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Brian A. Walker
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Journal Articles

Unraveling Diverse Mechanisms of Complex Structural Variant Interactions through Multiomic Data in Multiple Myeloma

Enze Liu, Nathan Becker, Parvathi Sudha, Aneta Mikulasova, Mohammad Abu Zaid, Attaya Suvannasankha, Kelvin P. Lee, Rafat Abonour, Brian A. Walker
Journal: Blood
Blood (2023) 142 (Supplement 1): 641.
https://doi.org/10.1182/blood-2023-186262
Published: 2023
Journal Articles

Prospective Molecular Characterization of Multiple Myeloma Patient Samples Identifies High-Risk Patients and Informs Treatment Sequences through Resistance Mechanisms to Immunotherapies

Phillip Pham, Parvathi Sudha, Lin Wang, Wen Niu, Cameron Morgan, Cameron Ligocki, Ramzi Al-Azzawi, Reynold Ly, Francesco Vetrini, Magdalena Czader, Marwan Tayeh, Mohammad Abu Zaid, Kelvin P. Lee, Attaya Suvannasankha, Rafat Abonour, Brian A. Walker
Journal: Blood
Blood (2023) 142 (Supplement 1): 4738.
https://doi.org/10.1182/blood-2023-180116
Published: 2023
Journal Articles

Investigating the Functional Impact of CRBN Mutations on Response to IMiD/Celmod Agents in Myeloma

Yakinthi Chrisochoidou, Yann-Vai LeBihan, Salomon Morales, Shannon Martin, Brian A. Walker, Yigen Li, Sarah Bird, Charlotte Pawlyn
Journal: Blood
Blood (2023) 142 (Supplement 1): 753.
https://doi.org/10.1182/blood-2023-179986
Published: 2023
Journal Articles

Targeting Loss of the Tumor Suppressor TENT5C in Multiple Myeloma

Oumaima Jaouadi, Nathan Becker, Enze Liu, Meng Jingwei, Brian A. Walker
Journal: Blood
Blood (2023) 142 (Supplement 1): 3297.
https://doi.org/10.1182/blood-2023-190217
Published: 2023
Journal Articles

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Patrick Blaney, Brian A. Walker, Aneta Mikulasova, Dylan Gagler, Bachisio Ziccheddu, Benjamin Diamond, Yubao Wang, Liming Hou, Sanxiong Liu, Alexandra Maria Poos, Anthony Cirrincione, Kylee H Maclachlan, Elias K. Mai, Hartmut Goldschmidt, Saad Z Usmani, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E. Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1401.
https://doi.org/10.1182/blood-2023-190473
Published: 2023
Journal Articles

The Oligosaccharyltransferase Complex: A Novel Vulnerability in Multiple Myeloma

Hong Phuong Nguyen, Anh Quynh Le, Enze Liu, Brian A. Walker, Ngoc Tung Tran
Journal: Blood
Blood (2023) 142 (Supplement 1): 4664.
https://doi.org/10.1182/blood-2023-178060
Published: 2023
Journal Articles

Synergistic Effects of Type I PRMT1 and Type II PRMT5 Inhibitors Against Multiple Myeloma

Hong Phuong Nguyen, Enze Liu, Brian A. Walker, Ngoc Tung Tran
Journal: Blood
Blood (2023) 142 (Supplement 1): 6593.
https://doi.org/10.1182/blood-2023-173852
Published: 2023
Journal Articles

The Frequency of Alternative Splicing in Multiple Myeloma Is Determined By the Non-Homologous End Joining Pathway

Enze Liu, Nathan Becker, Parvathi Sudha, Chuanpeng Dong, Yunlong Liu, Jonathan J Keats, Gareth J. Morgan, Brian A. Walker
Journal: Blood
Blood (2022) 140 (Supplement 1): 4259–4260.
https://doi.org/10.1182/blood-2022-167322
Published: 2022
Journal Articles

The Pre-Existing T Cell Landscape Is Associated with Response to High Dose Melphalan and Autologous Stem Cell Transplant in Multiple Myeloma

Mohammad Issam Abu Zaid, Parvathi Sudha, Travis S Johnson, Vivek S. Chopra, Cedric E. Dos Santos, Michael Nixon, Attaya Suvannasankha, Sherif S Farag, Kelvin P. Lee, Rafat Abonour, Brian A. Walker
Journal: Blood
Blood (2022) 140 (Supplement 1): 9919–9920.
https://doi.org/10.1182/blood-2022-167619
Published: 2022
Journal Articles

Variability in Pattern of Mutational Signatures in Multiple Myeloma As a Function of Racial Origin

Patrick Blaney, Eileen M Boyle, Kylee H Maclachlan, Louis S. Williams, Dylan Gagler, Parvathi Sudha, Alexandra M Poos, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, David Coffey, Benjamin Diamond, Bachisio Ziccheddu, Dickran Kazandjian, Urvi A Shah, Elizabeth E. Brown, Elisabet E. Manasanch, Alexander M Lesokhin, Niels Weinhold, Brian A. Walker, Saad Usmani, Ola Landgren, Faith E Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 430–432.
https://doi.org/10.1182/blood-2022-167390
Published: 2022
Journal Articles

The Impact of Autologous Stem Cell Transplantation on the Genetics of High-Risk Relapsed Multiple Myeloma

Mohamed Shahin, Charlotte Pawlyn, Niels Weinhold, Timothy Cody Ashby, Brian A. Walker, Christopher P. Wardell, David Cairns, Tom Menzies, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Mark T Drayson, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan, John R Jones
Journal: Blood
Blood (2022) 140 (Supplement 1): 4232–4233.
https://doi.org/10.1182/blood-2022-169628
Published: 2022
Journal Articles

