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Journal Articles

Pim Kinase Inhibitor Enhances FLT3 Inhibitor Efficacy through GSK-3β Activation and GSK-3β-Mediated Proteasomal Degradation of c-Myc

Jonelle K. Lee, Mario Scarpa, Aditi Chatterjee, Moaath Mustafa Ali, Prerna Singh, Shivani Kapoor, Rossana Trotta, Maria R. Baer

Blood (2021) 138 (Supplement 1): 1163.

https://doi.org/10.1182/blood-2021-151737

Published: 2021

Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Blood (2019) 134 (Supplement_1): 4141.

https://doi.org/10.1182/blood-2019-131113

Published: 2019

Journal Articles

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Blood (2017) 130 (Supplement 1): 45.

https://doi.org/10.1182/blood.V130.Suppl_1.45.45

Published: 2017

Journal Articles

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

Patrick R. Baldwin, PhD, Shivani Kapoor, B.S., Karthika Natarajan, PhD, Rossana Trotta, PhD, Adriana Tron, PhD, Dennis Huszar, PhD, Eduardo Davila, PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2016) 128 (22): 35.

https://doi.org/10.1182/blood.V128.22.35.35

Published: 2016

Journal Articles

Potential Targeting Ph + Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity

Justine Yu, B.S., Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Masashi Sanada, MD PhD, Tomoyuki Yamaguchi, PhD, Yang Du, PhD, Jukka Westermarck, MD PhD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, Dragana Milojkovic, MD, Jane F. Apperley, MD, Denis-Claude Roy, MD, Guido Marcucci, MD, Bruno Calabretta, MD PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD

Blood (2016) 128 (22): 2909.

https://doi.org/10.1182/blood.V128.22.2909.2909

Published: 2016

Journal Articles

Role of the MSC-Derived Exosomal and Endogenous JAK2-SET/PP2A-Beta Catenin-Modulator Mir-300 in Leukemic Stem/Progenitor Proliferation and Survival in CML

Blood (2015) 126 (23): 53.

https://doi.org/10.1182/blood.V126.23.53.53

Published: 2015

Journal Articles

MiR-300 Acts As a Tumor Supressor in Ph+ Progenitors By Modulating the JAK2-SET/PP2A/β-Catenin Interplay

Giovannino Silvestri, PhD, Justin Ellis, Lorenzo Stramucci, PhD, Jason G Harb, PhD, Paolo Neviani, PhD, Guido Marcucci, MD, Denis-Claude Roy, MD, Peter Hokland, MD DMSc, Dragana Milojkovic, Alistair Reid, Jane F. Apperley, Ferenc M Livak, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD

Blood (2014) 124 (21): 4529.

https://doi.org/10.1182/blood.V124.21.4529.4529

Published: 2014

Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Apoptosis Induction By Clinically Active FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and in Vivo through Synergistic Downregulation of Mcl-1 and of Bcl-xL

Karthika Natarajan, PhD, Trevor J Mathias, MS, Kshama A Doshi, MS, Adriana E Tron, PhD, Manfred Kraus, PhD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD, Dennis Huszar, PhD, Maria R Baer, MD

Blood (2014) 124 (21): 3601.

https://doi.org/10.1182/blood.V124.21.3601.3601

Published: 2014

Journal Articles

Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells

Rossana Trotta, Li Chen, Stefan Costinean, Srirama Josyula, Bethany L. Mundy-Bosse, David Ciarlariello, Charlene Mao, Edward L. Briercheck, Kathleen K. McConnell, Anjali Mishra, Lianbo Yu, Carlo M. Croce, Michael A. Caligiuri

Blood (2013) 121 (16): 3126–3134.

https://doi.org/10.1182/blood-2012-12-467597

Published: 2013

Journal Articles

Human Natural Killer (NK) Cells: Differential Expression of Phosphatase and Tensin Homologue Deleted On Chromosome Ten (PTEN) During NK Cell Development Regulates Its Cytolytic Activity Against Leukemic Target Cells

Edward L. Briercheck, B.Sc., Rossana Trotta, Ph.D., Jordan P. Cole, B.A., Tyler D. Cole, Alex S. Hartlage, Chelsea K. Martin, Ph.D., Gustavo Leone, Ph.D., Michael A. Caligiuri, M.D.

Blood (2012) 120 (21): 254.

https://doi.org/10.1182/blood.V120.21.254.254

Published: 2012

Journal Articles

miR-155 regulates IFN-γ production in natural killer cells

Rossana Trotta, Li Chen, David Ciarlariello, Srirama Josyula, Charlene Mao, Stefan Costinean, Lianbo Yu, Jonathan P. Butchar, Susheela Tridandapani, Carlo M. Croce, Michael A. Caligiuri

Blood (2012) 119 (15): 3478–3485.

https://doi.org/10.1182/blood-2011-12-398099

Published: 2012

Journal Articles

The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells

Rossana Trotta, David Ciarlariello, Jessica Dal Col, Hsiaoyin Mao, Li Chen, Edward Briercheck, Jianhua Yu, Jianying Zhang, Danilo Perrotti, Michael A. Caligiuri

