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Kathryn G Roberts
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Journal Articles

Outcomes in patients with ETV6::RUNX1 or high-hyperdiploid B-ALL treated in the St. Jude Total Therapy XV/XVI studies

Clinical Trials & Observations
Katelyn Purvis, Yinmei Zhou, Seth E. Karol, Jeffrey E. Rubnitz, Raul C. Ribeiro, Shawn HR Lee, Jun J. Yang, W. Paul Bowman, Lu Wang, Stephanie B Dixon, Kathryn G Roberts, Qingsong Gao, Cheng Cheng, Charles G. Mullighan, Sima Jeha, Ching-Hon Pui, Hiroto Inaba
Journal: Blood
Blood blood.2024024936.
https://doi.org/10.1182/blood.2024024936
Published: 2024
Includes: Supplemental data
Journal Articles

Genomic determinants of response and resistance to inotuzumab ozogamicin in B-cell ALL

Yaqi Zhao, Nicholas J. Short, Hagop M. Kantarjian, Ti-Cheng Chang, Pankaj S. Ghate, Chunxu Qu, Walid Macaron, Nitin Jain, Beenu Thakral, Aaron H. Phillips, Joseph Khoury, Guillermo Garcia-Manero, Wenchao Zhang, Yiping Fan, Hui Yang, Rebecca S. Garris, Lewis F. Nasr, Richard W. Kriwacki, Kathryn G. Roberts, Marina Konopleva, Elias J. Jabbour, Charles G. Mullighan
Journal: Blood
Blood (2024) 144 (1): 61–73.
https://doi.org/10.1182/blood.2024023930
Published: 2024
Includes: Supplemental data
Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Shunsuke Kimura, Petri Pölönen, Lindsey Montefiori, Kenneth Caldwell, Ilaria Iacobucci, Chelsey Chen, Anthony Brown, Katie Han, Yen-Chun Liu, Yunchao Chang, Zhongshan Cheng, Zhou Yinmei, Chun Shik Park, Sharnise Mitchell, Noemi Reyes, Allen Yeoh, Andishe Attarbaschi, Andrew Moore, Atsushi Manabe, Barbara Buldini, Kean Hui Chiew, Chi Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, Elisabeth Paietta, Franco Locatelli, Gabriele Escherich, Gao Qingsong, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A. de Groot-Kruseman, Jacob M. Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P.P. Meijerink, Junko Takita, Katarzyna Pawinska-Wasikowska, Kjeld Schmiegelow, Mariko Eguchi, Martin Schrappe, Martin Zimmermann, Masatoshi Takagi, Melissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Motohiro Kato, Orietta Spinelli, Pauline Mazilier, Paul G. Thomas, Riccardo Masetti, Rishi Sury Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Shuhong Shen, Sima Jeha, Steven M. Kornblau, Szymon Skoczen, Takako Miyamura, Tiffaney Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Zhaohui Gu, Kathryn G. Roberts, David T. Teachey, Kristine R Crews, Cheng Cheng, Jun J. Yang, Hiroto Inaba, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (Supplement 1): 845.
https://doi.org/10.1182/blood-2023-178688
Published: 2023
Journal Articles

Assessment of Outcomes of Consolidation Therapy By Number of Cycles of Blinatumomab Received in Newly Diagnosed Measurable Residual Disease Negative Patients with B-Lineage Acute Lymphoblastic Leukemia: In the ECOG-ACRIN E1910 Randomized Phase III National Clinical Trials Network Trial

Selina M Luger, Zhuoxin Sun, Ryan J Mattison, Elisabeth Paietta, Kathryn G. Roberts, Yanming Zhang, Janis Racevckis, Hillard M. Lazarus, Jacob M. Rowe, Daniel A. Arber, Matthew J. Wieduwilt, Michaela Liedtke, Julie Bergeron, Brent L. Wood, Yaqi Zhao, Gang Wu, Ti-Cheng Chang, Wenchao Zhang, Keith W Pratz, Shira N. Dinner, Noelle V. Frey, Steven D. Gore, Bhavana Bhatnagar, Ehab L. Atallah, Geoffrey L Uy, Deepa Jeyakumar, Tara L Lin, Cheryl L. Willman, Daniel J. DeAngelo, Elad Sharon, Richard F. Little, Harry P. Erba, Richard M Stone, Charles G. Mullighan, Mark R. Litzow, Martin S. Tallman
Journal: Blood
Blood (2023) 142 (Supplement 1): 2877.
https://doi.org/10.1182/blood-2023-189648
Published: 2023
Journal Articles

