michael A. Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S. Anstee, Boris Reljić, Sarah S. Gabriel, Tirta M. Djajawi, Chris D. Riffkin, Brandon J. Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David A. Stroud, Ashish Bajel, Ruth M. Kluck, Steven W. Lane, Marie Schoumacher, Sébastien Banquet, Ian J. Majewski, Andreas Strasser, Andrew W. Roberts, David C. S. Huang, Fiona C. Brown, Gemma L. Kelly, Andrew H. Wei
Journal: Blood
Blood (2021) 137 (20): 2721–2735.
https://doi.org/10.1182/blood.2020010167
Published: 2021
Includes: Supplemental data
Journal Articles

Loss of IRF4 Results in Multiple Myeloma Cell Apoptosis through the Transcriptional up-Regulation of the BH3-Only Proteins Bmf and BIM

Pasquale L. Fedele, MBBS PhDFRACP FRCPA, Yang Liao, PhD, Jianan Gong, PhD, Mark van Delft, PhD, Michael S.Y. Low, MBBS PhDFRACP FRCPA, Lin Tai, PhD, Marco J Herold, PhD, Julie Tellier, PhD, George Grigoriadis, MBBS PhDFRACP FRCPA, David C.S. Huang, MBBS MRCP PhD, Wei Shi, PhD, Stephen Nutt, PhD, Simon Willis, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3103.
https://doi.org/10.1182/blood-2019-126417
Published: 2019
Journal Articles

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas Strasser, Grant Dewson, Gemma L. Kelly, Marco J. Herold
Journal: Blood
Blood (2018) 132 (15): 1573–1583.
https://doi.org/10.1182/blood-2018-06-859405
Published: 2018
Includes: Supplemental data
Journal Articles

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Brandon J Aubrey, MBBS, FRACP, FRCPA, Ana Janic, PhD, Yunshun Chen, PhD, Gordon K Smyth, PhD, Andrew J Kueh, PhD, Stephen Wilcox, PhD, Margs S Brennan, Lin Tai, Daniel HD Gray, PhD, Charis Teh, PhD, Ann Lin, Catherine Chang, Lorraine A O'Reilly, PhD, Marco J Herold, PhD, Andreas Strasser, MSc, PhD FAA, Gemma L Kelly, PhD
Journal: Blood
Blood (2016) 128 (22): 1545.
https://doi.org/10.1182/blood.V128.22.1545.1545
Published: 2016
Journal Articles

Evidence for Mutant p53 Gain-of-Function Effects in Normal Haemopoietic Cells and Myc-Driven Lymphoma

Brandon James Aubrey, MBBS, FRACP, FRCPA, Andreas Strasser, PhD, Gemma Kelly, PhD, Lin Tai, Marco Herold, PhD
Journal: Blood
Blood (2014) 124 (21): 3589.
https://doi.org/10.1182/blood.V124.21.3589.3589
Published: 2014