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Amy Lehman
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Journal Articles

Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL

Sean D. Reiff, Elizabeth M. Muhowski, Daphne Guinn, Amy Lehman, Catherine A. Fabian, Carolyn Cheney, Rose Mantel, Lisa Smith, Amy J. Johnson, Wendy B. Young, Adam R. Johnson, Lichuan Liu, John C. Byrd, Jennifer A. Woyach
Journal: Blood
Blood (2018) 132 (10): 1039–1049.
https://doi.org/10.1182/blood-2017-10-809020
Published: 2018
Journal Articles

Targeting BTK through microRNA in chronic lymphocytic leukemia

Arianna Bottoni, Lara Rizzotto, Tzung-Huei Lai, Chaomei Liu, Lisa L. Smith, Rose Mantel, Sean Reiff, Dalia El-Gamal, Karilyn Larkin, Amy J. Johnson, Rosa Lapalombella, Amy Lehman, William Plunkett, John C. Byrd, James S. Blachly, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2016) 128 (26): 3101–3112.
https://doi.org/10.1182/blood-2016-07-727750
Published: 2016
Includes: Supplemental data
Journal Articles

Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

Ta-Ming Liu, Jennifer A. Woyach, Yiming Zhong, Arletta Lozanski, Gerard Lozanski, Shuai Dong, Ethan Strattan, Amy Lehman, Xiaoli Zhang, Jeffrey A. Jones, Joseph Flynn, Leslie A. Andritsos, Kami Maddocks, Samantha M. Jaglowski, Kristie A. Blum, John C. Byrd, Jason A. Dubovsky, Amy J. Johnson
Journal: Blood
Blood (2015) 126 (1): 61–68.
https://doi.org/10.1182/blood-2015-02-626846
Published: 2015
Includes: Supplemental data
Journal Articles

OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells

Ta-Ming Liu, Yonghua Ling, Jennifer A. Woyach, Kyle Beckwith, Yuh-Ying Yeh, Erin Hertlein, Xiaoli Zhang, Amy Lehman, Farrukh Awan, Jeffrey A. Jones, Leslie A. Andritsos, Kami Maddocks, Jessica MacMurray, Santosh B. Salunke, Ching-Shih Chen, Mitch A. Phelps, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2015) 125 (2): 284–295.
https://doi.org/10.1182/blood-2014-06-583518
Published: 2015
Includes: Supplemental data
Journal Articles

Pharmacologic Inhibition with Duvelisib (IPI-145) and Genetic Inhibition of PI3K p110δ Antagonizes Intrinsic and Extrinsic Survival Signals in Chronic Lymphocytic Leukemia (CLL)

Shuai Dong, MS, Daphne Guinn, Jason A Dubovsky, PhD, Yiming Zhong, PhD, Amy Lehman, Jeff Kutok, MD, PhD, Jennifer A. Woyach, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Journal: Blood
Blood (2014) 124 (21): 3324.
https://doi.org/10.1182/blood.V124.21.3324.3324
Published: 2014
Journal Articles

Expression of PRMT5 in B-Cell Chronic Lymphocytic Leukemia and Its Significance in Disease Progression and Richter's Transformation

Dalia El-Gamal, PhD, Taylor D LaFollette, Hongshan Lai, Li Chenglong, PhD, Deepa Sampath, PhD, Amy Lehman, Lianbo Yu, John C. Byrd, MD, Robert A. Baiocchi, MD PhD, Rosa Lapalombella, PhD
Journal: Blood
Blood (2014) 124 (21): 2197.
https://doi.org/10.1182/blood.V124.21.2197.2197
Published: 2014
Journal Articles

IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

Brief Report
Shuai Dong, Daphne Guinn, Jason A. Dubovsky, Yiming Zhong, Amy Lehman, Jeffery Kutok, Jennifer A. Woyach, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2014) 124 (24): 3583–3586.
https://doi.org/10.1182/blood-2014-07-587279
Published: 2014
Includes: Supplemental data
Journal Articles

