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Journal Articles

Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma

Brief Report
Ross S. Firestone, Nicholas D. Socci, Tala Shekarkhand, Menglei Zhu, Wei Ge Qin, Malin Hultcrantz, Sham Mailankody, Carlyn Rose Tan, Neha Korde, Alexander M. Lesokhin, Hani Hassoun, Urvi Shah, Kylee H. Maclachlan, Sridevi Rajeeve, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Oscar B. Lahoud, Sergio Giralt, Kazunori Murata, Saad Z. Usmani, David J. Chung
Journal: Blood
Blood (2024) 144 (4): 402–407.
https://doi.org/10.1182/blood.2023023557
Published: 2024
Includes: Supplemental data
Journal Articles

Evaluating the Effect of Evolving Changes in Serum Biomarkers on the Risk of Progression in Smoldering Multiple Myeloma

Theresia Akhlaghi, David Nemirovsky, Kylee H Maclachlan, Neha Korde, Sham Mailankody, Alexander Lesokhin, Hani Hassoun, Dhwani Patel, Urvi A Shah, Carlyn Tan, Oscar Boutros Lahoud, Heather Landau, Gunjan L. Shah, Michael Scordo, David Chung, Ola Landgren, Sergio A. Giralt, Saad Z Usmani, Andriy Derkach, Malin Hultcrantz
Journal: Blood
Blood (2023) 142 (Supplement 1): 877.
https://doi.org/10.1182/blood-2023-180315
Published: 2023
Journal Articles

Low Target Antigen Expression Mediates Resistance to BCMA CAR T Cell Therapy

Karlo Perica, Sarah Nataraj, Maria Lemdal Sjojstrand, Katherine Nagel, Emma Pavkovic, Erica Payson, Ana Cuenca, Anjali Patel, David Chung, Sham Mailankody, Gunjan L. Shah, Saad Z Usmani, Sergio A. Giralt, Michel Sadelain
Journal: Blood
Blood (2023) 142 (Supplement 1): 2124.
https://doi.org/10.1182/blood-2023-178954
Published: 2023
Journal Articles

Evaluating Tumor-Intrinsic and Patient-Specific Mechanisms of Resistance to Teclistamab in Anti-BCMA Exposed and Naïve Multiple Myeloma

Ross Firestone, Devin McAvoy, Tala Shekarkhand, Edith Serrano, Issam S. Hamadeh, Alice Wang, Menglei Zhu, Dhwani Patel, Carlyn Tan, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A Shah, Neha Korde, Kylee H Maclachlan, Heather Landau, Michael Scordo, Gunjan L. Shah, Oscar Boutros Lahoud, Sergio A. Giralt, Kinga K Hosszu, David Chung, Alexander Lesokhin, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 333.
https://doi.org/10.1182/blood-2023-187467
Published: 2023
Journal Articles

Identifying Causes of Unscheduled Healthcare Interactions and Changes to Patient Disposition in Individuals Receiving Outpatient Commercial Bispecific Antibody Therapy in Relapsed/Refractory Multiple Myeloma (RRMM)

Anna J Howard, Tala Shekarkhand, Issam S. Hamadeh, Alice Wang, Dhwani Patel, Carlyn Tan, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A Shah, Neha Korde, Kylee H Maclachlan, Heather Landau, Michael Scordo, Gunjan L. Shah, Oscar Boutros Lahoud, Sergio A. Giralt, David Chung, Alexander Lesokhin, Saad Z Usmani, Ross Firestone
Journal: Blood
Blood (2023) 142 (Supplement 1): 3707.
https://doi.org/10.1182/blood-2023-187889
Published: 2023
Journal Articles

Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Therapy in High-Risk Newly Diagnosed Multiple Myeloma

Carlyn Tan, Neha Korde, Andriy Derkach, Malin Hultcrantz, Kylee H Maclachlan, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Alexander Lesokhin, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Craig C. Hofmeister, Jonathan L. Kaufman, Ajay K. Nooka, Saad Z Usmani, Sagar Lonial, Nisha S. Joseph
Journal: Blood
Blood (2023) 142 (Supplement 1): 1996.
https://doi.org/10.1182/blood-2023-190279
Published: 2023
Journal Articles

Patterns of Cytokine Release Syndrome with Teclistamab in Relapsed/Refractory Multiple Myeloma with or without Prior T-Cell Redirection Therapy

Issam S. Hamadeh, Tala Shekarkhand, Colin Rueda, Ross Firestone, Alice Wang, Neha Korde, Malin Hultcrantz, Alexander Lesokhin, Sham Mailankody, Hani Hassoun, Urvi A Shah, Kylee H Maclachlan, Dhwani Patel, Gunjan L. Shah, Michael Scordo, Oscar Boutros Lahoud, David Chung, Heather Landau, Sergio A. Giralt, Saad Z Usmani, Carlyn Rose Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1961.
https://doi.org/10.1182/blood-2023-180283
Published: 2023
Journal Articles

