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Journal Articles

Phase 1 Trial of Orelabrutinib in Combination with Rituximab, Methotrexate, and Dexamethasone in Patients with Newly Diagnosed Primary CNS Lymphoma Implementing Bayesian Design for Dose-Seeking

Yan Yuan, Qian Wang, Dongxiao Zhuang, Tianling Ding, Hong Chen, Fengping Zhu, Kang Zheng, Rui Feng, Jiajun Zheng, Xiaoluo Zhang, Zunguo Du, Ping Zhu, Jinsong Wu, Ying Mao, Tong Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 6225.
https://doi.org/10.1182/blood-2023-181427
Published: 2023
Journal Articles

Efficacy and Safety of Clifutinib, a Novel, Highly Selective, Oral FLT3 Inhibitor, in Patients with FLT3-Mutated Relapsed or Refractory Acute Myeloid Leukemia：Updated Results from a Phase I Study

Jie Jin, Huafeng Wang, Wen-Juan Yu, Zheng Ge, Xudong Wei, Yuhua Li, Zhongxing Jiang, Yiqing Li, Xin Du, Linhua Yang, Lie Lin, Jishi Wang, Yazhou Yao, Xiaoping Hu, Jianping Lan, Xiuzhi Deng, Tong Chen, Xianqi Feng, Dengju Li, Ming Hou, Rong Fu, Siyong Huang, Jingbo Wang, Xin Du, Hui Yang, Haiping Yang, Yingzhi Jiang, Zhijie Wang, Deng Li, Bing Liu, Ning Kang, Yulei Zhuang, Yingjun Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4281.
https://doi.org/10.1182/blood-2023-188961
Published: 2023
Journal Articles

Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

Qi Zhang, He Li, Xuelan Chen, Fan Gu, Lanxin Zhang, Lu Zhang, Tong Chen, Qiang Chen, Wentong Meng, Yu Wu, Hong Chang, Ting Liu, Chong Chen, Hongbing Ma, Yu Liu
Journal: Blood
Blood (2023) 142 (17): 1494–1499.
https://doi.org/10.1182/blood.2023020619
Published: 2023
Includes: Supplemental data
Journal Articles

Iron Chelation of Hetrombopag in Aplastic Anemia: A Post Hoc Analysis of a Phase II Study

Wenrui Yang, Xin Zhao, Guangsheng He, Hong Chang, Bing Han, Sujun Gao, Shunqing Wang, Tong Chen, Fei Li, Yi Wang, Xiaoyan Ge, Rong Fu, Zheng Ge, Yingmei Li, Hong Liu, Xinjian Liu, Miao Miao, Liansheng Zhang, Fengkui Zhang
Journal: Blood
Blood (2022) 140 (Supplement 1): 5809–5810.
https://doi.org/10.1182/blood-2022-164560
Published: 2022
Journal Articles

NK Cells Suppress Hyperfunction of CTLs Via ATM-Mediated NKG2D/NKG2DLs Activation in Severe Aplastic Anemia

Congwei Zhong, Tong Chen, Chunyan Liu, Zonghong Shao, Rong Fu
Journal: Blood
Blood (2022) 140 (Supplement 1): 2933–2934.
https://doi.org/10.1182/blood-2022-165116
Published: 2022
Journal Articles

A National, Multicenter, Retrospective Study of Castleman Disease Implementing Cdcn Criteria: 'severe Imcd' Is Indeed Severe

Lu Zhang, Yujun Dong, Hongling Peng, Hao Li, Mingzhi Zhang, Hui-Han Wang, Qinhua Liu, Liping Su, Liye Zhong, Wenjun Wu, Liang Huang, Xiaojing Yan, Lei Fan, Wenjiao Tang, Zhenling Li, Lintao Bi, Yan Li, Guangxun Gao, Li Gao, Ting-Bo Liu, Yongqiang Wei, Yao Liu, Yu Li, Hui Zhou, Chunyan Sun, Wenbin Qian, Dehui Zou, Huilai Zhang, Kaiyang Ding, Xiaobo Wang, Ou Bai, Wenrong Huang, Bing Chen, Lin Yang, Jia Song, Da Gao, Tong Chen, Jun Luo, Shuye Wang, Liangming Ma, Jian Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 3609–3611.
https://doi.org/10.1182/blood-2022-158675
Published: 2022
Journal Articles