The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Qingsong Gao, Sarra L. Ryan, Ilaria Iacobucci, Pankaj S. Ghate, Ruth E. Cranston, Claire Schwab, Abdelrahman H. Elsayed, Lei Shi, Stanley Pounds, Shaohua Lei, Pradyuamna Baviskar, Deqing Pei, Cheng Cheng, Matthew Bashton, Paul Sinclair, David R. Bentley, Mark T. Ross, Zoya Kingsbury, Terena James, Kathryn G. Roberts, Meenakshi Devidas, Yiping Fan, Wenan Chen, Ti-Cheng Chang, Gang Wu, Andrew Carroll, Nyla Heerema, Virginia Valentine, Marcus Valentine, Wenjian Yang, Jun J. Yang, Anthony V. Moorman, Christine J. Harrison, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (8): 711–723.
https://doi.org/10.1182/blood.2022019094
Published: 2023
Includes: Supplemental data
Journal Articles

Pharmacotypes across the Genomic Landscape of Pediatric Acute Lymphoblastic Leukemia and Impact on Treatment Response

Shawn Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. Crews, Kathryn G Roberts, Sima Jeha, Cheng Cheng, Seth E. Karol, Mary V. Relling, Gary Rosner, Hiroto Inaba, Charles G. Mullighan, Ching-Hon Pui, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 1730–1731.
https://doi.org/10.1182/blood-2022-156699
Published: 2022
Journal Articles

IKZF1 plus Confers a Strong Adverse Prognostic Effect in Total Therapy Studies (XV/XVI)

Ruth Wangondu, Emily Ashcraft, Kathryn G Roberts, Cheng Cheng, Hiroto Inaba, Charles G. Mullighan
Journal: Blood
Blood (2022) 140 (Supplement 1): 118–120.
https://doi.org/10.1182/blood-2022-158319
Published: 2022
Journal Articles

Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia

Shunsuke Kimura, Lindsey Montefiori, Ilaria Iacobucci, Yaqi Zhao, Qingsong Gao, Elisabeth M. Paietta, Claudia Haferlach, A. Douglas Laird, Paul E. Mead, Zhaohui Gu, Wendy Stock, Mark Litzow, Jacob M. Rowe, Selina M. Luger, Stephen P. Hunger, Georgina L. Ryland, Breon Schmidt, Paul G. Ekert, Alicia Oshlack, Sean M. Grimmond, Jacqueline Rehn, James Breen, David Yeung, Deborah L. White, Ibrahim Aldoss, Elias J. Jabbour, Ching-Hon Pui, Manja Meggendorfer, Wencke Walter, Wolfgang Kern, Torsten Haferlach, Samuel Brady, Jinghui Zhang, Kathryn G. Roberts, Piers Blombery, Charles G. Mullighan
Journal: Blood
Blood (2022) 139 (24): 3519–3531.
https://doi.org/10.1182/blood.2022015444
Published: 2022
Includes: Supplemental data
Journal Articles

CDX2 and IDH1/2: new potential players in ALL

Kathryn G. Roberts
Journal: Blood
Blood (2022) 139 (12): 1778–1779.
https://doi.org/10.1182/blood.2021014429
Published: 2022
Journal Articles

Degradation of Janus kinases in CRLF2 -rearranged acute lymphoblastic leukemia

Yunchao Chang, Jaeki Min, Jamie A. Jarusiewicz, Marisa Actis, Shanshan Yu-Chen Bradford, Anand Mayasundari, Lei Yang, Divyabharathi Chepyala, Lisa J. Alcock, Kathryn G. Roberts, Stanley Nithianantham, Dylan Maxwell, Lauren Rowland, Randolph Larsen, Aman Seth, Hiroaki Goto, Toshihiko Imamura, Koshi Akahane, Baranda S. Hansen, Shondra M. Pruett-Miller, Elisabeth M. Paietta, Mark R. Litzow, Chunxu Qu, Jun J. Yang, Marcus Fischer, Zoran Rankovic, Charles G. Mullighan
Journal: Blood
Blood (2021) 138 (23): 2313–2326.
https://doi.org/10.1182/blood.2020006846
Published: 2021
Includes: Supplemental data
Journal Articles

The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13

Costanza Zanetti, Rahul Kumar, Joscha Ender, Parimala S. Godavarthy, Mark Hartmann, Joschka Hey, Kersten Breuer, Eva S. Weissenberger, Valentina R. Minciacchi, Christina Karantanou, Zhaohui Gu, Kathryn G. Roberts, Markus Metzler, Wendy Stock, Charles G. Mullighan, Clara D. Bloomfield, Natalie Filmann, Katrin Bankov, Sylvia Hartmann, Robert P. Hasserjian, Antony F. Cousins, Christina Halsey, Christoph Plass, Daniel B. Lipka, Daniela S. Krause
Journal: Blood
Blood (2021) 138 (19): 1870–1884.
https://doi.org/10.1182/blood.2021011557
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

The Impact of Genetic Ancestry on the Biology and Prognosis of Childhood Acute Lymphoblastic Leukemia