Stem Cell Utilization in the Era of Novel Therapies for Multiple Myeloma

Noriko Nishimura, David Nemirovsky, Sean M. Devlin, Parastoo B. Dahi, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Sham Mailankody, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Alexander Lesokhin, Urvi A Shah, Carlyn Tan, Gaurav Gupta, Elena Maryamchik, Rugved Pattarkine, Grace Linder, Saad Z Usmani, Sergio A. Giralt, David Chung
Journal: Blood
Blood (2023) 142 (Supplement 1): 2219.
https://doi.org/10.1182/blood-2023-188103
Published: 2023
Journal Articles

Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells

Xiaoli Mi, Alex Penson, Omar Abdel-Wahab, Sham Mailankody
Journal: Blood
Blood (2023) 142 (Supplement 1): 336.
https://doi.org/10.1182/blood-2023-190394
Published: 2023
Journal Articles

The Complex Structural Variant Chromothripsis Can be Defined on Targeted Sequencing Panels, Allowing Direct Clinical Translation in Order to Improve Multiple Myeloma Prognostication

Kylee H Maclachlan, Bachisio Ziccheddu, Carlyn Tan, Tala Shekarkhand, Colin Rueda, Edith Serrano, Benjamin Diamond, Hani Hassoun, Sham Mailankody, Urvi A Shah, Malin Hultcrantz, Sergio A. Giralt, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Yanming Zhang, Robert Cimera, Maria E. Arcila, Ola Landgren, Alexander Lesokhin, Neha Korde, Francesco Maura, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3343.
https://doi.org/10.1182/blood-2023-189316
Published: 2023
Journal Articles

Clinical Outcomes Associated with Del(17p) in Newly Diagnosed Multiple Myeloma Treated with Triplet and Daratumumab-Based Quadruplet Induction Regimens

Eric Jurgens, Ross Firestone, Kylee H Maclachlan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Tala Shekarkhand, Colin Rueda, Yanming Zhang, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Alexander Lesokhin, Neha Korde, Saad Z Usmani, Carlyn Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2024.
https://doi.org/10.1182/blood-2023-190728
Published: 2023
Journal Articles

Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) and Daratumumab, Carfilzomib, Lenalidomide and Dexamethasone (DKRd) As Induction Therapy in Newly Diagnosed Multiple Myeloma

Carlyn Tan, Kylee H Maclachlan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Tala Shekarkhand, Colin Rueda, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Alexander Lesokhin, Saad Z Usmani, Neha Korde
Journal: Blood
Blood (2023) 142 (Supplement 1): 4744.
https://doi.org/10.1182/blood-2023-181868
Published: 2023
Journal Articles

A Whole Foods Plant-Based Weight Loss Intervention Improves Quality of Life, Metabolic, Microbiome and Immune Profile in MGUS/SMM As Well As Progression Trajectory in a Subset - the Nutrivention Trial

Urvi A Shah, Francesca Castro, Andriy Derkach, Teng Fei, Kinga K Hosszu, Devin McAvoy, Susan DeWolf, Justin Cross, Ana Gradissimo, Alexis Nwankwo, Aishwarya Anuraj, Miranda Burge, Blaslov Jenna, Elizabeth Raynor, Jenna Wosleger, Peter Adintori, Michael Pollak, Jenny Paredes Sanchez, Thomas Atkinson, Kylee H Maclachlan, Sham Mailankody, Neha Korde, Carlyn Tan, Malin Hultcrantz, Hani Hassoun, Jonathan U. Peled, Gunjan L. Shah, Michael Scordo, Oscar Boutros Lahoud, David Chung, Heather Landau, Anita D'Souza, Ola Landgren, Sergio A. Giralt, Neil M. Iyengar, Saad Z Usmani, Alexander Lesokhin, Marcel R.M. van den Brink
Journal: Blood
Blood (2023) 142 (Supplement 1): 4771.
https://doi.org/10.1182/blood-2023-182878
Published: 2023
Journal Articles

A Comparative Analysis of Infectious Complications in Patients with Multiple Myeloma Treated with BCMA-Targeted Bispecific Antibodies and CAR T-Cell Therapy

Karthik Nath, Tala Shekarkhand, Bruno Almeida Costa, David Nemirovsky, Andriy Derkach, Noriko Nishimura, Tasmin Farzana, Colin Rueda, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee H Maclachlan, Neha Korde, Urvi A Shah, Carlyn Rose Tan, Malin Hultcrantz, Sergio A. Giralt, Saad Z Usmani, Zainab Shahid, Sham Mailankody, Alexander Lesokhin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2023-179413
Published: 2023
Journal Articles

