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Nathalie Grardel
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Journal Articles

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Clinical Trials & Observations
Mathieu Simonin, Loïc Vasseur, Etienne Lengliné, Ludovic Lhermitte, Aurélie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie-Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stéphane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Arnaud Petit, Philippe Rousselot, Jérôme Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (15): 1570–1580.
https://doi.org/10.1182/blood.2023023754
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic alterations and MRD refine risk assessment for KMT2A -rearranged B-cell precursor ALL in adults: a GRAALL study

Rathana Kim, Hugo Bergugnat, Cédric Pastoret, Florence Pasquier, Emmanuel Raffoux, Lise Larcher, Marie Passet, Nathalie Grardel, Eric Delabesse, Susanne Kubetzko, Aurélie Caye-Eude, Claus Meyer, Rolf Marschalek, Marine Lafage-Pochitaloff, Anne Thiebaut-Bertrand, Marie Balsat, Martine Escoffre-Barbe, Sabine Blum, Michael Baumann, Anne Banos, Nicole Straetmans, Maria-Pilar Gallego-Hernanz, Yves Chalandon, Carlos Graux, Jean Soulier, Thibaut Leguay, Mathilde Hunault, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2023) 142 (21): 1806–1817.
https://doi.org/10.1182/blood.2023021501
Published: 2023
Includes: Supplemental data
Journal Articles

NGS-Based Stratification Refines the Risk Stratification in T-ALL and Identifies a Very High-Risk Subgroup of Patients

Mathieu Simonin, Loïc Vasseur, Etienne Lengline, Ludovic Lhermitte, Aurelie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stephane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Herve Dombret, Elizabeth A. Macintyre, Arnaud Petit, Philippe Rousselot, Jerome Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 142 (Supplement 1): 844.
https://doi.org/10.1182/blood-2023-179298
Published: 2023
Journal Articles

Involvement of the JAK-STAT Pathway in the Molecular Landscape of Fusion-Free Myeloid Neoplasms with Eosinophilia

Matthieu Groh, Laurène Fenwarth, Augustin Boudry, Elise Fournier, Alice Marceau-Renaut, Julie Abraham, Marly Barry, Philippe Blanche, Quentin Bodard, Thorsten Braun, Safia Chebrek, Rafael Daltro De Oliveira, Matthieu Decamp, Cécile Audrey Durel, Edouard Forcade, Mathieu Gerfaud-Valentin, Camille Golfier, Clement Gourguechon, Nathalie Grardel, Olivier Kosmider, Mathilde Labro, Sarah Melboucy Belkhir, Fatiha Merabet, Adrien Michon, Nihal Martis, Cécile Morice, Stephane Moreau, Antoine Néel, Franck E. Nicolini, Laurent Pascal, Florence Pasquier, Andrea Pieragostini, Catherine Roche-Lestienne, Philippe Rousselot, Anne Thiebaut, Jean-Francois Viallard, Mathieu Wemeau, Claude Preudhomme, Jean-Emmanuel Kahn, Guillaume Lefèvre, Nicolas Duployez
Journal: Blood
Blood (2023) 142 (Supplement 1): 78.
https://doi.org/10.1182/blood-2023-181250
Published: 2023
Journal Articles

Frontline Consolidation with Nelarabine for Adults with High-Risk T-Cell Acute Lymphoblastic Leukemia. Results of the Graall-2014/T Atriall Phase 2 Study

Nicolas Boissel, Carlos Graux, Francoise Huguet, Florence Pasquier, Aurore Touzart, Thomas Cluzeau, Ludovic Lhermitte, Eric Delabesse, Patrice Chevallier, Mathilde Hunault, Cedric Pastoret, Sebastien Maury, Nathalie Grardel, Martine Escoffre Barbe, Pascal Turlure, Beat Schafer, Marie Balsat, Philippe Rousselot, Thibaut Leguay, Eric Jourdan, Delphine Pranger, Michael Gregor, Emilie Lemasle, Anne Marie Ronchetti, Ana Berceanu, Ingrid Lafon, Madalina Uzunov, Etienne Lengline, Norbert Ifrah, Yves Chalandon, Véronique Lhéritier, Vahid Asnafi, Herve Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 962.
https://doi.org/10.1182/blood-2023-177696
Published: 2023
Journal Articles