Trial in Progress: A Phase 4 Multicenter Study of Brentuximab Vedotin Treatment in Chinese Patients with CD30-Positive Cutaneous T-Cell Lymphoma

Qian Wang, Ming Jiang, Chunlei Zhang, Sheng Wu, Wenhan Jiang, Meng Ji, Tong Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 12044–12045.
https://doi.org/10.1182/blood-2022-166617
Published: 2022
Journal Articles

Clinical Outcomes of CD19 CAR-T-Cell Therapy with Axi-Cel in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) with and without Prior Autologous Stem Cell Transplant

David Tong Chen, Olga Goloubeva, Hanan Alkhaldi, Aaron P. Rapoport, Saurabh Dahiya, Nancy M. Hardy, Djordje Atanackovic, Mehmet Hakan Kocoglu, Forat Lutfi, Jean A. Yared
Journal: Blood
Blood (2022) 140 (Supplement 1): 9526–9527.
https://doi.org/10.1182/blood-2022-158281
Published: 2022
Journal Articles

Preliminary Result of Phase 1 Trial of Orelabrutinib in Combination with Rituximab, Methotrexate, and Dexamethasone in Patients with Newly Diagnosed Primary CNS Lymphoma Implementing Bayesian Design for Dose-Seeking

Yan Yuan, Qian Wang, Dongxiao Zhuang, Tianling Ding, Hong Chen, Fengping Zhu, Kang Zheng, Rui Feng, Jiajun Zheng, Xiaoluo Zhang, Zunguo Du, Ping Zhu, Jinsong Wu, Ying Mao, Tong Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 6629–6630.
https://doi.org/10.1182/blood-2022-159309
Published: 2022
Journal Articles

A Multicenter, Open-Label, Single-Arm, Phase 2 Study to Evaluate the Efficacy and Safety of Hetrombopag in Patients with Severe Aplastic Anemia (SAA)

Fengkui Zhang, Guangxin Peng, Guangsheng He, MD PhD, Hong Chang, Sujun Gao, Xinjian Liu, Tong Chen, MD PhD, Pei Li, Bing Han, Miao Miao, Zheng Ge, MDPhD, Xiaoyan Ge, Fei Li, Yingmei Li, Shunqing Wang, Yi Wang, MD, Yaqi Shen, Yanfei Tai, Tao Zhang, Bo Zhu, Jianjun Zou
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-137319
Published: 2020
Journal Articles

Efficient Enucleation and In Vivo Circulation of Differentiated Human Erythroblasts Derived from Peripheral Blood Mononuclear Cells after Extensive Expansion

Senquan Liu, PhD, Mengyao Wu, PhD, Yongxing Gao, MS, Jiusheng Deng, PhD, John D Roback, MD PhD, Tong Chen, MD PhD, Linzhao Cheng, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-142226
Published: 2020
Journal Articles

Comparison of Subcutaneous Injection Versus Intravenous Infusion of Cytarabine for Induction Therapy in Young Adult Acute Myeloid Leukemia: Results of a Prospective, Multicenter, Noninferiority, Randomized Trial

Huafeng Wang, MD, LU LIU, MD, Jianfeng Zhou, MD PhD, Jianyong Li, MD PhD, Ying Lu, MD, Jianping Shen, MD, Chunyan Ji, MD, Tong Chen, MD PhD, Kang Yu, MD, Hanyun Ren, MD, Yan Li, MD, Dengju Li, MD, Ying Chen, MD, Shaolei Zang, MD, Bin Liang, MD, Sijing Kang, MD, Jinghan Wang, MDPhD, Wei Cheng, PhD, Haitao Meng, MD PhD, Wen-Juan Yu, Yanhong Tong, Honghu Zhu, MD, Jie Jin, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-143426
Published: 2020
Journal Articles