Blood (2011) 117 (8): 2378–2384.

https://doi.org/10.1182/blood-2010-05-285130

Published: 2011

Journal Articles

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

Farrukh T. Awan, Rosa Lapalombella, Rossana Trotta, Jonathan P. Butchar, Bo Yu, Don M. Benson, Jr, Julie M. Roda, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Jones, Joseph Flynn, David Jarjoura, John R. Desjarlais, Susheela Tridandapani, Michael A. Caligiuri, Natarajan Muthusamy, John C. Byrd

Blood (2010) 115 (6): 1204–1213.

https://doi.org/10.1182/blood-2009-06-229039

Published: 2010

Journal Articles

CD94 surface density identifies a functional intermediary between the CD56 bright and CD56 dim human NK-cell subsets

Jianhua Yu, Hsiaoyin C. Mao, Min Wei, Tiffany Hughes, Jianying Zhang, Il-kyoo Park, Shujun Liu, Susan McClory, Guido Marcucci, Rossana Trotta, Michael A. Caligiuri

Blood (2010) 115 (2): 274–281.

https://doi.org/10.1182/blood-2009-04-215491

Published: 2010

Includes: Supplemental data

Journal Articles

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

Farrukh Awan, MD, MS, Rosa Lapalombella, PhD, Rossana Trotta, PhD, Jonathan P Butchar, Ph.D., Bo Yu, Don Benson, MD, PhD, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Alan Jones, MD, MPH, Joseph M Flynn, David Jarjoura, Robert A. Baiocchi, MD, PhD, John Desjarlais, Susheela Tridandapani, Ph.D., Michael A. Caligiuri, M.D., Natarajan Muthusamy, PhD, John C. Byrd

Blood (2009) 114 (22): 3725.

https://doi.org/10.1182/blood.V114.22.3725.3725

Published: 2009

Journal Articles

Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ- MiR-155 transgenic mice

Stefan Costinean, Sukhinder K. Sandhu, Irene M. Pedersen, Esmerina Tili, Rossana Trotta, Danilo Perrotti, David Ciarlariello, Paolo Neviani, Jason Harb, Lauren Rachel Kauffman, Aaditya Shidham, Carlo Maria Croce

Blood (2009) 114 (7): 1374–1382.

https://doi.org/10.1182/blood-2009-05-220814

Published: 2009

Includes: Supplemental data

Journal Articles

TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

Blood (2009) 113 (22): 5558–5567.

https://doi.org/10.1182/blood-2009-02-205732

Published: 2009

Includes: Supplemental data

Journal Articles

Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells

Don M. Benson, Jr, Jianhua Yu, Brian Becknell, Min Wei, Aharon G. Freud, Amy K. Ferketich, Rossana Trotta, Danilo Perrotti, Roger Briesewitz, Michael A. Caligiuri

Blood (2009) 113 (12): 2706–2714.

https://doi.org/10.1182/blood-2008-05-159285

Published: 2009

Journal Articles

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

Il-Kyoo Park, Chiara Giovenzana, Tiffany L. Hughes, Jianhua Yu, Rossana Trotta, Michael A. Caligiuri

Blood (2009) 113 (11): 2470–2477.

https://doi.org/10.1182/blood-2008-05-157073

Published: 2009

Journal Articles

The Axl/Gas6 Pathway Is Required for Human Natural Killer Cell Development.

Il-Kyoo Park, Chiara Giovenzana, Tiffany L. Hughes, Jianhua Yu, Rossana Trotta, Michael A. Caligiuri

Blood (2007) 110 (11): 2305.

https://doi.org/10.1182/blood.V110.11.2305.2305

Published: 2007

NARROW

Pim Kinase Inhibitor Enhances FLT3 Inhibitor Efficacy through GSK-3β Activation and GSK-3β-Mediated Proteasomal Degradation of c-Myc

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

Potential Targeting Ph + Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity

Role of the MSC-Derived Exosomal and Endogenous JAK2-SET/PP2A-Beta Catenin-Modulator Mir-300 in Leukemic Stem/Progenitor Proliferation and Survival in CML

MiR-300 Acts As a Tumor Supressor in Ph+ Progenitors By Modulating the JAK2-SET/PP2A/β-Catenin Interplay

The Pim Kinase Inhibitor AZD1208 Enhances Apoptosis Induction By Clinically Active FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and in Vivo through Synergistic Downregulation of Mcl-1 and of Bcl-xL

Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells

Human Natural Killer (NK) Cells: Differential Expression of Phosphatase and Tensin Homologue Deleted On Chromosome Ten (PTEN) During NK Cell Development Regulates Its Cytolytic Activity Against Leukemic Target Cells

miR-155 regulates IFN-γ production in natural killer cells

The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells

CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

CD94 surface density identifies a functional intermediary between the CD56 bright and CD56 dim human NK-cell subsets

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ- MiR-155 transgenic mice

TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

The Axl/Gas6 Pathway Is Required for Human Natural Killer Cell Development.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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