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Journal Articles

Chromothripsis drives high-risk multiple myeloma by copy number abnormalities and rewiring the epigenome to activate oncogenic programs.

Enze Liu, Nathan Becker, Sreejeta Mondal, Attaya Suvannasankha, David Coffey, Benjamin Diamond, Abhishek Pandey, Kelvin Lee, Dickran Kazandjian, Rafat Abonour, Aneta Mikulasova, Gareth Morgan, Ola Landgren, Brian Walker

Blood (2025) 146 (Supplement 1): 5693.

https://doi.org/10.1182/blood-2025-5693

Published: 2025

Journal Articles

Cyclin D1 beyond the cell cycle: A new role in t(11;14) multiple myeloma

Blood (2025) 146 (Supplement 1): 3939.

https://doi.org/10.1182/blood-2025-3939

Published: 2025

Journal Articles

Multiomic evidence of coordinated complex rearrangements, enhancer hijacking, and epigenomic signatures in the first whole-chromosome-phased myeloma genomes

Nathan Becker, Enze Liu, Zackary Sanborn, Attaya Suvannasankha, Kelvin Lee, Dickran Kazandjian, James Hoffman, Benjamin Diamond, Abhishek Pandey, Rafat Abonour, Ola Landgren, Lisa Munding, Aneta Mikulasova, Brian Walker

Blood (2025) 146 (Supplement 1): 3928.

https://doi.org/10.1182/blood-2025-3928

Published: 2025

Journal Articles

Characterization of multiple myeloma genomes with LinkPrep™ assay enables sensitive detection of somatic variation and SV-driven interactions of the 3D genome.

Nathan Becker, Enze Liu, Alexander Fortuna, Jonathon Torchia, Aneta Mikulasova, Zackary Sanborn, Lisa Munding, Brian Walker

Blood (2025) 146 (Supplement 1): 6775.

https://doi.org/10.1182/blood-2025-6775

Published: 2025

Journal Articles

Mutationally Enriched Regions of the Non-Coding Genome Harbor Functionally Impactful Mutations That Dysregulate Key Genes Involved in Multiple Myeloma Pathogenesis

Blood (2024) 144 (Supplement 1): 4655.

https://doi.org/10.1182/blood-2024-211012

Published: 2024

Journal Articles

Reconstructing Catastrophic Chromothripsis Events Using Multiomic Data Reveals Their Functional Impact in Multiple Myeloma

Enze Liu, Nathan Becker, Parvathi Sudha, Aneta Mikulasova, Rafat Abonour, Brian A. Walker

Blood (2024) 144 (Supplement 1): 4644.

https://doi.org/10.1182/blood-2024-205167

Published: 2024

Journal Articles

Phylogenetic Analysis Reveals Distinct Evolutionary Patterns in Multiple Myeloma Patient Derived Xenografts

Nathan Becker, Enze Liu, Parvathi Sudha, Riya Sharma, Travis Johnson, Aneta Mikulasova, Rafat Abonour, Brian A. Walker

Blood (2024) 144 (Supplement 1): 1882.

https://doi.org/10.1182/blood-2024-203953

Published: 2024

Journal Articles

Multiomics Data Integration in the Complete Myeloma Genome Reveals Frequent Centromeric Rearrangements and Their Epigenomic Consequences

Aneta Mikulasova, Enze Liu, Nathan Becker, Parvathi Sudha, Rafat Abonour, Brian A. Walker

Blood (2024) 144 (Supplement 1): 768.

https://doi.org/10.1182/blood-2024-200043

Published: 2024

Journal Articles

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Blood (2023) 142 (Supplement 1): 1401.

https://doi.org/10.1182/blood-2023-190473

Published: 2023

Journal Articles

Unraveling Diverse Mechanisms of Complex Structural Variant Interactions through Multiomic Data in Multiple Myeloma

Enze Liu, Nathan Becker, Parvathi Sudha, Aneta Mikulasova, Mohammad Abu Zaid, Attaya Suvannasankha, Kelvin P. Lee, Rafat Abonour, Brian A. Walker

Blood (2023) 142 (Supplement 1): 641.

https://doi.org/10.1182/blood-2023-186262

Published: 2023

Journal Articles

Patient Derived Xenografts Highlight Mouse-Specific Tumor Evolution Patterns and Genomic Diversity of Multiple Myeloma

Nathan Becker, Enze Liu, Parvathi Sudha, Aneta Mikulasova, Travis S Johnson, Attaya Suvannasankha, Mohammad Issam Abu Zaid, Rafat Abonour, Brian A. Walker

Blood (2022) 140 (Supplement 1): 9970–9971.

https://doi.org/10.1182/blood-2022-157086

Published: 2022

Journal Articles

Whole-Genome Sequencing Reveals Evidence of Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Myeloma Precursor Disease

Blood (2020) 136 (Supplement 1): 47–48.

https://doi.org/10.1182/blood-2020-136403

Published: 2020

Journal Articles

Germline TET2 loss of function causes childhood immunodeficiency and lymphoma

Blood (2020) 136 (9): 1055–1066.

https://doi.org/10.1182/blood.2020005844

Published: 2020

Includes: Supplemental data

Journal Articles

Chromothripsis and Chromoplexy Are Associated with DNA Instability and Adverse Clinical Outcome in Multiple Myeloma

Blood (2018) 132 (Supplement 1): 408.

https://doi.org/10.1182/blood-2018-99-117359

Published: 2018

Journal Articles

MYC Rearrangements in Multiple Myeloma Are Complex, Can Involve More Than Five Different Chromosomes, and Correlate with Increased Expression of MYC and a Distinct Downstream Gene Expression Pattern