Shawn Lee, Federico Antillón, Deqing Pei, Wenjian Yang, Kathryn G Roberts, Zhenhua Li, Meenakshi Devidas, Wentao Yang, Cesar Najera, Hai Peng Lin, Ah Moy Tan, Hany Ariffin, Cheng Cheng, William E. Evans, Stephen P Hunger, Sima Jeha, Charles G. Mullighan, Mignon L. Loh, Allen Eng Juh Yeoh, Ching-Hon Pui, Jun J. Yang
Journal: Blood
Blood (2021) 138 (Supplement 1): 3476.
https://doi.org/10.1182/blood-2021-145655
Published: 2021
Journal Articles

Comparison of Current and Enhanced Risk Stratification of 21,199 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Using Objective Risk Categorization Criteria: A Children's Oncology Group Report

Natalie Delrocco, Mignon L. Loh, Michael Borowitz, Karen R Rabin, Patrick A Zweidler-McKay, Kelly W Maloney, Leonard A. Mattano, Eric C Larsen, Anne L Angiolillo, Reuven J Schore, Michael J. Burke, Wanda L Salzer, Brent L. Wood, Andrew J Carroll, Nyla A. Heerema, Shalini C Reshmi, Julie M Gastier-Foster, Richard C Harvey, I-Ming L Chen, Kathryn G Roberts, Charles G. Mullighan, Cheryl L Willman, Naomi J Winick, William L. Carroll, Stephen P. Hunger, Elizabeth A. Raetz, Meenakshi Devidas, John Kairalla
Journal: Blood
Blood (2021) 138 (Supplement 1): 2382.
https://doi.org/10.1182/blood-2021-148593
Published: 2021
Journal Articles

Amino Acid Stress Response Genes Promote L-Asparaginase Resistance in Pediatric Acute Lymphoblastic Leukemia

Daniel Ferguson, J. Robert McCorkle, Qian Dong, Erik Bonten, Wenjian Yang, Brennan P. Bergeron, Robert J Autry, Jonathan Diedrich, Yoshihiro Gocho, Richa Bajpai, Kristine R. Crews, Shondra M. Pruett-Miller, Kathryn G Roberts, Wendy Stock, Charles G. Mullighan, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Jun J. Yang, Mary V. Relling, William E. Evans, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2021-152940
Published: 2021
Journal Articles

Molecular classification improves risk assessment in adult BCR-ABL1– negative B-ALL

Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A. N. Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow
Journal: Blood
Blood (2021) 138 (11): 948–958.
https://doi.org/10.1182/blood.2020010144
Published: 2021
Includes: Supplemental data
Journal Articles

Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL

Clinical Trials & Observations
Yaqi Zhao, Ibrahim Aldoss, Chunxu Qu, Jeremy Chase Crawford, Zhaohui Gu, Emma K. Allen, Anthony E. Zamora, Thomas B. Alexander, Jeremy Wang, Hiroaki Goto, Toshihiko Imamura, Koshi Akahane, Guido Marcucci, Anthony S. Stein, Ravi Bhatia, Paul G. Thomas, Stephen J. Forman, Charles G. Mullighan, Kathryn G. Roberts
Journal: Blood
Blood (2021) 137 (4): 471–484.
https://doi.org/10.1182/blood.2020006287
Published: 2021
Includes: Supplemental data
Journal Articles

Enhanced Risk Stratification of 21,178 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia (ALL) Incorporating White Blood Count (WBC), Age, and Minimal Residual Disease (MRD) at Day 8 and 29 As Continuous Variables: A Children's Oncology Group (COG) Report

Mignon L. Loh, MD, Natalie DelRocco, Michael J Borowitz, MD PhD, Karen R Rabin, MDPhD, Patrick A Zweidler-McKay, MDPhD, Kelly W Maloney, MD, Leonard A. Mattano, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Brent L Wood, MD PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Cheryl L Willman, MD, Naomi J Winick, MD, William Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Meenakshi Devidas, PhD, John Kairalla, Kathryn G Roberts, PhD, Charles G Mullighan, MBBS, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-139081
Published: 2020
Journal Articles

Outcomes of Patients with Down Syndrome and CRLF2 -Overexpressing Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group (COG)

Karen R Rabin, MDPhD, Meenakshi Devidas, PhD, Zhiguo Chen, Yunfeng Dai, PhD, Sarah K Tasian, MD, Johann K Hitzler, MD, Kathryn G Roberts, PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Richard C Harvey, PhD, I-Ming L Chen, Cheryl L Willman, MD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Kelly W Maloney, MD, Eric C Larsen, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Elizabeth A. Raetz, MD, Anne Angiolillo, MD, Mignon L. Loh, MD, Stephen P Hunger, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-143165
Published: 2020
Journal Articles

Outcomes of Patients with CRLF2 -Overexpressing Acute Lymphoblastic Leukemia without Down Syndrome: A Report from the Children's Oncology Group

Sarah K Tasian, MD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Kathryn G Roberts, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Cheryl L Willman, MD, Kelly W Maloney, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Karen R Rabin, MDPhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-134327
Published: 2020