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Ian J. Majewski
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Journal Articles

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L. Garnham, Jafar S. Jabbari, Hongke Peng, Thomas E. Lew, Charis E. Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M. Djajawi, Constantine S. Tam, John F. Seymour, Piers Blombery, Daniel H.D. Gray, Ian J. Majewski, Matthew E. Ritchie, Andrew W. Roberts, David C.S. Huang
Journal: Blood
Blood (2022) 140 (20): 2127–2141.
https://doi.org/10.1182/blood.2022016040
Published: 2022
Includes: Supplemental data
Journal Articles

The crux of Cux1 in myeloid neoplasms

Ian J. Majewski
Journal: Blood
Blood (2021) 138 (9): 743–744.
https://doi.org/10.1182/blood.2021012342
Published: 2021
Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X. Shi, Michael A. Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S. Anstee, Boris Reljić, Sarah S. Gabriel, Tirta M. Djajawi, Chris D. Riffkin, Brandon J. Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David A. Stroud, Ashish Bajel, Ruth M. Kluck, Steven W. Lane, Marie Schoumacher, Sébastien Banquet, Ian J. Majewski, Andreas Strasser, Andrew W. Roberts, David C. S. Huang, Fiona C. Brown, Gemma L. Kelly, Andrew H. Wei
Journal: Blood
Blood (2021) 137 (20): 2721–2735.
https://doi.org/10.1182/blood.2020010167
Published: 2021
Includes: Supplemental data
Journal Articles

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Stefan Fröhling, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, Bob Löwenberg, Andrew W. Roberts, Peter J. M. Valk, Ian J. Majewski
Journal: Blood
Blood (2018) 132 (14): 1526–1534.
https://doi.org/10.1182/blood-2018-05-852566
Published: 2018
Includes: Supplemental data
Journal Articles

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

Mary Ann Anderson, Jing Deng, John F. Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R. Brown, David Westerman, Eric G. Si, Ian J. Majewski, David Segal, Sari L. Heitner Enschede, David C. S. Huang, Matthew S. Davids, Anthony Letai, Andrew W. Roberts
Journal: Blood
Blood (2016) 127 (25): 3215–3224.
https://doi.org/10.1182/blood-2016-01-688796
Published: 2016
Includes: Supplemental data
Journal Articles

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Stanley C. W. Lee, Sarah Miller, Craig Hyland, Maria Kauppi, Marion Lebois, Ladina Di Rago, Donald Metcalf, Sarah A. Kinkel, Emma C. Josefsson, Marnie E. Blewitt, Ian J. Majewski, Warren S. Alexander
Journal: Blood
Blood (2015) 126 (2): 167–175.
https://doi.org/10.1182/blood-2014-12-615898
Published: 2015
Includes: Supplemental data
Journal Articles

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

Sarah A. Kinkel, Roman Galeev, Christoffer Flensburg, Andrew Keniry, Kelsey Breslin, Omer Gilan, Stanley Lee, Joy Liu, Kelan Chen, Linden J. Gearing, Darcy L. Moore, Warren S. Alexander, Mark Dawson, Ian J. Majewski, Alicia Oshlack, Jonas Larsson, Marnie E. Blewitt
Journal: Blood
Blood (2015) 125 (12): 1890–1900.
https://doi.org/10.1182/blood-2014-10-603969
Published: 2015
Includes: Supplemental data
Journal Articles

Polycomb repressive complex 2 (PRC2) suppresses Eμ- myc lymphoma

Stanley C. W. Lee, Belinda Phipson, Craig D. Hyland, Huei San Leong, Rhys S. Allan, Aaron Lun, Douglas J. Hilton, Stephen L. Nutt, Marnie E. Blewitt, Gordon K. Smyth, Warren S. Alexander, Ian J. Majewski
Journal: Blood
Blood (2013) 122 (15): 2654–2663.
https://doi.org/10.1182/blood-2013-02-484055
Published: 2013
Includes: Supplemental data
Journal Articles

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

Ian J. Majewski, Matthew E. Ritchie, Belinda Phipson, Jason Corbin, Miha Pakusch, Anja Ebert, Meinrad Busslinger, Haruhiko Koseki, Yifang Hu, Gordon K. Smyth, Warren S. Alexander, Douglas J. Hilton, Marnie E. Blewitt
Journal: Blood
Blood (2010) 116 (5): 731–739.
https://doi.org/10.1182/blood-2009-12-260760
Published: 2010
Includes: Supplemental data
Journal Articles

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

Catherine L. Carmichael, Ian J. Majewski, Warren S. Alexander, Donald Metcalf, Douglas J. Hilton, Chelsee A. Hewitt, Hamish S. Scott
Journal: Blood
Blood (2009) 113 (9): 1929–1937.
https://doi.org/10.1182/blood-2008-06-161422
Published: 2009
Includes: Supplemental data
Journal Articles

Hls5 regulated erythroid differentiation by modulating GATA-1 activity

Brief Report
Raelene Endersby, Ian J. Majewski, Louise Winteringham, Jennifer G. Beaumont, Amy Samuels, Robin Scaife, Esther Lim, Merlin Crossley, S. Peter Klinken, Jean-Philippe Lalonde
Journal: Blood
Blood (2008) 111 (4): 1946–1950.
https://doi.org/10.1182/blood-2007-04-085746
Published: 2008
Journal Articles

Genes Identified in a Hemopoietic Lineage Switch Influence Transcription.

Louise N. Winteringham, PhD, Raelene Endersby, PhD, Ian J. Majewski, Jennifer Beaumont, Simon Kobelke, Jean-Philippe Lalonde, MD, Svend Peter Klinken, PhD
Journal: Blood
Blood (2007) 110 (11): 1250.
https://doi.org/10.1182/blood.V110.11.1250.1250
Published: 2007