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Saad Z. Usmani
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Journal Articles

Dexamethasone dose intensity does not impact outcomes in newly diagnosed multiple myeloma: a secondary SWOG analysis

Clinical Trials & Observations
Rahul Banerjee, Rachael Sexton, Andrew J. Cowan, Aaron S. Rosenberg, Sikander Ailawadhi, S. Vincent Rajkumar, Shaji K Kumar, Angela Dispenzieri, Sagar Lonial, Brian G.M. Durie, Paul G. Richardson, Saad Z Usmani, Antje Hoering, Robert Z Orlowski
Journal: Blood
Blood blood.2024025939.
https://doi.org/10.1182/blood.2024025939
Published: 2024
Includes: Supplemental data
Journal Articles

Efficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies

Clinical Trials & Observations
Cyrille Touzeau, Amrita Y Krishnan, Philippe Moreau, Aurore Perrot, Saad Z Usmani, Salomon Manier, Michele Cavo, Carmen Martinez Chamorro, Ajay K. Nooka, Thomas G Martin, Lionel Karlin, Xavier Leleu, Nizar J. Bahlis, Britta Besemer, Lixia Pei, Sarah Stein, Shun Xin Wang Lin, Danielle Trancucci, Raluca Verona, Suzette Girgis, Xin Miao, Clarissa Uhlar, Katherine Chastain, Alfred Garfall
Journal: Blood
Blood blood.2023023616.
https://doi.org/10.1182/blood.2023023616
Published: 2024
Includes: Supplemental data
Journal Articles

Correlation of immune fitness with response to teclistamab in relapsed/refractory multiple myeloma in the MajesTEC-1 study

Clinical Trials & Observations
Diana Cortes-Selva, Tatiana Perova, Sheri Skerget, Deeksha Vishwamitra, Sarah Stein, Rengasamy Boominathan, Onsay Lau, Karl Calara-Nielsen, Cuc Davis, Jaymala Patel, Arnob Banerjee, Tara Stephenson, Clarissa Uhlar, Rachel Kobos, Jenna Goldberg, Lixia Pei, Danielle Trancucci, Suzette Girgis, Shun Xin Wang Lin, Liviawati S. Wu, Philippe Moreau, Saad Z. Usmani, Nizar J. Bahlis, Niels W. C. J. van de Donk, Raluca I. Verona
Journal: Blood
Blood (2024) 144 (6): 615–628.
https://doi.org/10.1182/blood.2023022823
Published: 2024
Includes: Supplemental data
Journal Articles

Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma

Brief Report
Ross S. Firestone, Nicholas D. Socci, Tala Shekarkhand, Menglei Zhu, Wei Ge Qin, Malin Hultcrantz, Sham Mailankody, Carlyn Rose Tan, Neha Korde, Alexander M. Lesokhin, Hani Hassoun, Urvi Shah, Kylee H. Maclachlan, Sridevi Rajeeve, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Oscar B. Lahoud, Sergio Giralt, Kazunori Murata, Saad Z. Usmani, David J. Chung
Journal: Blood
Blood (2024) 144 (4): 402–407.
https://doi.org/10.1182/blood.2023023557
Published: 2024
Includes: Supplemental data
Journal Articles

Patterns of Cytokine Release Syndrome with Teclistamab in Relapsed/Refractory Multiple Myeloma with or without Prior T-Cell Redirection Therapy

Issam S. Hamadeh, Tala Shekarkhand, Colin Rueda, Ross Firestone, Alice Wang, Neha Korde, Malin Hultcrantz, Alexander Lesokhin, Sham Mailankody, Hani Hassoun, Urvi A Shah, Kylee H Maclachlan, Dhwani Patel, Gunjan L. Shah, Michael Scordo, Oscar Boutros Lahoud, David Chung, Heather Landau, Sergio A. Giralt, Saad Z Usmani, Carlyn Rose Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1961.
https://doi.org/10.1182/blood-2023-180283
Published: 2023
Journal Articles

Real World Outcomes with Idecabtagene Vicleucel (Ide-Cel) CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Surbhi Sidana, Nausheen Ahmed, Othman S Akhtar, Michael Heim, Ruta Brazauskas, Doris K. Hansen, Christopher Ferreri, Ciara Louise L. Freeman, Aimaz Afrough, Larry D. Anderson, Jr., Binod Dhakal, Devender Dhanda, Lohith Gowda, Hamza Hashmi, Melanie Harrison, Amani Kitali, Sayeef Mirza, Jinalben Patel, Pallavi Patwardhan, Saad Z Usmani, Krina K. Patel, Siddhartha Ganguly, Marcelo Pasquini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1027.
https://doi.org/10.1182/blood-2023-181762
Published: 2023
Journal Articles