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL

Dalia El-Gamal, Katie Williams, Taylor D. LaFollette, Matthew Cannon, James S. Blachly, Yiming Zhong, Jennifer A. Woyach, Erich Williams, Farrukh T. Awan, Jeffrey Jones, Leslie Andritsos, Kami Maddocks, Chia-Hsien Wu, Ching-Shih Chen, Amy Lehman, Xiaoli Zhang, Rosa Lapalombella, John C. Byrd
Journal: Blood
Blood (2014) 124 (9): 1481–1491.
https://doi.org/10.1182/blood-2014-05-574830
Published: 2014
Includes: Supplemental data
Journal Articles

The Hsp90 Inhibitor 17-DMAG Increases SOCS3 and Regulates Cytokine Production, Migration and Cell Death in Chronic Lymphocytic Leukemia

Erin K Hertlein, PhD, Timothy L. Chen, Rainer Claus, MD, Christoph Plass, PhD, Amy Lehman, David Jarjoura, PhD, Kami Maddocks, MD, Jeffrey A. Jones, MD, MPH, David M. Lucas, PhD, Amy J. Johnson, PhD, John C. Byrd, MD
Journal: Blood
Blood (2012) 120 (21): 1362.
https://doi.org/10.1182/blood.V120.21.1362.1362
Published: 2012
Journal Articles

Ibrutinib Is an Irreversible Molecular Inhibitor of Interleukin-2 Inducible Kinase: Expanding Therapeutic Potential and Modulating a Th1 Selective Pressure in CD4 T-Cells

Jason A Dubovsky, Ph.D, Kyle A Beckwith, B.S., Jennifer A. Woyach, MD, Samantha M. Jaglowski, MD, MPH, Joshua Hessler, Betty Y. Chang, PhD, Karilyn Larkin, Matthew R Stefanovski, B.S., Frank W Frissora, M.S., Lisa L. Smith, Kelly A Smucker, Joseph M. Flynn, DO, MPH, Jeffrey A. Jones, MD, MPH, Leslie A Andritsos, MD, Kami Maddocks, MD, Amy Lehman, Richard R. Furman, MD, Jeff Sharman, MD, Anjali Mishra, Ph.D., Michael A. Caligiuri, M.D., Joseph J. Buggy, PhD, Natarajan Muthusamy, DVM, Ph.D, Amy J Johnson, PhD, John C. Byrd, MD
Journal: Blood
Blood (2012) 120 (21): 775.
https://doi.org/10.1182/blood.V120.21.775.775
Published: 2012
Journal Articles

ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol

Emilia Mahoney, David M. Lucas, Sneha V. Gupta, Amy J. Wagner, Sarah E. M. Herman, Lisa L. Smith, Yuh-Ying Yeh, Leslie Andritsos, Jeffrey A. Jones, Joseph M. Flynn, Kristie A. Blum, Xiaoli Zhang, Amy Lehman, Hui Kong, Metin Gurcan, Michael R. Grever, Amy J. Johnson, John C. Byrd
Journal: Blood
Blood (2012) 120 (6): 1262–1273.
https://doi.org/10.1182/blood-2011-12-400184
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,

Lapo Alinari, MD., Ph.D., Ryan B. Edwards, Courtney J. Prince, William H. Towns, Rajeswaran Mani, DVM, Amy Lehman, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Li Pan, PhD, A. Douglas Kinghorn, PhD, DSc, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D., David M. Lucas, PhD
Journal: Blood
Blood (2011) 118 (21): 3498.
https://doi.org/10.1182/blood.V118.21.3498.3498
Published: 2011
Journal Articles

Dinaciclib (SCH727965) Is a Novel Cyclin Dependent Kinase Inhibitor That Promotes Selective Apoptosis In CLL Cells and Abrogates the Protective Effects of Microenvironment Cytokines

Amy J. Johnson, PhD, Lisa L. Smith, Amy J. Wagner, Joshua Hessler, Joseph M. Flynn, DO, MPH, Jeffrey A. Jones, MD, MPH, Xiaoli Zhang, Amy Lehman, David Jarjoura, Michael R. Grever, M.D., Rajat Bannerji, MD, PHD, John C. Byrd, MD
Journal: Blood
Blood (2010) 116 (21): 971.
https://doi.org/10.1182/blood.V116.21.971.971
Published: 2010
Journal Articles

Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway

Rosa Lapalombella, Leslie Andritsos, Qing Liu, Sarah E. May, Rebekah Browning, Lan V. Pham, Kristie A. Blum, William Blum, Asha Ramanunni, Chelsey A. Raymond, Lisa L. Smith, Amy Lehman, Xiaokui Mo, David Jarjoura, Ching-Shih Chen, Richard Ford, Jr, Christoph Rader, Natarajan Muthusamy, Amy J. Johnson, John C. Byrd
Journal: Blood
Blood (2010) 115 (13): 2619–2629.
https://doi.org/10.1182/blood-2009-09-242438
Published: 2010
Includes: Supplemental data
Journal Articles

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

Farrukh T. Awan, Rosa Lapalombella, Rossana Trotta, Jonathan P. Butchar, Bo Yu, Don M. Benson, Jr, Julie M. Roda, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Jones, Joseph Flynn, David Jarjoura, John R. Desjarlais, Susheela Tridandapani, Michael A. Caligiuri, Natarajan Muthusamy, John C. Byrd
Journal: Blood
Blood (2010) 115 (6): 1204–1213.
https://doi.org/10.1182/blood-2009-06-229039
Published: 2010
Journal Articles

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

Farrukh Awan, MD, MS, Rosa Lapalombella, PhD, Rossana Trotta, PhD, Jonathan P Butchar, Ph.D., Bo Yu, Don Benson, MD, PhD, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Alan Jones, MD, MPH, Joseph M Flynn, David Jarjoura, Robert A. Baiocchi, MD, PhD, John Desjarlais, Susheela Tridandapani, Ph.D., Michael A. Caligiuri, M.D., Natarajan Muthusamy, PhD, John C. Byrd
Journal: Blood
Blood (2009) 114 (22): 3725.
https://doi.org/10.1182/blood.V114.22.3725.3725
Published: 2009
Journal Articles

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

David M. Lucas, Ryan B. Edwards, Gerard Lozanski, Derek A. West, Jungook D. Shin, Melissa A. Vargo, Melanie E. Davis, Darlene M. Rozewski, Amy J. Johnson, Bao-Ning Su, Virginia M. Goettl, Nyla A. Heerema, Thomas S. Lin, Amy Lehman, Xiaoli Zhang, David Jarjoura, David J. Newman, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Blood
Blood (2009) 113 (19): 4656–4666.
https://doi.org/10.1182/blood-2008-09-175430
Published: 2009
Journal Articles

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

Rosa Lapalombella, Bo Yu, Georgia Triantafillou, Qing Liu, Jonathan P. Butchar, Gerard Lozanski, Asha Ramanunni, Lisa L. Smith, William Blum, Leslie Andritsos, Da-Sheng Wang, Amy Lehman, Ching-Shih Chen, Amy J. Johnson, Guido Marcucci, Robert J. Lee, L. James Lee, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd
Journal: Blood
Blood (2008) 112 (13): 5180–5189.
https://doi.org/10.1182/blood-2008-01-133108
Published: 2008
Journal Articles

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Aruna Gowda, Julie Roda, Syed-Rehan A. Hussain, Asha Ramanunni, Trupti Joshi, Susan Schmidt, Xiaoli Zhang, Amy Lehman, David Jarjoura, William E. Carson, Wayne Kindsvogel, Carolyn Cheney, Michael A. Caligiuri, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd
Journal: Blood
Blood (2008) 111 (9): 4723–4730.
https://doi.org/10.1182/blood-2007-07-099531
Published: 2008
Journal Articles

Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-γ

Sri Vidya Kondadasula, Julie M. Roda, Robin Parihar, Jianhua Yu, Amy Lehman, Michael A. Caligiuri, Susheela Tridandapani, Richard W. Burry, William E. Carson, III
Journal: Blood
Blood (2008) 111 (8): 4173–4183.
https://doi.org/10.1182/blood-2007-01-068908
Published: 2008