Prognostic value and oncogenic landscape of TP53 alterations in adult and pediatric T-ALL

Clinical Trials & Observations
Mathieu Simonin, Guillaume P. Andrieu, Rudy Birsen, Marie Balsat, Guillaume Hypolite, Lucien Courtois, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Françoise Huguet, Yves Chalandon, Yannick Le Bris, Elizabeth Macintyre, Virginie Gandemer, Arnaud Petit, Philippe Rousselot, André Baruchel, Didier Bouscary, Olivier Hermine, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 141 (11): 1353–1358.
https://doi.org/10.1182/blood.2022017755
Published: 2023
Includes: Supplemental data
Journal Articles

Blinatumomab during Consolidation in High-Risk Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL) Adult Patients: A Two-Cohort Comparison within the Graall-2014/B Study

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Mathilde Hunault, Rathana KIM, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Sébastien Maury, Anne Thiebaut-Bertrand, Florence Van Obbergh, Thomas Cluzeau, Martine Escoffre-Barbe, Nicole Straetmans, Johanna Konopacki, Amine Belhabri, Alban Villate, Florence Pasquier, Ioana Vaida, Laurence Sanhes, Magda Alexis, Cedric Pastoret, Mathlide Lamarque, Laure Farnault, Nathalie Grardel, Celine Berthon, Eric Delabesse, Veronique Lheritier, Norbert Ifrah, Carlos Graux, Yves Chalandon, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2022) 140 (Supplement 1): 507–509.
https://doi.org/10.1182/blood-2022-159397
Published: 2022
Journal Articles

In Adults with Ph-Negative Acute Lymphoblastic Leukemia (ALL), Age-Adapted Chemotherapy Intensity and MRD-Driven Transplant Indication Significantly Reduces Treatment-Related Mortality (TRM) and Improves Overall Survival - Results from the Graall-2014 Trial

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Hunault-Berger Mathilde, Carlos Graux, Yves Chalandon, Eric Delabesse, Yosr Hicheri, Patrice Chevallier, Marie Balsat, Cedric Pastoret, Martine Escoffre-Barbe, Florence Pasquier, Jean-Pierre Marolleau, Anne Thiebaut-Bertrand, Anne Huynh, Nathalie Dhedin, Emilie Lemasle, Caroline Bonmati, Sébastien Maury, Gaëlle Guillerm, Anna Berceanu, Urs Schanz, Thomas Cluzeau, Pascal Turlure, Philippe Rousselot, Bernard J.M. De Prijck, Nathalie Grardel, Marie C Bene, Marine Lafage, Norbert Ifrah, Veronique Lheritier, Vahid Asnafi, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2022) 140 (Supplement 1): 112–114.
https://doi.org/10.1182/blood-2022-157903
Published: 2022
Journal Articles

IKZF1 alterations predict poor prognosis in adult and pediatric T-ALL

Clinical Trials & Observations
Mathieu Simonin, Ludovic Lhermitte, Marie-Emilie Dourthe, Etienne Lengliné, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Arnaud Petit, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2021) 137 (12): 1690–1694.
https://doi.org/10.1182/blood.2020007959
Published: 2021
Includes: Supplemental data
Journal Articles

Optical Mapping, a Promising Alternative to Gold Standard Cytogenetic Approaches in Acute Lymphoblastic Leukemias: A Blind Comparison on 10 Patients

Valentin Lestringant, Nicolas Duployez, PharmD, PhD, Dominique Penther, MD, Nathalie Grardel, MD, Anne Lutun, MD, Claude Preudhomme, MD PhD, Michaela West, Joyce Lee, Jean-Pierre Marolleau, MD PhD, Loïc Garçon, Yann Ferret, PharmD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-136257
Published: 2020
Journal Articles

Clinical Spectrum, Long-Term Outcomes and Predictors of Relapse after Imatinib Discontinuation in FIP1L1-Pdgfra-Associated Chronic Eosinophilic Leukemia: Data from 150 Patients