Evaluating the Effect of Evolving Changes in Serum Biomarkers on the Risk of Progression in Smoldering Multiple Myeloma

Theresia Akhlaghi, David Nemirovsky, Kylee H Maclachlan, Neha Korde, Sham Mailankody, Alexander Lesokhin, Hani Hassoun, Dhwani Patel, Urvi A Shah, Carlyn Tan, Oscar Boutros Lahoud, Heather Landau, Gunjan L. Shah, Michael Scordo, David Chung, Ola Landgren, Sergio A. Giralt, Saad Z Usmani, Andriy Derkach, Malin Hultcrantz
Journal: Blood
Blood (2023) 142 (Supplement 1): 877.
https://doi.org/10.1182/blood-2023-180315
Published: 2023
Journal Articles

The Temporal Evolution of Chromosome 1q Gain and Hyperdiploidy and Its Impact on Clinical Outcomes in Multiple Myeloma

Francesco Maura, Marcella Kaddoura, Alexandra Maria Poos, Anthony Cirrincione, Benjamin Diamond, Kylee H Maclachlan, Bachisio Ziccheddu, Elias K. Mai, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Gareth J. Morgan, Saad Z Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold
Journal: Blood
Blood (2023) 142 (Supplement 1): 638.
https://doi.org/10.1182/blood-2023-182267
Published: 2023
Journal Articles

Low Target Antigen Expression Mediates Resistance to BCMA CAR T Cell Therapy

Karlo Perica, Sarah Nataraj, Maria Lemdal Sjojstrand, Katherine Nagel, Emma Pavkovic, Erica Payson, Ana Cuenca, Anjali Patel, David Chung, Sham Mailankody, Gunjan L. Shah, Saad Z Usmani, Sergio A. Giralt, Michel Sadelain
Journal: Blood
Blood (2023) 142 (Supplement 1): 2124.
https://doi.org/10.1182/blood-2023-178954
Published: 2023
Journal Articles

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Patrick Blaney, Brian A. Walker, Aneta Mikulasova, Dylan Gagler, Bachisio Ziccheddu, Benjamin Diamond, Yubao Wang, Liming Hou, Sanxiong Liu, Alexandra Maria Poos, Anthony Cirrincione, Kylee H Maclachlan, Elias K. Mai, Hartmut Goldschmidt, Saad Z Usmani, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E. Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1401.
https://doi.org/10.1182/blood-2023-190473
Published: 2023
Journal Articles

Evaluating Tumor-Intrinsic and Patient-Specific Mechanisms of Resistance to Teclistamab in Anti-BCMA Exposed and Naïve Multiple Myeloma

Ross Firestone, Devin McAvoy, Tala Shekarkhand, Edith Serrano, Issam S. Hamadeh, Alice Wang, Menglei Zhu, Dhwani Patel, Carlyn Tan, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A Shah, Neha Korde, Kylee H Maclachlan, Heather Landau, Michael Scordo, Gunjan L. Shah, Oscar Boutros Lahoud, Sergio A. Giralt, Kinga K Hosszu, David Chung, Alexander Lesokhin, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 333.
https://doi.org/10.1182/blood-2023-187467
Published: 2023
Journal Articles

Identifying Causes of Unscheduled Healthcare Interactions and Changes to Patient Disposition in Individuals Receiving Outpatient Commercial Bispecific Antibody Therapy in Relapsed/Refractory Multiple Myeloma (RRMM)

Anna J Howard, Tala Shekarkhand, Issam S. Hamadeh, Alice Wang, Dhwani Patel, Carlyn Tan, Malin Hultcrantz, Sham Mailankody, Hani Hassoun, Urvi A Shah, Neha Korde, Kylee H Maclachlan, Heather Landau, Michael Scordo, Gunjan L. Shah, Oscar Boutros Lahoud, Sergio A. Giralt, David Chung, Alexander Lesokhin, Saad Z Usmani, Ross Firestone
Journal: Blood
Blood (2023) 142 (Supplement 1): 3707.
https://doi.org/10.1182/blood-2023-187889
Published: 2023
Journal Articles

Clinical Outcomes Associated with Del(17p) in Newly Diagnosed Multiple Myeloma Treated with Triplet and Daratumumab-Based Quadruplet Induction Regimens

Eric Jurgens, Ross Firestone, Kylee H Maclachlan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Sridevi Rajeeve, Dhwani Patel, Tala Shekarkhand, Colin Rueda, Yanming Zhang, Oscar Boutros Lahoud, Gunjan L. Shah, Michael Scordo, David Chung, Heather Landau, Sergio A. Giralt, Alexander Lesokhin, Neha Korde, Saad Z Usmani, Carlyn Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2024.
https://doi.org/10.1182/blood-2023-190728
Published: 2023
Journal Articles