The gut microbial metabolite trimethylamine N -oxide aggravates GVHD by inducing M1 macrophage polarization in mice

Kunpeng Wu, Yan Yuan, Huihui Yu, Xin Dai, Shu Wang, Zhengxu Sun, Fen Wang, He Fei, Qiwang Lin, Hua Jiang, Tong Chen
Journal: Blood
Blood (2020) 136 (4): 501–515.
https://doi.org/10.1182/blood.2019003990
Published: 2020
Includes: Supplemental data
Journal Articles

Elucidating an Essential Role of Promoting Endothelial-to-Hematopoietic Transition By a Key EMT-Regulator ZEB2 Using a Human iPSC-Based Model

Mengyao Wu, Senquan Liu, Linzhao Cheng, PhD, Tong Chen, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3716.
https://doi.org/10.1182/blood-2019-126908
Published: 2019
Journal Articles

The Role of Decreased TIM-3 Expression of Natural Killer Cells in the Immune Pathogenesis of Severe Aplastic Anemia

Rong Fu, Jr., PhD, Shaoxue Ding, MD, Chunyan Liu, Bingnan Liu, Hui Liu, Liu Zhaoyun, Tong Chen, MD, Tian Zhang, Zonghong Shao, MD, Ting Wang
Journal: Blood
Blood (2019) 134 (Supplement_1): 3747.
https://doi.org/10.1182/blood-2019-127769
Published: 2019
Journal Articles

Monocytic Myeloid-Derived Suppress Cells Restore Adipogenic Bone Marrow Microenvironment in Aplastic Anemia By Inhibiting Intra-BM CD8 + T Cells Proliferation

Ying Qu, PhD, Zhengxu Sun, PhD, Yan Yuan, MD PhD, Fen Wang, PhD, Kunpeng Wu, MS, Yunfeng Cheng, MD PhD, Hua Jiang, MD PhD, Tong Chen, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1211.
https://doi.org/10.1182/blood-2019-125059
Published: 2019
Journal Articles

In Vivo flow Cytometry Combined with Intravital Microscopy to Monitor Synchronous Kinetics of Transplanted BM-MNCs in Peripheral Blood and Bone Marrow

Fen Wang, MS, Dan Wei, Yuanzhen Suo, Xi Zhu, Yan Yuan, MD PhD, Hua Jiang, MDPhD, Xunbin Wei, PhD, Tong Chen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3312.
https://doi.org/10.1182/blood-2018-99-114379
Published: 2018
Journal Articles

Myeloid-Derived Suppressor Cells in Immune-Related Bone Marrow Failure: Novel Therapeutic Implication

Ying Qu, PhD, Yan Yuan, MD PhD, Zhengxu Sun, MS, Fen Wang, MS, Pengfei Li, MS, Mengyao Wu, Hua Jiang, MDPhD, Tong Chen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2453.
https://doi.org/10.1182/blood.V130.Suppl_1.2453.2453
Published: 2017
Journal Articles

Human Hematopoietic Progenitor Cells and Erythrocytes Generated from Human iPSCs Lacking CD55

Mengyao Wu, Senquan Liu, Hao Bai, PhD, Yongxing Gao, Rachel Evans, David Sullivan, Tong Chen, MD, Linzhao Cheng, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2204.
https://doi.org/10.1182/blood.V130.Suppl_1.2204.2204
Published: 2017
Journal Articles

Quantities and Functions of NK Cells in Severe Aplastic Anemia

Rong Fu, PhD, Tong Chen, MD, Chunyan Liu, Tian Zhang, Hui Liu, Zonghong Shao, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1173.
https://doi.org/10.1182/blood.V130.Suppl_1.1173.1173
Published: 2017