Julien Rohmer, MD, Matthieu Groh, MD, Julie Trichereau, Kewin Panel, Claude Preudhomme, PharmD, PhD, Fanny Legrand, PhD PharmD, Felix Ackermann, MD, Amélie Couteau-Chardon, MD, Mikael Ebbo, MD PhD, Olivier Fain, MD, Lionel Galicier, MD, Mohamed Hamidou, Mathilde Hunault, MD PhD, Etienne Lengline, MD, Catherine Mohr, MD, Franck E Nicolini, MD PhD, Jerome Rey, Louis Terriou, MD, Chafika Morati Hafsaoui, MD, Suzanne Tavitian, MD, Irene Machelart, Katayoun Jondeau, MD, Bertrand Arnulf, Jean-Christophe Ianotto, MD PhD, Jean-Marc Zini, Viviane Dubruille, MD, Francoise Huguet, MD, Borhane Slama, MD, Fabrice Jardin, Didier Adiko, Elise Toussaint, MD, Aurelien Guffroy, MD PhD, Faustine Lhomme, MD PhD, Nathalie Grardel, Cyrielle Gesquieres, Guillaume Lefèvre, MD PhD, Jean Emmanuel Kahn, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 840.
https://doi.org/10.1182/blood-2019-130009
Published: 2019
Journal Articles

PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome

Marie Passet, Nicolas Boissel, François Sigaux, Colombe Saillard, Mario Bargetzi, Ibrahima Ba, Xavier Thomas, Carlos Graux, Yves Chalandon, Thibaut Leguay, Etienne Lengliné, Johanna Konopacki, Samuel Quentin, Eric Delabesse, Marina Lafage-Pochitaloff, Cédric Pastoret, Nathalie Grardel, Vahid Asnafi, Véronique Lhéritier, Jean Soulier, Hervé Dombret, Emmanuelle Clappier
Journal: Blood
Blood (2019) 133 (3): 280–284.
https://doi.org/10.1182/blood-2018-10-882142
Published: 2019
Includes: Supplemental data
Journal Articles

Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia

CME Clinical Trials & Observations
Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi
Journal: Blood
Blood (2018) 131 (3): 289–300.
https://doi.org/10.1182/blood-2017-04-778829
Published: 2018
Includes: Supplemental data
Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) with t(5;14)(q31;q32)/ IL3-IGH Rearrangement and Eosinophilia: A Peculiar IGH BCP-ALL

Benjamin Fournier, Estelle Balducci, PharmD, Nicolas Duployez, PharmD, PhD, Emmanuelle Clappier, PharmD,PhD, Wendy Cuccuini, Elodie Bottolier-Colomb, MD, Denis Caillot, MD, Helene Cave, PharmD, PhD, Aurélie Caye-Eude, PharmD, Eric Delabesse, MD PhD, Coralie Derrieux, PharmD, Nathalie Dhedin, MD, Florent Dumezy, MD, Pascaline Etancelin, PharmD, Odile Fenneteau, MD, Jamilé Frayfer, MD, Antoine Gourmel, MD, Marie Loosveld, MD PhD, Gerard Michel, MD, Nathalie Nadal, Claire-Helene Oudin, Dominique Penther, MD, Isabelle Tigaud, MD, Nathalie Grardel, MD, Marine Lafage, MD, Andre Baruchel, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2572.
https://doi.org/10.1182/blood.V130.Suppl_1.2572.2572
Published: 2017
Journal Articles

Impact of cytogenetic abnormalities in adults with Ph-negative B-cell precursor acute lymphoblastic leukemia

Clinical Trials & Observations
Marina Lafage-Pochitaloff, Laurence Baranger, Mathilde Hunault, Wendy Cuccuini, Christine Lefebvre, Audrey Bidet, Isabelle Tigaud, Virginie Eclache, Eric Delabesse, Chrystèle Bilhou-Nabéra, Christine Terré, Elise Chapiro, Nathalie Gachard, Marie-Joelle Mozziconacci, Geneviève Ameye, Sarah Porter, Nathalie Grardel, Marie C. Béné, Yves Chalandon, Carlos Graux, Françoise Huguet, Véronique Lhéritier, Norbert Ifrah, Hervé Dombret
Journal: Blood
Blood (2017) 130 (16): 1832–1844.
https://doi.org/10.1182/blood-2017-05-783852
Published: 2017
Includes: Supplemental data
Journal Articles