Single Cell Whole Genome Measurement of Genomic Heterogeneity and Clonal Evolution in Multiple Myeloma

Andrew McPherson, Kylee H Maclachlan, Matthew Myers, Gryte Satas, Ola Landgren, Saad Z Usmani, Sohrab P Shah, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 4722.
https://doi.org/10.1182/blood-2023-191065
Published: 2023
Journal Articles

Trial in Progress: A Phase 1 Study of KTX-1001, an Oral, First-in-Class, Selective MMSET Inhibitor in Patients with Relapsed and Refractory Multiple Myeloma

Jesus G. Berdeja, David Dingli, Sagar Lonial, Andrew J. Yee, Alfred Chung, Cristina Gasparetto, P. Leif Bergsagel, Vivek Roy, Al-Ola Abdallah, Sharmilan Thanendrarajan, Aimaz Afrough, Laura Rosiñol, Suzanne Trudel, Paula Rodriguez Otero, Cyrille Touzeau, Pierre Bories, Soo Bang, Terry Connolly, Michelle Kim, Chad A. Lewis, Bao-Van Tran Linberg, M. Travis Quigley, Ola Landgren, Saad Z Usmani, Maria-Victoria Mateos, David S. Siegel
Journal: Blood
Blood (2023) 142 (Supplement 1): 3391.
https://doi.org/10.1182/blood-2023-174550
Published: 2023
Journal Articles

Artificial Intelligence Enabled ECG Interpretation Informs Outcomes after Autologous Transplantation for Multiple Myeloma

Brian C. Shaffer, Itzhak Zachi Attia, Grace Greason, Stephanie Chinapen, Samantha Brown, David Chung, Oscar Boutros Lahoud, Francisco Lopez-Jimenez, Wendy Schaffer, Jennifer Liu, Sergio A. Giralt, Gunjan L. Shah, Heather Landau, Saad Z Usmani, Paul A Friedman, Bernard J Gersh, Peter Noseworthy, Ioanna Kosmidou
Journal: Blood
Blood (2023) 142 (Supplement 1): 4965.
https://doi.org/10.1182/blood-2023-184725
Published: 2023
Journal Articles

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Mark B Meads, Kylee H Maclachlan, Saad Z Usmani, Marc S. Raab, Gareth J. Morgan, Niels Weinhold, Kenneth H. Shain, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 639.
https://doi.org/10.1182/blood-2023-184784
Published: 2023
Journal Articles

Impact of Dexamethasone (Dex) Dose Strength on Outcomes in Newly Diagnosed Multiple Myeloma (NDMM): A Secondary Analysis of SWOG Studies S0777 and S1211

Rahul Banerjee, Rachael Sexton, Andrew J. Cowan, Sikander Ailawadhi, S. Vincent Rajkumar, Shaji Kunnathu Kumar, Sagar Lonial, Bart Barlogie, Brian GM Durie, Saad Z Usmani, Antje Hoering, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1066.
https://doi.org/10.1182/blood-2023-181744
Published: 2023
Journal Articles

Revealing Novel Mechanisms Underlying Inactivation of Tumor Suppressor Genes on Duplicated Chromosomes in Multiple Myeloma

Anthony Cirrincione, Marcella Kaddoura, Alexandra Maria Poos, Bachisio Ziccheddu, Kylee H Maclachlan, Monika Chojnacka, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander Lesokhin, Faith E. Davies, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Elias K. Mai, Neha Korde, Gareth J. Morgan, Marc S. Raab, Saad Z Usmani, Ola Landgren, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 874.
https://doi.org/10.1182/blood-2023-186802
Published: 2023
Journal Articles

Comprehensive Genomic Characterization of Response and Resistance to Daratumumab-Based Quadruplet Induction in Newly Diagnosed Multiple Myeloma Patients

Kylee H Maclachlan, Carlyn Rose Tan, Tala Shekarkhand, Colin Rueda, Edith Serrano, David Nemirovsky, Andriy Derkach, Andrew McPherson, Benjamin Diamond, Bachisio Ziccheddu, Eileen Boyle, Hani Hassoun, Sham Mailankody, Urvi A Shah, Malin Hultcrantz, Sergio A. Giralt, David Chung, Heather Landau, Oscar Boutros Lahoud, Michael Scordo, Gunjan L. Shah, Yanming Zhang, Robert Cimera, Maria E. Arcila, Ahmet Dogan, Alexander Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura, Neha Korde, Saad Z Usmani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3370.
https://doi.org/10.1182/blood-2023-187891
Published: 2023