Single Cell Multiomic Analysis Reveals Relapsed and Refractory Multiple Myeloma Cells Associated with 1q, TP53 , and PHF19 alterations That Affect Subclonal Chromatin Accessibility

Travis S Johnson, Parvathi Sudha, Enze Liu, Vivek S. Chopra, Cedric E. Dos Santos, Michael Nixon, Kun Huang, Rafat Abonour, Mohammad Issam Abu Zaid, Brian A. Walker
Journal: Blood
Blood (2022) 140 (Supplement 1): 598–599.
https://doi.org/10.1182/blood-2022-167301
Published: 2022
Journal Articles

Individualized Treatment-Adjusted Risk Stratification in Newly Diagnosed Multiple Myeloma

Francesco Maura, Arjun Raj Rajanna, Andriy Derkach, Bachisio Ziccheddu, Niels Weinhold, Kylee H Maclachlan, Benjamin Diamond, Faith E. Davies, Eileen Boyle, Brian A. Walker, Alexandra M Poos, Malin Hultcrantz, Ariosto Siqueira Silva, Oliver Hampton, Jamie Teer, Niccolò Bolli, Graham Jackson, Martin F. Kaiser, Charlotte Pawlyn, Gordon Cook, Dennis Verducci, Dickran Kazandjian, Frits van Rhee, Saad Usmani, Ken H. Shain, Marc S Raab, Gareth J. Morgan, Ola Landgren
Journal: Blood
Blood (2022) 140 (Supplement 1): 1561–1563.
https://doi.org/10.1182/blood-2022-160215
Published: 2022
Journal Articles

Structural Heterogeneity of Chromosome 1q Drives Outcome in Newly Diagnoses Myeloma

Eileen M Boyle, Patrick Blaney, James Stoeckle, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, Lydia Montes, Jill Corre, Even H Rustad, Ola Landgren, Francesco Maura, Benedetto Bruno, Aristotelis Tsirigos, Brian A. Walker, Faith E Davies, Dylan Gagler, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 4253–4254.
https://doi.org/10.1182/blood-2022-165467
Published: 2022
Journal Articles

Multiomics Analysis of IMiD/CELMoD Resistant Multiple Myeloma Models Uncovers Novel and Targetable Vulnerabilities in the SREBP Lipid Synthesis Pathway

Sarah A. Bird, Amy Barber, Fernando J. Sialana, Marco P. Licciardello, Harvey Che, Habib Bouguenina, Yura Grabovska, Enze Liu, Yakinthi Chrisochoidou, Shannon Martin, Jyoti Choudhary, Brian A. Walker, Ian Collins, Paul Clarke, Charlotte Pawlyn
Journal: Blood
Blood (2022) 140 (Supplement 1): 600–601.
https://doi.org/10.1182/blood-2022-166444
Published: 2022
Journal Articles

Patient Derived Xenografts Highlight Mouse-Specific Tumor Evolution Patterns and Genomic Diversity of Multiple Myeloma

Nathan Becker, Enze Liu, Parvathi Sudha, Aneta Mikulasova, Travis S Johnson, Attaya Suvannasankha, Mohammad Issam Abu Zaid, Rafat Abonour, Brian A. Walker
Journal: Blood
Blood (2022) 140 (Supplement 1): 9970–9971.
https://doi.org/10.1182/blood-2022-157086
Published: 2022
Journal Articles

Hispanic or Latin American Ancestry Is Associated with a Similar Genomic Profile and a Trend Toward Inferior Outcomes in Newly Diagnosed Multiple Myeloma As Compared to Non-Hispanic White Patients in the Multiple Myeloma Research Foundation (MMRF) CoMMpassstudy

Louis Williams, Patrick Blaney, Eileen M Boyle, Hussein Ghamlouch, Yubao Wang, Jinyoung Choi, Michael A Bauer, Ariel Siegel, James Stoeckle, Beatrice Razzo, Daniel Auclair, David Kaminetzky, Marc Braunstein, Benedetto Bruno, Arnaldo A. Arbini, Brian A Walker, Faith E. Davies, Gareth J Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 4117.
https://doi.org/10.1182/blood-2021-148854
Published: 2021
Journal Articles

The Impact of gain1q on Mutational Structure and Clonal Evolution in a Uniformly Treated High-Risk Series of Patients at First Relapse

John R Jones, Charlotte Pawlyn, Niels Weinhold, Timothy Cody Ashby, Brian A Walker, Christopher P. Wardell, David Cairns, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Mark T Drayson, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2683.
https://doi.org/10.1182/blood-2021-152123
Published: 2021
Journal Articles

The Alternative Splicing Landscape in Multiple Myeloma Is Determined By IGH Translocations and Mutations of RNA Processing Genes

Enze Liu, Sabine Wenzel, Brian A Walker
Journal: Blood
Blood (2021) 138 (Supplement 1): 2689.
https://doi.org/10.1182/blood-2021-153113
Published: 2021
Journal Articles

A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma

Parvathi Sudha, Aarif Ahsan, Akhil Khera, Mohammad H Kazeroun, Tasneem Kausar, Lin Wang, Mirian Angulo Salazar, Evelyn Fitzsimons, Outi Salminen, Timothy Cody Ashby, Patrick Blaney, Magdalena Czader, Gail Vance, Jon Williams, Mohammad Issam Abu Zaid, Karthik Ramasamy, Kwee Yong, Gareth J. Morgan, Frits van Rhee, Rafat Abonour, Erin Flynt, Naser Ansari-Pour, Sarah Gooding, Anjan Thakurta, Brian A Walker
Journal: Blood
Blood (2021) 138 (Supplement 1): 2676.
https://doi.org/10.1182/blood-2021-148692
Published: 2021