Aneta Mikulasova, PhD, Cody Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Michael Bauer, PhD, Konstantimos Mavrommatis, PhD, Christopher P. Wardell, PhD, Matthew Trotter, PhD, Shayu Deshpande, Owen W. Stephens, Erming Tian, PhD MBA, Graham Jackson, Faith E. Davies, MD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD

Blood (2017) 130 (Supplement 1): 65.

https://doi.org/10.1182/blood.V130.Suppl_1.65.65

Published: 2017

Journal Articles

Whole Exome Sequencing of Plasma Cells Precancerosis MGUS and Malignant AL Amyloidosis Reveals Small Number of Shared Mutated Genes

Zuzana Kufova, Katerina Growkova, Petr Vojta, MSc, Jana Filipova, Michal Simicek, PhD, Tomas Jelinek, Martina Zatopkova, Sebastian Grosicki, MD PhD, Aneta Mikulasova, PhD, Marian Hajduch, MD PhD, Ludek Pour, Doc,MD PhD, Martin Stork, MD, Tereza Sevcikova, PhD, Roman Hajek

Blood (2017) 130 (Supplement 1): 4364.

https://doi.org/10.1182/blood.V130.Suppl_1.4364.4364

Published: 2017

Journal Articles

Whole Genome Sequencing Reveals the Extent of Structural Variants in Multiple Myeloma and Identifies Recurrent Mutational Hotspots within the Non-Coding Regions

Cody Cody Ashby, PhD, Michael Bauer, PhD, Owen W. Stephens, Christopher P. Wardell, PhD, Ruslana G. Tytarenko, MS, Aneta Mikulasova, PhD, Purvi Patel, Shayu Deshpande, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Niels Weinhold, PhD, Leo Rasche, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD

Blood (2017) 130 (Supplement 1): 3032.

https://doi.org/10.1182/blood.V130.Suppl_1.3032.3032

Published: 2017

Journal Articles

Prediction of Progression of Smouldering into Therapy Requiring Multiple Myeloma By Easily Accessible Clinical Factors [in 527 Patients]

Blood (2014) 124 (21): 2071.

https://doi.org/10.1182/blood.V124.21.2071.2071

Published: 2014

Journal Articles

Exome Sequencing to Define a Genetic Signature of Plasma Cells in Systemic AL Amyloidosis

Eileen M Boyle, MD, Brian A Walker, PhD, Dorota Rowczienio, MSc, Christopher P Wardell, PhD, Alexander Murison, PhD, Aneta Mikulasova, M.Sc., Sajitha Sachchithanantham, BSc,MBBS,MRCP,FRCPath,, Anna Baginska, Shameem Mahmood, MRCP. FRCPath, Julian D Gillmore, Helen J Lachmann, MD FRCP, Philip N Hawkins, MD FRCP, FMedSci, Xavier Leleu, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Ashutosh Wechalekar, MDFRCPath

Blood (2014) 124 (21): 726.

https://doi.org/10.1182/blood.V124.21.726.726

Published: 2014

Journal Articles

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

Blood (2014) 124 (21): 637.

https://doi.org/10.1182/blood.V124.21.637.637

Published: 2014

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Chromothripsis drives high-risk multiple myeloma by copy number abnormalities and rewiring the epigenome to activate oncogenic programs.

Cyclin D1 beyond the cell cycle: A new role in t(11;14) multiple myeloma

Multiomic evidence of coordinated complex rearrangements, enhancer hijacking, and epigenomic signatures in the first whole-chromosome-phased myeloma genomes

Characterization of multiple myeloma genomes with LinkPrep™ assay enables sensitive detection of somatic variation and SV-driven interactions of the 3D genome.

Mutationally Enriched Regions of the Non-Coding Genome Harbor Functionally Impactful Mutations That Dysregulate Key Genes Involved in Multiple Myeloma Pathogenesis

Reconstructing Catastrophic Chromothripsis Events Using Multiomic Data Reveals Their Functional Impact in Multiple Myeloma

Phylogenetic Analysis Reveals Distinct Evolutionary Patterns in Multiple Myeloma Patient Derived Xenografts

Multiomics Data Integration in the Complete Myeloma Genome Reveals Frequent Centromeric Rearrangements and Their Epigenomic Consequences

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Unraveling Diverse Mechanisms of Complex Structural Variant Interactions through Multiomic Data in Multiple Myeloma

Patient Derived Xenografts Highlight Mouse-Specific Tumor Evolution Patterns and Genomic Diversity of Multiple Myeloma

Whole-Genome Sequencing Reveals Evidence of Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Myeloma Precursor Disease

Germline TET2 loss of function causes childhood immunodeficiency and lymphoma

Chromothripsis and Chromoplexy Are Associated with DNA Instability and Adverse Clinical Outcome in Multiple Myeloma

MYC Rearrangements in Multiple Myeloma Are Complex, Can Involve More Than Five Different Chromosomes, and Correlate with Increased Expression of MYC and a Distinct Downstream Gene Expression Pattern

Whole Exome Sequencing of Plasma Cells Precancerosis MGUS and Malignant AL Amyloidosis Reveals Small Number of Shared Mutated Genes

Whole Genome Sequencing Reveals the Extent of Structural Variants in Multiple Myeloma and Identifies Recurrent Mutational Hotspots within the Non-Coding Regions

Prediction of Progression of Smouldering into Therapy Requiring Multiple Myeloma By Easily Accessible Clinical Factors [in 527 Patients]

Exome Sequencing to Define a Genetic Signature of Plasma Cells in Systemic AL Amyloidosis

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

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