Oncogenetic Risk Classification Based on NOTCH1/FBXW7/RAS/PTEN Mutation Profiles Improves Outcome Prediction in Pediatric T-Cell Acute Lymphoblastic Leukemia, Treated According the Fralle 2000 T Guidelines

Arnaud Petit, MD PhD, Amélie Trinquand, MD, Sylvie Chevret, MD PhD, Paola Fabiola Ballerini, MD PhD, Jean-Michel Cayuela, MD, Nathalie Grardel, MD, Aurore Touzart, MD, Benoit Brethon, MD, Hélène Lapillonne, MD PhD, Pascal Chastagner, MD, Claire Berger, MD, Gerard Michel, MD, Claude Preudhomme, MD PhD, Jean Soulier, MD PhD, Judith Landman-Parker, MD, Guy Leverger, MD, Elizabeth Macintyre, MD PhD, Andre Baruchel, MD PhD, Vahid Asnafi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1083.
https://doi.org/10.1182/blood.V128.22.1083.1083
Published: 2016
Journal Articles

t(12;21)/ ETV6 - RUNX1 Confers a Specific Pattern of In Vivo Sensitivity to Treatments in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL): Results of the Randomized Trials 58881 and 58951 of the EORTC Children Leukemia Group

Caroline Piette, Stefan Suciu, Emmanuelle Clappier, Yves Bertrand, MDPhD, Genevieve Plat, MD, Christophe Chantrain, Vitor Costa, Nicole Dastugue, Alina Ferster, Caroline Gilotay, Sandrine Girard, Nathalie Grardel, Patrick Lutz, Francoise Mazingue, MD, Odile Minckes, Martine Munzer, Emmanuel Plouvier, MD, Nicolas Sirvent, Anne Uyttebroeck, Nadine van Roy, MD, Karima Yakouben, MD, Yves Benoit, Hélène Cavé
Journal: Blood
Blood (2015) 126 (23): 793.
https://doi.org/10.1182/blood.V126.23.793.793
Published: 2015
Journal Articles

Prognostic Relevance of CD200 /Btla Deletions in Pediatric Precursor-B Cell Acute Lymphoblastic Leukemia Treated According to the EORTC-CLG 58951 Protocol

Farzaneh Ghazavi, Tim Lammens, Emmanuelle Clappier, Stefan Suciu, Aurélie Caye, Samira Zegrari, Marleen Bakkus, Nathalie Grardel, Yves Benoit, Yves Bertrand, Odile Minckes, Vitor Costa, Alina Ferster, Françoise Mazingue, Geneviève Plat, Emmanuel Plouvier, Marilyne Poirée, Anne Uyttebroeck, Jutte Van der Werff Ten Bosch, Hetty Helsmoortel, Magali Meul, Nadine Van Roy, Jan Philippé, Frank Speleman, Hélène Cavé, Pieter Van Vlierberghe, Barbara De Moerloose
Journal: Blood
Blood (2014) 124 (21): 2394.
https://doi.org/10.1182/blood.V124.21.2394.2394
Published: 2014
Journal Articles

Value of EVI1 Gene Expression Level in Adult Acute Lymphoblastic Leukemia (ALL): A Study from the Group for Research on Adult ALL (GRAALL)

Claire Abbal, Raouf Ben Abdelali, Marina Lafage, Françoise Huguet, Thibaut Leguay, Olivier Spertini, Nicolas Boissel, Claude Gardin, Carlos Graux, Jean-Michel Cayuela, Marie-Laure Boulland, Nathalie Grardel, Anne Bouvier, Michel Duchosal, MD, Véronique Lhéritier, Yves Chalandon, Vahid Asnafi, MDPhD, Norbert Ifrah, Hervé Dombret, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1081.
https://doi.org/10.1182/blood.V124.21.1081.1081
Published: 2014
Journal Articles

Multiclonal Diagnosis and MRD Follow-up in ALL with HTS Coupled with a Bioinformatic Analysis

Nathalie Grardel, Mikaël Salson, Aurélie Caillault, Marc Duez, Céline Villenet, Christophe Roumier, Martin Figeac, Brigitte Nelken, Bruno Quesnel, MD PhD, Claude Preudhomme, PharmD, PhD, Mathieu Giraud
Journal: Blood
Blood (2014) 124 (21): 1083.
https://doi.org/10.1182/blood.V124.21.1083.1083
Published: 2014