Comprehensive Genomic Characterization of Response and Resistance to Daratumumab-Based Quadruplet Induction in Newly Diagnosed Multiple Myeloma Patients

Kylee H Maclachlan, Carlyn Rose Tan, Tala Shekarkhand, Colin Rueda, Edith Serrano, David Nemirovsky, Andriy Derkach, Andrew McPherson, Benjamin Diamond, Bachisio Ziccheddu, Eileen Boyle, Hani Hassoun, Sham Mailankody, Urvi A Shah, Malin Hultcrantz, Sergio A. Giralt, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Yanming Zhang, Robert Cimera, Maria E. Arcila, Ahmet Dogan, Alexander Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura, Neha Korde, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3370.
https://doi.org/10.1182/blood-2023-187891
Published: 2023
Journal Articles

T-Cell Exhaustion Signature Predicts Early Relapse after Autologous Stem Cell Transplant for Multiple Myeloma: BMT CTN 0702 Secondary Immune Analysis

Nezar Mehanna, Andriy Derkach, Billel Gasmi, Theodora Anagnostou, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Sham Mailankody, Urvi A Shah, Carlyn Rose Tan, Saad Z Usmani, Sergio A. Giralt, Alexander Lesokhin, David Chung
Journal: Blood
Blood (2023) 142 (Supplement 1): 3326.
https://doi.org/10.1182/blood-2023-177960
Published: 2023
Journal Articles

Interventions and outcomes of patients with multiple myeloma receiving salvage therapy after BCMA-directed CAR T therapy

Clinical Trials & Observations
Oliver Van Oekelen, Karthik Nath, Tarek H. Mouhieddine, Tasmin Farzana, Adolfo Aleman, David T. Melnekoff, Yogita Ghodke-Puranik, Gunjan L. Shah, Alexander Lesokhin, Sergio Giralt, Santiago Thibaud, Adriana Rossi, Cesar Rodriguez, Larysa Sanchez, Joshua Richter, Shambavi Richard, Hearn J. Cho, Ajai Chari, Saad Z. Usmani, Sundar Jagannath, Urvi A. Shah, Sham Mailankody, Samir Parekh
Journal: Blood
Blood (2023) 141 (7): 756–765.
https://doi.org/10.1182/blood.2022017848
Published: 2023
Includes: Supplemental data
Journal Articles

Fc-Mediated Antibody Effector Function, Inflammation Resolution and Oligoclonality on TCR Rearrangements Predict Sustained MRD Negativity in Newly Diagnosed Multiple Myeloma Treated with Immunotherapy Regimens

Eileen M Boyle, Francesco Maura, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Hussein Ghamlouch, Dylan Gagler, Patrick Blaney, Bachisio Ziccheddu, Yubao Wang, Emily Guzman, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, James E Hoffman, Dickran Kazandjian, Hani Hassoun, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E Davies, Saad Usmani, Neha Korde, Ola Landgren, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 249–251.
https://doi.org/10.1182/blood-2022-165500
Published: 2022
Journal Articles

A Phase 2 Trial of Colesevelam for Lenalidomide-Associated Diarrhea

Malin Hultcrantz, Hani Hassoun, Neha Korde, Sham Mailankody, Tala Shekarkhand, Miranda Burge, Kylee H Maclachlan, Dhwani Patel, Urvi A Shah, David J. Chung, Michael Scordo, Kelly Barnett, Jenna Blaslov, Meghan Salcedo, Julia Caple, Linh Tran, Selena Hamid, Oscar B Lahoud, Heather Landau, Gunjan L. Shah, Sergio A Giralt, Andriy Derkach, Carlyn Tan, Cody Peer, William D. Figg, Sr., Saad Usmani, Ola Landgren, Alexander M Lesokhin
Journal: Blood
Blood (2022) 140 (Supplement 1): 4454–4456.
https://doi.org/10.1182/blood-2022-164851
Published: 2022
Journal Articles

Universal Updated Phase 1 Data Highlights Role of Allogeneic Anti-BCMA ALLO-715 Therapy for Relapsed/Refractory Multiple Myeloma

Sham Mailankody, Jeffrey V. Matous, Michaela Liedtke, Surbhi Sidana, Olalekan O. Oluwole, Meera Mohan, Jose C. Cruz, Rajneesh Nath, Faiz Anwer, Adriana Rossi, Myo Htut, Shahbaz A. Malik, Srinivas Ghatta, Myles Dillon, Wendy Ying, Lynn Navale, Erin E. Karski, Arun Balakumaran, Shaji K. Kumar
Journal: Blood
Blood (2022) 140 (Supplement 1): 4620–4622.
https://doi.org/10.1182/blood-2022-158231
Published: 2022