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Ryan B. Edwards
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Journal Articles

Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,

Lapo Alinari, MD., Ph.D., Ryan B. Edwards, Courtney J. Prince, William H. Towns, Rajeswaran Mani, DVM, Amy Lehman, Xiaoli Zhang, PhD, MS, David Jarjoura, PhD, Li Pan, PhD, A. Douglas Kinghorn, PhD, DSc, Michael R. Grever, M.D., Robert A. Baiocchi, M.D., Ph.D., David M. Lucas, PhD
Journal: Blood
Blood (2011) 118 (21): 3498.
https://doi.org/10.1182/blood.V118.21.3498.3498
Published: 2011
Journal Articles

Resistance to the Novel Translation Inhibitor Silvestrol Is Mediated by Elevated Mcl-1 Expression.

David M. Lucas, Ellen J. Sass, Ryan B. Edwards, Li Pan, Gerard Lozanski, Nyla A. Heerema, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Blood
Blood (2009) 114 (22): 1737.
https://doi.org/10.1182/blood.V114.22.1737.1737
Published: 2009
Journal Articles

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

David M. Lucas, Ryan B. Edwards, Gerard Lozanski, Derek A. West, Jungook D. Shin, Melissa A. Vargo, Melanie E. Davis, Darlene M. Rozewski, Amy J. Johnson, Bao-Ning Su, Virginia M. Goettl, Nyla A. Heerema, Thomas S. Lin, Amy Lehman, Xiaoli Zhang, David Jarjoura, David J. Newman, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Blood
Blood (2009) 113 (19): 4656–4666.
https://doi.org/10.1182/blood-2008-09-175430
Published: 2009
Journal Articles

The Plant-Derived Agent Silvestrol Has B-Cell Selective Activity In Vitro in Chronic Lymphocytic Leukemia Patient Cells and In Vivo in the Tcl-1 Mouse Model of CLL.

David M. Lucas, PhD, Ryan B. Edwards, Michael D. De Lay, Derek A. West, Gerard Lozanski, MD, Amy J. Johnson, PhD, Angela A. Salim, PhD, Thomas S. Lin, MD, PhD, John C. Byrd, MD, A. Douglas Kinghorn, PhD, Michael R. Grever, MD
Journal: Blood
Blood (2007) 110 (11): 3123.
https://doi.org/10.1182/blood.V110.11.3123.3123
Published: 2007
Journal Articles

Silvestrol, a Rocaglate Derivative from the Indonesian Plant Aglaia foveolata , Has Significant Bcl-2- and p53-Independent Anti-Tumor Activity against Chronic Lymphocytic Leukemia Cells.

Ryan B. Edwards, BS, David M. Lucas, PhD, Gerard Lozanski, MD, Amy J. Johnson, PhD, Bao-Ning Su, PhD, Thomas S. Lin, MD, John C. Byrd, MD, A. Douglas Kinghorn, PhD, Michael R. Grever, MD
Journal: Blood
Blood (2006) 108 (11): 2600.
https://doi.org/10.1182/blood.V108.11.2600.2600
Published: 2006
Journal Articles

Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

Amy J. Johnson, David M. Lucas, Natarajan Muthusamy, Lisa L. Smith, Ryan B. Edwards, Michael D. De Lay, Carlo M. Croce, Michael R. Grever, John C. Byrd
Journal: Blood
Blood (2006) 108 (4): 1334–1338.
https://doi.org/10.1182/blood-2005-12-011213
Published: 2006